冻干微流控单分散微泡作为新一代超声造影剂
Freeze-dried microfluidic monodisperse microbubbles as a new generation of ultrasound contrast agents
摘要：
在本文中，我们成功地冷冻干燥单分散微泡，而不降低其尺寸和声学性能。我们使用微流控技术来产生高度单分散（变异系数，CV<5%）的微泡，并优化它们的配方以及冷冻保护剂。通过使用特定的技术检索的气泡，我们表明，冷冻干燥的微泡不改变其尺寸分布。为了比较气泡的基本共振特性，我们进行了背散射声学特性测量。我们的实验结果表明，冷冻干燥过程中保存的气泡的声学特性。新鲜和冷冻干燥的单分散PVA气泡的最大后向散射功率振幅比体外相似浓度的SonoVue高约108倍。通过解决单分散气泡的储存和运输问题，我们的工作促进了它们在UCA领域的渗透，用于执行新的任务和开发新的非侵入性测量，如压力，现有的商业化气泡无法访问。
英文摘要：
In the paper, we succeeded to freeze-dry monodisperse microbubbles without degrading their size and acoustic properties. We used microfluidic technology to generate highly monodisperse (coefficient of variation, CV<5%) microbubbles and optimized their formulation along with a cryoprotectant. By using a specific technique of retrieval of the bubble, we showed that freeze-drying the microbubbles does not alter their size distribution. To compare the fundamental resonance properties of the bubbles, we performed backscattered acoustic characterization measurements. Our experimental results revealed that the freeze-drying process conserved the acoustic properties of the bubbles. The maximum backscattering power amplitude of fresh and freeze-dried monodisperse PVA bubbles was around ten eight times higher than that of SonoVue at a similar concentration in vitro. By solving the question of storage and transportation of monodisperse bubbles, our work facilitates their penetration in the domain of UCAs, for performing new tasks and developing novel non-invasive measurements, such as pressure, unaccessible to the existing commercialized bubbles.
机构、总结、中文摘要均由AI分析而来，可能存在错误，请以论文正文为准。
