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arXiv 2104.14525stat.ME
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聚类信号的检测与估计

Testing and estimation of clustered signals

Hongyuan Cao, Wei Biao Wu

摘要:

针对大规模多重检验问题,提出了一种变点检测方法。与经典的变点设置不同,信号在一个集群中的大小可以不同。信号上的聚类结构使我们能够有效地描绘信号和非信号段之间的边界。新的检验统计量提出了一个和/或多个实现的观察。导出了它们的渐近分布。我们还研究了相关的方差估计问题。我们允许的方差是异方差的多个实现的情况下,这大大扩展了所提出的方法的适用性。仿真研究表明,该方法具有良好的性能。我们的程序被应用到{基于阵列的比较基因组杂交(aCGH)}数据集。

英文摘要:

We propose a change-point detection method for large scale multiple testing problems with data having clustered signals. Unlike the classic change-point setup, the signals can vary in size within a cluster. The clustering structure on the signals enables us to effectively delineate the boundaries between signal and non-signal segments. New test statistics are proposed for observations from one and/or multiple realizations. Their asymptotic distributions are derived. We also study the associated variance estimation problem. We allow the variances to be heteroscedastic in the multiple realization case, which substantially expands the applicability of the proposed method. Simulation studies demonstrate that the proposed approach has a favorable performance. Our procedure is applied to {an array based Comparative Genomic Hybridization (aCGH)} dataset.

机构、总结、中文摘要均由AI分析而来,可能存在错误,请以论文正文为准。

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