Convolutional neural networks are showing promise in the automatic diagnosis of thoracic pathologies on chest x-rays. Their black-box nature has sparked many recent works to explain the prediction via input feature attribution methods (aka saliency methods). However, input feature attribution methods merely identify the importance of input regions for the prediction and lack semantic interpretation of model behavior. In this work, we first identify the semantics associated with internal units (feature maps) of the network. We proceed to investigate the following questions; Does a regression model that is only trained with COVID-19 severity scores implicitly learn visual patterns associated with thoracic pathologies? Does a network that is trained on weakly labeled data (e.g. healthy, unhealthy) implicitly learn pathologies? Moreover, we investigate the effect of pretraining and data imbalance on the interpretability of learned features. In addition to the analysis, we propose semantic attribution to semantically explain each prediction. We present our findings using publicly available chest pathologies (CheXpert, NIH ChestX-ray8) and COVID-19 datasets (BrixIA, and COVID-19 chest X-ray segmentation dataset). The Code is publicly available.
Technical University of Munich（慕尼黑工业大学）；Kyung Hee University（庆熙大学）；Johns Hopkins University（约翰斯·霍普金斯大学）
Neural networks have demonstrated remarkable performance in classification and regression tasks on chest X-rays. In order to establish trust in the clinical routine, the networks' prediction mechanism needs to be interpretable. One principal approach to interpretation is feature attribution. Feature attribution methods identify the importance of input features for the output prediction. Building on Information Bottleneck Attribution (IBA) method, for each prediction we identify the chest X-ray regions that have high mutual information with the network's output. Original IBA identifies input re…
Instance level detection of thoracic diseases or abnormalities are crucial for automatic diagnosis in chest X-ray images. Most existing works on chest X-rays focus on disease classification and weakly supervised localization. In order to push forward the research on disease classification and localization on chest X-rays. We provide a new benchmark called ChestX-Det10, including box-level annotations of 10 categories of disease/abnormality of $\sim$ 3,500 images. The annotations are located at https://github.com/Deepwise-AILab/ChestX-Det10-Dataset.
Radboud University Medical Center（拉德堡德大学医学中心）；Meander Medical Center（米安德医疗中心）；Jewish National Health（犹太国家健康中心）
Chronic Obstructive Pulmonary Disease (COPD) is a leading cause of morbidity and mortality. While COPD diagnosis is based on lung function tests, early stages and progression of different aspects of the disease can be visible and quantitatively assessed on computed tomography (CT) scans. Many studies have been published that quantify imaging biomarkers related to COPD. In this paper we present a convolutional neural network that directly computes visual emphysema scores and predicts the outcome of lung function tests for 195 CT scans from the COPDGene study. Contrary to previous work, the prop…
Diagnosis of COVID-19 at point of care is vital to the containment of the global pandemic. Point of care ultrasound (POCUS) provides rapid imagery of lungs to detect COVID-19 in patients in a repeatable and cost effective way. Previous work has used public datasets of POCUS videos to train an AI model for diagnosis that obtains high sensitivity. Due to the high stakes application we propose the use of robust and explainable techniques. We demonstrate experimentally that robust models have more stable predictions and offer improved interpretability. A framework of contrastive explanations based…
Deep Reinforcement Learning Framework for Thoracic Diseases Classification via Prior Knowledge Guidance
Tianjin University（天津大学）；Tianjin Medical University General Hospital（天津医科大学总医院）；Chest Hospital, Tianjin University（天津大学胸科医院）；Tianjin Medical University（天津医科大学）；Tianjin Institute of Anesthesiology（天津麻醉学研究所）
Perceptra Co., Ltd.（Perceptra有限公司）；Mahidol University（玛希隆大学）；King Mongkut’s University of Technology Thonburi（国王科技大学吞武里分校）
Despite much promising research in the area of artificial intelligence for medical image diagnosis, there has been no large-scale validation study done in Thailand to confirm the accuracy and utility of such algorithms when applied to local datasets. Here we present a wide-reaching development and testing of a deep learning algorithm for automated thoracic disease detection, utilizing 421,859 local chest radiographs. Our study shows that convolutional neural networks can achieve remarkable performance in detecting 13 common abnormality conditions on chest X-ray, and the incorporation of local …
There are multiple papers published about different AI models for the COVID-19 diagnosis with promising results. Unfortunately according to the reviews many of the papers do not reach the level of sophistication needed for a clinically usable model. In this paper I go through multiple review papers, guidelines, and other relevant material in order to generate more comprehensive requirements for the future papers proposing a AI based diagnosis of the COVID-19 from chest X-ray data (CXR). Main findings are that a clinically usable AI needs to have an extremely good documentation, comprehensive s…
Radiological image is currently adopted as the visual evidence for COVID-19 diagnosis in clinical. Using deep models to realize automated infection measurement and COVID-19 diagnosis is important for faster examination based on radiological imaging. Unfortunately, collecting large training data systematically in the early stage is difficult. To address this problem, we explore the feasibility of learning deep models for COVID-19 diagnosis from a single radiological image by resorting to synthesizing diverse radiological images. Specifically, we propose a novel conditional generative model, cal…
We introduce a new dataset called Synthetic COVID-19 Chest X-ray Dataset for training machine learning models. The dataset consists of 21,295 synthetic COVID-19 chest X-ray images to be used for computer-aided diagnosis. These images, generated via an unsupervised domain adaptation approach, are of high quality. We find that the synthetic images not only improve performance of various deep learning architectures when used as additional training data under heavy imbalance conditions, but also detect the target class with high confidence. We also find that comparable performance can also be achi…
Shahid Beheshti University of Medical Sciences（沙希德·贝赫什提医科大学）；Student Research Committee（学生研究委员会）；School of Allied Medical Science（Allied Medical Science学院）；Department of Health Information Technology and Management（卫生信息技术与管理系）
Purpose: Early detection and diagnosis of Covid-19 and accurate separation of patients with non-Covid-19 cases at the lowest cost and in the early stages of the disease are one of the main challenges in the epidemic of Covid-19. Concerning the novelty of the disease, the diagnostic methods based on radiological images suffer shortcomings despite their many uses in diagnostic centers. Accordingly, medical and computer researchers tended to use machine-learning models to analyze radiology images. Methods: Present systematic review was conducted by searching three databases of PubMed, Scopus, and…
Dr. Babasaheb Ambedkar Technological University（巴巴萨海布·安贝德卡尔技术大学）；Chitkara University（奇卡拉大学）；Pravara Rural Engineering College（普拉瓦拉农村工程学院）；Sri Guru Granth Sahib World University（圣古鲁格兰特 sahib 世界大学）
The aim of the work is to use deep neural network models for solving the problem of image recognition. These days, every human being is threatened by a harmful coronavirus disease, also called COVID-19 disease. The spread of coronavirus affects the economy of many countries in the world. To find COVID-19 patients early is very essential to avoid the spread and harm to society. Pathological tests and Chromatography(CT) scans are helpful for the diagnosis of COVID-19. However, these tests are having drawbacks such as a large number of false positives, and cost of these tests are so expensive. He…
This paper presents a novel lightweight COVID-19 diagnosis framework using CT scans. Our system utilises a novel two-stage approach to generate robust and efficient diagnoses across heterogeneous patient level inputs. We use a powerful backbone network as a feature extractor to capture discriminative slice-level features. These features are aggregated by a lightweight network to obtain a patient level diagnosis. The aggregation network is carefully designed to have a small number of trainable parameters while also possessing sufficient capacity to generalise to diverse variations within differ…
Maulana Azad National Institute of Technology（毛拉纳·阿扎德国家理工学院）
Automatic and rapid screening of COVID-19 from the chest X-ray images has become an urgent need in this pandemic situation of SARS-CoV-2 worldwide in 2020. However, accurate and reliable screening of patients is a massive challenge due to the discrepancy between COVID-19 and other viral pneumonia in X-ray images. In this paper, we design a new stacked convolutional neural network model for the automatic diagnosis of COVID-19 disease from the chest X-ray images. We obtain different sub-models from the VGG19 and developed a 30-layered CNN model (named as CovNet30) during the training, and obtain…
Concordia University（康考迪亚大学）；Sunnybrook Health Sciences Centre（桑尼布鲁克健康科学中心）；University of Toronto（多伦多大学）
Novel Coronavirus disease (COVID-19) has abruptly and undoubtedly changed the world as we know it at the end of the 2nd decade of the 21st century. COVID-19 is extremely contagious and quickly spreading globally making its early diagnosis of paramount importance. Early diagnosis of COVID-19 enables health care professionals and government authorities to break the chain of transition and flatten the epidemic curve. The common type of COVID-19 diagnosis test, however, requires specific equipment and has relatively low sensitivity. Computed tomography (CT) scans and X-ray images, on the other han…
University of New South Wales（新南威尔士大学）；Inception Institute of Artificial Intelligence（Inception人工智能研究院）；Stanford University（斯坦福大学）
The current pandemic, caused by the outbreak of a novel coronavirus (COVID-19) in December 2019, has led to a global emergency that has significantly impacted economies, healthcare systems and personal wellbeing all around the world. Controlling the rapidly evolving disease requires highly sensitive and specific diagnostics. While real-time RT-PCR is the most commonly used, these can take up to 8 hours, and require significant effort from healthcare professionals. As such, there is a critical need for a quick and automatic diagnostic system. Diagnosis from chest CT images is a promising direct…
Coronavirus disease 2019 (COVID-19) is a Public Health Emergency of International Concern infecting more than 40 million people across 188 countries and territories. Chest computed tomography (CT) imaging technique benefits from its high diagnostic accuracy and robustness, it has become an indispensable way for COVID-19 mass testing. Recently, deep learning approaches have become an effective tool for automatic screening of medical images, and it is also being considered for COVID-19 diagnosis. However, the high infection risk involved with COVID-19 leads to relative sparseness of collected la…
Concordia Institute for Information Systems Engineering (CIISE)（康考迪亚信息系统工程研究所）；Concordia University（康考迪亚大学）；Sunnybrook Health Sciences Centre（森尼布鲁克健康科学中心）；University of Toronto（多伦多大学）；McGill University Health Center-Research Institute（麦吉尔大学健康中心研究所）；University of Calgary（卡尔加里大学）
The novel Coronavirus disease, COVID-19, has rapidly and abruptly changed the world as we knew in 2020. It becomes the most unprecedent challenge to analytic epidemiology in general and signal processing theories in specific. Given its high contingency nature and adverse effects across the world, it is important to develop efficient processing/learning models to overcome this pandemic and be prepared for potential future ones. In this regard, medical imaging plays an important role for the management of COVID-19. Human-centered interpretation of medical images is, however, tedious and can be s…
University of New South Wales（新南威尔士大学）；The Commonwealth Scientific and Industrial Research Organisation (CSIRO)（联邦科学与工业研究组织（CSIRO））
Coronavirus Disease 2019 (COVID-19) has spread globally and become a health crisis faced by humanity since first reported. Radiology imaging technologies such as computer tomography (CT) and chest X-ray imaging (CXR) are effective tools for diagnosing COVID-19. However, in CT and CXR images, the infected area occupies only a small part of the image. Some common deep learning methods that integrate large-scale receptive fields may cause the loss of image detail, resulting in the omission of the region of interest (ROI) in COVID-19 images and are therefore not suitable for further processing. To…
The infection of respiratory coronavirus disease 2019 (COVID-19) starts with the upper respiratory tract and as the virus grows, the infection can progress to lungs and develop pneumonia. The conventional way of COVID-19 diagnosis is reverse transcription polymerase chain reaction (RT-PCR), which is less sensitive during early stages; especially if the patient is asymptomatic, which may further cause more severe pneumonia. In this context, several deep learning models have been proposed to identify pulmonary infections using publicly available chest X-ray (CXR) image datasets for early diagnos…
University of Waterloo（滑铁卢大学）；University of Calgary（卡尔加里大学）
Novel coronavirus (COVID-19) outbreak, has raised a calamitous situation all over the world and has become one of the most acute and severe ailments in the past hundred years. The prevalence rate of COVID-19 is rapidly rising every day throughout the globe. Although no vaccines for this pandemic have been discovered yet, deep learning techniques proved themselves to be a powerful tool in the arsenal used by clinicians for the automatic diagnosis of COVID-19. This paper aims to overview the recently developed systems based on deep learning techniques using different medical imaging modalities l…
Recently, the coronavirus disease 2019 (COVID-19) has caused a pandemic disease in over 200 countries, influencing billions of humans. To control the infection, identifying and separating the infected people is the most crucial step. The main diagnostic tool is the Reverse Transcription Polymerase Chain Reaction (RT-PCR) test. Still, the sensitivity of the RT-PCR test is not high enough to effectively prevent the pandemic. The chest CT scan test provides a valuable complementary tool to the RT-PCR test, and it can identify the patients in the early-stage with high sensitivity. However, the che…
The Coronavirus disease 2019 (COVID-19) was first identified in Wuhan, China, in early December 2019 and now becoming a pandemic. When COVID-19 patients undergo radiography examination, radiologists can observe the present of radiographic abnormalities from their chest X-ray (CXR) images. In this study, a deep convolutional neural network (CNN) model was proposed to aid radiologists in diagnosing COVID-19 patients. First, this work conducted a comparative study on the performance of modified VGG-16, ResNet-50 and DenseNet-121 to classify CXR images into normal, COVID-19 and viral pneumonia. Th…
The University of Sydney（悉尼大学）；Shanghai Jiao Tong University（上海交通大学）；Shandong First Medical University（山东第一医科大学）；Shandong Academy of Medical Sciences（山东省医学科学院）；Shandong Cancer Hospital and Institute（山东省肿瘤医院）
There is an urgent need for automated methods to assist accurate and effective assessment of COVID-19. Radiology and nucleic acid test (NAT) are complementary COVID-19 diagnosis methods. In this paper, we present an end-to-end multitask learning (MTL) framework (COVID-MTL) that is capable of automated and simultaneous detection (against both radiology and NAT) and severity assessment of COVID-19. COVID-MTL learns different COVID-19 tasks in parallel through our novel random-weighted loss function, which assigns learning weights under Dirichlet distribution to prevent task dominance; our new 3D…
Coronavirus disease (COVID-19) is a contagious infection caused by severe acute respiratory syndrome coronavirus-2 (SARS-COV-2) and it has infected and killed millions of people across the globe. In the absence of specific drugs or vaccines for the treatment of COVID-19 and the limitation of prevailing diagnostic techniques, there is a requirement for some alternate automatic screening systems that can be used by the physicians to quickly identify and isolate the infected patients. A chest X-ray (CXR) image can be used as an alternative modality to detect and diagnose the COVID-19. In this stu…
The novel coronavirus 2019 (COVID-19) is a respiratory syndrome that resembles pneumonia. The current diagnostic procedure of COVID-19 follows reverse-transcriptase polymerase chain reaction (RT-PCR) based approach which however is less sensitive to identify the virus at the initial stage. Hence, a more robust and alternate diagnosis technique is desirable. Recently, with the release of publicly available datasets of corona positive patients comprising of computed tomography (CT) and chest X-ray (CXR) imaging; scientists, researchers and healthcare experts are contributing for faster and autom…
University of Science and Technology of China（中国科学技术大学）；Huawei（华为）
Early detection of the coronavirus disease 2019 (COVID-19) helps to treat patients timely and increase the cure rate, thus further suppressing the spread of the disease. In this study, we propose a novel deep learning based detection and similar case recommendation network to help control the epidemic. Our proposed network contains two stages: the first one is a lung region segmentation step and is used to exclude irrelevant factors, and the second is a detection and recommendation stage. Under this framework, in the second stage, we develop a dual-children network (DuCN) based on a pre-traine…
RADLogics；Tel-Aviv University（特拉维夫大学）；Affiliated Taizhou Hospital of Wenzhou Medical University（温州医科大学附属台州医院）；Mount Sinai Hospital（西奈山医院）；University of Maryland School of Medicine（马里兰大学医学院）
Purpose: Develop AI-based automated CT image analysis tools for detection, quantification, and tracking of Coronavirus; demonstrate they can differentiate coronavirus patients from non-patients. Materials and Methods: Multiple international datasets, including from Chinese disease-infected areas were included. We present a system that utilizes robust 2D and 3D deep learning models, modifying and adapting existing AI models and combining them with clinical understanding. We conducted multiple retrospective experiments to analyze the performance of the system in the detection of suspected COVID-…
Christian Brothers University（基督教兄弟大学）；University of Dayton（代顿大学）
With a Coronavirus disease (COVID-19) case count exceeding 10 million worldwide, there is an increased need for a diagnostic capability. The main variables in increasing diagnostic capability are reduced cost, turnaround or diagnosis time, and upfront equipment cost and accessibility. Two candidates for machine learning COVID-19 diagnosis are Computed Tomography (CT) scans and plain chest X-rays. While CT scans score higher in sensitivity, they have a higher cost, maintenance requirement, and turnaround time as compared to plain chest X-rays. The use of portable chest X-radiograph (CXR) is rec…
Emory School of Medicine（埃默里医学院）；MentorGraphics Indian Pvt. Ltd.（MentorGraphics印度私人有限公司）；K. N. Toosi University of Technology（K.N.托西理工大学）；EMORY Hospital（埃默里医院）
Purpose: Since the recent COVID-19 outbreak, there has been an avalanche of research papers applying deep learning based image processing to chest radiographs for detection of the disease. To test the performance of the two top models for CXR COVID-19 diagnosis on external datasets to assess model generalizability. Methods: In this paper, we present our argument regarding the efficiency and applicability of existing deep learning models for COVID-19 diagnosis. We provide results from two popular models - COVID-Net and CoroNet evaluated on three publicly available datasets and an additional ins…
One of the critical tools for early detection and subsequent evaluation of the incidence of lung diseases is chest radiography. This study presents a real-world implementation of a convolutional neural network (CNN) based Carebot Covid app to detect COVID-19 from chest X-ray (CXR) images. Our proposed model takes the form of a simple and intuitive application. Used CNN can be deployed as a STOW-RS prediction endpoint for direct implementation into DICOM viewers. The results of this study show that the deep learning model based on DenseNet and ResNet architecture can detect SARS-CoV-2 from CXR …
COVID-19, due to its accelerated spread has brought in the need to use assistive tools for faster diagnosis in addition to typical lab swab testing. Chest X-Rays for COVID cases tend to show changes in the lungs such as ground glass opacities and peripheral consolidations which can be detected by deep neural networks. However, traditional convolutional networks use point estimate for predictions, lacking in capture of uncertainty, which makes them less reliable for adoption. There have been several works so far in predicting COVID positive cases with chest X-Rays. However, not much has been ex…
Stony Brook University（石溪大学）；Stony Brook University Hospital（石溪大学医院）
Significant work has been done towards deep learning (DL) models for automatic lung and lesion segmentation and classification of COVID-19 on chest CT data. However, comprehensive visualization systems focused on supporting the dual visual+DL diagnosis of COVID-19 are non-existent. We present COVID-view, a visualization application specially tailored for radiologists to diagnose COVID-19 from chest CT data. The system incorporates a complete pipeline of automatic lungs segmentation, localization/ isolation of lung abnormalities, followed by visualization, visual and DL analysis, and measuremen…
Corona virus or COVID-19 is a pandemic illness, which has influenced more than million of causalities worldwide and infected a few large number of individuals .Innovative instrument empowering quick screening of the COVID-19 contamination with high precision can be critically useful to the medical care experts. The primary clinical device presently being used for the analysis of COVID-19 is the Reverse record polymerase chain response as known as RT-PCR, which is costly, less-delicate and requires specific clinical work force. X-Ray imaging is an effectively available apparatus that can be a g…
The Coronavirus disease 2019 (COVID-19) has rapidly spread all over the world since its first report in December 2019 and thoracic computed tomography (CT) has become one of the main tools for its diagnosis. In recent years, deep learning-based approaches have shown impressive performance in myriad image recognition tasks. However, they usually require a large number of annotated data for training. Inspired by Ground Glass Opacity (GGO), a common finding in COIVD-19 patient's CT scans, we proposed in this paper a novel self-supervised pretraining method based on pseudo lesions generation and r…
Shahid Bahonar University of Kerman（克尔曼沙希德·巴霍纳尔大学）
Diagnosis of COVID-19 is necessary to prevent and control the disease. Deep learning methods have been considered a fast and accurate method. In this paper, by the parallel combination of three well-known pre-trained networks, we attempted to distinguish coronavirus-infected samples from healthy samples. The negative log-likelihood loss function has been used for model training. CT scan images in the SARS-CoV-2 dataset were used for diagnosis. The SARS-CoV-2 dataset contains 2482 images of lung CT scans, of which 1252 images belong to COVID-19-infected samples. The proposed model was close to …
Concordia University（康考迪亚大学）；University of Toronto（多伦多大学）；McGill University Health Center-Research Institute（麦吉尔大学健康中心-研究所）；Sunnybrook Health Sciences Centre（新宁健康科学中心）；University of Montreal（蒙特利尔大学）；National Cancer Institute（国家癌症研究所）
Reverse transcription-polymerase chain reaction (RT-PCR) is currently the gold standard in COVID-19 diagnosis. It can, however, take days to provide the diagnosis, and false negative rate is relatively high. Imaging, in particular chest computed tomography (CT), can assist with diagnosis and assessment of this disease. Nevertheless, it is shown that standard dose CT scan gives significant radiation burden to patients, especially those in need of multiple scans. In this study, we consider low-dose and ultra-low-dose (LDCT and ULDCT) scan protocols that reduce the radiation exposure close to tha…
Korea Advanced Institute of Science and Technology（韩国科学技术院）；Asan Medical Center（峨山医院）；University of Ulsan College of Medicine（蔚山大学医学院）；College of Medicine, Yeungnam University（岭南大学医学院）；School of Medicine, Kyungpook National University（庆北国立大学医学院）
Under the global COVID-19 crisis, developing robust diagnosis algorithm for COVID-19 using CXR is hampered by the lack of the well-curated COVID-19 data set, although CXR data with other disease are abundant. This situation is suitable for vision transformer architecture that can exploit the abundant unlabeled data using pre-training. However, the direct use of existing vision transformer that uses the corpus generated by the ResNet is not optimal for correct feature embedding. To mitigate this problem, we propose a novel vision Transformer by using the low-level CXR feature corpus that are ob…
Lung-CADex: Fully automatic Zero-Shot Detection and Classification of Lung Nodules in Thoracic CT Images
Faculty of Electronics and Electrical Engineering, University of Engineering and Technology, Taxila（塔克西拉工程技术大学电子与电气工程学院）；Center for Research in Computer Vision, University of Central Florida（中佛罗里达大学计算机视觉研究中心）；Sheikh Zayed Institute for Pediatric Surgical Innovation, Childrens National Hospital（儿童国家医院谢赫扎耶德儿科外科创新研究所）；School of Medicine and Health Sciences, George Washington University（乔治华盛顿大学医学与健康科学学院）
With the outbreak of COVID-19, a large number of relevant studies have emerged in recent years. We propose an automatic COVID-19 diagnosis framework based on lung CT scan images, the PVT-COV19D. In order to accommodate the different dimensions of the image input, we first classified the images using Transformer models, then sampled the images in the dataset according to normal distribution, and fed the sampling results into the modified PVTv2 model for training. A large number of experiments on the COV19-CT-DB dataset demonstrate the effectiveness of the proposed method.
IIIT-Delhi（印度德里信息技术学院）；IIT Jodhpur（印度焦特布尔理工学院）；Ashwini Hospital（阿什维尼医院）；Ramakant Heart Care Centre（拉马坎特心脏护理中心）；TeleRadiology Solutions（远程放射学解决方案公司）
With increasing number of COVID-19 cases globally, all the countries are ramping up the testing numbers. While the RT-PCR kits are available in sufficient quantity in several countries, others are facing challenges with limited availability of testing kits and processing centers in remote areas. This has motivated researchers to find alternate methods of testing which are reliable, easily accessible and faster. Chest X-Ray is one of the modalities that is gaining acceptance as a screening modality. Towards this direction, the paper has two primary contributions. Firstly, we present the COVID-1…
Because the infection by Severe Acute Respiratory Syndrome Coronavirus 2 (COVID-19) causes the pneumonia-like effect in the lungs, the examination of chest x-rays can help to diagnose the diseases. For automatic analysis of images, they are represented in machines by a set of semantic features. Deep Learning (DL) models are widely used to extract features from images. General deep features may not be appropriate to represent chest x-rays as they have a few semantic regions. Though the Bag of Visual Words (BoVW) based features are shown to be more appropriate for x-ray type of images, existing …
K. N. Toosi University of Technology（卡纳齐·图西科技大学）；Ferdowsi University of Mashhad（菲尔多西大学）；University of La Rioja（拉里奥哈大学）；Indian Institute of Technology Indore（印度理工学院印多尔分校）；Universidad de Granada（格拉纳达大学）
The outbreak of the corona virus disease (COVID-19) has changed the lives of most people on Earth. Given the high prevalence of this disease, its correct diagnosis in order to quarantine patients is of the utmost importance in steps of fighting this pandemic. Among the various modalities used for diagnosis, medical imaging, especially computed tomography (CT) imaging, has been the focus of many previous studies due to its accuracy and availability. In addition, automation of diagnostic methods can be of great help to physicians. In this paper, a method based on pre-trained deep neural networks…
College of Intelligence and Computing, Tianjin University（天津大学智能与计算学院）；Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology（华中科技大学同济医学院附属同济医院放射科）；Department of Radiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine（上海交通大学医学院附属瑞金医院放射科）；Department of Research and Development, Shanghai United Imaging Intelligence Co., Ltd.（上海联影智能医疗科技有限公司研发部）；Department of Radiology, China-Japan Union Hospital of Jilin University（吉林大学中日联谊医院放射科）
Recently, the outbreak of Coronavirus Disease 2019 (COVID-19) has spread rapidly across the world. Due to the large number of affected patients and heavy labor for doctors, computer-aided diagnosis with machine learning algorithm is urgently needed, and could largely reduce the efforts of clinicians and accelerate the diagnosis process. Chest computed tomography (CT) has been recognized as an informative tool for diagnosis of the disease. In this study, we propose to conduct the diagnosis of COVID-19 with a series of features extracted from CT images. To fully explore multiple features describ…
Multi-Scale Feature Fusion using Parallel-Attention Block for COVID-19 Chest X-ray Diagnosis
Rutgers Cancer Institute of New Jersey（罗格斯新泽西癌症研究所）；Rutgers Robert Wood Johnson Medical School（罗格斯罗伯特·伍德·约翰逊医学院）；The University of British Columbia（不列颠哥伦比亚大学）
National Research Council Canada（加拿大国家研究委员会）；University of Waterloo（滑铁卢大学）
Besides vaccination, as an effective way to mitigate the further spread of COVID-19, fast and accurate screening of individuals to test for the disease is yet necessary to ensure public health safety. We propose COVID-Net UV, an end-to-end hybrid spatio-temporal deep neural network architecture, to detect COVID-19 infection from lung point-of-care ultrasound videos captured by convex transducers. COVID-Net UV comprises a convolutional neural network that extracts spatial features and a recurrent neural network that learns temporal dependence. After careful hyperparameter tuning, the network ac…
Automatic lesion segmentation on thoracic CT enables rapid quantitative analysis of lung involvement in COVID-19 infections. However, obtaining a large amount of voxel-level annotations for training segmentation networks is prohibitively expensive. Therefore, we propose a weakly-supervised segmentation method based on dense regression activation maps (dRAMs). Most weakly-supervised segmentation approaches exploit class activation maps (CAMs) to localize objects. However, because CAMs were trained for classification, they do not align precisely with the object segmentations. Instead, we produce…
Manchester Metropolitan University（曼彻斯特城市大学）；Brunel University（布鲁内尔大学）；Whiston Hospital（惠斯顿医院）；St Helens and Knowsley Teaching Hospitals NHS Trust（圣海伦斯和诺斯利教学医院国民保健服务信托）；University of Sheffield（谢菲尔德大学）
Accurate and rapid detection of COVID-19 pneumonia is crucial for optimal patient treatment. Chest X-Ray (CXR) is the first line imaging test for COVID-19 pneumonia diagnosis as it is fast, cheap and easily accessible. Inspired by the success of deep learning (DL) in computer vision, many DL-models have been proposed to detect COVID-19 pneumonia using CXR images. Unfortunately, these deep classifiers lack the transparency in interpreting findings, which may limit their applications in clinical practice. The existing commonly used visual explanation methods are either too noisy or imprecise, wi…
COVID-19 has led to hundreds of millions of cases and millions of deaths worldwide since its onset. The fight against this pandemic is on-going on multiple fronts. While vaccinations are picking up speed, there are still billions of unvaccinated people. In this fight against the virus, diagnosis of the disease and isolation of the patients to prevent any spread play a huge role. Machine Learning approaches have assisted in the diagnosis of COVID-19 cases by analyzing chest X-rays and CT-scan images of patients. To push algorithm development and research in this direction of radiological diagno…
School of Computing and Information Technology, University of Wollongong（卧龙岗大学计算与信息技术学院）
The Coronavirus Disease 2019 (COVID-19) is affecting increasingly large number of people worldwide, posing significant stress to the health care systems. Early and accurate diagnosis of COVID-19 is critical in screening of infected patients and breaking the person-to-person transmission. Chest X-ray (CXR) based computer-aided diagnosis of COVID-19 using deep learning becomes a promising solution to this end. However, the diverse and various radiographic features of COVID-19 make it challenging, especially when considering each CXR scan typically only generates one single image. Data scarcity i…
Bangladesh University of Engineering and Technology（孟加拉国工程技术大学）；University of Cincinnati College of Medicine（辛辛那提大学医学院）；University of Cincinnati（辛辛那提大学）
The outbreak of novel coronavirus disease (COVID- 19) has claimed millions of lives and has affected all aspects of human life. This paper focuses on the application of deep learning (DL) models to medical imaging and drug discovery for managing COVID-19 disease. In this article, we detail various medical imaging-based studies such as X-rays and computed tomography (CT) images along with DL methods for classifying COVID-19 affected versus pneumonia. The applications of DL techniques to medical images are further described in terms of image localization, segmentation, registration, and classifi…
Early and reliable COVID-19 diagnosis based on chest 3-D CT scans can assist medical specialists in vital circumstances. Deep learning methodologies constitute a main approach for chest CT scan analysis and disease prediction. However, large annotated databases are necessary for developing deep learning models that are able to provide COVID-19 diagnosis across various medical environments in different countries. Due to privacy issues, publicly available COVID-19 CT datasets are highly difficult to obtain, which hinders the research and development of AI-enabled diagnosis methods of COVID-19 ba…
Deakin University（迪肯大学）；National University of Singapore（新加坡国立大学）
The early and reliable detection of COVID-19 infected patients is essential to prevent and limit its outbreak. The PCR tests for COVID-19 detection are not available in many countries and also there are genuine concerns about their reliability and performance. Motivated by these shortcomings, this paper proposes a deep uncertainty-aware transfer learning framework for COVID-19 detection using medical images. Four popular convolutional neural networks (CNNs) including VGG16, ResNet50, DenseNet121, and InceptionResNetV2 are first applied to extract deep features from chest X-ray and computed tom…
Korea Advanced Institute of Science and Technology (KAIST)（韩国科学技术院）；Asan Medical Center, University of Ulsan College of Medicine（蔚山大学医学院峨山医学中心）；College of Medicine, Yeungnam University（岭南大学医学院）；School of Medicine, Kyungpook National University（庆北国立大学医学院）
Developing a robust algorithm to diagnose and quantify the severity of COVID-19 using Chest X-ray (CXR) requires a large number of well-curated COVID-19 datasets, which is difficult to collect under the global COVID-19 pandemic. On the other hand, CXR data with other findings are abundant. This situation is ideally suited for the Vision Transformer (ViT) architecture, where a lot of unlabeled data can be used through structural modeling by the self-attention mechanism. However, the use of existing ViT is not optimal, since feature embedding through direct patch flattening or ResNet backbone in…
Amirkabir University of Technology（阿米尔卡比尔理工大学）；Semnan University（塞姆南大学）
The new coronavirus (known as COVID-19) was first identified in Wuhan and quickly spread worldwide, wreaking havoc on the economy and people's everyday lives. Fever, cough, sore throat, headache, exhaustion, muscular aches, and difficulty breathing are all typical symptoms of COVID-19. A reliable detection technique is needed to identify affected individuals and care for them in the early stages of COVID-19 and reduce the virus's transmission. The most accessible method for COVID-19 identification is RT-PCR; however, due to its time commitment and false-negative results, alternative options mu…
In this paper, a 3D-RegNet-based neural network is proposed for diagnosing the physical condition of patients with coronavirus (Covid-19) infection. In the application of clinical medicine, lung CT images are utilized by practitioners to determine whether a patient is infected with coronavirus. However, there are some laybacks can be considered regarding to this diagnostic method, such as time consuming and low accuracy. As a relatively large organ of human body, important spatial features would be lost if the lungs were diagnosed utilizing two dimensional slice image. Therefore, in this paper…
