BrainPainter v2：小鼠脑可视化软件
BrainPainter v2: Mouse Brain Visualization Software
摘要：
BrainPainter是一款用于人类大脑结构3D可视化的软件;它使用用户定义的每个大脑区域的生物标志物数据生成彩色大脑图像。然而，BrainPainter只能生成人脑图像。在本文中，我们提出了更新现有的BrainPainter软件，使小鼠大脑图像的生成。我们将基于Allen Mouse Brain Atlas的每个小鼠大脑区域的网格加载到Blender中，Blender是一个功能强大的3D计算机图形引擎。然后，我们使用Blender为每个区域着色，并生成皮层下、外皮层、内皮层、顶部和底部视图渲染的图像。除了这些视图之外，我们还为左右半球添加了新的渲染角度和单独的可视化设置。虽然BrainPainter传统上从浏览器（https://brainpainter.csail.mit.edu）运行，但我们还创建了一个图形用户界面，通过Docker API连接到Blender后端，以用户友好的方式启动图像生成请求。我们举例说明了BrainPainter的一个用例，用于在小鼠研究中对tau蛋白积累的进展进行建模。我们的贡献可以帮助神经科学家在小鼠研究中可视化大脑并显示疾病进展。此外，集成到Blender中可以随后使用移动相机生成复杂的动画，生成模拟肿瘤和其他病理的复杂网格变形，以及使用Blender的粒子系统可视化有毒蛋白质。
英文摘要：
BrainPainter is a software for the 3D visualization of human brain structures; it generates colored brain images using user-defined biomarker data for each brain region. However, BrainPainter is only able to generate human brain images. In this paper, we present updates to the existing BrainPainter software which enables the generation of mouse brain images. We load meshes for each mouse brain region, based on the Allen Mouse Brain Atlas, into Blender, a powerful 3D computer graphics engine. We then use Blender to color each region and generate images of subcortical, outer-cortical, inner-cortical, top and bottom view renders. In addition to those views, we add new render angles and separate visualization settings for the left and right hemispheres. While BrainPainter traditionally ran from the browser ( https://brainpainter.csail.mit.edu ), we also created a graphical user interface that launches image-generation requests in a user-friendly way, by connecting to the Blender backend via a Docker API. We illustrate a use case of BrainPainter for modeling the progression of tau protein accumulation in a mouse study. Our contributions can help neuroscientists visualize brains in mouse studies and show disease progression. In addition, integration into Blender can subsequently enable the generation of complex animations using a moving camera, generation of complex mesh deformations that simulate tumors and other pathologies, as well as visualization of toxic proteins using Blender's particle system.
机构、总结、中文摘要均由AI分析而来，可能存在错误，请以论文正文为准。
