小鼠解剖学背景下基因表达信息的可视化
Visualization of gene expression information within the context of the mouse anatomy
摘要：
背景资料：eMouse Atlas of Gene Expression（EMAGE）是一个在线资源，发布了发育小鼠原位基因表达实验的结果。该资源提供了全面的搜索工具，但很少有分析工具或可视化机制来导航数据集。为了解决缺少视觉导航的问题，本文探讨了EMAGE中朝阳和冰柱可视化的应用。结果：原型解决方案提供了一个简单的用户界面，帮助用户查询EMAGE并生成朝阳/冰柱图。EMAGE工作人员对测试对象进行了评估，研究了可视化效果，并提出了一系列改进建议。此外，评估发现，除了提供一种浏览数据的视觉手段外，当分组时，朝阳还提供了一种交互式概览，有助于分析相关基因集。结论：朝阳和冰柱可视化已被证明是总结基因表达数据的有效工具。发现具有节省空间的放射状布局的朝阳对于提供基因家族或途径的概述特别有用。目前正在努力将这些可视化纳入EMAGE。
英文摘要：
Background: The eMouse Atlas of Gene Expression (EMAGE) is an online resource that publishes the results of in situ gene expression experiments on the developmental mouse. The resource provides comprehensive search facilities, but few analytical tools or visual mechanisms for navigating the data set. To deal with the missing visual navigation, this paper explores the application of sunburst and icicle visualizations within EMAGE. Results: A prototype solution delivered a simple user interface that helps the user query EMAGE and generate a sunburst/icicle diagram. An evaluation featuring test subjects from the EMAGE staff studied the visualizations and provided a range of suggested improvements. Moreover the evaluation discovered that in addition to providing a visual means of walking through the data, when grouped, the sunburst delivers an interactive overview that assists with analysing sets of related genes. Conclusions: The sunburst and icicle visualizations have been shown to be effective tools for summarising gene expression data. The sunburst with its space saving radial layout was found especially useful for providing an overview of gene families or pathways. Work is ongoing to integrate these visualizations into EMAGE.
机构、总结、中文摘要均由AI分析而来，可能存在错误，请以论文正文为准。
