Despite the widespread availability of in-treatment room cone beam computed tomography (CBCT) imaging, due to the lack of reliable segmentation methods, CBCT is only used for gross set up corrections in lung radiotherapies. Accurate and reliable auto-segmentation tools could potentiate volumetric response assessment and geometry-guided adaptive radiation therapies. Therefore, we developed a new deep learning CBCT lung tumor segmentation method. Methods: The key idea of our approach called cross modality educed distillation (CMEDL) is to use magnetic resonance imaging (MRI) to guide a CBCT segmentation network training to extract more informative features during training. We accomplish this by training an end-to-end network comprised of unpaired domain adaptation (UDA) and cross-domain segmentation distillation networks (SDN) using unpaired CBCT and MRI datasets. Feature distillation regularizes the student network to extract CBCT features that match the statistical distribution of MRI features extracted by the teacher network and obtain better differentiation of tumor from background.} We also compared against an alternative framework that used UDA with MR segmentation network, whereby segmentation was done on the synthesized pseudo MRI representation. All networks were trained with 216 weekly CBCTs and 82 T2-weighted turbo spin echo MRI acquired from different patient cohorts. Validation was done on 20 weekly CBCTs from patients not used in training. Independent testing was done on 38 weekly CBCTs from patients not used in training or validation. Segmentation accuracy was measured using surface Dice similarity coefficient (SDSC) and Hausdroff distance at 95th percentile (HD95) metrics.
Can Foundation Models Really Segment Tumors? A Benchmarking Odyssey in Lung CT Imaging
College of Computer Science and Software Engineering, Shenzhen University（计算机科学与软件工程学院，深圳大学）；Department of Naval, Electrical, Electronics and Telecommunications Engineering, University of Genoa（海军、电气、电子与电信工程部门，热那亚大学）
Lung cancer is one of the deadliest cancers, and in part its effective diagnosis and treatment depend on the accurate delineation of the tumor. Human-centered segmentation, which is currently the most common approach, is subject to inter-observer variability, and is also time-consuming, considering the fact that only experts are capable of providing annotations. Automatic and semi-automatic tumor segmentation methods have recently shown promising results. However, as different researchers have validated their algorithms using various datasets and performance metrics, reliably evaluating these …
Shanghai Jiao Tong University（上海交通大学）；Shanghai Institute for Advanced Communication and Data Science（上海先进通信与数据科学研究院）；AI Institute Shanghai Jiao Tong University（上海交通大学人工智能研究院）；Shanghai Chest Hospital（上海市胸科医院）；Shanghai General Hospital（上海市第一人民医院）
Follow-up serves an important role in the management of pulmonary nodules for lung cancer. Imaging diagnostic guidelines with expert consensus have been made to help radiologists make clinical decision for each patient. However, tumor growth is such a complicated process that it is difficult to stratify high-risk nodules from low-risk ones based on morphologic characteristics. On the other hand, recent deep learning studies using convolutional neural networks (CNNs) to predict the malignancy score of nodules, only provides clinicians with black-box predictions. To this end, we propose a unifie…
Memorial Sloan Kettering Cancer Center（纪念斯隆·凯特琳癌症中心）
Accurate and robust segmentation of lung cancers from CT, even those located close to mediastinum, is needed to more accurately plan and deliver radiotherapy and to measure treatment response. Therefore, we developed a new cross-modality educed distillation (CMEDL) approach, using unpaired CT and MRI scans, whereby an informative teacher MRI network guides a student CT network to extract features that signal the difference between foreground and background. Our contribution eliminates two requirements of distillation methods: (i) paired image sets by using an image to image (I2I) translation a…
Memorial Sloan Kettering Cancer Center（纪念斯隆·凯特琳癌症中心）
Lung tumors, especially those located close to or surrounded by soft tissues like the mediastinum, are difficult to segment due to the low soft tissue contrast on computed tomography images. Magnetic resonance images contain superior soft-tissue contrast information that can be leveraged if both modalities were available for training. Therefore, we developed a cross-modality educed learning approach where MR information that is educed from CT is used to hallucinate MRI and improve CT segmentation. Our approach, called cross-modality educed deep learning segmentation (CMEDL) combines CT and pse…
Deep learning algorithms, in particular 2D and 3D fully convolutional neural networks (FCNs), have rapidly become the mainstream methodology for volumetric medical image segmentation. However, 2D convolutions cannot fully leverage the rich spatial information along the third axis, while 3D convolutions suffer from the demanding computation and high GPU memory consumption. In this paper, we propose to automatically search the network architecture tailoring to volumetric medical image segmentation problem. Concretely, we formulate the structure learning as differentiable neural architecture sear…
Memorial Sloan Kettering Cancer Center（纪念斯隆-凯特琳癌症中心）
Purpose: Radiotherapy presents unique challenges and clinical requirements for longitudinal tumor and organ-at-risk (OAR) prediction during treatment. The challenges include tumor inflammation/edema and radiation-induced changes in organ geometry, whereas the clinical requirements demand flexibility in input/output sequence timepoints to update the predictions on rolling basis and the grounding of all predictions in relationship to the pre-treatment imaging information for response and toxicity assessment in adaptive radiotherapy. Methods: To deal with the aforementioned challenges and to comp…
BUET（孟加拉国工程技术大学）；United International University（联合国际大学）
Lung cancer is a leading cause of death in most countries of the world. Since prompt diagnosis of tumors can allow oncologists to discern their nature, type and the mode of treatment, tumor detection and segmentation from CT Scan images is a crucial field of study worldwide. This paper approaches lung tumor segmentation by applying two-dimensional discrete wavelet transform (DWT) on the LOTUS dataset for more meticulous texture analysis whilst integrating information from neighboring CT slices before feeding them to a Deeply Supervised MultiResUNet model. Variations in learning rates, decay an…
Deep neural networks (DNNs) have been widely used for medical image analysis. However, the lack of access a to large-scale annotated dataset poses a great challenge, especially in the case of rare diseases, or new domains for the research society. Transfer of pre-trained features, from the relatively large dataset is a considerable solution. In this paper, we have explored supervised segmentation using domain adaptation for optic nerve and orbital tumor, when only small sampled CT images are given. Even the lung image database consortium image collection (LIDC-IDRI) is a cross-domain to orbita…
Multimodal positron emission tomography-computed tomography (PET-CT) is used routinely in the assessment of cancer. PET-CT combines the high sensitivity for tumor detection with PET and anatomical information from CT. Tumor segmentation is a critical element of PET-CT but at present, there is not an accurate automated segmentation method. Segmentation tends to be done manually by different imaging experts and it is labor-intensive and prone to errors and inconsistency. Previous automated segmentation methods largely focused on fusing information that is extracted separately from the PET and CT…
A CT Image Classification Network Framework for Lung Tumors Based on Pre-trained MobileNetV2 Model and Transfer learning, And Its Application and Market Analysis in the Medical field
Magnetic resonance delta radiomics to track radiation response in lung tumors receiving stereotactic MRI-guided radiotherapy
Mass General Brigham（麻省总医院布里格姆医疗系统）；Harvard Medical School（哈佛医学院）；Dana-Farber Cancer Institute（丹娜-法伯癌症研究所）；Harvard T.H. Chan School of Public Health（哈佛大学陈曾熙公共卫生学院）；Maastricht University（马斯特里赫特大学）
Norwegian University of Science and Technology（挪威科技大学）；SINTEF（挪威科技工业研究院）；St. Olavs hospital, Trondheim University Hospital（圣奥拉夫医院，特隆赫姆大学医院）
Purpose: Automating tasks such as lung tumor localization and segmentation in radiological images can free valuable time for radiologists and other clinical personnel. Convolutional neural networks may be suited for such tasks, but require substantial amounts of labeled data to train. Obtaining labeled data is a challenge, especially in the medical domain. Methods: This paper investigates the use of a teacher-student design to utilize datasets with different types of supervision to train an automatic model performing pulmonary tumor segmentation on computed tomography images. The framework con…
University of Oxford（牛津大学）；Eindhoven University of Technology（埃因霍温理工大学）；Utrecht Medical Center（乌得勒支医学中心）
Early detection of lung cancer has been proven to decrease mortality significantly. A recent development in computed tomography (CT), spectral CT, can potentially improve diagnostic accuracy, as it yields more information per scan than regular CT. However, the shear workload involved with analyzing a large number of scans drives the need for automated diagnosis methods. Therefore, we propose a detection and classification system for lung nodules in CT scans. Furthermore, we want to observe whether spectral images can increase classifier performance. For the detection of nodules we trained a VG…
The performance of a computer-aided automated diagnosis system of lung cancer from Computed Tomography (CT) volumetric images greatly depends on the accurate detection and segmentation of tumor regions. In this paper, we present Recurrent 3D-DenseUNet, a novel deep learning based architecture for volumetric lung tumor segmentation from CT scans. The proposed architecture consists of a 3D encoder block that learns to extract fine-grained spatial and coarse-grained temporal features, a recurrent block of multiple Convolutional Long Short-Term Memory (ConvLSTM) layers to extract fine-grained spat…
Using Spatio-Temporal Dual-Stream Network with Self-Supervised Learning for Lung Tumor Classification on Radial Probe Endobronchial Ultrasound Video
National Yang Ming Chiao Tung University（国立阳明交通大学）；National Taiwan University Cancer Center（台湾大学癌症中心）；National Taiwan University Hospital（台湾大学医院）；National Taiwan University Hsin-Chu Hospital（台湾大学新竹医院）
The University of Tokyo（东京大学）；National Institute for Quantum and Radiological Science and Technology（国立量子与放射科学技术研究所）
During the radiotherapy treatment of patients with lung cancer, the radiation delivered to healthy tissue around the tumor needs to be minimized, which is difficult because of respiratory motion and the latency of linear accelerator systems. In the proposed study, we first use the Lucas-Kanade pyramidal optical flow algorithm to perform deformable image registration of chest computed tomography scan images of four patients with lung cancer. We then track three internal points close to the lung tumor based on the previously computed deformation field and predict their position with a recurrent …
Lung cancer has emerged as a severe disease that threatens human life and health. The precise segmentation of lung regions is a crucial prerequisite for localizing tumors, which can provide accurate information for lung image analysis. In this work, we first propose a lung image segmentation model using the NASNet-Large as an encoder and then followed by a decoder architecture, which is one of the most commonly used architectures in deep learning for image segmentation. The proposed NASNet-Large-decoder architecture can extract high-level information and expand the feature map to recover the s…
University of Turin（都灵大学）；Fondazione Ricerca Molinette Onlus（莫利内特研究基金会（非营利组织））
The accurate and consistent border segmentation plays an important role in the tumor volume estimation and its treatment in the field of Medical Image Segmentation. Globally, Lung cancer is one of the leading causes of death and the early detection of lung nodules is essential for the early cancer diagnosis and survival rate of patients. The goal of this study was to demonstrate the feasibility of Deephealth toolkit including PyECVL and PyEDDL libraries to precisely segment lung nodules. Experiments for lung nodules segmentation has been carried out on UniToChest using PyECVL and PyEDDL, for d…
Herein we propose a deep learning-based approach for the prediction of lung lesion response based on radiomic features extracted from clinical CT scans of patients in non-small cell lung cancer trials. The approach starts with the classification of lung lesions from the set of primary and metastatic lesions at various anatomic locations. Focusing on the lung lesions, we perform automatic segmentation to extract their 3D volumes. Radiomic features are then extracted from the lesion on the pre-treatment scan and the first follow-up scan to predict which lesions will shrink at least 30% in diamet…
ICTEAM（ICTEAM研究所）；Université catholique de Louvain（鲁汶天主教大学）；Indian Institute of Technology Ropar（印度理工学院罗巴尔分校）
The importance of radiomics features for predicting patient outcome is now well-established. Early study of prognostic features can lead to a more efficient treatment personalisation. For this reason new radiomics features obtained through mathematical morphology-based operations are proposed. Their study is conducted on an open database of patients suffering from Nonsmall Cells Lung Carcinoma (NSCLC). The tumor features are extracted from the CT images and analyzed via PCA and a Kaplan-Meier survival analysis in order to select the most relevant ones. Among the 1,589 studied features, 32 are …
Stress-testing cross-cancer generalizability of 3D nnU-Net for PET-CT tumor segmentation: multi-cohort evaluation with novel oesophageal and lung cancer datasets
QIMR Berghofer Medical Research Institute（昆士兰医学研究 institute）；Australian Institute for Bioengineering and Nanotechnology（澳大利亚生物工程与纳米技术研究所）；The University of Queensland（昆士兰大学）；Frazer Institute（弗拉泽研究所）；Princess Alexandra Hospital（亚历山大公主医院）；Faculty of Health, Medicine and Behavioural Sciences（健康、医学与行为科学学院）；School of Biomedical Sciences（生物医学科学学院）；Uppsala University（乌普萨拉大学）；Rohtak Nuclear Medcare Imaging Therapy and Research Center（罗塔克核医学成像治疗与研究中心）
Tianjin University（天津大学）；CSIRO Data61（澳大利亚联邦科学与工业研究组织Data61）；La Trobe University（乐卓博大学）；Tianjin University of Traditional Chinese Medicine（天津中医药大学）
The insufficiency of annotated medical imaging scans for cancer makes it challenging to train and validate data-hungry deep learning models in precision oncology. We propose a new richer generative adversarial network for free-form 3D tumor/lesion synthesis in computed tomography (CT) images. The network is composed of a new richer convolutional feature enhanced dilated-gated generator (RicherDG) and a hybrid loss function. The RicherDG has dilated-gated convolution layers to enable tumor-painting and to enlarge perceptive fields; and it has a novel richer convolutional feature association bra…
Guangdong Provincial People’s Hospital（广东省人民医院）；Guangdong Academy of Medical Sciences（广东省医学科学院）；Guilin University of Electronic Technology（桂林电子科技大学）；Guangdong Provicial People’s Hospital Ganzhou Hospital（广东省人民医院赣州医院）
Lung cancer is the leading cause of cancer death worldwide, and adenocarcinoma (LUAD) is the most common subtype. Exploiting the potential value of the histopathology images can promote precision medicine in oncology. Tissue segmentation is the basic upstream task of histopathology image analysis. Existing deep learning models have achieved superior segmentation performance but require sufficient pixel-level annotations, which is time-consuming and expensive. To enrich the label resources of LUAD and to alleviate the annotation efforts, we organize this challenge WSSS4LUAD to call for the outs…
University of Iowa（爱荷华大学）；Stanford University（斯坦福大学）
Non-small-cell lung cancer (NSCLC) represents approximately 80-85% of lung cancer diagnoses and is the leading cause of cancer-related death worldwide. Recent studies indicate that image-based radiomics features from positron emission tomography-computed tomography (PET/CT) images have predictive power on NSCLC outcomes. To this end, easily calculated functional features such as the maximum and the mean of standard uptake value (SUV) and total lesion glycolysis (TLG) are most commonly used for NSCLC prognostication, but their prognostic value remains controversial. Meanwhile, convolutional neu…
Concordia Institute for Information Systems Engineering, Concordia University（康考迪亚大学信息系统工程研究所）；Sunnybrook Health Sciences Centre, University of Toronto（多伦多大学桑尼布鲁克健康科学中心）；McGill University Health Center- Research Institute（麦吉尔大学健康中心研究所）；Babak Imaging Center（巴布克影像中心）；Department of Electrical and Computer Engineering, University of Toronto（多伦多大学电气与计算机工程系）
Lung diseases including infections such as Pneumonia, Tuberculosis, and novel Coronavirus (COVID-19), together with Lung Cancer are significantly widespread and are, typically, considered life threatening. In particular, lung cancer is among the most common and deadliest cancers with a low 5-year survival rate. Timely diagnosis of lung cancer is, therefore, of paramount importance as it can save countless lives. In this regard, deep learning radiomics solutions have the promise of extracting the most useful features on their own in an end-to-end fashion without having access to the annotated b…
The objective of this study was to develop a PET tumor-segmentation framework that addresses the challenges of limited spatial resolution, high image noise, and lack of clinical training data with ground-truth tumor boundaries in PET imaging. We propose a three-module PET-segmentation framework in the context of segmenting primary tumors in 3D FDG-PET images of patients with lung cancer on a per-slice basis. The first module generates PET images containing highly realistic tumors with known ground-truth using a new stochastic and physics-based approach, addressing lack of training data. The se…
Identifying image features that are robust with respect to segmentation variability and domain shift is a tough challenge in radiomics. So far, this problem has mainly been tackled in test-retest analyses. In this work we analyze radiomics feature stability based on probabilistic segmentations. Based on a public lung cancer dataset, we generate an arbitrary number of plausible segmentations using a Probabilistic U-Net. From these segmentations, we extract a high number of plausible feature vectors for each lung tumor and analyze feature variance with respect to the segmentations. Our results s…
Segmentation of Non-Small Cell Lung Carcinomas: Introducing DRU-Net and Multi-Lens Distortion
Norwegian University of Science and Technology (NTNU)（挪威科技大学）；Levanger hospital, Nord-Trøndelag Health Trust（北特伦德拉格健康信托利旺格医院）；St. Olavs hospital, Trondheim University Hospital（特隆赫姆大学医院圣奥拉夫斯医院）；Sopra Steria（索拉斯特里亚）；SINTEF Digital（辛特夫数字研究院）
Memorial Sloan Kettering Cancer Center（纪念斯隆凯特琳癌症中心）
We developed a new joint probabilistic segmentation and image distribution matching generative adversarial network (PSIGAN) for unsupervised domain adaptation (UDA) and multi-organ segmentation from magnetic resonance (MRI) images. Our UDA approach models the co-dependency between images and their segmentation as a joint probability distribution using a new structure discriminator. The structure discriminator computes structure of interest focused adversarial loss by combining the generated pseudo MRI with probabilistic segmentations produced by a simultaneously trained segmentation sub-networ…
Lung-DDPM: Semantic Layout-guided Diffusion Models for Thoracic CT Image Synthesis
Centre de recherche du CHU de Québec-Université Laval（魁北克大学拉瓦尔医院研究中心）；Centre de recherche de l’Institut universitaire de cardiologie et de pneumologie de Québec-Université Laval（魁北克大学拉瓦尔心血管与呼吸病学研究所）
University of Michigan（密歇根大学）；Imbio LLC（Imbio有限责任公司）
Early detection of lung cancer is critical for improvement of patient survival. To address the clinical need for efficacious treatments, genetically engineered mouse models (GEMM) have become integral in identifying and evaluating the molecular underpinnings of this complex disease that may be exploited as therapeutic targets. Assessment of GEMM tumor burden on histopathological sections performed by manual inspection is both time consuming and prone to subjective bias. Therefore, an interplay of needs and challenges exists for computer-aided diagnostic tools, for accurate and efficient analys…
Osteosarcoma is the most common primary malignant bone tumor, which has high mortality due to easy lung metastasis. Osteosarcoma is a highly anaplastic, pleomorphic tumor with a variety of tumor cell morphology, including fusiform, oval, epithelial, lymphocyte like, small round, transparent cells, etc. Due to the multiple patterns of osteosarcoma cell morphology, pathologists have differences in the classification (viable tumor, necrotic tumor, non-tumor) of osteosarcoma. Therefore, automatic and accurate recognition algorithms can help pathologists greatly reduce time and improve diagnostic a…
Washington University in St. Louis（圣路易斯华盛顿大学）；Washington University School of Medicine（华盛顿大学医学院）；Mallinckrodt Institute of Radiology（马林克罗德放射研究所）
Tumor segmentation in oncological PET is challenging, a major reason being the partial-volume effects that arise due to low system resolution and finite voxel size. The latter results in tissue-fraction effects, i.e. voxels contain a mixture of tissue classes. Conventional segmentation methods are typically designed to assign each voxel in the image as belonging to a certain tissue class. Thus, these methods are inherently limited in modeling tissue-fraction effects. To address the challenge of accounting for partial-volume effects, and in particular, tissue-fraction effects, we propose a Baye…
Henry Ford Health System（亨利福特医疗系统）；Wayne State University（韦恩州立大学）
Deep learning models have had a great success in disease classifications using large data pools of skin cancer images or lung X-rays. However, data scarcity has been the roadblock of applying deep learning models directly on prostate multiparametric MRI (mpMRI). Although model interpretation has been heavily studied for natural images for the past few years, there has been a lack of interpretation of deep learning models trained on medical images. This work designs a customized workflow for the small and imbalanced data set of prostate mpMRI where features were extracted from a deep learning m…
Birla Institute of Technology and Science, Pilani（博拉理工学院皮拉尼校区）；Hiroshima University（广岛大学）；Keimyung University Dongsan Medical Center（启明大学东山医疗中心）
Lung cancer is one of the most deadly diseases in the world. Detecting such tumors at an early stage can be a tedious task. Existing deep learning architecture for lung nodule identification used complex architecture with large number of parameters. This study developed a cascaded architecture which can accurately segment and classify the benign or malignant lung nodules on computed tomography (CT) images. The main contribution of this study is to introduce a segmentation network where the first stage trained on a public data set can help to recognize the images which included a nodule from an…
University of Sydney（悉尼大学）；Shanghai Jiao Tong University（上海交通大学）
Multi-modality Fluorodeoxyglucose (FDG) positron emission tomography / computed tomography (PET/CT) has been routinely used in the assessment of common cancers, such as lung cancer, lymphoma, and melanoma. This is mainly attributed to the fact that PET/CT combines the high sensitivity for tumor detection of PET and anatomical information from CT. In PET/CT image assessment, automatic tumor segmentation is an important step, and in recent years, deep learning based methods have become the state-of-the-art. Unfortunately, existing methods tend to over-segment the tumor regions and include region…
A tissue and cell-level annotated H&E and PD-L1 histopathology image dataset in non-small cell lung cancer
Radboud University Medical Center（拉德堡德大学医学中心）；University of Brescia（布雷西亚大学）；Ospedale Sacro Cuore（圣十字医院）；Provincial Hospital of Bolzano (SABES-ASDAA)（博尔扎诺省医院）；University and Hospital Trust of Verona（威尼斯大学与医院信托）；Karolinska University Hospital（卡罗林斯卡大学医院）；Biopticka Laboratory, Ltd（Biopticka实验室）
Charles Sturt University（查尔斯特大学）；Western Sydney University（西悉尼大学）；Kent Institute Australia（澳大利亚肯特学院）；Asia Pacific International College（亚太国际学院）；Massasoit Community College（马萨索伊特社区学院）；University of Kurdistan Hewler（库尔德斯坦休勒大学）；Al Iraqia University（伊拉克大学）
Background and Purpose: Convolutional neural network is widely used for image recognition in the medical area at nowadays. However, overall accuracy in predicting lung tumor is low and the processing time is high as the error occurred while reconstructing the CT image. The aim of this work is to increase the overall prediction accuracy along with reducing processing time by using multispace image in pooling layer of convolution neural network. Methodology: The proposed method has the autoencoder system to improve the overall accuracy, and to predict lung cancer by using multispace image in poo…
NEC Laboratories America（NEC美国实验室）；NEC Corporation（NEC公司）；Hokkaido University Hospital（北海道大学医院）
We propose a method to accurately obtain the ratio of tumor cells over an entire histological slide. We use deep fully convolutional neural network models trained to detect and classify cells on images of H&E-stained tissue sections. Pathologists' labels consisting of exhaustive nuclei locations and tumor regions were used to trained the model in a supervised fashion. We show that combining two models, each working at a different magnification allows the system to capture both cell-level details and surrounding context to enable successful detection and classification of cells as either tumor-…
University of Glasgow（格拉斯哥大学）；New York University（纽约大学）
Deep learning based analysis of histopathology images shows promise in advancing the understanding of tumor progression, tumor micro-environment, and their underpinning biological processes. So far, these approaches have focused on extracting information associated with annotations. In this work, we ask how much information can be learned from the tissue architecture itself. We present an adversarial learning model to extract feature representations of cancer tissue, without the need for manual annotations. We show that these representations are able to identify a variety of morphological char…
Generative Adversarial Networks (GANs) are state of the art for image synthesis. Here, we present dapi2ck, a novel GAN-based approach to synthesize cytokeratin (CK) staining from immunofluorescent (IF) DAPI staining of nuclei in non-small cell lung cancer (NSCLC) images. We use the synthetic CK to segment epithelial regions, which, compared to expert annotations, yield equally good results as segmentation on stained CK. Considering the limited number of markers in a multiplexed IF (mIF) panel, our approach allows to replace CK by another marker addressing the complexity of the tumor micro-envi…
College of Medicine and Biological Information Engineering, Northeastern University（东北大学生物医学与信息工程学院）；Department of Electrical and Computer Engineering, Steven Institute of Technology（史蒂文斯理工学院电气与计算机工程系）；Key Laboratory of Intelligent Computing in Medical Image, Ministry of Education（医学影像智能计算教育部重点实验室）
Whole-body PET/CT scan is an important tool for diagnosing various malignancies (e.g., malignant melanoma, lymphoma, or lung cancer), and accurate segmentation of tumors is a key part for subsequent treatment. In recent years, CNN-based segmentation methods have been extensively investigated. However, these methods often give inaccurate segmentation results, such as over-segmentation and under-segmentation. Therefore, to address such issues, we propose a post-processing method based on a graph convolutional neural network (GCN) to refine inaccurate segmentation parts and improve the overall se…
Indian Institute of Technology Kharagpur（印度理工学院卡拉克普尔分校）；Tata Medical Center, Kolkata（塔塔医疗中心（加尔各答））；Arden Cancer Centre（阿登癌症中心）；Department of Computer Science and Engineering（计算机科学与工程系）；Department of Radiation Oncology（放射肿瘤学系）；Department of Nuclear Medicine（核医学系）；Department of Medical Physics（医学物理系）
We report a model to predict patient's radiological response to curative radiation therapy (RT) for non-small-cell lung cancer (NSCLC). Cone-Beam Computed Tomography images acquired weekly during the six-week course of RT were contoured with the Gross Tumor Volume (GTV) by senior radiation oncologists for 53 patients (7 images per patient). Deformable registration of the images yielded six deformation fields for each pair of consecutive images per patient. Jacobian of a field provides a measure of local expansion/contraction and is used in our model. Delineations were compared post-registratio…
