Distance metrics and their nonlinear variant play a crucial role in machine learning based real-world problem solving. We demonstrated how Euclidean and cosine distance measures differ not only theoretically but also in real-world medical application, namely, outcome prediction of drug prescription. Euclidean distance exhibits favorable properties in the local geometry problem. To this regard, Euclidean distance can be applied under short-term disease with low-variation outcome observation. Moreover, when presenting to highly variant chronic disease, it is preferable to use cosine distance. These different geometric properties lead to different submanifolds in the original embedded space, and hence, to different optimizing nonlinear kernel embedding frameworks. We first established the geometric properties that we needed in these frameworks. From these properties interpreted their differences in certain perspectives. Our evaluation on real-world, large-scale electronic health records and embedding space visualization empirically validated our approach.
An Offline Smartphone Check for Drug Interactions and Past Reactions in Handwritten Prescriptions: A Technical Feasibility Study in Rural Bangladeshi Outpatient Care
Learning-based Computer-aided Prescription Model for Parkinson's Disease: A Data-driven Perspective
State Key Laboratory for Novel Software Technology, Nanjing University（南京大学计算机软件新技术国家重点实验室）；National Institute of Healthcare Data Science, Nanjing University（南京大学国家健康医疗大数据研究院）；School of Computer Science, Nanjing Normal University（南京师范大学计算机科学与技术学院）；Department of Radiology and BRIC, UNC Chapel Hill（北卡罗来纳大学教堂山分校放射学系与生物医学研究成像中心）；Inception Institute of Artificial Intelligence（起源人工智能研究院）；Nanjing Medical University（南京医科大学）；Nanjing Brain Hospital（南京脑科医院）；Department of Research and Development, Shanghai United Imaging Intelligence Co., Ltd.（上海联影智能医疗科技有限公司研发部）；Department of Brain and Cognitive Engineering, Korea University（高丽大学脑与认知工程系）
Drug response prediction by inferring pathway-response associations with Kernelized Bayesian Matrix Factorization
Helsinki Institute for Information Technology HIIT（赫尔辛基信息技术研究所）；Aalto University（阿尔托大学）；Institute for Molecular Medicine Finland FIMM（芬兰分子医学研究所）；University of Helsinki（赫尔辛基大学）；Science for Life Laboratory（生命科学实验室）；Karolinska Institutet（卡罗林斯卡学院）；University of Turku（图尔库大学）
A robust kernel machine regression towards biomarker selection in multi-omics datasets of osteoporosis for drug discovery
Tulane Center for Biomedical Informatics and Genomics（杜兰大学生物医学信息学与基因组学中心）；Division of Biomedical Informatics and Genomics（生物医学信息学与基因组学部门）；Deming Department of Medicine（戴明医学系）；Tulane University（杜兰大学）
Identifying multi-omics interactions for lung cancer drug targets discovery using Kernel Machine Regression
Department of Information and Communication Technology, Mawlana Bhashani Science and Technology University, Santosh, Tangail, 1902, Dhaka, Bangladesh（信息与通信技术系，穆拉纳巴沙尼科学与技术大学）；Department of Computer Science, Tulane University, New Orleans, LA, USA（计算机科学系，杜兰大学）；Bioinformatics Institute (BII), Agency for Science, Technology and Research (A*STAR), 138632, Singapore（生物信息学研究所（BII），科技研究局（A*STAR））；Tulane Center for Biomedical Informatics and Genomics, Deming Department of Medicine, Tulane University, New Orleans, LA 70112, USA（杜兰大学生物医学信息学与基因组学中心，医学部）；Ochsner Center for Outcomes Research, Ochsner Research, New Orleans, LA 70121, USA（Ochsner研究中心，Ochsner研究）
