Weak Signal Asymptotics for Sequentially Randomized Experiments
Stanford Graduate School of Business(斯坦福大学商学院)
Xu Kuang, Stefan Wager
备注:
Forthcoming in Management Science. An earlier draft of this paper was circulated under the title "Diffusion Asymptotics for Sequential Experiments.'' Xu Kuang published under a different full name in earlier versions of this manuscript. Please use X. Kuang and S. Wager when citing this paper
We use the lens of weak signal asymptotics to study a class of sequentially randomized experiments, including those that arise in solving multi-armed bandit problems. In an experiment with $n$ time steps, we let the mean reward gaps between actions scale to the order $1/\sqrt{n}$ so as to preserve the difficulty of the learning task as $n$ grows. In this regime, we show that the sample paths of a class of sequentially randomized experiments -- adapted to this scaling regime and with arm selection probabilities that vary continuously with state -- converge weakly to a diffusion limit, given as the solution to a stochastic differential equation. The diffusion limit enables us to derive refined, instance-specific characterization of stochastic dynamics, and to obtain several insights on the regret and belief evolution of a number of sequential experiments including Thompson sampling (but not UCB, which does not satisfy our continuity assumption). We show that all sequential experiments whose randomization probabilities have a Lipschitz-continuous dependence on the observed data suffer from sub-optimal regret performance when the reward gaps are relatively large. Conversely, we find that a version of Thompson sampling with an asymptotically uninformative prior variance achieves near-optimal instance-specific regret scaling, including with large reward gaps, but these good regret properties come at the cost of highly unstable posterior beliefs.
Scientific researchers utilize randomized experiments to draw casual statements. Most early studies as well as current work on experiments with sequential intervention decisions has been focusing on estimating the causal effects among sequential treatments, ignoring the non-compliance issues that experimental units might not be compliant with the treatment assignments that they were originally allocated. A series of methodologies have been developed to address the non-compliance issues in randomized experiments with time-fixed treatment. However, to our best knowledge, there is little literatu…
Regression adjustments are often considered by investigators to improve the estimation efficiency of causal effect in randomized experiments when there exists many pre-experiment covariates. In this paper, we provide conditions that guarantee the penalized regression including the Ridge, Elastic Net and Adapive Lasso adjusted causal effect estimators are asymptotic normal and we show that their asymptotic variances are no greater than that of the simple difference-in-means estimator, as long as the penalized estimators are risk consistent. We also provide conservative estimators for the asympt…
Randomized experiments have become important tools in empirical research. In a completely randomized treatment-control experiment, the simple difference in means of the outcome is unbiased for the average treatment effect, and covariate adjustment can further improve the efficiency without assuming a correctly specified outcome model. In modern applications, experimenters often have access to many covariates, motivating the need for a theory of covariate adjustment under the asymptotic regime with a diverging number of covariates. We study the asymptotic properties of covariate adjustment unde…
Researchers often use linear regression to analyse randomized experiments to improve treatment effect estimation by adjusting for imbalances of covariates in the treatment and control groups. Our work offers a randomization-based inference framework for regression adjustment in stratified randomized experiments. Under mild conditions, we re-establish the finite population central limit theorem for a stratified experiment. We prove that both the stratified difference-in-means and the regression-adjusted average treatment effect estimators are consistent and asymptotically normal. The asymptotic…
We study conditions under which treatment effect estimators constructed under the no-interference assumption in randomized experiments are asymptotically normal in the presence of interference. We prove that the standard Horvitz-Thompson estimator is asymptotically normal under a restricted interference condition characterized by limiting the degree of the dependency graph. The amount of interference is allowed to grow with the population size. We then provide a central limit theorem for the difference-in-means estimator that can handle interference that exists between all pairs of units, prov…
Causal inference in completely randomized treatment-control studies with binary outcomes is discussed from Fisherian, Neymanian and Bayesian perspectives, using the potential outcomes framework. A randomization-based justification of Fisher's exact test is provided. Arguing that the crucial assumption of constant causal effect is often unrealistic, and holds only for extreme cases, some new asymptotic and Bayesian inferential procedures are proposed. The proposed procedures exploit the intrinsic non-additivity of unit-level causal effects, can be applied to linear and non-linear estimands, and…
We propose a dynamic allocation procedure that increases power and efficiency when measuring an average treatment effect in sequential randomized trials exploiting some subjects' previous assessed responses. Subjects arrive sequentially and are either randomized or paired to a previously randomized subject and administered the alternate treatment. The pairing is made via a dynamic matching criterion that iteratively learns which specific covariates are important to the response. We develop estimators for the average treatment effect as well as an exact test. We illustrate our method's increase…
We propose a consistent estimator of sharp bounds on the variance of the difference-in-means estimator in completely randomized experiments. Generalizing Robins [Stat. Med. 7 (1988) 773-785], our results resolve a well-known identification problem in causal inference posed by Neyman [Statist. Sci. 5 (1990) 465-472. Reprint of the original 1923 paper]. A practical implication of our results is that the upper bound estimator facilitates the asymptotically narrowest conservative Wald-type confidence intervals, with applications in randomized controlled and clinical trials.
Stratification and rerandomization are two well-known methods used in randomized experiments for balancing the baseline covariates. Renowned scholars in experimental design have recommended combining these two methods; however, limited studies have addressed the statistical properties of this combination. This paper proposes two rerandomization methods to be used in stratified randomized experiments, based on the overall and stratum-specific Mahalanobis distances. The first method is applicable for nearly arbitrary numbers of strata, strata sizes, and stratum-specific proportions of the treate…
This paper develops a flexible method for decreasing the variance of estimators for complex experiment effect metrics (e.g. ratio metrics) while retaining asymptotic unbiasedness. This method uses the auxiliary information about the experiment units to decrease the variance. The method can incorporate almost any arbitrary predictive model (e.g. linear regression, regularization, neural networks) to adjust the estimators. The adjustment involves some free parameters which can be optimized to achieve the smallest variance reduction given the predictive model performance. Also we approximate the …
The use and development of mobile interventions are experiencing rapid growth. In "just-in-time" mobile interventions, treatments are provided via a mobile device and they are intended to help an individual make healthy decisions "in the moment," and thus have a proximal, near future impact. Currently the development of mobile interventions is proceeding at a much faster pace than that of associated data science methods. A first step toward developing data-based methods is to provide an experimental design for testing the proximal effects of these just-in-time treatments. In this paper, we pro…
Regression adjustment is widely used for the analysis of randomized experiments to improve the estimation efficiency of the treatment effect. This paper reexamines a weighted regression adjustment method termed as tyranny-of-the-minority (ToM), wherein units in the minority group are given greater weights. We demonstrate that the ToM regression adjustment is more robust than Lin 2013's regression adjustment with treatment-covariate interactions, even though these two regression adjustment methods are asymptotically equivalent in completely randomized experiments. Moreover, we extend ToM regres…
Clinical trials are complex and usually involve multiple objectives such as controlling type I error rate, increasing power to detect treatment difference, assigning more patients to better treatment, and more. In literature, both response-adaptive randomization (RAR) procedures (by changing randomization procedure sequentially) and sequential monitoring (by changing analysis procedure sequentially) have been proposed to achieve these objectives to some degree. In this paper, we propose to sequentially monitor response-adaptive randomized clinical trial and study it's properties. We prove that…
We provide a principled way for investigators to analyze randomized experiments when the number of covariates is large. Investigators often use linear multivariate regression to analyze randomized experiments instead of simply reporting the difference of means between treatment and control groups. Their aim is to reduce the variance of the estimated treatment effect by adjusting for covariates. If there are a large number of covariates relative to the number of observations, regression may perform poorly because of overfitting. In such cases, the Lasso may be helpful. We study the resulting La…
Shape-Preserving Covariate Adjustment via Empirical Likelihood in Randomized Experiment
Zhejiang University of Finance and Economics(浙江财经大学);University of Wisconsin, Madison(威斯康星大学麦迪逊分校);University of Washington(华盛顿大学);Eli Lilly and Company(礼来公司)
Regression adjustment is broadly applied in randomized trials under the premise that it usually improves the precision of a treatment effect estimator. However, previous work has shown that this is not always true. To further understand this phenomenon, we develop a unified comparison of the asymptotic variance of a class of linear regression-adjusted estimators. Our analysis is based on the classical theory for linear regression with heteroscedastic errors and thus does not assume that the postulated linear model is correct. For a completely randomized binary treatment, we provide sufficient …
A small n, sequential, multiple assignment, randomized trial (snSMART) is a small sample, two-stage design where participants receive up to two treatments sequentially, but the second treatment depends on response to the first treatment. The treatment effect of interest in an snSMART is the first-stage response rate, but outcomes from both stages can be used to obtain more information from a small sample. A novel way to incorporate the outcomes from both stages applies power prior models, in which first stage outcomes from an snSMART are regarded as the primary data and second stage outcomes a…
Non-randomized treatment effect models are widely used for the assessment of treatment effects in various fields and in particular social science disciplines like political science, psychometry, psychology. More specifically, these are situations where treatment is assigned to an individual based on some of their characteristics (e.g. scholarship is allocated based on merit or antihypertensive treatments are allocated based on blood pressure level) instead of being allocated randomly, as is the case, for example, in randomized clinical trials. Popular methods that have been largely employed ti…
There is a growing interest in leveraging the prevalence of mobile technology to improve health by delivering momentary, contextualized interventions to individuals' smartphones. A just-in-time adaptive intervention (JITAI) adjusts to an individual's changing state and/or context to provide the right treatment, at the right time, in the right place. Micro-randomized trials (MRTs) allow for the collection of data which aid in the construction of an optimized JITAI by sequentially randomizing participants to different treatment options at each of many decision points throughout the study. Often,…
Rerandomization is a strategy of increasing efficiency as compared to complete randomization. The idea with rerandomization is that of removing allocations with imbalance in the observed covariates and then randomizing within the set of allocations with balance in these covariates. Standard asymptotic inference based on mean difference estimator is however conservative after rerandomization. Given a Mahalanobis distance criterion for removing imbalanced allocations, Li et al. (2018) derived the asymptotic distribution of the mean difference estimator and suggested a consistent estimator of its…
The purpose of this work is to improve the efficiency in estimating the average causal effect (ACE) on the survival scale where right-censoring exists and high-dimensional covariate information is available. We propose new estimators using regularized survival regression and survival random forests (SRF) to make the adjustment for the high dimensional covariates to improve efficiency. We study the behavior of the adjusted estimator under mild assumptions and show theoretical guarantees that the proposed estimators are more efficient than the unadjusted ones asymptotically when using SRF for ad…
Graduate School of Business, Stanford University(斯坦福大学商学院);Airbnb(爱彼迎);Management Science and Engineering Department, Stanford University(斯坦福大学管理科学与工程系)
In randomized experiments, the actual treatments received by some experimental units may differ from their treatment assignments. This non-compliance issue often occurs in clinical trials, social experiments, and the applications of randomized experiments in many other fields. Under certain assumptions, the average treatment effect for the compliers is identifiable and equal to the ratio of the intention-to-treat effects of the potential outcomes to that of the potential treatment received. To improve the estimation efficiency, we propose three model-assisted estimators for the complier averag…
Missing outcome data is one of the principal threats to the validity of treatment effect estimates from randomized trials. The outcome distributions of participants with missing and observed data are often different, which increases the risk of bias. Causal inference methods may aid in reducing the bias and improving efficiency by incorporating baseline variables into the analysis. In particular, doubly robust estimators incorporate estimates of two nuisance parameters: the outcome regression and the missingness mechanism, to adjust for differences in the observed and unobserved groups that ca…
We present methods for causally interpretable meta-analyses that combine information from multiple randomized trials to estimate potential (counterfactual) outcome means and average treatment effects in a target population. We consider identifiability conditions, derive implications of the conditions for the law of the observed data, and obtain identification results for transporting causal inferences from a collection of independent randomized trials to a new target population in which experimental data may not be available. We propose an estimator for the potential (counterfactual) outcome m…
Many policy evaluations occur in settings where treatment is randomized at the cluster level, and there is treatment noncompliance within each cluster. For example, villages might be assigned to treatment and control, but residents in each village may choose to comply or not with their assigned treatment status. When noncompliance is present, the instrumental variables framework can be used to identify and estimate causal effects. While a large literature exists on instrumental variables estimation methods, relatively little work has been focused on settings with clustered treatments. Here, we…
For the classical continuous-time quickest change-point detection problem it is shown that the randomized Shiryaev-Roberts-Pollak procedure is asymptotically nearly minimax-optimal (in the sense of Pollak 1985) in the class of randomized procedures with vanishingly small false alarm risk. The proof is explicit in that all of the relevant performance characteristics are found analytically and in a closed form. The rate of convergence to the (unknown) optimum is elucidated as well. The obtained optimality result is a one-order improvement of that previously obtained by Burnaev et al. (2009) for …
University of California, Davis(加利福尼亚大学戴维斯分校);University of Toronto(多伦多大学);Vector Institute(矢量研究所)
The randomized midpoint method, proposed by [SL19], has emerged as an optimal discretization procedure for simulating the continuous time Langevin diffusions. Focusing on the case of strong-convex and smooth potentials, in this paper, we analyze several probabilistic properties of the randomized midpoint discretization method for both overdamped and underdamped Langevin diffusions. We first characterize the stationary distribution of the discrete chain obtained with constant step-size discretization and show that it is biased away from the target distribution. Notably, the step-size needs to g…
Inspired by sample splitting and the reusable holdout introduced in the field of differential privacy, we consider selective inference with a randomized response. We discuss two major advantages of using a randomized response for model selection. First, the selectively valid tests are more powerful after randomized selection. Second, it allows consistent estimation and weak convergence of selective inference procedures. Under independent sampling, we prove a selective (or privatized) central limit theorem that transfers procedures valid under asymptotic normality without selection to their cor…
The University of Georgia(佐治亚大学);University of California at San Diego(加利福尼亚大学圣地亚哥分校);Harvard University(哈佛大学);Central University of Finance and Economics(中央财经大学);International Computer Science Institute(国际计算机科学研究所);University of California at Berkeley(加利福尼亚大学伯克利分校)
The statistical analysis of Randomized Numerical Linear Algebra (RandNLA) algorithms within the past few years has mostly focused on their performance as point estimators. However, this is insufficient for conducting statistical inference, e.g., constructing confidence intervals and hypothesis testing, since the distribution of the estimator is lacking. In this article, we develop an asymptotic analysis to derive the distribution of RandNLA sampling estimators for the least-squares problem. In particular, we derive the asymptotic distribution of a general sampling estimator with arbitrary samp…
Randomization tests are based on a re-randomization of existing data to gain data-dependent critical values that lead to exact hypothesis tests under special circumstances. However, it is not always possible to re-randomize data in accordance to the physical randomization from which the data has been obained. As a consequence, most statistical tests cannot control the type I error probability. Still, similarly as the bootstrap, data re-randomization can be used to improve the type I error control. However, no general asymptotic theory under weak null hypotheses has been developed for such rand…
Logistic regression is a well-known statistical model which is commonly used in the situation where the output is a binary random variable. It has a wide range of applications including machine learning, public health, social sciences, ecology and econometry. In order to estimate the unknown parameters of logistic regression with data streams arriving sequentially and at high speed, we focus our attention on a recursive stochastic algorithm. More precisely, we investigate the asymptotic behavior of a new stochastic Newton algorithm. It enables to easily update the estimates when the data arriv…