Superselective adsorption of multivalent polymeric particles
英文摘要：
Multivalency is a common biological mechanism of formation of strong reversible and selective bonds by grouping weak bonds. Polymers often act as a scaffold to which multiple binding groups are attached. Here I present an analytical theory allowing to calculate avidity and selectivity for multivalent polymeric particles using tools from the theory of associating fluids. I explicitly take into account conformational degrees of freedom of a polymeric scaffold and discuss how they affect superselectivity. I also consider linear polymeric particles with two types of ligands and show that superselectivity does not depend on the sequence of ligands along the backbone for a Gaussian chain with short linkers.
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