超选择性作为受体涨落响应
Superselectivity as a Receptor-Fluctuation Response
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中文总结 AI 辅助
该研究针对超选择性多价结合的微观响应机制，推导了选择性的响应分解关系，通过模拟验证了相关规律，建立了关联多价选择性与局部受体涨落的框架。
中文摘要 AI 辅助
超选择性多价结合能在靶向和传感中实现对受体密度的敏锐区分，但其对数响应的微观含义尚不明确。本文推导了选择性的精确响应分解，将其分为受体状态重加权和直接占据响应两部分。在稀溶液淬火泊松极限下，直接项消失，选择性恰好为结合粒子下方的受体平均过量，可通过足够大的共定位受体-粒子图像在单一密度下测量。超出泊松统计时，过量值需用线性计数响应的法诺因子归一化，而分布形状的变化则需完整的计数分辨响应。晶格模拟验证了这些关系适用于不同受体统计情况，非晶格模拟显示粒子拥挤通过直接项起作用。这些结果建立了一个涨落响应框架，将多价选择性与吸附优先采样的局部受体涨落关联起来。
英文摘要
Superselective multivalent binding enables sharp receptor-density discrimination in targeting and sensing, but what its logarithmic response measures microscopically remains unclear. Here, we derive an exact response decomposition of the selectivity into receptor-state reweighting and a direct occupation response. In the dilute quenched Poisson limit, the direct term vanishes and selectivity is exactly the mean receptor excess beneath bound particles, which can be measured at a single density from a sufficiently large co-registered receptor-particle image. Beyond Poisson statistics, the excess is normalized by the Fano factor for a linear count response, while changes in distribution shape require the full count-resolved response. Lattice simulations verify these relations across distinct receptor statistics, while off-lattice simulations show that particle crowding enters through the direct term. These results establish a fluctuation-response framework linking multivalent selectivity to the local receptor fluctuations preferentially sampled by adsorption.
