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arXiv 2012.12085stat.AP
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多队列数据的贝叶斯结构方程模型

Bayesian structural equation modeling for data from multiple cohorts

Khue-Dung Dang, Louise M. Ryan, Tugba Akkaya-Hocagil, Richard J. Cook, Gale A. Richardson, Nancy L. Day, Claire D. Coles, Heather Carmichael Olson, Sandra W. Ja… 展开作者

Khue-Dung Dang, Louise M. Ryan, Tugba Akkaya-Hocagil, Richard J. Cook, Gale A. Richardson, Nancy L. Day, Claire D. Coles, Heather Carmichael Olson, Sandra W. Jacobson, Joseph L. Jacobson

摘要:

虽然众所周知,高水平的产前酒精暴露(PAE)会导致儿童严重的认知缺陷,但剂量反应的确切性质尚不清楚。特别是,迫切需要确定与临床显著不良反应风险增加相关的PAE水平。为了解决这一问题,我们结合了美国6项纵向出生队列研究的数据,这些研究评估了PAE对从学龄早期到青春期测量的认知结果的影响。结构方程模型(SEM)通常用于捕获多个观察结果之间的关联,以确定感兴趣的潜在变量(在这种情况下,认知),然后将其与PAE相关联。然而,在我们的背景下不可能应用经典的SEM软件,因为在六项研究中测量了不同的结果。在本文中,我们将展示如何使用贝叶斯方法来拟合多组多层次结构模型,该模型将认知映射到多个年龄段测量的广泛观察变量。这些变量映射到几个不同的认知子域,并在使用倾向得分调整混杂因素后检查与PAE的关系。该模型还测试了剂量反应函数中变化点的可能性。

英文摘要:

While it is well known that high levels of prenatal alcohol exposure (PAE) result in significant cognitive deficits in children, the exact nature of the dose response is less well understood. In particular, there is a pressing need to identify the levels of PAE associated with an increased risk of clinically significant adverse effects. To address this issue, data have been combined from six longitudinal birth cohort studies in the United States that assessed the effects of PAE on cognitive outcomes measured from early school age through adolescence. Structural equation models (SEMs) are commonly used to capture the association among multiple observed outcomes in order to characterise the underlying variable of interest (in this case, cognition) and then relate it to PAE. However, it was not possible to apply classic SEM software in our context because different outcomes were measured in the six studies. In this paper we show how a Bayesian approach can be used to fit a multi-group multi-level structural model that maps cognition to a broad range of observed variables measured at multiple ages. These variables map to several different cognitive subdomains and are examined in relation to PAE after adjusting for confounding using propensity scores. The model also tests the possibility of a change point in the dose-response function.

机构、总结、中文摘要均由AI分析而来,可能存在错误,请以论文正文为准。

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