Improving 3D convolutional neural network comprehensibility via interactive visualization of relevance maps: Evaluation in Alzheimer's disease

Morphological feature visualization of Alzheimer's disease via Multidirectional Perception GAN

The diagnosis of early stages of Alzheimer's disease (AD) is essential for timely treatment to slow further deterioration. Visualizing the morphological features for the early stages of AD is of great clinical value. In this work, a novel Multidirectional Perception Generative Adversarial Network (MP-GAN) is proposed to visualize the morphological features indicating the severity of AD for patients of different stages. Specifically, by introducing a novel multidirectional mapping mechanism into the model, the proposed MP-GAN can capture the salient global features efficiently. Thus, by utilizi…

Comparison of Convolutional neural network training parameters for detecting Alzheimers disease and effect on visualization

Convolutional neural networks (CNN) have become a powerful tool for detecting patterns in image data. Recent papers report promising results in the domain of disease detection using brain MRI data. Despite the high accuracy obtained from CNN models for MRI data so far, almost no papers provided information on the features or image regions driving this accuracy as adequate methods were missing or challenging to apply. Recently, the toolbox iNNvestigate has become available, implementing various state of the art methods for deep learning visualizations. Currently, there is a great demand for a c…

利用R2*图和谱聚类识别卷积神经网络分类器的阿尔茨海默病预测策略

Identifying Alzheimer's Disease Prediction Strategies of Convolutional Neural Network Classifiers using R2* Maps and Spectral Clustering

本研究通过LRP和谱聚类分析基于R2*图的3D CNN阿尔茨海默病分类决策策略，发现预处理和训练配置显著影响模型决策模式，并验证了谱聚类用于识别分类策略差异的有效性。

Understanding 3D CNN Behavior for Alzheimer's Disease Diagnosis from Brain PET Scan

In recent days, Convolutional Neural Networks (CNN) have demonstrated impressive performance in medical image analysis. However, there is a lack of clear understanding of why and how the Convolutional Neural Network performs so well for image analysis task. How CNN analyzes an image and discriminates among samples of different classes are usually considered as non-transparent. As a result, it becomes difficult to apply CNN based approaches in clinical procedures and automated disease diagnosis systems. In this paper, we consider this issue and work on visualizing and understanding the decision…

Learning Shape Features and Abstractions in 3D Convolutional Neural Networks for Detecting Alzheimer's Disease

Deep Neural Networks - especially Convolutional Neural Network (ConvNet) has become the state-of-the-art for image classification, pattern recognition and various computer vision tasks. ConvNet has a huge potential in medical domain for analyzing medical data to diagnose diseases in an efficient way. Based on extracted features by ConvNet model from MRI data, early diagnosis is very crucial for preventing progress and treating the Alzheimer's disease. Despite having the ability to deliver great performance, absence of interpretability of the model's decision can lead to misdiagnosis which can …

Visualization approach to assess the robustness of neural networks for medical image classification

The use of neural networks for diagnosis classification is becoming more and more prevalent in the medical imaging community. However, deep learning method outputs remain hard to explain. Another difficulty is to choose among the large number of techniques developed to analyze how networks learn, as all present different limitations. In this paper, we extended the framework of Fong and Vedaldi [IEEE International Conference on Computer Vision (ICCV), 2017] to visualize the training of convolutional neural networks (CNNs) on 3D quantitative neuroimaging data. Our application focuses on the dete…