We consider the estimation of densities in multiple subpopulations, where the available sample size in each subpopulation greatly varies. This problem occurs in epidemiology, for example, where different diseases may share similar pathogenic mechanism but differ in their prevalence. Without specifying a parametric form, our proposed method pools information from the population and estimate the density in each subpopulation in a data-driven fashion. Drawing from functional data analysis, low-dimensional approximating density families in the form of exponential families are constructed from the principal modes of variation in the log-densities. Subpopulation densities are subsequently fitted in the approximating families based on likelihood principles and shrinkage. The approximating families increase in their flexibility as the number of components increases and can approximate arbitrary infinite-dimensional densities. We also derive convergence results of the density estimates with discrete observations. The proposed methods are shown to be interpretable and efficient in simulation as well as applications to electronic medical record and rainfall data.
In the last decade, simplified vine copula models have been an active area of research. They build a high dimensional probability density from the product of marginals densities and bivariate copula densities. Besides parametric models, several approaches to nonparametric estimation of vine copulas have been proposed. In this article, we extend these approaches and compare them in an extensive simulation study and a real data application. We identify several factors driving the relative performance of the estimators. The most important one is the strength of dependence. No method was found to …
In an empirical Bayes analysis, we use data from repeated sampling to imitate inferences made by an oracle Bayesian with extensive knowledge of the data-generating distribution. Existing results provide a comprehensive characterization of when and why empirical Bayes point estimates accurately recover oracle Bayes behavior. In this paper, we develop flexible and practical confidence intervals that provide asymptotic frequentist coverage of empirical Bayes estimands, such as the posterior mean or the local false sign rate. The coverage statements hold even when the estimands are only partially …
In this paper we study nonparametric estimators of copulas and copula densities. We first focus our study on a density copula estimator based on a polynomial orthogonal projection of the joint density. A new copula estimator is then deduced. Its asymptotic properties are studied: we provide a large functional class for which this construction is optimal in the minimax and maxiset sense and we propose a method selection for the smoothing parameter. An intensive simulation study shows the very good performance of both copulas and copula densities estimators which we compare to a large panel of c…
In this paper we study the problem of pointwise density estimation from observations with multiplicative measurement errors. We elucidate the main feature of this problem: the influence of the estimation point on the estimation accuracy. In particular, we show that, depending on whether this point is separated away from zero or not, there are two different regimes in terms of the rates of convergence of the minimax risk. In both regimes we develop kernel--type density estimators and prove upper bounds on their maximal risk over suitable nonparametric classes of densities. We show that the prop…
The present paper deals with a nonparametric M-estimation for right censored regression model with stationary ergodic data. Defined as an implicit function, a kernel type estimator of a family of robust regression is considered when the covariate take its values in R^d (d >= 1) and the data are sampled from stationary ergodic process. The strong consistency (with rate) and the asymptotic distribution of the estimator are established under mild assumptions. Moreover, a usable confidence interval is provided which does not depend on any unknown quantity. Our results hold without any mixing condi…
Nonparametric statistics for distribution functions F or densities f=F' under qualitative shape constraints provides an interesting alternative to classical parametric or entirely nonparametric approaches. We contribute to this area by considering a new shape constraint: F is said to be bi-log-concave, if both log(F) and log(1 - F) are concave. Many commonly considered distributions are compatible with this constraint. For instance, any c.d.f. F with log-concave density f = F' is bi-log-concave. But in contrast to the latter constraint, bi-log-concavity allows for multimodal densities. We prov…
This paper proposes a model-free nonparametric estimator of conditional quantile of a time series regression model where the covariate vector is repeated many times for different values of the response. This type of data is abound in climate studies. To tackle such problems, our proposed method exploits the replicated nature of the data and improves on restrictive linear model structure of conventional quantile regression. Relevant asymptotic theory for the nonparametric estimators of the mean and variance function of the model are derived under a very general framework. We provide a detailed …
Maximum likelihood estimators are proposed for the parameters and the densities in a semiparametric density ratio model in which the nonparametric baseline density is approximated by the Bernstein polynomial model. The EM algorithm is used to obtain the maximum approximate Bernstein likelihood estimates. Simulation study shows that the performance of the proposed method is much better than the existing ones. The proposed method is illustrated by real data examples. Some asymptotic results are also presented and proved.
In this paper, we consider the problem of estimating a conditional density in moderately large dimensions. Much more informative than regression functions, conditional densities are of main interest in recent methods, particularly in the Bayesian framework (studying the posterior distribution, finding its modes...). Considering a recently studied family of kernel estimators, we select a pointwise multivariate bandwidth by revisiting the greedy algorithm Rodeo (Regularisation Of Derivative Expectation Operator). The method addresses several issues: being greedy and computationally efficient by …
In the regime of change-point detection, a nonparametric framework based on scan statistics utilizing graphs representing similarities among observations is gaining attention due to its flexibility and good performances for high-dimensional and non-Euclidean data sequences, which are ubiquitous in this big data era. However, this graph-based framework encounters problems when there are repeated observations in the sequence, which often happens for discrete data, such as network data. In this work, we extend the graph-based framework to solve this problem by averaging or taking union of all pos…
We study the Nonparametric Maximum Likelihood Estimator (NPMLE) for estimating Gaussian location mixture densities in $d$-dimensions from independent observations. Unlike usual likelihood-based methods for fitting mixtures, NPMLEs are based on convex optimization. We prove finite sample results on the Hellinger accuracy of every NPMLE. Our results imply, in particular, that every NPMLE achieves near parametric risk (up to logarithmic multiplicative factors) when the true density is a discrete Gaussian mixture without any prior information on the number of mixture components. NPMLEs can natural…
Discontinuity in density functions is of economic importance and interest. For instance, in studies on regression discontinuity designs, discontinuity in the density of a running variable suggests violation of the no-manipulation assumption. In this paper we develop estimation and testing procedures on discontinuity in densities with positive support. Our approach is built on splitting the gamma kernel (Chen, 2000) into two parts at a given (dis)continuity point and constructing two truncated kernels. The jump-size magnitude of the density at the point can be estimated nonparametrically by two…
We introduce a nonparametric prior on the conditional distribution of a (univariate or multivariate) response given a set of predictors. The prior is constructed in the form of a two-stage generative procedure, which in the first stage recursively partitions the predictor space, and then in the second stage generates the conditional distribution by a multi-scale nonparametric density model on each predictor partition block generated in the first stage. This design allows adaptive smoothing on both the predictor space and the response space, and it results in the full posterior conjugacy of the…
In some applications (e.g., in cosmology and economics), the regression E[Z|x] is not adequate to represent the association between a predictor x and a response Z because of multi-modality and asymmetry of f(z|x); using the full density instead of a single-point estimate can then lead to less bias in subsequent analysis. As of now, there are no effective ways of estimating f(z|x) when x represents high-dimensional, complex data. In this paper, we propose a new nonparametric estimator of f(z|x) that adapts to sparse (low-dimensional) structure in x. By directly expanding f(z|x) in the eigenfunc…
We study the multivariate nonparametric change point detection problem, where the data are a sequence of independent $p$-dimensional random vectors whose distributions are piecewise-constant with Lipschitz densities changing at unknown times, called change points. We quantify the size of the distributional change at any change point with the supremum norm of the difference between the corresponding densities. We are concerned with the localization task of estimating the positions of the change points. In our analysis, we allow for the model parameters to vary with the total number of time poin…
In repeated measures factorial designs involving clustered units, parametric methods such as linear mixed effects models are used to handle within subject correlations. However, assumptions of these parametric models such as continuity and normality are usually hard to come by in many cases. The homoscedasticity assumption is rather hard to verify in practice. Furthermore, these assumptions may not even be realistic when data are measured in a non-metric scale as commonly happens, for example, in Quality of Life outcomes. In this article, nonparametric effect-size measures for clustered data i…
This paper develops a method to construct uniform confidence bands for a nonparametric regression function where a predictor variable is subject to a measurement error. We allow for the distribution of the measurement error to be unknown, but assume the availability of validation data or repeated measurements on the latent predictor variable. The proposed confidence band builds on the deconvolution kernel estimation and a novel application of the multiplier bootstrap method. We establish asymptotic validity of the proposed confidence band. To our knowledge, this is the first paper to derive as…
In this paper, we introduce a new estimator for the emission densities of a nonparametric hidden Markov model. It is adaptive and minimax with respect to each state's regularity--as opposed to globally minimax estimators, which adapt to the worst regularity among the emission densities. Our method is based on Goldenshluger and Lepski's methodology. It is computationally efficient and only requires a family of preliminary estimators, without any restriction on the type of estimators considered. We present two such estimators that allow to reach minimax rates up to a logarithmic term: a spectral…
In this article, we revisit the problem of fitting a mixture model under the assumption that the mixture components are symmetric and log-concave. To this end, we first study the nonparametric maximum likelihood estimation (NPMLE) of a monotone log-concave probability density. By following the arguments of Rufibach (2006), we show that the NPMLE is uniformly consistent with respect to the supremum norm on compact subsets of the interior of the support. To fit the mixture model, we propose a semiparametric EM (SEM) algorithm, which can be adapted to other semiparametric mixture models. In our n…
Identifying heterogeneity in a population's response to a health or policy intervention is crucial for evaluating and informing policy decisions. We propose a novel heterogeneous treatment effect estimator in the difference-in-differences design with repeated cross sectional data, where we observe different samples of a population at two time periods separated by the onset of a policy intervention, as well as samples of a population that serves as the control. Our estimator has orthogonality properties that enable fast rates on learning the treatment effect while allowing slower rates for esti…
Split-plot or repeated measures designs are frequently used for planning experiments in the life or social sciences. Typical examples include the comparison of different treatments over time, where both factors may possess an additional factorial structure. For such designs, the statistical analysis usually consists of several steps. If the global null is rejected, multiple comparisons are usually performed. Usually, general factorial repeated measures designs are inferred by classical linear mixed models. Common underlying assumptions, such as normality or variance homogeneity are often not m…
In this paper, we develop a method for the simultaneous estimation of spectral density functions (SDFs) for a collection of stationary time series that share some common features. Due to the similarities among the SDFs, the log-SDF can be represented using a common set of basis functions. The basis shared by the collection of the log-SDFs is estimated as a low-dimensional manifold of a large space spanned by a pre-specified rich basis. A collective estimation approach pools information and borrows strength across the SDFs to achieve better estimation efficiency. Also, each estimated spectral d…
We study nonparametric density estimation problems where error is measured in the Wasserstein distance, a metric on probability distributions popular in many areas of statistics and machine learning. We give the first minimax-optimal rates for this problem for general Wasserstein distances, and show that, unlike classical nonparametric density estimation, these rates depend on whether the densities in question are bounded below. Motivated by variational problems involving the Wasserstein distance, we also show how to construct discretely supported measures, suitable for computational purposes,…
Phylogenetic trees are key data objects in biology, and the method of phylogenetic reconstruction has been highly developed. The space of phylogenetic trees is a nonpositively curved metric space. Recently, statistical methods to analyze the set of trees on this space are being developed utilizing this property. Meanwhile, in Euclidean space, the log-concave maximum likelihood method has emerged as a new nonparametric method for probability density estimation. In this paper, we derive a sufficient condition for the existence and uniqueness of the log-concave maximum likelihood estimator on tre…
A central goal of causal inference is to detect and estimate the treatment effects of a given treatment or intervention on an outcome variable of interest, where a member known as the heterogeneous treatment effect (HTE) is of growing popularity in recent practical applications such as the personalized medicine. In this paper, we model the HTE as a smooth nonparametric difference between two less smooth baseline functions, and determine the tight statistical limits of the nonparametric HTE estimation as a function of the covariate geometry. In particular, a two-stage nearest-neighbor-based est…
This paper studies multivariate nonparametric change point localization and inference problems. The data consists of a multivariate time series with potentially short range dependence. The distribution of this data is assumed to be piecewise constant with densities in a Hölder class. The change points, or times at which the distribution changes, are unknown. We derive the limiting distributions of the change point estimators when the minimal jump size vanishes or remains constant, a first in the literature on change point settings. We are introducing two new features: a consistent estimator th…
This paper introduces the kernel mixture network, a new method for nonparametric estimation of conditional probability densities using neural networks. We model arbitrarily complex conditional densities as linear combinations of a family of kernel functions centered at a subset of training points. The weights are determined by the outer layer of a deep neural network, trained by minimizing the negative log likelihood. This generalizes the popular quantized softmax approach, which can be seen as a kernel mixture network with square and non-overlapping kernels. We test the performance of our met…
We consider the problem of comparing probability densities between two groups. A new probabilistic tensor product smoothing spline framework is developed to model the joint density of two variables. Under such a framework, the probability density comparison is equivalent to testing the presence/absence of interactions. We propose a penalized likelihood ratio test for such interaction testing and show that the test statistic is asymptotically chi-square distributed under the null hypothesis. Furthermore, we derive a sharp minimax testing rate based on the Bernstein width for nonparametric two-s…
Given a nonparametric Hidden Markov Model (HMM) with two states, the question of constructing efficient multiple testing procedures is considered, treating one of the states as an unknown null hypothesis. A procedure is introduced, based on nonparametric empirical Bayes ideas, that controls the False Discovery Rate (FDR) at a user--specified level. Guarantees on power are also provided, in the form of a control of the true positive rate. One of the key steps in the construction requires supremum--norm convergence of preliminary estimators of the emission densities of the HMM. We provide the ex…
We provide necessary and sufficient conditions of uniform consistency of nonparametric sets of alternatives of chi-squared test for testing of hypothesis of homogeneity. The number of cells of chi-squared test increases with sample size growth. Nonparametric sets of alternatives can be defined both in terms of densities and distribution functions.
Comparison of two univariate distributions based on independent samples from them is a fundamental problem in statistics, with applications in a wide variety of scientific disciplines. In many situations, we might hypothesize that the two distributions are stochastically ordered, meaning intuitively that samples from one distribution tend to be larger than those from the other. One type of stochastic order that arises in economics, biomedicine, and elsewhere is the likelihood ratio order, also known as the density ratio order, in which the ratio of the density functions of the two distribution…
Estimating the score, i.e., the gradient of log density function, from a set of samples generated by an unknown distribution is a fundamental task in inference and learning of probabilistic models that involve flexible yet intractable densities. Kernel estimators based on Stein's methods or score matching have shown promise, however their theoretical properties and relationships have not been fully-understood. We provide a unifying view of these estimators under the framework of regularized nonparametric regression. It allows us to analyse existing estimators and construct new ones with desira…
