Computed Tomography (CT) is an advanced imaging technology used in many important applications. Here we present a deep-learning (DL) based CT super-resolution (SR) method that can reconstruct low-resolution (LR) sinograms into high resolution (HR) CT images. The method synergistically combines a SR model in sinogram domain, a deblur model in image domain, and the iterative framework into a CT SR algorithm super resolution and deblur based iterative reconstruction (SADIR). We incorporated the CT domain knowledge into the SADIR and unrolled it into a DL network (SADIR Net). The SADIR Net is a zero shot learning (ZSL) network, which can be trained and tested with a single sinogram in the test time. The SADIR was evaluated via SR CT imaging of a Catphan700 physical phantom and a biological ham, and its performance was compared to the other state of the art (SotA) DL-based methods. The results show that the zero-shot SADIR-Net can indeed provide a performance comparable to the other SotA methods for CT SR reconstruction, especially in situations where training data is limited. The SADIR method can find use in improving CT resolution beyond hardware limits or lowering requirement on CT hardware.
Purpose: To introduce a fast and improved direct reconstruction method for multi-shot diffusion weighted (msDW) scans for high-resolution studies. Methods:Multi-shot EPI methods can enable higher spatial resolution for diffusion MRI studies. Traditionally, such acquisitions required specialized reconstructions involving phase compensation to correct for inter-shot motion artifacts. The recently proposed MUSSELS reconstruction belongs to a new class of parallel imaging-based methods that recover artifact-free DWIs from msDW data without needing phase compensation. However, computational demands…
T2 weighted imaging of the spine is commonly performed using fast spin echo (FSE/TSE) based sequences, resulting in long scan times and vulnerability to motion artifacts. While single shot fast spin echo sequences have been attempted, their adoption has been limited by poor spatial resolution and specific absorption rate (SAR) limitations. We investigate the use of a half-Fourier acquisition single-shot turbo spin-echo variable flip angle (HASTE-VFA) sequence for T2 weighted spine imaging. A variable refocusing flip angle echo train was first optimized for the spine to improve the point spread…
White light phase-shifting interference microscopy (WL-PSIM) is a prominent technique for high-resolution quantitative phase imaging (QPI) of industrial and biological specimens. However, multiple interferograms with accurate phase-shifts are essentially required in WL-PSIM for measuring the accurate phase of the object. Here, we present single-shot phase-shifting interferometric techniques for accurate phase measurement using filtered white light phase-shifting interference microscopy (F-WL-PSIM) and deep neural network (DNN). The methods are incorporated by training the DNN to generate 1) fo…
Structured illumination microscopy (SIM) can double the resolution beyond the light diffraction limit, but it comes at the cost of multiple camera exposures and the heavy computation burden of multiple Fourier transforms. In this paper, we report a novel technique termed single-shot SIM, to overcome these limitations. A multi-task joint deep-learning strategy is proposed. Generative adversative networks (GAN) are employed to generate five structured illumination images based on the single-shot structured illumination image. U-Net is employed to reconstruct the super-resolution image from these…
Multi-shot echo planar imaging (msEPI) is a promising approach to achieve high in-plane resolution with high sampling efficiency and low T2* blurring. However, due to the geometric distortion, shot-to-shot phase variations and potential subject motion, msEPI continues to be a challenge in MRI. In this work, we introduce acquisition and reconstruction strategies for robust, high-quality msEPI without phase navigators. We propose Blip Up-Down Acquisition (BUDA) using interleaved blip-up and -down phase encoding, and incorporate B0 forward-modeling into Hankel structured low-rank model to enable …
Fourier ptychographic microscopy allows for the collection of images with a high space-bandwidth product at the cost of temporal resolution. In Fourier ptychographic microscopy, the light source of a conventional widefield microscope is replaced with a light-emitting diode (LED) matrix, and multiple images are collected with different LED illumination patterns. From these images, a higher-resolution image can be computationally reconstructed without sacrificing field-of-view. We use deep learning to achieve single-shot imaging without sacrificing the space-bandwidth product, reducing the acqui…
We propose a novel approach and algorithm based on two preliminary tests of the optical system elements to enhance the super-resolved complex-valued imaging. The approach is developed for inverse phase imaging in a single-shot lensless optical setup. Imaging is based on wavefront modulation by a single binary phase mask. The preliminary tests compensate errors in the optical system and correct a carrying wavefront, reducing the gap between real-life experiments and computational modeling, which improve imaging significantly both qualitatively and quantitatively. These two tests are performed f…
The Weizmann Institute of Science（魏茨曼科学研究所）；Institute for Advanced Study, Princeton（普林斯顿高等研究院）
Deep Learning has led to a dramatic leap in Super-Resolution (SR) performance in the past few years. However, being supervised, these SR methods are restricted to specific training data, where the acquisition of the low-resolution (LR) images from their high-resolution (HR) counterparts is predetermined (e.g., bicubic downscaling), without any distracting artifacts (e.g., sensor noise, image compression, non-ideal PSF, etc). Real LR images, however, rarely obey these restrictions, resulting in poor SR results by SotA (State of the Art) methods. In this paper we introduce "Zero-Shot" SR, which …
University College London（伦敦大学学院）；UCLH（伦敦大学学院医院）；Mauna Kea Technologies（莫纳克亚技术公司）；Medtronic（美敦力公司）；Royal Academy of Engineering（英国皇家工程学院）
Super-resolution (SR) methods have seen significant advances thanks to the development of convolutional neural networks (CNNs). CNNs have been successfully employed to improve the quality of endomicroscopy imaging. Yet, the inherent limitation of research on SR in endomicroscopy remains the lack of ground truth high-resolution (HR) images, commonly used for both supervised training and reference-based image quality assessment (IQA). Therefore, alternative methods, such as unsupervised SR are being explored. To address the need for non-reference image quality improvement, we designed a novel ze…
Purpose: This work aims to develop a novel distortion-free 3D-EPI acquisition and image reconstruction technique for fast and robust, high-resolution, whole-brain imaging as well as quantitative T2* mapping. Methods: 3D-Blip-Up and -Down Acquisition (3D-BUDA) sequence is designed for both single- and multi-echo 3D GRE-EPI imaging using multiple shots with blip-up and -down readouts to encode B0 field map information. Complementary k-space coverage is achieved using controlled aliasing in parallel imaging (CAIPI) sampling across the shots. For image reconstruction, an iterative hard-thresholdin…
Zero-Shot Image Denoising for High-Resolution Electron Microscopy
School of Information Science and Technology, ShanghaiTech University（上海科技大学信息科学与技术学院）；Lingang Laboratory（临港实验室）；School of Physical Science and Technology, ShanghaiTech University（上海科技大学物理科学与技术学院）；School of Software, Tsinghua University（清华大学软件学院）；School of Biomedical Engineering and Institute of Medical Robotics, Shanghai Jiao Tong University（上海交通大学生物医学工程学院与医学机器人研究所）
CuNeRF: Cube-Based Neural Radiance Field for Zero-Shot Medical Image Arbitrary-Scale Super Resolution
School of Computer Science and Engineering, Sun Yat-sen University（中山大学计算机科学与工程学院）；Guangdong Province Key Laboratory of Information Security Technology（广东省信息安全技术重点实验室）；Key Laboratory of Machine Intelligence and Advanced Computing, Ministry of Education, China（教育部机器智能与先进计算重点实验室）
Light field microscopy (LFM) uses a microlens array (MLA) near the sensor plane of a microscope to achieve single-shot 3D imaging of a sample without any moving parts. Unfortunately, the 3D capability of LFM comes with a significant loss of lateral resolution at the focal plane. Placing the MLA near the pupil plane of the microscope, instead of the image plane, can mitigate the artifacts and provide an efficient forward model, at the expense of field-of-view (FOV). Here, we demonstrate improved resolution across a large volume with Fourier DiffuserScope, which uses a diffuser in the pupil plan…
Athinoula A. Martinos Center for Biomedical Imaging（阿西努拉·A·马蒂诺斯生物医学成像中心）；Harvard Medical School（哈佛医学院）；Harvard-MIT Health Sciences and Technology（哈佛-麻省理工健康科学与技术项目）；MIT（麻省理工学院）；National Nanotechnology Center, National Science and Technology Development Agency（国家科学技术发展局国家纳米技术中心）
Purpose: To introduce a combined machine learning (ML) and physics-based image reconstruction framework that enables navigator-free, highly accelerated multishot echo planar imaging (msEPI), and demonstrate its application in high-resolution structural and diffusion imaging. Methods: Singleshot EPI is an efficient encoding technique, but does not lend itself well to high-resolution imaging due to severe distortion artifacts and blurring. While msEPI can mitigate these artifacts, high-quality msEPI has been elusive because of phase mismatch arising from shot-to-shot variations which preclude th…
Miniature fluorescence microscopes are a standard tool in systems biology. However, widefield miniature microscopes capture only 2D information, and modifications that enable 3D capabilities increase the size and weight and have poor resolution outside a narrow depth range. Here, we achieve the 3D capability by replacing the tube lens of a conventional 2D Miniscope with an optimized multifocal phase mask at the objective's aperture stop. Placing the phase mask at the aperture stop significantly reduces the size of the device, and varying the focal lengths enables a uniform resolution across a …
In recent years nanoscale coherent imaging has emerged as an indispensable imaging modality allowing to surpass the resolution limit given by classical imaging optics. At the same time, attosecond science has experienced enormous progress and has revealed the ultrafast dynamics in atoms, molecules, and complex materials. Combining attosecond temporal resolution of pump-probe experiments with nanometer spatial resolution would allow studying ultrafast dynamics on the smallest spatio-temporal scales but has not been demonstrated yet. Unfortunately, the large bandwidth of attosecond pulses usuall…
Improved Multi-Shot Diffusion-Weighted MRI with Zero-Shot Self-Supervised Learning Reconstruction
Athinoula A. Martinos Center for Biomedical Imaging（阿瑟诺拉·A·马蒂诺斯生物医学成像中心）；Harvard Medical School（哈佛医学院）；University of São Paulo（圣保罗大学）；Technische Universität München（慕尼黑工业大学）；Harvard-MIT Health Sciences and Technology（哈佛-麻省理工健康科学与技术部）
Fluorescence imaging is indispensable to biology and neuroscience. The need for large-scale imaging in freely behaving animals has further driven the development in miniaturized microscopes (miniscopes). However, conventional microscopes / miniscopes are inherently constrained by their limited space-bandwidth-product, shallow depth-of-field, and the inability to resolve 3D distributed emitters. Here, we present a Computational Miniature Mesoscope (CM$^2$) that overcomes these bottlenecks and enables single-shot 3D imaging across an 8 $\times$ 7-mm$^2$ field-of-view and 2.5-mm depth-of-field, a…
In real-world applications (e.g., change detection), annotating images is very expensive. To build effective deep learning models in these applications, deep few-shot learning methods have been developed and prove to be a robust approach in small training data. The analysis of building change detection from high spatial resolution remote sensing observations is important research in photogrammetry, computer vision, and remote sensing nowadays, which can be widely used in a variety of real-world applications, such as map updating. As manual high resolution image interpretation is expensive and …
