Monitoring treatment response in longitudinal studies plays an important role in clinical practice. Accurately identifying lesions across serial imaging follow-up is the core to the monitoring procedure. Typically this incorporates both image and anatomical considerations. However, matching lesions manually is labor-intensive and time-consuming. In this work, we present deep lesion tracker (DLT), a deep learning approach that uses both appearance- and anatomical-based signals. To incorporate anatomical constraints, we propose an anatomical signal encoder, which prevents lesions being matched with visually similar but spurious regions. In addition, we present a new formulation for Siamese networks that avoids the heavy computational loads of 3D cross-correlation. To present our network with greater varieties of images, we also propose a self-supervised learning (SSL) strategy to train trackers with unpaired images, overcoming barriers to data collection. To train and evaluate our tracker, we introduce and release the first lesion tracking benchmark, consisting of 3891 lesion pairs from the public DeepLesion database. The proposed method, DLT, locates lesion centers with a mean error distance of 7 mm. This is 5% better than a leading registration algorithm while running 14 times faster on whole CT volumes. We demonstrate even greater improvements over detector or similarity-learning alternatives. DLT also generalizes well on an external clinical test set of 100 longitudinal studies, achieving 88% accuracy. Finally, we plug DLT into an automatic tumor monitoring workflow where it leads to an accuracy of 85% in assessing lesion treatment responses, which is only 0.46% lower than the accuracy of manual inputs.
Technical University of Denmark（丹麦技术大学）；Athinoula A. Martinos Center for Biomedical Imaging（阿西努拉·A·马丁诺斯生物医学成像中心）；Massachusetts General Hospital（麻省总医院）；Harvard Medical School（哈佛医学院）；Technical University of Munich（慕尼黑工业大学）
In this paper we propose a novel method for the segmentation of longitudinal brain MRI scans of patients suffering from Multiple Sclerosis. The method builds upon an existing cross-sectional method for simultaneous whole-brain and lesion segmentation, introducing subject-specific latent variables to encourage temporal consistency between longitudinal scans. It is very generally applicable, as it does not make any prior assumptions on the scanner, the MRI protocol, or the number and timing of longitudinal follow-up scans. Preliminary experiments on three longitudinal datasets indicate that the …
SegHeD: Segmentation of Heterogeneous Data for Multiple Sclerosis Lesions with Anatomical Constraints
Imperial College London（伦敦帝国学院）；Data Science Institute, Imperial College London（伦敦帝国学院数据科学研究所）；Beijing Institute of Technology（北京理工大学）；UK Dementia Research Institute（英国痴呆症研究所）；Rosalind Franklin Institute（罗莎琳德·富兰克林研究所）
Exploiting Longitudinal Context in Clinician-Verified Interactive Lesion Tracking
German Cancer Research Center (DKFZ) Heidelberg, Division of Medical Image Computing, Germany（德国癌症研究中心（DKFZ）海德堡，医学图像计算部，德国）；Faculty of Mathematics and Computer Science, Heidelberg University, Germany（海德堡大学数学与计算机科学学院，德国）；HIDSS4Health -- Helmholtz Information and Data Science School for Health, Karlsruhe/Heidelberg, Germany（HIDSS4Health——海德堡信息与数据科学健康学校，卡尔斯鲁厄/海德堡，德国）；Medical Faculty, Heidelberg University, Germany（海德堡大学医学学院，德国）；University Hospital Brandenburg an der Havel, Brandenburg Medical School Theodor Fontane, Germany（勃兰登堡运河大学医院，布兰登堡泰奥多尔·冯·_fontane医学学校，德国）；Pattern Analysis and Learning Group, Department of Radiation Oncology, Heidelberg University Hospital, Germany（放射肿瘤科模式分析与学习组，海德堡大学医院，德国）
InferVision Medical Technology Co., Ltd.（推想医疗科技股份有限公司）
Evaluating lesion progression and treatment response via longitudinal lesion tracking plays a critical role in clinical practice. Automated approaches for this task are motivated by prohibitive labor costs and time consumption when lesion matching is done manually. Previous methods typically lack the integration of local and global information. In this work, we propose a transformer-based approach, termed Transformer Lesion Tracker (TLT). Specifically, we design a Cross Attention-based Transformer (CAT) to capture and combine both global and local information to enhance feature extraction. We …
Revisiting Lesion Tracking in 3D Total Body Photography
Johns Hopkins University（约翰斯·霍普金斯大学）；Eunice Kennedy Shriver National Institute of Child Health and Human Development（尤妮斯·肯尼迪·施莱弗国家儿童健康与人类发展研究所）；Lumo Imaging（卢莫影像公司）；Johns Hopkins School of Medicine（约翰斯·霍普金斯医学院）；University of Arkansas（阿肯色大学）
Istituto Italiano di Tecnologia（意大利理工学院）；University of Genoa（热那亚大学）；Fondation Campus Biotech Geneva（日内瓦校园生物技术基金会）；San Raffaele Scientific Institute（圣拉斐尔科学研究所）；University of Verona（维罗纳大学）；Fondazione Bruno Kessler（布鲁诺·凯斯勒基金会）
In this paper, we present an automated approach for segmenting multiple sclerosis (MS) lesions from multi-modal brain magnetic resonance images. Our method is based on a deep end-to-end 2D convolutional neural network (CNN) for slice-based segmentation of 3D volumetric data. The proposed CNN includes a multi-branch downsampling path, which enables the network to encode information from multiple modalities separately. Multi-scale feature fusion blocks are proposed to combine feature maps from different modalities at different stages of the network. Then, multi-scale feature upsampling blocks ar…
ISLES'24 -- A Real-World Longitudinal Multimodal Stroke Dataset
Technical University of Munich（慕尼黑工业大学）；University of Zurich（苏黎世大学）；University Hospital of Zurich（苏黎世大学医院）；Zurich University of Applied Sciences（苏黎世应用科学大学）；icometrix（icometrix公司）；University of Girona（赫罗纳大学）；Inselspital（伯尔尼医院）；University Hospital Bern（伯尔尼大学医院）；University of Bern（伯尔尼大学）；Eindhoven University of Technology（埃因霍温理工大学）；Imperial College London（帝国理工学院）
Longitudinal tracking of multiple sclerosis lesions in the spinal cord: A validation study
Polytechnique Montreal（蒙特利尔理工学院）；TUM University Hospital（慕尼黑工业大学附属医院）；University of British Columbia（不列颠哥伦比亚大学）；University of Calgary（卡尔加里大学）；University of Toronto（多伦多大学）；Université de Montréal（蒙特利尔大学）；University of Alberta（阿尔伯塔大学）
Inverse Bayesian Inference for Extracting Lesion Dynamics from Longitudinal Spectral CT
University Hospital Augsburg（奥格斯堡大学医院）；Technical University of Munich（慕尼黑工业大学）；Bavarian Center for Cancer Research (BZKF)（巴伐利亚癌症研究中心）；University of Augsburg（奥格斯堡大学）
Massachusetts General Hospital（麻省总医院）；Harvard Medical School（哈佛医学院）；Copenhagen University Hospital Amager and Hvidovre（哥本哈根大学阿玛格-海维德夫医院）；Copenhagen University Hospital Bispebjerg and Frederiksberg（哥本哈根大学比斯珀比约-腓特烈斯贝医院）；University of Copenhagen（哥本哈根大学）；Technical University of Munich（慕尼黑工业大学）；Technical University of Denmark（丹麦技术大学）
In this paper we describe and validate a longitudinal method for whole-brain segmentation of longitudinal MRI scans. It builds upon an existing whole-brain segmentation method that can handle multi-contrast data and robustly analyze images with white matter lesions. This method is here extended with subject-specific latent variables that encourage temporal consistency between its segmentation results, enabling it to better track subtle morphological changes in dozens of neuroanatomical structures and white matter lesions. We validate the proposed method on multiple datasets of control subjects…
Medical Image Analysis Lab, School of Computing Science（计算科学学院医学图像分析实验室）；Simon Fraser University（西蒙弗雷泽大学）
We present an automated approach to detect and longitudinally track skin lesions on 3D total-body skin surface scans. The acquired 3D mesh of the subject is unwrapped to a 2D texture image, where a trained objected detection model, Faster R-CNN, localizes the lesions within the 2D domain. These detected skin lesions are mapped back to the 3D surface of the subject and, for subjects imaged multiple times, we construct a graph-based matching procedure to longitudinally track lesions that considers the anatomical correspondences among pairs of meshes and the geodesic proximity of corresponding le…
Promptable Longitudinal Lesion Segmentation in Whole-Body CT
German Cancer Research Center (DKFZ) Heidelberg（德国癌症研究中心（DKFZ）海德堡）；Division of Medical Image Computing（医学影像计算 division）；HIDSS4Health - Helmholtz Information and Data Science School for Health（HIDSS4Health - 赫尔姆霍茨信息与数据科学健康学校）；Faculty of Mathematics and Computer Science（数学与计算机科学学院）；Heidelberg University（海德堡大学）；Helmholtz Imaging（赫尔姆霍茨成像）；Pattern Analysis and Learning Group（模式分析与学习小组）；Department of Radiation Oncology（放射肿瘤科）
Flinders University（弗林德斯大学）；Flinders Medical Centre（弗林德斯医疗中心）；Dr Jones & Partners Medical Imaging（琼斯博士及合伙人医疗影像中心）；University of Oxford（牛津大学）；University of Adelaide（阿德莱德大学）
Longitudinal imaging forms an essential component in the management and follow-up of many medical conditions. The presence of lesion changes on serial imaging can have significant impact on clinical decision making, highlighting the important role for automated change detection. Lesion changes can represent anomalies in serial imaging, which implies a limited availability of annotations and a wide variety of possible changes that need to be considered. Hence, we introduce a new unsupervised anomaly detection and localisation method trained exclusively with serial images that do not contain any…
Technical University of Munich（慕尼黑工业大学）；University of Ljubljana（卢布尔雅那大学）；Johns Hopkins University（约翰斯·霍普金斯大学）
Segmentation of Multiple Sclerosis (MS) lesions in longitudinal brain MR scans is performed for monitoring the progression of MS lesions. We hypothesize that the spatio-temporal cues in longitudinal data can aid the segmentation algorithm. Therefore, we propose a multi-task learning approach by defining an auxiliary self-supervised task of deformable registration between two time-points to guide the neural network toward learning from spatio-temporal changes. We show the efficacy of our method on a clinical dataset comprised of 70 patients with one follow-up study for each patient. Our results…
Univ. Bordeaux（波尔多大学）；Bordeaux INP（波尔多国立理工学院）；CNRS（法国国家科学研究中心）；Universitat Politècnica de València（瓦伦西亚理工大学）；INSERM（法国国家健康与医学研究院）；Neurocentre Magendie（马让迪神经中心）
The detection of new multiple sclerosis (MS) lesions is an important marker of the evolution of the disease. The applicability of learning-based methods could automate this task efficiently. However, the lack of annotated longitudinal data with new-appearing lesions is a limiting factor for the training of robust and generalizing models. In this work, we describe a deep-learning-based pipeline addressing the challenging task of detecting and segmenting new MS lesions. First, we propose to use transfer-learning from a model trained on a segmentation task using single time-points. Therefore, we …
LesiOnTime -- Joint Temporal and Clinical Modeling for Small Breast Lesion Segmentation in Longitudinal DCE-MRI
Computational Imaging Research Lab, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Austria（医学影像研究实验室，生物医学影像与影像引导治疗系，维也纳医科大学）；Comprehensive Center for AI in Medicine, Medical University of Vienna, Austria（医学人工智能综合中心，维也纳医科大学）；Breast Health Center, Privatklinik Döbling, Austria（乳腺健康中心，多克林根私人诊所）；Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Austria（生物医学影像与影像引导治疗系，维也纳医科大学）；Department of Obstetrics and Gynecology, Medical University of Vienna, Austria（妇产科系，维也纳医科大学）；Department of Pathology, Medical University of Vienna, Austria（病理学系，维也纳医科大学）；Comprehensive Cancer Center, Medical University of Vienna, Austria（综合癌症中心，维也纳医科大学）
AI-based response assessment and prediction in longitudinal imaging for brain metastases treated with stereotactic radiosurgery
Institute of Informatics, HES-SO Valais-Wallis（信息学院，瑞士瓦莱-德瓦兹大学）；Department of Oncology, Geneva University Hospitals (HUG)（日内瓦大学医院肿瘤科）；Department of Oncology, Lausanne University Hospital (CHUV)（洛桑大学医院肿瘤科）；University of Lausanne (UNIL)（洛桑大学）；Lundin Family Brain Tumour Research Centre, CHUV and UNIL（伦丁脑肿瘤研究中心，CHUV和UNIL）；Department of Medical Radiology, Service of Diagnostic and Interventional Radiology, Neuroradiology Unit, CHUV and UNIL（医学放射科，诊断和介入放射科，神经放射科单位，CHUV和UNIL）；Department of Oncology, Service of Radiation Oncology, CHUV and UNIL（肿瘤科，放疗科，CHUV和UNIL）；Department of Medical Radiology, Service of Nuclear Medicine（医学放射科，核医学科）；Department of Neuroscience, CHUV（神经科学系，CHUV）
Longitudinal Segmentation of MS Lesions via Temporal Difference Weighting
German Cancer Research Center (DKFZ)（德国癌症研究中心）；Heidelberg University（海德堡大学）；Helmholtz Information and Data Science School for Health（亥姆霍兹健康信息与数据科学学院）；Helmholtz Imaging（亥姆霍兹影像中心）
Skin Lesion Correspondence Localization in Total Body Photography
Johns Hopkins University（约翰斯·霍普金斯大学）；Lumo Imaging；Johns Hopkins School of Medicine（约翰斯·霍普金斯医学院）；Eunice Kennedy Shriver National Institute of Child Health and Human Development（尤尼斯·肯尼迪·施莱弗国家儿童健康与人类发展研究所）；Johns Hopkins University, Department of Orthopaedic Surgery（约翰斯·霍普金斯大学骨科）
Registration of Longitudinal Spine CTs for Monitoring Lesion Growth
Harvard Medical School（哈佛医学院）；Beth Israel Deaconess Medical Center（贝斯以色列女执事医疗中心）；Brigham and Women’s Hospital（布莱根妇女医院）；Isomics Inc（伊索米克斯公司）；Dana-Farber Cancer Institute（达纳-法伯癌症研究所）
KU Leuven（鲁汶大学）；icometrix（伊科梅特里克斯公司）；Technical University of Denmark（丹麦技术大学）
The evaluation of white matter lesion progression is an important biomarker in the follow-up of MS patients and plays a crucial role when deciding the course of treatment. Current automated lesion segmentation algorithms are susceptible to variability in image characteristics related to MRI scanner or protocol differences. We propose a model that improves the consistency of MS lesion segmentations in inter-scanner studies. First, we train a CNN base model to approximate the performance of icobrain, an FDA-approved clinically available lesion segmentation software. A discriminator model is then…
SegHeD+: Segmentation of Heterogeneous Data for Multiple Sclerosis Lesions with Anatomical Constraints and Lesion-aware Augmentation
Imperial College London（帝国理工学院）；Data Science Institute, Imperial College London（帝国理工学院数据科学研究所）；UK Dementia Research Institute, Imperial College London（帝国理工学院英国痴呆症研究所）；Rosalind Franklin Institute（罗莎琳德·富兰克林研究所）
Volumetric segmentation of lesions on CT scans is important for many types of analysis, including lesion growth kinetic modeling in clinical trials and machine learning of radiomic features. Manual segmentation is laborious, and impractical for large-scale use. For routine clinical use, and in clinical trials that apply the Response Evaluation Criteria In Solid Tumors (RECIST), clinicians typically outline the boundaries of a lesion on a single slice to extract diameter measurements. In this work, we have collected a large-scale database, named LesionVis, with pixel-wise manual 2D lesion delin…
Springbok, Inc.（斯普林博克公司）；University of Virginia（弗吉尼亚大学）
Deep neural networks (DNN) have shown promises in the lesion segmentation of multiple sclerosis (MS) from multicontrast MRI including T1, T2, proton density (PD) and FLAIR sequences. However, one challenge in deploying such networks into clinical practice is the variability of imaging protocols, which often differ from the training dataset as certain MRI sequences may be unavailable or unusable. Therefore, trained networks need to adapt to practical situations when imaging protocols are different in deployment. In this paper, we propose a DNN-based MS lesion segmentation framework with a novel…
Boston Children's Hospital（波士顿儿童医院）；Harvard Medical School（哈佛医学院）；Northeastern University（东北大学）
Fully convolutional deep neural networks have been asserted to be fast and precise frameworks with great potential in image segmentation. One of the major challenges in training such networks raises when data is unbalanced, which is common in many medical imaging applications such as lesion segmentation where lesion class voxels are often much lower in numbers than non-lesion voxels. A trained network with unbalanced data may make predictions with high precision and low recall, being severely biased towards the non-lesion class which is particularly undesired in most medical applications where…
Multiple Sclerosis (MS) is a chronic progressive neurological disease characterized by the development of lesions in the white matter of the brain. T2-fluid-attenuated inversion recovery (FLAIR) brain magnetic resonance imaging (MRI) provides superior visualization and characterization of MS lesions, relative to other MRI modalities. Longitudinal brain FLAIR MRI in MS, involving repetitively imaging a patient over time, provides helpful information for clinicians towards monitoring disease progression. Predicting future whole brain MRI examinations with variable time lag has only been attempte…
Ecole Centrale de Nantes（南特中央理工学院）；Keosys Medical Imaging（Keosys医学影像公司）；University of Nantes（南特大学）；University of Angers（昂热大学）；ICO Cancer Center（ICO癌症中心）
Longitudinal image registration is challenging and has not yet benefited from major performance improvements thanks to deep-learning. Inspired by Deep Image Prior, this paper introduces a different use of deep architectures as regularizers to tackle the image registration question. We propose a subject-specific deformable registration method called MIRRBA, relying on a deep pyramidal architecture to be the prior parametric model constraining the deformation field. Diverging from the supervised learning paradigm, MIRRBA does not require a learning database, but only the pair of images to be reg…
Vanderbilt University（范德堡大学）；Vanderbilt University Medical Center（范德堡大学医学中心）
Features learned from single radiologic images are unable to provide information about whether and how much a lesion may be changing over time. Time-dependent features computed from repeated images can capture those changes and help identify malignant lesions by their temporal behavior. However, longitudinal medical imaging presents the unique challenge of sparse, irregular time intervals in data acquisition. While self-attention has been shown to be a versatile and efficient learning mechanism for time series and natural images, its potential for interpreting temporal distance between sparse,…
Univ. Bordeaux（波尔多大学）；Bordeaux INP（波尔多国立理工学院）；CNRS（法国国家科学研究中心）；INSERM（法国国家健康与医学研究院）；Neurocentre Magendie（马让迪神经中心）；Universitat Politècnica de València（瓦伦西亚理工大学）
Recently, segmentation methods based on Convolutional Neural Networks (CNNs) showed promising performance in automatic Multiple Sclerosis (MS) lesions segmentation. These techniques have even outperformed human experts in controlled evaluation conditions such as Longitudinal MS Lesion Segmentation Challenge (ISBI Challenge). However state-of-the-art approaches trained to perform well on highly-controlled datasets fail to generalize on clinical data from unseen datasets. Instead of proposing another improvement of the segmentation accuracy, we propose a novel method robust to domain shift and p…
UNISELF: A Unified Network with Instance Normalization and Self-Ensembled Lesion Fusion for Multiple Sclerosis Lesion Segmentation
Department of Electrical and Computer Engineering, Johns Hopkins University, Baltimore, MD 21218, USA（电气与计算机工程系，约翰霍普金斯大学）；Department of Electrical and Computer Engineering, Vanderbilt University, Nashville, TN 37215, USA（电气与计算机工程系，范德比尔特大学）；Department of Neurology, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA（神经病学系，约翰霍普金斯医学院）；Department of Computer Science, Johns Hopkins University, Baltimore, MD 21218, USA（计算机科学系，约翰霍普金斯大学）；Department of Radiology, Uniformed Services University of the Health Sciences, Bethesda, MD, 20814, USA（放射学系，统一服务大学健康科学学院）
Is Complete Labeling Necessary? Understanding Active Learning in Longitudinal Medical Imaging
School of Computer Science, University College Dublin（都柏林大学计算机科学学院）；Insight Centre for Data Analytics（数据分析研究中心）；School of Medicine, University College Dublin（都柏林大学医学院）；Department of Radiology, St Vincent’s University Hospital（圣文森大学医院放射科）；Great Ormond Street Hospital for Children（儿童医院）
Simultaneous column-based deep learning progression analysis of atrophy associated with AMD in longitudinal OCT studies
School of Computer Science and Engineering, The Hebrew University of Jerusalem（耶路撒冷希伯来大学计算机科学与工程学院）；The Alexander Grass Center for Bioengineering, The Hebrew University of Jerusalem（耶路撒冷希伯来大学亚历山大·格拉斯生物工程中心）；Hadassah Medical Center（哈达萨医疗中心）
How We Won the ISLES'24 Challenge by Preprocessing
Department of Mechanical Engineering, University of Washington（华盛顿大学机械工程系）；Paul G. Allen School of Computer Science, University of Washington（华盛顿大学保罗·G·阿伦计算机科学学院）；Department of Bioengineering, University of Washington（华盛顿大学生物工程系）
USC Stevens Neuroimaging and Informatics Institute（南加州大学史蒂文斯神经影像与信息学研究所）；Zilkha Neurogenetic Institute, Keck School of Medicine of USC（南加州大学凯克医学院齐尔卡神经遗传学研究所）；Martinos Center for Biomedical Imaging, Massachusetts General Hospital（麻省总医院马蒂诺斯生物医学成像中心）；Yale University（耶鲁大学）；University of Iowa（爱荷华大学）；Augusta University（奥古斯塔大学）；University of Texas（德克萨斯大学）；Kennedy Krieger Institute, Johns Hopkins University（约翰斯·霍普金斯大学肯尼迪·克里格研究所）
While ischemic stroke is a leading cause of death worldwide, there has been little success translating putative cerebroprotectants from rodent preclinical trials to human patients. We investigated computational image-based assessment tools for practical improvement of the quality, scalability, and outlook for large scale preclinical screening for potential therapeutic interventions in rodent models. We developed, evaluated, and deployed a pipeline for image-based stroke outcome quantification for the Stroke Preclinical Assessment Network (SPAN), a multi-site, multi-arm, multi-stage study evalu…
Modelling Geographic Atrophy Progression using Implicit Neural Representations
University of Basel（巴塞尔大学）；University Hospital Basel（巴塞尔大学医院）；Moorfields Eye Hospital NHS Foundation Trust（摩尔菲尔兹眼科医院NHS基金会信托）；Vienna University of Natural Resources and Life Sciences（维也纳自然资源与生命科学大学）
The University of Tokyo Hospital（东京大学医院）；Chiba University（千叶大学）
From birth to death, we all experience surprisingly ubiquitous changes over time due to aging. If we can predict aging in the digital domain, that is, the digital twin of the human body, we would be able to detect lesions in their very early stages, thereby enhancing the quality of life and extending the life span. We observed that none of the previously developed digital twins of the adult human body explicitly trained longitudinal conversion rules between volumetric medical images with deep generative models, potentially resulting in poor prediction performance of, for example, ventricular v…
ISLES'24: Final Infarct Prediction with Multimodal Imaging and Clinical Data. Where Do We Stand?
Department of Quantitative Biomedicine, University of Zurich, Zurich, Switzerland.；Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, the Netherlands.；ARTORG Center for Biomedical Research, University of Bern, Bern, Switzerland.；Department of Radiation Oncology, University Hospital Bern, University of Bern.；Support Center of Advanced Neuroimaging (SCAN), University Institute of Diagnostic；University Institute of Diagnostic；Interventional Neuroradiology, University Hospital Bern, Inselspital, University of Bern, Bern, Switzerland.；Department of Neurology, University Hospital of Zurich, Zurich, Switzerland.；University of Zurich, Zurich, Switzerland.；Department of Diagnostic；Interventional Neuroradiology, School of Medicine；Health, TUM Klinikum, Technical University of Munich, Germany.；TranslaTUM, Center for Translational Cancer Research, Technical University of Munich, Germany.；Therapy, School of Medicine；Health, Technical University of Munich, Munich, Germany.；Department of Biomedical Engineering；Physics, Amsterdam UMC location University of Amsterdam, Amsterdam, the Netherlands；Department of Radiology, University of Calgary, Calgary, Canada；Hotchkiss Brain Institute, University of Calgary, Calgary, Canada；Alberta Children’s Hospital Research Institute, University of Calgary, Calgary, Canada；Heuron Co., Ltd., Seoul, South Korea；School of Electrical Engineering, Korea University, Seoul, Korea；University of Alberta, Alberta, Canada；Hawkes Institute, Department of Computer Science, University College London, London, United Kingdom；Lung Institute, Faculty of Medicine, Imperial College London, London, United Kingdom；University of Calgary, Canada；University of Washington, Washington, United States；CREATIS, Universite Claude Bernard Lyon 1, INSA Lyon, UMR CNRS 5220, Inserm U1294, Villeurbanne, France；Department of Neurology, University Hospital Zurich, Zurich, Switzerland
MedDIFT: Multi-Scale Diffusion-Based Correspondence in 3D Medical Imaging
1 School of Computation, Information；Technology, Technical University of Munich 2 Institute of Machine Learning in Biomedical Imaging, Helmholtz Munich 3 Munich Center for Machine Learning (MCML) 4 Institute for Diagnostic；Interventional Radiology, Klinkum Rechts der Isar 5 School of Biomedical Engineering \& Imaging Sciences, King’s College London
UAE: Universal Anatomical Embedding on Multi-modality Medical Images
National Engineering Laboratory for Integrated Aero-Space-Ground-Ocean Big Data Application Technology, School of Computer Science and Engineering, Northwestern Polytechnical University（西北工业大学计算机科学与工程学院，空天地海一体化大数据应用技术国家工程实验室）；Department of Electronic Engineering, The Chinese University of Hong Kong（香港中文大学电子工程系）；Beijing United Family Hospital（北京和睦家医院）；The First Affiliated Hospital, Zhejiang University（浙江大学医学院附属第一医院）；Peking Union Medical College Hospital（北京协和医院）
Automatic Quantification of Serial PET/CT Images for Pediatric Hodgkin Lymphoma Patients Using a Longitudinally-Aware Segmentation Network
University of Wisconsin（威斯康星大学）；University of Wisconsin Carbone Comprehensive Cancer Center（威斯康星大学卡本综合癌症中心）；Emory University School of Medicine（埃默里大学医学院）；Aflac Cancer and Blood Disorders Center（aflac癌症与血液疾病中心）；Roswell Park Comprehensive Cancer Center（罗斯威尔公园综合癌症中心）；University at Buffalo Jacobs School of Medicine and Biomedical Sciences（布法罗大学雅各布斯医学与生物医学科学学院）；Imaging and Radiation Oncology Core Rhode Island（罗德岛影像与放射肿瘤学核心机构）
Alzahra University（阿尔扎赫拉大学）；The University of Winnipeg（温尼伯大学）；Shahid Beheshti University of Medical Science（沙希德·贝赫什提医科大学）
The automatic analysis of subtle changes between longitudinal MR images is an important task as it is still a challenging issue in scope of the breast medical image processing. In this paper we propose an effective automatic change detection framework composed of two phases since previously used methods have features with low distinctive power. First, in the preprocessing phase an intensity normalization method is suggested based on Hierarchical Histogram Matching (HHM) that is more robust to noise than previous methods. To eliminate undesirable changes and extract the regions containing signi…
WoundNet-Ensemble: A Novel IoMT System Integrating Self-Supervised Deep Learning and Multi-Model Fusion for Automated, High-Accuracy Wound Classification and Healing Progression Monitoring
The Catholic University of America（美国天主教大学）；Center for Advanced Research in Computer Engineering（计算机工程高级研究中心）
HACA3: A Unified Approach for Multi-site MR Image Harmonization
Johns Hopkins University（约翰斯·霍普金斯大学）；National Institute on Aging, National Institutes of Health（美国国立卫生研究院国家老龄化研究所）；Johns Hopkins School of Medicine（约翰斯·霍普金斯大学医学院）
