Differences between human and machine perception in medical diagnosis
New York University（纽约大学）；NYU Langone Health（纽约大学朗格尼医学中心）；Warsaw University of Technology（华沙理工大学）
Taro Makino, Stanislaw Jastrzebski, Witold Oleszkiewicz, Celin Chacko, Robin Ehrenpreis, Naziya Samreen, Chloe Chhor, Eric Kim, Jiyon Lee, Kristine Pysarenko, B… 展开作者
Taro Makino, Stanislaw Jastrzebski, Witold Oleszkiewicz, Celin Chacko, Robin Ehrenpreis, Naziya Samreen, Chloe Chhor, Eric Kim, Jiyon Lee, Kristine Pysarenko, Beatriu Reig, Hildegard Toth, Divya Awal, Linda Du, Alice Kim, James Park, Daniel K. Sodickson, Laura Heacock, Linda Moy, Kyunghyun Cho, Krzysztof J. Geras
Deep neural networks (DNNs) show promise in image-based medical diagnosis, but cannot be fully trusted since their performance can be severely degraded by dataset shifts to which human perception remains invariant. If we can better understand the differences between human and machine perception, we can potentially characterize and mitigate this effect. We therefore propose a framework for comparing human and machine perception in medical diagnosis. The two are compared with respect to their sensitivity to the removal of clinically meaningful information, and to the regions of an image deemed most suspicious. Drawing inspiration from the natural image domain, we frame both comparisons in terms of perturbation robustness. The novelty of our framework is that separate analyses are performed for subgroups with clinically meaningful differences. We argue that this is necessary in order to avert Simpson's paradox and draw correct conclusions. We demonstrate our framework with a case study in breast cancer screening, and reveal significant differences between radiologists and DNNs. We compare the two with respect to their robustness to Gaussian low-pass filtering, performing a subgroup analysis on microcalcifications and soft tissue lesions. For microcalcifications, DNNs use a separate set of high frequency components than radiologists, some of which lie outside the image regions considered most suspicious by radiologists. These features run the risk of being spurious, but if not, could represent potential new biomarkers. For soft tissue lesions, the divergence between radiologists and DNNs is even starker, with DNNs relying heavily on spurious high frequency components ignored by radiologists. Importantly, this deviation in soft tissue lesions was only observable through subgroup analysis, which highlights the importance of incorporating medical domain knowledge into our comparison framework.
Graduate School at Shenzhen, Tsinghua University（清华大学深圳研究生院）；Computer Science and Engineering, University of South Carolina（南卡罗来纳大学计算机科学与工程系）
The implementation of medical AI has always been a problem. The effect of traditional perceptual AI algorithm in medical image processing needs to be improved. Here we propose a method of knowledge AI, which is a combination of perceptual AI and clinical knowledge and experience. Based on this method, the geometric information mining of medical images can represent the experience and information and evaluate the quality of medical images.
A ChatGPT Aided Explainable Framework for Zero-Shot Medical Image Diagnosis
Zhejiang University-University of Illinois at Urbana-Champaign Institute（浙江大学伊利诺伊大学厄巴纳香槟校区联合学院）；Zhejiang University（浙江大学）；National University of Singapore（新加坡国立大学）；Angelalign Inc.（时代天使公司）
Beijing Institute of Technology（北京理工大学）；Xuanwu Hospital, Capital Medical University（首都医科大学宣武医院）；National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College（中国医学科学院北京协和医学院肿瘤医院（国家癌症中心/国家肿瘤临床医学研究中心））
Current Computer-Aided Diagnosis (CAD) methods mainly depend on medical images. The clinical information, which usually needs to be considered in practical clinical diagnosis, has not been fully employed in CAD. In this paper, we propose a novel deep learning-based method for fusing Magnetic Resonance Imaging (MRI)/Computed Tomography (CT) images and clinical information for diagnostic tasks. Two paths of neural layers are performed to extract image features and clinical features, respectively, and at the same time clinical features are employed as the attention to guide the extraction of imag…
While facial biometrics has been widely used for identification purpose, it has recently been researched as medical biometrics for a range of diseases. In this chapter, we investigate the facial landmark detection for atypical 3D facial modelling in facial palsy cases, while potentially such modelling can assist the medical diagnosis using atypical facial features. In our work, a study of landmarks localisation methods such as stacked hourglass networks is conducted and evaluated to ascertain their accuracy when presented with unseen atypical faces. The evaluation highlights that the state-of-…
Deep neural networks (DNN) have achieved unprecedented performance in computer-vision tasks almost ubiquitously in business, technology, and science. While substantial efforts are made to engineer highly accurate architectures and provide usable model explanations, most state-of-the-art approaches are first designed for natural vision and then translated to the medical domain. This dissertation seeks to address this gap by proposing novel architectures that integrate the domain-specific constraints of medical imaging into the DNN model and explanation design.
Large language models (LLMs) have recently demonstrated their potential in clinical applications, providing valuable medical knowledge and advice. For example, a large dialog LLM like ChatGPT has successfully passed part of the US medical licensing exam. However, LLMs currently have difficulty processing images, making it challenging to interpret information from medical images, which are rich in information that supports clinical decisions. On the other hand, computer-aided diagnosis (CAD) networks for medical images have seen significant success in the medical field by using advanced deep-le…
BIDMC（贝斯以色列女执事医疗中心）；Harvard Medical School（哈佛医学院）；Carnegie Mellon University（卡内基梅隆大学）；Johns Hopkins University（约翰斯·霍普金斯大学）；Beijing University of Posts and Telecommunications（北京邮电大学）
The labels in medical diagnosis task are usually discrete and successively distributed. For example, the Diabetic Retinopathy Diagnosis (DR) involves five health risk levels: no DR (0), mild DR (1), moderate DR (2), severe DR (3) and proliferative DR (4). This labeling system is common for medical disease. Previous methods usually construct a multi-binary-classification task or propose some re-parameter schemes in the output unit. In this paper, we target on this task from the perspective of loss function. More specifically, the Wasserstein distance is utilized as an alternative, explicitly in…
University of Central Florida（中佛罗里达大学）；Northwestern University（西北大学）；Mayo Clinic（梅奥诊所）；Sheikh Shakhbout Medical City（谢赫·沙赫布特医疗城）
Current data augmentation techniques and transformations are well suited for improving the size and quality of natural image datasets but are not yet optimized for medical imaging. We hypothesize that sub-optimal data augmentations can easily distort or occlude medical images, leading to false positives or negatives during patient diagnosis, prediction, or therapy/surgery evaluation. In our experimental results, we found that utilizing commonly used intensity-based data augmentation distorts the MRI scans and leads to texture information loss, thus negatively affecting the overall performance …
Medical images have been indispensable and useful tools for supporting medical experts in making diagnostic decisions. However, taken medical images especially throat and endoscopy images are normally hazy, lack of focus, or uneven illumination. Thus, these could difficult the diagnosis process for doctors. In this paper, we propose MIINet, a novel image-to-image translation network for improving quality of medical images by unsupervised translating low-quality images to the high-quality clean version. Our MIINet is not only capable of generating high-resolution clean images, but also preservi…
South China University of Technology（华南理工大学）；Pazhou Lab（琶洲实验室）；Tencent AI Lab（腾讯人工智能实验室）
Deep learning based medical image diagnosis has shown great potential in clinical medicine. However, it often suffers two major difficulties in real-world applications: 1) only limited labels are available for model training, due to expensive annotation costs over medical images; 2) labeled images may contain considerable label noise (e.g., mislabeling labels) due to diagnostic difficulties of diseases. To address these, we seek to exploit rich labeled data from relevant domains to help the learning in the target task via {Unsupervised Domain Adaptation} (UDA). Unlike most UDA methods that rel…
In Zambia, there is a serious shortage of medical staff where each practitioner attends to about 17000 patients in a given district while still, other patients travel over 10 km to access the basic medical services. In this research, we implement a deep learning model that can perform the clinical diagnosis process. The study will prove whether image analysis is capable of performing clinical diagnosis. It will also enable us to understand if we can use image analysis to lessen the workload on medical practitioners by delegating some tasks to an AI. The success of this study has the potential …
Institute for Systems and Robotics（系统与机器人研究所）；Interactive Technologies Institute（交互技术研究所）
This paper describes the field research, design and comparative deployment of a multimodal medical imaging user interface for breast screening. The main contributions described here are threefold: 1) The design of an advanced visual interface for multimodal diagnosis of breast cancer (BreastScreening); 2) Insights from the field comparison of single vs multimodality screening of breast cancer diagnosis with 31 clinicians and 566 images, and 3) The visualization of the two main types of breast lesions in the following image modalities: (i) MammoGraphy (MG) in both Craniocaudal (CC) and Mediolat…
University of Science and Technology of China（中国科学技术大学）；Huawei（华为）
Early detection of the coronavirus disease 2019 (COVID-19) helps to treat patients timely and increase the cure rate, thus further suppressing the spread of the disease. In this study, we propose a novel deep learning based detection and similar case recommendation network to help control the epidemic. Our proposed network contains two stages: the first one is a lung region segmentation step and is used to exclude irrelevant factors, and the second is a detection and recommendation stage. Under this framework, in the second stage, we develop a dual-children network (DuCN) based on a pre-traine…
Shahid Beheshti University（沙希德·贝赫什提大学）；Shahid Beheshti University of Medical Sciences（沙希德·贝赫什提医科大学）；University of Leeds（利兹大学）；Royal Adelaide Hospital（阿德莱德皇家医院）；The University of Adelaide（阿德莱德大学）；Tehran University of Medical Sciences（德黑兰医科大学）
Coronavirus disease (COVID-19) is an infectious disease caused by a newly discovered coronavirus. The disease presents with symptoms such as shortness of breath, fever, dry cough, and chronic fatigue, amongst others. Sometimes the symptoms of the disease increase so much they lead to the death of the patients. The disease may be asymptomatic in some patients in the early stages, which can lead to increased transmission of the disease to others. Many studies have tried to use medical imaging for early diagnosis of COVID-19. This study attempts to review papers on automatic methods for medical i…
Huazhong University of Science and Technology（华中科技大学）；Guizhou Normal University（贵州师范大学）；Hubei University（湖北大学）
Mapping X-ray images, radiology reports, and other medical data as binary codes in the common space, which can assist clinicians to retrieve pathology-related data from heterogeneous modalities (i.e., hashing-based cross-modal medical data retrieval), provides a new view to promot computeraided diagnosis. Nevertheless, there remains a barrier to boost medical retrieval accuracy: how to reveal the ambiguous semantics of medical data without the distraction of superfluous information. To circumvent this drawback, we propose Deep Supervised Information Bottleneck Hashing (DSIBH), which effectivel…
Graph Neural Networks (GNNs) have been shown to be a powerful tool for generating predictions from biological data. Their application to neuroimaging data such as functional magnetic resonance imaging (fMRI) scans has been limited. However, applying GNNs to fMRI scans may substantially improve predictive accuracy and could be used to inform clinical diagnosis in the future. In this paper, we present a novel approach to representing resting-state fMRI data as a graph containing nodes and edges without omitting any of the voxels and thus reducing information loss. We compare multiple GNN archite…
Thomas Jefferson High School for Science and Technology（托马斯·杰斐逊科学技术高中）
According to the WHO, Cerebrovascular Stroke, or CS, is the second largest cause of death worldwide. Current diagnosis of CS relies on labor and cost intensive neuroimaging techniques, unsuitable for areas with inadequate access to quality medical facilities. Thus, there is a great need for an efficient diagnosis alternative. StrokeSave is a platform for users to self-diagnose for prevalence to stroke. The mobile app is continuously updated with heart rate, blood pressure, and blood oxygen data from sensors on the patient wrist. Once these measurements reach a threshold for possible stroke, th…
Hebei University of Technology（河北工业大学）；University of Oxford（牛津大学）；Hospital of Joint Logistics Support Force（联勤保障部队第九八三医院）
Computer-Aided Diagnosis and Treatment of Tumors is a hot topic of deep learning in recent years, which constitutes a series of medical tasks, such as detection of tumor markers, the outline of tumor leisures, subtypes and stages of tumors, prediction of therapeutic effect, and drug development. Meanwhile, there are some deep learning models with precise positioning and excellent performance produced in mainstream task scenarios. Thus follow to introduce deep learning methods from task-orient, mainly focus on the improvements for medical tasks. Then to summarize the recent progress in four sta…
CBIDR: A novel method for information retrieval combining image and data by means of TOPSIS applied to medical diagnosis
Labcin - Nature-inspired computing Lab. - Federal University of Espírito Santo - Vitória, ES, Brazil（自然启发计算实验室 - 芬斯大学 - 维蒂利亚）；Graduate Program in Computer Science, PPGI, UFES - Federal University of Espírito Santo - Vitória, ES, Brazil（计算机科学研究生项目，PPGI，UFES - 芬斯大学 - 维蒂利亚）
Tencent Jarvis Lab（腾讯Jarvis实验室）；Institute of Computing Technology Chinese Academy of Sciences（中国科学院计算技术研究所）；University of Chinese Academy of Sciences（中国科学院大学）；The First Affiliated Hospital of Anhui Medical University（安徽医科大学第一附属医院）；University of Science and Technology of China（中国科学技术大学）
Fast screening and diagnosis are critical in COVID-19 patient treatment. In addition to the gold standard RT-PCR, radiological imaging like X-ray and CT also works as an important means in patient screening and follow-up. However, due to the excessive number of patients, writing reports becomes a heavy burden for radiologists. To reduce the workload of radiologists, we propose DeltaNet to generate medical reports automatically. Different from typical image captioning approaches that generate reports with an encoder and a decoder, DeltaNet applies a conditional generation process. In particular…
Deep learning-based Computer-Aided Diagnosis (CAD) has attracted appealing attention in academic researches and clinical applications. Nevertheless, the Convolutional Neural Networks (CNNs) diagnosis system heavily relies on the well-labeled lesion dataset, and the sensitivity to the variation of data distribution also restricts the potential application of CNNs in CAD. Unsupervised Domain Adaptation (UDA) methods are developed to solve the expensive annotation and domain gaps problem and have achieved remarkable success in medical image analysis. Yet existing UDA approaches only adapt knowled…
COVID-19 (Coronavirus disease 2019) has been quickly spreading since its outbreak, impacting financial markets and healthcare systems globally. Countries all around the world have adopted a number of extraordinary steps to restrict the spreading virus, where early COVID-19 diagnosis is essential. Medical images such as X-ray images and Computed Tomography scans are becoming one of the main diagnostic tools to combat COVID-19 with the aid of deep learning-based systems. In this survey, we investigate the main contributions of deep learning applications using medical images in fighting against C…
As interpretability has been pointed out as the obstacle to the adoption of Deep Neural Networks (DNNs), there is an increasing interest in solving a transparency issue to guarantee the impressive performance. In this paper, we demonstrate the efficiency of recent attribution techniques to explain the diagnostic decision by visualizing the significant factors in the input image. By utilizing the characteristics of objectness that DNNs have learned, fully decomposing the network prediction visualizes clear localization of target lesion. To verify our work, we conduct our experiments on Chest X-…
Optimization of Convolutional Neural Network Hyperparameter for Medical Image Diagnosis using Metaheuristic Algorithms: A short Recent Review (2019-2022)
Universiti Sains Malaysia（马来西亚理科大学）；King Fahd University of Petroleum and Minerals（法赫德国王石油与矿业大学）；University of Information Technology and Communications（信息技术与通信大学）
COVID-19 Computer-aided Diagnosis through AI-assisted CT Imaging Analysis: Deploying a Medical AI System
University of Ioannina（约阿尼纳大学）；AIandMe SMPC（AIandMe SMPC公司）；National Technical University of Athens（雅典国立技术大学）；Queen Mary University of London（伦敦大学玛丽皇后学院）
Ontology-based knowledge representation for bone disease diagnosis: a foundation for safe and sustainable medical artificial intelligence systems
University of Science, VNUHCM（胡志明市国家大学科学大学）；Viet Nam National University, Ho Chi Minh City（越南国家大学胡志明市分校）；Ho Chi Minh City Hospital for Traumatology and Orthopedics（胡志明市创伤与骨科医院）
The paper is a short review of medical image segmentation using U-Net and its variants. As we understand going through a medical images is not an easy job for any clinician either radiologist or pathologist. Analysing medical images is the only way to perform non-invasive diagnosis. Segmenting out the regions of interest has significant importance in medical images and is key for diagnosis. This paper also gives a bird eye view of how medical image segmentation has evolved. Also discusses challenge's and success of the deep neural architectures. Following how different hybrid architectures hav…
An integrated approach is proposed across visual and textual data to both determine and justify a medical diagnosis by a neural network. As deep learning techniques improve, interest grows to apply them in medical applications. To enable a transition to workflows in a medical context that are aided by machine learning, the need exists for such algorithms to help justify the obtained outcome so human clinicians can judge their validity. In this work, deep learning methods are used to map a frontal X-Ray image to a continuous textual representation. This textual representation is decoded into a …
Recent developments in AI have provided assisting tools to support pathologists' diagnoses. However, it remains challenging to incorporate such tools into pathologists' practice; one main concern is AI's insufficient workflow integration with medical decisions. We observed pathologists' examination and discovered that the main hindering factor to integrate AI is its incompatibility with pathologists' workflow. To bridge the gap between pathologists and AI, we developed a human-AI collaborative diagnosis tool -- xPath -- that shares a similar examination process to that of pathologists, which c…
