Towards decoding the coupled decision-making of metabolism and epithelial-mesenchymal transition in cancer
Dongya Jia, Jun Hyoung Park, Harsimran Kaur, Kwang Hwa Jung, Sukjin Yang, Shubham Tripathi, Madeline Galbraith, Youyuan Deng, Mohit Kumar Jolly, Benny Abraham K… 展开作者
Dongya Jia, Jun Hyoung Park, Harsimran Kaur, Kwang Hwa Jung, Sukjin Yang, Shubham Tripathi, Madeline Galbraith, Youyuan Deng, Mohit Kumar Jolly, Benny Abraham Kaipparettu, Jose N. Onuchic, Herbert Levine
Cancer cells have the plasticity to adjust their metabolic phenotypes for survival and metastasis. During metastasis, a developmental program known as the epithelial-mesenchymal transition (EMT) plays a critical role. There is extensive cross-talk between metabolism and EMT, but how this leads to coordinated physiological changes is still uncertain. The elusive connection between metabolism and EMT compromises the efficacy of metabolic therapies targeting metastasis. In this review, we aim for clarifying causation between metabolism and EMT based on recent experimental studies and propose integrated theoretical-experimental efforts to better understand the coupled decision-making of metabolism and EMT.
Marangoni-Driven Redistribution and Activity of Piezo1 Molecules in Epithelial and Cancer Cells
University of Belgrade（贝尔格莱德大学）；Victor Chang Cardiac Research Institute（维克多·陈心脏研究所）；University of New South Wales（新南威尔士大学）；Lancaster University（兰开斯特大学）
A multiscale approach to the migration of cancer stem cells: mathematical modelling and simulations
Institute of Mathematics, Johannes Gutenberg-University（数学研究所，约翰内斯·古腾堡大学）；Institute of Molecular Biophysics, Johannes Gutenberg-University（分子生物物理研究所，约翰内斯·古腾堡大学）
