解读肿瘤进展中上皮-间充质转化和肿瘤干细胞的动力学
Deciphering the dynamics of Epithelial-Mesenchymal Transition and Cancer Stem Cells in tumor progression
摘要：
审核目的：上皮-间充质转化（EMT）和癌症干细胞（CSC）的产生是促成肿瘤生长、获得对治疗的抗性、转移的形成和肿瘤复发的两个基本方面。识别调节EMT和CSC的电路的最新实验数据已经推动了捕获这些电路的动力学以及因此肿瘤进展的各个方面的计算模型的发展。近期发现：我们回顾了这些模型在以下方面所做的贡献：a）概括实验观察到的行为，b）进行实验可检验的预测，c）推动该领域的新兴概念，包括强调混合上皮/间充质（E/M）表型的侵袭潜力。我们讨论了在细胞内和人口水平的EMT和CSC的动态，以及那些专注于这两个过程之间的相互联系的动力学和统计模型。总结：这些模型突出了通过数学建模方法获得的见解，并强调可以通过分析潜在的调节电路来解释混合E/M表型和干性之间的联系。这种实验策划的模型有可能作为更好的治疗设计策略的平台。
英文摘要：
Purpose of review: The epithelial-Mesenchymal Transition (EMT) and the generation of Cancer Stem Cells (CSC) are two fundamental aspects contributing to tumor growth, acquisition of resistance to therapy, formation of metastases, and tumor relapse. Recent experimental data identifying the circuits regulating EMT and CSCs have driven the development of computational models capturing the dynamics of these circuits and consequently various aspects of tumor progression. Recent findings: We review the contribution made by these models in a) recapitulating experimentally observed behavior, b) making experimentally testable predictions, and c) driving emerging notions in the field, including the emphasis on the aggressive potential of hybrid epithelial/mesenchymal (E/M) phenotype(s). We discuss dynamical and statistical models at intracellular and population level relating to dynamics of EMT and CSCs, and those focusing on interconnections between these two processes. Summary: These models highlight the insights gained via mathematical modeling approaches, and emphasizes that the connections between hybrid E/M phenotype(s) and stemness can be explained by analyzing underlying regulatory circuits. Such experimentally curated models have the potential of serving as platforms for better therapeutic design strategies.
机构、总结、中文摘要均由AI分析而来，可能存在错误，请以论文正文为准。
