磁性MnFe $_2$ O $_4$纳米颗粒的低维组装体和偶极相互作用驱动的增强加热的直接体外测量：磁热疗的意义
Low Dimensional Assemblies of Magnetic MnFe$_2$O$_4$ Nanoparticles and Direct In Vitro Measurements of Enhanced Heating Driven by Dipolar Interactions: Implications for Magnetic Hyperthermia
摘要：
磁流体热疗（MFH），使用磁性纳米颗粒（MNP）作为加热剂提高肿瘤细胞温度的过程，已被证明在治疗某些类型的癌症方面是成功的。然而，在生理条件下产生的低加热功率使得在肿瘤部位需要高局部浓度的MNP。在这里，我们报告了如何在体外的磁性软MnFe $_2$ O $_4$纳米粒子的加热功率可以通过细胞内的低维集群通过一种策略，包括：a）的设计的MNP保留Néel磁弛豫在高粘度介质中，和b）培养MNP负载的细胞下，磁场产生细长的细胞内团聚体。我们的直接体外测量表明，与在细胞内自由形成的聚集体中测量的$SLP=305\pm25$ W/g相比，在直流磁场下原位培养BV 2细胞诱导的细长聚集体（$SLP=576\pm33$ W/g）的比损耗功率（SLP）增加了2倍。一个数值平均场模型，包括偶极相互作用，定量再现这些集群的SLP在phantomy和在体外，这表明它捕获的相关机制背后的高粘度条件下的功率损失。这些结果表明，在原位组装成低维结构的MNP是一个健全的可能的方式来改善在MFH的加热性能。
英文摘要：
Magnetic fluid hyperthermia (MFH), the procedure of raising the temperature of tumor cells using magnetic nanoparticles (MNPs) as heating agents, has proven successful in treating some types of cancer. However, the low heating power generated under physiological conditions makes necessary a high local concentration of MNPs at tumor sites. Here, we report how the in vitro heating power of magnetically soft MnFe$_2$O$_4$ nanoparticles can be enhanced by intracellular low-dimensional clusters through a strategy that includes: a) the design of the MNPs to retain Néel magnetic relaxation in high viscosity media, and b) culturing MNP-loaded cells under magnetic fields to produce elongated intracellular agglomerates. Our direct in vitro measurements demonstrated that the specific loss power (SLP) of elongated agglomerates ($SLP=576\pm33$ W/g) induced by culturing BV2 cells in situ under a dc magnetic field was increased by a factor of 2 compared to the $SLP=305\pm25$ W/g measured in aggregates freely formed within cells. A numerical mean-field model that included dipolar interactions quantitatively reproduced the SLPs of these clusters both in phantoms and in vitro, suggesting that it captures the relevant mechanisms behind power losses under high-viscosity conditions. These results indicate that in situ assembling of MNPs into low-dimensional structures is a sound possible way to improve the heating performance in MFH.
机构、总结、中文摘要均由AI分析而来，可能存在错误，请以论文正文为准。
