Fractures of the cervical spine are a medical emergency and may lead to permanent paralysis and even death. Accurate diagnosis in patients with suspected fractures by computed tomography (CT) is critical to patient management. In this paper, we propose a deep convolutional neural network (DCNN) with a bidirectional long-short term memory (BLSTM) layer for the automated detection of cervical spine fractures in CT axial images. We used an annotated dataset of 3,666 CT scans (729 positive and 2,937 negative cases) to train and validate the model. The validation results show a classification accuracy of 70.92% and 79.18% on the balanced (104 positive and 104 negative cases) and imbalanced (104 positive and 419 negative cases) test datasets, respectively.
Expert Validation of Synthetic Cervical Spine Radiographs Generated with a Denoising Diffusion Probabilistic Model
Cumming School of Medicine, University of Calgary（卡里尔大学医学学院）；Division of Neurosurgery, Department of Clinical Neurosciences, University of Calgary（卡里尔大学临床神经科学系神经外科部）；Department of Radiology, University of Calgary（卡里尔大学放射科）；Division of Neurosurgery, Department of Surgery, University of Toronto（多伦多大学外科系神经外科部）；Department of Medical Imaging, University of Toronto（多伦多大学医学影像科）；Project neuroArm, Department of Clinical Sciences, University of Calgary（卡里尔大学临床科学部neuroArm项目）
MSR:Hybrid Field Modeling for CT-MRI Rigid-Deformable Registration of the Cervical Spine with an Annotated Dataset
School of Biomedical Engineering, Southern Medical University, Guangzhou, 510515, China.（南方医科大学生物医学工程学院）；Guangdong Provincial Key Laboratory of Medical Image Processing, Guangzhou, 510515, China.（广东省医学图像处理重点实验室）；Guangdong Province Engineering Laboratory for Medical Imaging（广东省医学影像与诊断技术工程实验室）；Information Center, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.（南方医科大学南华医院信息中心）；Division of Spine Surgery, Department of Orthopaedics, Nanfang hospital, Southern Medical University, Guangzhou, Guangdong, 510515, China.（南方医科大学南华医院骨科脊柱外科）
Osteoporosis induced fractures occur worldwide about every 3 seconds. Vertebral compression fractures are early signs of the disease and considered risk predictors for secondary osteoporotic fractures. We present a detection method to opportunistically screen spine-containing CT images for the presence of these vertebral fractures. Inspired by radiology practice, existing methods are based on 2D and 2.5D features but we present, to the best of our knowledge, the first method for detecting vertebral fractures in CT using automatically learned 3D feature maps. The presented method explicitly loc…
Helmholtz Zentrum Muenchen（慕尼黑亥姆霍兹中心）；Technische Universitaet Muenchen（慕尼黑工业大学）；Reply SpA（瑞普公司）；Johns Hopkins University（约翰斯·霍普金斯大学）
Symptomatic spinal vertebral compression fractures (VCFs) often require osteoplasty treatment. A cement-like material is injected into the bone to stabilize the fracture, restore the vertebral body height and alleviate pain. Leakage is a common complication and may occur due to too much cement being injected. In this work, we propose an automated patient-specific framework that can allow physicians to calculate an upper bound of cement for the injection and estimate the optimal outcome of osteoplasty. The framework uses the patient CT scan and the fractured vertebra label to build a virtual he…
HCA-Net: Hierarchical Context Attention Network for Intervertebral Disc Semantic Labeling
University of Regensburg（雷根斯堡大学）；South Dakota State University（南达科他州立大学）；RWTH Aachen University（亚琛工业大学）；Northwestern University（西北大学）；Fraunhofer Institute for Digital Medicine MEVIS（弗劳恩霍夫数字医学研究所）
University of Oxford（牛津大学）；Plexalis Ltd（Plexalis有限公司）
We propose a novel convolutional method for the detection and identification of vertebrae in whole spine MRIs. This involves using a learnt vector field to group detected vertebrae corners together into individual vertebral bodies and convolutional image-to-image translation followed by beam search to label vertebral levels in a self-consistent manner. The method can be applied without modification to lumbar, cervical and thoracic-only scans across a range of different MR sequences. The resulting system achieves 98.1% detection rate and 96.5% identification rate on a challenging clinical datas…
RWTH Aachen University（亚琛工业大学）；Iran University of Science and Technology（伊朗科技大学）；University of Montreal（蒙特利尔大学）；Polytechnique Montreal（蒙特利尔理工学院）；Mila, Quebec AI Institute（米拉魁北克人工智能研究所）；Stanford University（斯坦福大学）；Fraunhofer Institute for Digital Medicine MEVIS（弗劳恩霍夫数字医学MEVIS研究所）
Accurate and automatic segmentation of intervertebral discs from medical images is a critical task for the assessment of spine-related diseases such as osteoporosis, vertebral fractures, and intervertebral disc herniation. To date, various approaches have been developed in the literature which routinely relies on detecting the discs as the primary step. A disadvantage of many cohort studies is that the localization algorithm also yields false-positive detections. In this study, we aim to alleviate this problem by proposing a novel U-Net-based structure to predict a set of candidates for interv…
Technical University of Munich（慕尼黑工业大学）；Klinikum rechts der Isar, Technical University of Munich（慕尼黑工业大学伊萨尔河畔医院）
Osteoporotic vertebral fractures have a severe impact on patients' overall well-being but are severely under-diagnosed. These fractures present themselves at various levels of severity measured using the Genant's grading scale. Insufficient annotated datasets, severe data-imbalance, and minor difference in appearances between fractured and healthy vertebrae make naive classification approaches result in poor discriminatory performance. Addressing this, we propose a representation learning-inspired approach for automated vertebral fracture detection, aimed at learning latent representations eff…
Weizmann Institute of Science（魏茨曼科学研究所）；Zebra Medical Vision Ltd（斑马医疗视觉有限公司）
An osteoporosis-related fracture occurs every three seconds worldwide, affecting one in three women and one in five men aged over 50. The early detection of at-risk patients facilitates effective and well-evidenced preventative interventions, reducing the incidence of major osteoporotic fractures. In this study, we present an automatic system for identification of vertebral compression fractures on Computed Tomography images, which are often an undiagnosed precursor to major osteoporosis-related fractures. The system integrates a compact 3D representation of the spine, utilizing a Convolutiona…
SALT: Introducing a Framework for Hierarchical Segmentations in Medical Imaging using Softmax for Arbitrary Label Trees
Institute of Interventional and Diagnostic Radiology and Neuroradiology, University Hospital Essen（埃森大学医院介入与诊断放射学及神经放射学研究所）；Institute for Artificial Intelligence in Medicine (IKIM), University Hospital Essen（埃森大学医院医学人工智能研究所）；Institute for Transfusion Medicine, University Hospital Essen（埃森大学医院输血医学研究所）；Institute for Medical Informatics, Biometry and Epidemiology (IMIBE), University Hospital Essen（埃森大学医院医学信息学、生物统计学与流行病学研究所）；Faculty of Computer Science, University of Applied Sciences and Arts（应用科学与艺术大学计算机科学系）
Sharif University of Technology（谢里夫理工大学）；Polytechnique Montreal（蒙特利尔理工学院）；Mila, Quebec AI Institute（米拉魁北克人工智能研究所）；University of Montreal（蒙特利尔大学）
Labeling vertebral discs from MRI scans is important for the proper diagnosis of spinal related diseases, including multiple sclerosis, amyotrophic lateral sclerosis, degenerative cervical myelopathy and cancer. Automatic labeling of the vertebral discs in MRI data is a difficult task because of the similarity between discs and bone area, the variability in the geometry of the spine and surrounding tissues across individuals, and the variability across scans (manufacturers, pulse sequence, image contrast, resolution and artefacts). In previous studies, vertebral disc labeling is often done aft…
National Institutes of Health Clinical Center（美国国立卫生研究院临床中心）；University of Wisconsin, Madison（威斯康星大学麦迪逊分校）
The vertebral levels of the spine provide a useful coordinate system when making measurements of plaque, muscle, fat, and bone mineral density. Correctly classifying vertebral levels with high accuracy is challenging due to the similar appearance of each vertebra, the curvature of the spine, and the possibility of anomalies such as fractured vertebrae, implants, lumbarization of the sacrum, and sacralization of L5. The goal of this work is to develop a system that can accurately and robustly identify the L1 level in large heterogeneous datasets. The first approach we study is using a 3D U-Net …
Field strength-dependent performance variability in deep learning-based analysis of magnetic resonance imaging
Purdue University（普渡大学）；Indiana University School of Medicine（印第安纳大学医学院）；Medical Faculty and University Hospital Dresden, TUD Dresden University of Technology（德累斯顿工业大学德累斯顿医学院与大学医院）
