In recent years, with the growing amount of biomedical documents, coupled with advancement in natural language processing algorithms, the research on biomedical named entity recognition (BioNER) has increased exponentially. However, BioNER research is challenging as NER in the biomedical domain are: (i) often restricted due to limited amount of training data, (ii) an entity can refer to multiple types and concepts depending on its context and, (iii) heavy reliance on acronyms that are sub-domain specific. Existing BioNER approaches often neglect these issues and directly adopt the state-of-the-art (SOTA) models trained in general corpora which often yields unsatisfactory results. We propose biomedical ALBERT (A Lite Bidirectional Encoder Representations from Transformers for Biomedical Text Mining) bioALBERT, an effective domain-specific language model trained on large-scale biomedical corpora designed to capture biomedical context-dependent NER. We adopted a self-supervised loss used in ALBERT that focuses on modelling inter-sentence coherence to better learn context-dependent representations and incorporated parameter reduction techniques to lower memory consumption and increase the training speed in BioNER. In our experiments, BioALBERT outperformed comparative SOTA BioNER models on eight biomedical NER benchmark datasets with four different entity types. We trained four different variants of BioALBERT models which are available for the research community to be used in future research.
The availability of biomedical text data and advances in natural language processing (NLP) have made new applications in biomedical NLP possible. Language models trained or fine tuned using domain specific corpora can outperform general models, but work to date in biomedical NLP has been limited in terms of corpora and tasks. We present BioALBERT, a domain-specific adaptation of A Lite Bidirectional Encoder Representations from Transformers (ALBERT), trained on biomedical (PubMed and PubMed Central) and clinical (MIMIC-III) corpora and fine tuned for 6 different tasks across 20 benchmark datas…
National Institute of Technology Trichy（蒂鲁吉拉伯利国立理工学院）
Transformer-based pretrained language models (PLMs) have started a new era in modern natural language processing (NLP). These models combine the power of transformers, transfer learning, and self-supervised learning (SSL). Following the success of these models in the general domain, the biomedical research community has developed various in-domain PLMs starting from BioBERT to the latest BioELECTRA and BioALBERT models. We strongly believe there is a need for a survey paper that can provide a comprehensive survey of various transformer-based biomedical pretrained language models (BPLMs). In th…
Pretrained language models have shown success in many natural language processing tasks. Many works explore incorporating knowledge into language models. In the biomedical domain, experts have taken decades of effort on building large-scale knowledge bases. For example, the Unified Medical Language System (UMLS) contains millions of entities with their synonyms and defines hundreds of relations among entities. Leveraging this knowledge can benefit a variety of downstream tasks such as named entity recognition and relation extraction. To this end, we propose KeBioLM, a biomedical pretrained lan…
IBM Research（IBM研究院）；University of Texas at Austin（德克萨斯大学奥斯汀分校）；Northeastern University（东北大学）
Pre-trained language models induce dense entity representations that offer strong performance on entity-centric NLP tasks, but such representations are not immediately interpretable. This can be a barrier to model uptake in important domains such as biomedicine. There has been recent work on general interpretable representation learning (Onoe and Durrett, 2020), but these domain-agnostic representations do not readily transfer to the important domain of biomedicine. In this paper, we create a new entity type system and training set from a large corpus of biomedical texts by mapping entities to…
VANER: Leveraging Large Language Model for Versatile and Adaptive Biomedical Named Entity Recognition
School of Computer Science, Fudan University（复旦大学计算机科学技术学院）；Shanghai Key Lab of Intelligent Information Processing, Fudan University（复旦大学上海市智能信息处理重点实验室）；Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University（复旦大学脑智能科学与技术研究院）；School of Computing and Mathematics, Charles Sturt University（查尔斯斯特大学计算与数学学院）；Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence (Fudan University), Ministry of Education（教育部计算神经科学与脑智能重点实验室）；MOE Frontiers Center for Brain Science, Fudan University（复旦大学教育部脑科学前沿中心）；Zhangjiang Fudan International Innovation Center（张江复旦国际创新中心）
Analysing Lightweight Large Language Models for Biomedical Named Entity Recognition on Diverse Ouput Formats
Inria, Inserm, Université Paris Cité, HeKA, UMR 1346, Paris, France（法国国家科学研究中心（Inria）、法国国家医学研究院（Inserm）、巴黎城市大学（Université Paris Cité）、HeKA、法国国家科研机构（UMR 1346）、巴黎）；Télécom Paris, Institut Polytechnique de Paris, France（巴黎电信学院（Télécom Paris）、巴黎理工学院（Institut Polytechnique de Paris）、法国）
University of Warwick（华威大学）；The Alan Turing Institute（艾伦·图灵研究所）；Queen Mary University of London（伦敦玛丽女王大学）
Biomedical question-answering (QA) has gained increased attention for its capability to provide users with high-quality information from a vast scientific literature. Although an increasing number of biomedical QA datasets has been recently made available, those resources are still rather limited and expensive to produce. Transfer learning via pre-trained language models (LMs) has been shown as a promising approach to leverage existing general-purpose knowledge. However, finetuning these large models can be costly and time consuming, often yielding limited benefits when adapting to specific th…
Off-the-shelf biomedical embeddings obtained from the recently released various pre-trained language models (such as BERT, XLNET) have demonstrated state-of-the-art results (in terms of accuracy) for the various natural language understanding tasks (NLU) in the biomedical domain. Relation Classification (RC) falls into one of the most critical tasks. In this paper, we explore how to incorporate domain knowledge of the biomedical entities (such as drug, disease, genes), obtained from Knowledge Graph (KG) Embeddings, for predicting Drug-Drug Interaction from textual corpus. We propose a new meth…
KBioXLM: A Knowledge-anchored Biomedical Multilingual Pretrained Language Model
Institute of Artificial Intelligence, Soochow University（苏州大学人工智能研究院）；Peking University（北京大学）；The Hong Kong Polytechnic University（香港理工大学）；Pharmcube（药智魔方）；Changping Laboratory（昌平实验室）
Harnessing Large Language Models for Biomedical Named Entity Recognition
Department of Data Science and Big Data Technology, Hainan University, Haikou 570228, China（数据科学与大数据技术学院，海南大学，海口570228，中国）；Department of Mathematics, Hainan University, Haikou 570228, China（数学学院，海南大学，海口570228，中国）；Department of Population Health Sciences, Weill Cornell Medicine, New York 10022, USA（流行病学与公共卫生科学学院，韦尔·柯尔医学中心，纽约10022，美国）
University of Pittsburgh（匹兹堡大学）；Carnegie Mellon University（卡内基梅隆大学）；Google, Inc.（谷歌公司）
Contextualized word embeddings derived from pre-trained language models (LMs) show significant improvements on downstream NLP tasks. Pre-training on domain-specific corpora, such as biomedical articles, further improves their performance. In this paper, we conduct probing experiments to determine what additional information is carried intrinsically by the in-domain trained contextualized embeddings. For this we use the pre-trained LMs as fixed feature extractors and restrict the downstream task models to not have additional sequence modeling layers. We compare BERT, ELMo, BioBERT and BioELMo, …
BioCoref: Benchmarking Biomedical Coreference Resolution with LLMs
Computational Bioscience Program University of Colorado Anschutz Medical Campus（科学生物学程序，科罗拉多大学安舒茨医学校区）；Department of Pediatrics University of Chicago（儿科学系，芝加哥大学）
Nara Institute of Science and Technology（奈良先端科学技术大学院大学）；Megagon Labs（Megagon实验室）
We introduce BioCoM, a contrastive learning framework for biomedical entity linking that uses only two resources: a small-sized dictionary and a large number of raw biomedical articles. Specifically, we build the training instances from raw PubMed articles by dictionary matching and use them to train a context-aware entity linking model with contrastive learning. We predict the normalized biomedical entity at inference time through a nearest-neighbor search. Results found that BioCoM substantially outperforms state-of-the-art models, especially in low-resource settings, by effectively using th…
Korea University（高丽大学）；AIRS Company, Hyundai Motor Group（现代汽车集团AIRS公司）；AIGEN Sciences（AIGEN科学公司）
In biomedical natural language processing, named entity recognition (NER) and named entity normalization (NEN) are key tasks that enable the automatic extraction of biomedical entities (e.g. diseases and drugs) from the ever-growing biomedical literature. In this article, we present BERN2 (Advanced Biomedical Entity Recognition and Normalization), a tool that improves the previous neural network-based NER tool by employing a multi-task NER model and neural network-based NEN models to achieve much faster and more accurate inference. We hope that our tool can help annotate large-scale biomedical…
Institut Polytechnique de Paris（巴黎综合理工学院）；Inria（法国国家信息与自动化研究所）；CEA（法国原子能和替代能源委员会）
Biomedical entity linking aims to map biomedical mentions, such as diseases and drugs, to standard entities in a given knowledge base. The specific challenge in this context is that the same biomedical entity can have a wide range of names, including synonyms, morphological variations, and names with different word orderings. Recently, BERT-based methods have advanced the state-of-the-art by allowing for rich representations of word sequences. However, they often have hundreds of millions of parameters and require heavy computing resources, which limits their applications in resource-limited s…
Rutgers University–New Brunswick（罗格斯大学新伯朗士威校区）；Hasso Plattner Institute（哈索·普拉特纳研究所）；University of Potsdam（波茨坦大学）
Biomedical entity linking is the task of identifying mentions of biomedical concepts in text documents and mapping them to canonical entities in a target thesaurus. Recent advancements in entity linking using BERT-based models follow a retrieve and rerank paradigm, where the candidate entities are first selected using a retriever model, and then the retrieved candidates are ranked by a reranker model. While this paradigm produces state-of-the-art results, they are slow both at training and test time as they can process only one mention at a time. To mitigate these issues, we propose a BERT-bas…
College of Information and Computer Sciences University of Massachusetts Amherst（马萨诸塞大学阿默斯特分校信息与计算机科学学院）；Chan Zuckerberg Initiative（陈-扎克伯格倡议）
Due to large number of entities in biomedical knowledge bases, only a small fraction of entities have corresponding labelled training data. This necessitates entity linking models which are able to link mentions of unseen entities using learned representations of entities. Previous approaches link each mention independently, ignoring the relationships within and across documents between the entity mentions. These relations can be very useful for linking mentions in biomedical text where linking decisions are often difficult due mentions having a generic or a highly specialized form. In this pa…
We present SwellShark, a framework for building biomedical named entity recognition (NER) systems quickly and without hand-labeled data. Our approach views biomedical resources like lexicons as function primitives for autogenerating weak supervision. We then use a generative model to unify and denoise this supervision and construct large-scale, probabilistically labeled datasets for training high-accuracy NER taggers. In three biomedical NER tasks, SwellShark achieves competitive scores with state-of-the-art supervised benchmarks using no hand-labeled training data. In a drug name extraction t…
The number of biomedical literature on new biomedical concepts is rapidly increasing, which necessitates a reliable biomedical named entity recognition (BioNER) model for identifying new and unseen entity mentions. However, it is questionable whether existing models can effectively handle them. In this work, we systematically analyze the three types of recognition abilities of BioNER models: memorization, synonym generalization, and concept generalization. We find that although current best models achieve state-of-the-art performance on benchmarks based on overall performance, they have limita…
Entities lie in the heart of biomedical natural language understanding, and the biomedical entity linking (EL) task remains challenging due to the fine-grained and diversiform concept names. Generative methods achieve remarkable performances in general domain EL with less memory usage while requiring expensive pre-training. Previous biomedical EL methods leverage synonyms from knowledge bases (KB) which is not trivial to inject into a generative method. In this work, we use a generative approach to model biomedical EL and propose to inject synonyms knowledge in it. We propose KB-guided pre-tra…
Nara Institute of Science and Technology（奈良先端科学技术大学院大学）；Megagon Labs（Megagon实验室）
Disease name recognition and normalization, which is generally called biomedical entity linking, is a fundamental process in biomedical text mining. Recently, neural joint learning of both tasks has been proposed to utilize the mutual benefits. While this approach achieves high performance, disease concepts that do not appear in the training dataset cannot be accurately predicted. This study introduces a novel end-to-end approach that combines span representations with dictionary-matching features to address this problem. Our model handles unseen concepts by referring to a dictionary while mai…
Microsoft Research（微软研究院）；University of Illinois at Urbana-Champaign（伊利诺伊大学厄巴纳-香槟分校）
Entity linking faces significant challenges such as prolific variations and prevalent ambiguities, especially in high-value domains with myriad entities. Standard classification approaches suffer from the annotation bottleneck and cannot effectively handle unseen entities. Zero-shot entity linking has emerged as a promising direction for generalizing to new entities, but it still requires example gold entity mentions during training and canonical descriptions for all entities, both of which are rarely available outside of Wikipedia. In this paper, we explore Knowledge-RIch Self-Supervision ($\…
BioMNER: A Dataset for Biomedical Method Entity Recognition
University of Surrey（萨里大学）；The University of Manchester（曼彻斯特大学）；University of Pittsburgh（匹兹堡大学）；Chinese Academy of Sciences（中国科学院）；Durham University（杜伦大学）
Humboldt-Universität zu Berlin（柏林洪堡大学）；GFZ German Research Centre for Geosciences（德国地学研究中心）
Summary: Named Entity Recognition (NER) is an important step in biomedical information extraction pipelines. Tools for NER should be easy to use, cover multiple entity types, highly accurate, and robust towards variations in text genre and style. To this end, we propose HunFlair, an NER tagger covering multiple entity types integrated into the widely used NLP framework Flair. HunFlair outperforms other state-of-the-art standalone NER tools with an average gain of 7.26 pp over the next best tool, can be installed with a single command and is applied with only four lines of code. Availability: H…
Automated entity relation extraction (RE) from literature provides an important source for constructing biomedical database, which is more efficient and extensible than manual curation. However, existing RE models usually ignore the information contained in sentence structures and target entities. In this paper, we propose BERE, a deep learning based model which uses Gumbel Tree-GRU to learn sentence structures and joint embedding to incorporate entity information. It also employs word-level attention for improved relation extraction and sentence-level attention to suit the distantly supervise…
Allen Institute for Artificial Intelligence（艾伦人工智能研究所）；University of Washington（华盛顿大学）
Ontology alignment is the task of identifying semantically equivalent entities from two given ontologies. Different ontologies have different representations of the same entity, resulting in a need to de-duplicate entities when merging ontologies. We propose a method for enriching entities in an ontology with external definition and context information, and use this additional information for ontology alignment. We develop a neural architecture capable of encoding the additional information when available, and show that the addition of external data results in an F1-score of 0.69 on the Ontolo…
In biomedical literature, it is common for entity boundaries to not align with word boundaries. Therefore, effective identification of entity spans requires approaches capable of considering tokens that are smaller than words. We introduce a novel, subword approach for named entity recognition (NER) that uses byte-pair encodings (BPE) in combination with convolutional and recurrent neural networks to produce byte-level tags of entities. We present experimental results on several standard biomedical datasets, namely the BioCreative VI Bio-ID, JNLPBA, and GENETAG datasets. We demonstrate competi…
Dalian University of Technology（大连理工大学）；Beijing Institute of Health Administration and Medical Information（北京卫生健康经济研究和医学信息研究所）
Recognition of biomedical entities from literature is a challenging research focus, which is the foundation for extracting a large amount of biomedical knowledge existing in unstructured texts into structured formats. Using the sequence labeling framework to implement biomedical named entity recognition (BioNER) is currently a conventional method. This method, however, often cannot take full advantage of the semantic information in the dataset, and the performance is not always satisfactory. In this work, instead of treating the BioNER task as a sequence labeling problem, we formulate it as a …
GLiNER-BioMed: A Suite of Efficient Models for Open Biomedical Named Entity Recognition
Department of Radiology and Medical Informatics, Faculty of Medicine, University of Geneva（日内瓦大学医学院放射学与医学信息学系）；Knowledgator Engineering（Knowledgator工程）
University of Illinois at Urbana-Champaign（伊利诺伊大学厄巴纳-香槟分校）；Adobe Research（Adobe研究院）
Compared to the general news domain, information extraction (IE) from biomedical text requires much broader domain knowledge. However, many previous IE methods do not utilize any external knowledge during inference. Due to the exponential growth of biomedical publications, models that do not go beyond their fixed set of parameters will likely fall behind. Inspired by how humans look up relevant information to comprehend a scientific text, we present a novel framework that utilizes external knowledge for joint entity and relation extraction named KECI (Knowledge-Enhanced Collective Inference). …
Training-Free BioNEL-RAG: Advancing Biomedical Entity Linking through Retrieval-Augmented Generation and Large Language Model
University of Science and Technology of China（中国科学技术大学）；School of Biomedical Engineering（生物医学工程学院）；Division of Life Sciences and Medicine（生命科学与医学部）；Department of Precision Machinery and Precision Instruments（精密机械与精密仪器系）
Biomedical named entity recognition (NER) is a fundamental task in text mining of medical documents and has many applications. Deep learning based approaches to this task have been gaining increasing attention in recent years as their parameters can be learned end-to-end without the need for hand-engineered features. However, these approaches rely on high-quality labeled data, which is expensive to obtain. To address this issue, we investigate how to use unlabeled text data to improve the performance of NER models. Specifically, we train a bidirectional language model (BiLM) on unlabeled data …
Benha University（本哈大学）；Mangalore University（门格洛尔大学）；Nara Institute of Science and Technology（奈良科学技术研究所）
Biomedical Named Entity Recognition (BioNER) is a crucial step for analyzing Biomedical texts, which aims at extracting biomedical named entities from a given text. Different supervised machine learning algorithms have been applied for BioNER by various researchers. The main requirement of these approaches is an annotated dataset used for learning the parameters of machine learning algorithms. Segment Representation (SR) models comprise of different tag sets used for representing the annotated data, such as IOB2, IOE2 and IOBES. In this paper, we propose an extension of IOBES model to improve …
Augmenting Biomedical Named Entity Recognition with General-domain Resources
University of Liverpool（利物浦大学）；Korea University（高丽大学）；National Center for Biotechnology Information（美国国家生物技术信息中心）；National Library of Medicine（美国国家医学图书馆）；National Institutes of Health（美国国立卫生研究院）；Yale University（耶鲁大学）
University of Massachusetts Amherst, USA（马萨诸塞大学阿默斯特分校（美国））；Chan Zuckerberg Initiative, USA（陈-扎克伯格倡议组织（美国））
We explore the suitability of unsupervised representation learning methods on biomedical text -- BioBERT, SciBERT, and BioSentVec -- for biomedical question answering. To further improve unsupervised representations for biomedical QA, we introduce a new pre-training task from unlabeled data designed to reason about biomedical entities in the context. Our pre-training method consists of corrupting a given context by randomly replacing some mention of a biomedical entity with a random entity mention and then querying the model with the correct entity mention in order to locate the corrupted part…
