The detection of retinal blood vessels, especially the changes of small vessel condition is the most important indicator to identify the vascular network of the human body. Existing techniques focused mainly on shape of the large vessels, which is not appropriate for the disconnected small and isolated vessels. Paying attention to the low contrast small blood vessel in fundus region, first time we proposed to combine graph based smoothing regularizer with the loss function in the U-net framework. The proposed regularizer treated the image as two graphs by calculating the graph laplacians on vessel regions and the background regions on the image. The potential of the proposed graph based smoothing regularizer in reconstructing small vessel is compared over the classical U-net with or without regularizer. Numerical and visual results shows that our developed regularizer proved its effectiveness in segmenting the small vessels and reconnecting the fragmented retinal blood vessels.
In recent years, several automatic segmentation methods have been proposed for blood vessels in retinal fundus images, ranging from using cheap and fast trainable filters to complicated neural networks and even deep learning. One example of a filted-based segmentation method is B-COSFIRE. In this approach the image filter is trained with example prototype patterns, to which the filter becomes selective by finding points in a Difference of Gaussian response on circles around the center with large intensity variation. In this paper we discuss and evaluate several of these vessel segmentation met…
Beijing University of Posts and Telecommunications（北京邮电大学）
Accurate retinal vessel segmentation is a challenging problem in color fundus image analysis. An automatic retinal vessel segmentation system can effectively facilitate clinical diagnosis and ophthalmological research. Technically, this problem suffers from various degrees of vessel thickness, perception of details, and contextual feature fusion. For addressing these challenges, a deep learning based method has been proposed and several customized modules have been integrated into the well-known encoder-decoder architecture U-net, which is mainly employed in medical image segmentation. Structu…
Helmholtz Zentrum München（慕尼黑亥姆霍兹中心）；Technical University of Munich（慕尼黑工业大学）
Fundus photography is the primary method for retinal imaging and essential for diabetic retinopathy prevention. Automated segmentation of fundus photographs would improve the quality, capacity, and cost-effectiveness of eye care screening programs. However, current segmentation methods are not robust towards the diversity in imaging conditions and pathologies typical for real-world clinical applications. To overcome these limitations, we utilized contrastive self-supervised learning to exploit the large variety of unlabeled fundus images in the publicly available EyePACS dataset. We pre-traine…
GrInAdapt: Scaling Retinal Vessel Structural Map Segmentation Through Grounding, Integrating and Adapting Multi-device, Multi-site, and Multi-modal Fundus Domains
Department of Bioengineering, University of Washington（华盛顿大学生物工程系）；Department of Electrical and Computer Engineering, University of Washington（华盛顿大学电气与计算机工程系）；Department of Ophthalmology, University of Washington（华盛顿大学眼科系）
Explainable Convolutional Neural Networks for Retinal Fundus Classification and Cutting-Edge Segmentation Models for Retinal Blood Vessels from Fundus Images
Ahsanullah University of Science and Technology（阿萨努拉科技大学）
Detecting diabetic retinopathy severity through fundus images using an ensemble of classifiers
Technical University of Cluj-Napoca（克卢日-纳波卡技术大学）；“Iuliu Hatieganu” University of Medicine and Pharmacy（“尤利乌·哈采加努”医药大学）；Emergency County Hospital（急诊县医院）
Accurate measurements of abnormalities like Artery-Vein ratio and tortuosity in fundus images is an actively researched task. Most of the research seems to compute such features independently. However, in this work, we have devised a fully automated technique to measure any vascular abnormalities. This paper is a follow-up paper on vessel topology estimation and extraction, we use the extracted topology to perform A-V state-of-the-art Artery-Vein classification, AV ratio calculation, and vessel tortuosity measurement, all fully automated. Existing techniques tend to only work on the partial re…
Friedrich-Alexander University（弗里德里希-亚历山大大学）；International Max Planck Research School Physics of Light (IMPRS-PL)（国际马克斯·普朗克光物理研究学院（IMPRS-PL））；MIT（麻省理工学院）
Fundus photography and Optical Coherence Tomography Angiography (OCT-A) are two commonly used modalities in ophthalmic imaging. With the development of deep learning algorithms, fundus image processing, especially retinal vessel segmentation, has been extensively studied. Built upon the known operator theory, interpretable deep network pipelines with well-defined modules have been constructed on fundus images. In this work, we firstly train a modularized network pipeline for the task of retinal vessel segmentation on the fundus database DRIVE. The pretrained preprocessing module from the pipel…
Heritage Institute of Technology（遗产理工学院）；Tata Consultancy Services（塔塔咨询服务公司）
Diabetic Retinopathy (DR) is a complication of long-standing, unchecked diabetes and one of the leading causes of blindness in the world. This paper focuses on improved and robust methods to extract some of the features of DR, viz. Blood Vessels and Exudates. Blood vessels are segmented using multiple morphological and thresholding operations. For the segmentation of exudates, k-means clustering and contour detection on the original images are used. Extensive noise reduction is performed to remove false positives from the vessel segmentation algorithm's results. The localization of Optic Disc …
ITER, Siksha ‘O’ Anusandhan (Deemed to be University)（ITER，锡克沙·奥·阿努桑德汉（被视为大学））
In the medical domain, different computer-aided diagnosis systems have been proposed to extract blood vessels from retinal fundus images for the clinical treatment of vascular diseases. Accurate extraction of blood vessels from the fundus images using a computer-generated method can help the clinician to produce timely and accurate reports for the patient suffering from these diseases. In this article, we integrate top-hat based preprocessing approach with fine-tuned B-COSFIRE filter to achieve more accurate segregation of blood vessel pixels from the background. The use of top-hat transformat…
A Deep Convolutional Neural Network-Based Novel Class Balancing for Imbalance Data Segmentation
Department of Computer Science, COMSATS University Islambad, Lahore Campus, Pakistan（计算机科学系，卡姆斯大学伊斯法罕，拉合尔校区，巴基斯坦）；Hamad Medical Corporation, Qatar（卡塔尔哈马姆医疗集团）；University of Stirling, UK（斯特林大学，英国）
We propose an encoder-decoder framework for the segmentation of blood vessels in retinal images that relies on the extraction of large-scale patches at multiple image-scales during training. Experiments on three fundus image datasets demonstrate that this approach achieves state-of-the-art results and can be implemented using a simple and efficient fully-convolutional network with a parameter count of less than 0.8M. Furthermore, we show that this framework - called VLight - avoids overfitting to specific training images and generalizes well across different datasets, which makes it highly sui…
Siksha ‘O’ Anusandhan (Deemed to be University)（锡克沙奥阿努山丹大学（被认定为大学））；ITER, Siksha ‘O’ Anusandhan (Deemed to be University)（锡克沙奥阿努山丹大学（被认定为大学）ITER学院）；Center for the Internet of Things, ITER, Siksha ‘O’ Anusandhan (Deemed to be University)（锡克沙奥阿努山丹大学（被认定为大学）ITER学院物联网中心）
Extracting blood vessels from retinal fundus images plays a decisive role in diagnosing the progression in pertinent diseases. In medical image analysis, vessel extraction is a semantic binary segmentation problem, where blood vasculature needs to be extracted from the background. Here, we present an image enhancement technique based on the morphological preprocessing coupled with a scaled U-net architecture. Despite a relatively less number of trainable network parameters, the scaled version of U-net architecture provides better performance compare to other methods in the domain. We validated…
A fundus image usually contains the optic disc, pathologies and other structures in addition to vessels to be segmented. This study proposes a deep network for vessel segmentation, whose architecture is inspired by inception modules. The network contains three sub-networks, each with a different filter size, which are connected in the last layer of the proposed network. According to experiments conducted in the DRIVE and IOSTAR, the performance of our network is found to be better than or comparable to that of the previous methods. We also observe that the sub-networks pay attention to differe…
MAF-Net: Multiple attention-guided fusion network for fundus vascular image segmentation
School of Electrical and Automation Engineering, East China Jiaotong University（华东交通大学电气与自动化工程学院）；School of Computer Science, Northwestern Polytechnical University（西北工业大学计算机学院）
The task of image segmentation is to classify each pixel in the image based on the appropriate label. Various deep learning approaches have been proposed for image segmentation that offers high accuracy and deep architecture. However, the deep learning technique uses a pixel-wise loss function for the training process. Using pixel-wise loss neglected the pixel neighbor relationships in the network learning process. The neighboring relationship of the pixels is essential information in the image. Utilizing neighboring pixel information provides an advantage over using only pixel-to-pixel inform…
Centro de Investigación CITIC（CITIC研究中心）；Universidade da Coruña（拉科鲁尼亚大学）；Instituto de Investigación Biomédica de A Coruña (INIBIC)（拉科鲁尼亚生物医学研究所（INIBIC））
The study of the retinal vasculature is a fundamental stage in the screening and diagnosis of many diseases. A complete retinal vascular analysis requires to segment and classify the blood vessels of the retina into arteries and veins (A/V). Early automatic methods approached these segmentation and classification tasks in two sequential stages. However, currently, these tasks are approached as a joint semantic segmentation task, as the classification results highly depend on the effectiveness of the vessel segmentation. In that regard, we propose a novel approach for the simultaneous segmentat…
Bahcesehir University（巴赫切谢希尔大学）；American University of Malta（马耳他美国大学）
Clinical screening with low-quality fundus images is challenging and significantly leads to misdiagnosis. This paper addresses the issue of improving the retinal image quality and vessel segmentation through retinal image restoration. More specifically, a cycle-consistent generative adversarial network (CycleGAN) with a convolution block attention module (CBAM) is used for retinal image restoration. A modified UNet is used for retinal vessel segmentation for the restored retinal images (CBAM-UNet). The proposed model consists of two generators and two discriminators. Generators translate image…
The Computer-Assisted Diagnosis systems could save workloads and give objective diagnostic to ophthalmologists. At first, feature extraction is a fundamental step. One of these retinal features is the fovea. The fovea is a small fossa on the fundus. The main vessels diverge from the optic nerve head and follow a specific course that can be geometrically modeled as a parabola, with a common vertex inside the optic nerve head and the fovea located along the apex of this parabola curve. Therefore, based on this assumption, the main retinal blood vessels are segmented and fitted to a parabolic mod…
Indian Institute of Technology Jodhpur（印度理工学院焦特布尔分校）
Segmentation plays a crucial role in diagnosis. Studying the retinal vasculatures from fundus images help identify early signs of many crucial illnesses such as diabetic retinopathy. Due to the varying shape, size, and patterns of retinal vessels, along with artefacts and noises in fundus images, no one-stage method can accurately segment retinal vessels. In this work, we propose a multi-scale, multi-level attention embedded CNN architecture ((M)SLAe-Net) to address the issue of multi-stage processing for robust and precise segmentation of retinal vessels. We do this by extracting features at …
Retinal vessel segmentation is a fundamental step in screening, diagnosis, and treatment of various cardiovascular and ophthalmic diseases. Robustness is one of the most critical requirements for practical utilization, since the test images may be captured using different fundus cameras, or be affected by various pathological changes. We investigate this problem from a data augmentation perspective, with the merits of no additional training data or inference time. In this paper, we propose two new data augmentation modules, namely, channel-wise random Gamma correction and channel-wise random v…
University of Science and Technology of China（中国科学技术大学）；Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences（中国科学院苏州生物医学工程技术研究所）；Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences（中国科学院脑科学与智能技术卓越创新中心）；the Third People’s Hospital of Changzhou（常州市第三人民医院）
Fluorescein angiography can provide a map of retinal vascular structure and function, which is commonly used in ophthalmology diagnosis, however, this imaging modality may pose risks of harm to the patients. To help physicians reduce the potential risks of diagnosis, an image translation method is adopted. In this work, we proposed a conditional generative adversarial network(GAN) - based method to directly learn the mapping relationship between structure fundus images and fundus fluorescence angiography images. Moreover, local saliency maps, which define each pixel's importance, are used to d…
Inception Institute of Artificial Intelligence（人工智能起源研究所）
Retinal fundus images are widely used for the clinical screening and diagnosis of eye diseases. However, fundus images captured by operators with various levels of experience have a large variation in quality. Low-quality fundus images increase uncertainty in clinical observation and lead to the risk of misdiagnosis. However, due to the special optical beam of fundus imaging and structure of the retina, natural image enhancement methods cannot be utilized directly to address this. In this paper, we first analyze the ophthalmoscope imaging system and simulate a reliable degradation of major inf…
Xiamen University（厦门大学）；Chinese PLA General Hospital（中国人民解放军总医院）；Deepwise AI Laboratory（深睿智慧人工智能实验室）
The analysis of organ vessels is essential for computer-aided diagnosis and surgical planning. But it is not a easy task since the fine-detailed connected regions of organ vessel bring a lot of ambiguity in vessel segmentation and sub-type recognition, especially for the low-contrast capillary regions. Furthermore, recent two-staged approaches would accumulate and even amplify these inaccuracies from the first-stage whole vessel segmentation into the second-stage sub-type vessel pixel-wise classification. Moreover, the scarcity of manual annotation in organ vessels poses another challenge. In …
Tsinghua-Berkeley Shenzhen Institute（清华-伯克利深圳学院）；University of California, Berkeley（加州大学伯克利分校）；Affiliated Eye Hospital of Nanchang University（南昌大学附属眼科医院）
Retinopathy of prematurity (ROP) is an abnormal blood vessel development in the retina of a prematurely-born infant or an infant with low birth weight. ROP is one of the leading causes for infant blindness globally. Early detection of ROP is critical to slow down and avert the progression to vision impairment caused by ROP. Yet there is limited awareness of ROP even among medical professionals. Consequently, dataset for ROP is limited if ever available, and is in general extremely imbalanced in terms of the ratio between negative images and positive ones. In this study, we formulate the proble…
University of California, Los Angeles（加利福尼亚大学洛杉矶分校）
The morphological attributes of retinal vessels, such as length, width, tortuosity and branching pattern and angles, play an important role in diagnosis, screening, treatment, and evaluation of various cardiovascular and ophthalmologic diseases such as diabetes, hypertension and arteriosclerosis. The crucial step before extracting these morphological characteristics of retinal vessels from retinal fundus images is vessel segmentation. In this work, we propose a method for retinal vessel segmentation based on fully convolutional networks. Thousands of patches are extracted from each retinal ima…
Monash University（莫纳什大学）；Airdoc；NVIDIA AI Technology Center（英伟达人工智能技术中心）
Retinal vessel segmentation plays a key role in computer-aided screening, diagnosis, and treatment of various cardiovascular and ophthalmic diseases. Recently, deep learning-based retinal vessel segmentation algorithms have achieved remarkable performance. However, due to the domain shift problem, the performance of these algorithms often degrades when they are applied to new data that is different from the training data. Manually labeling new data for each test domain is often a time-consuming and laborious task. In this work, we explore unsupervised domain adaptation in retinal vessel segmen…
Vessel segmentation in fundus is a key diagnostic capability in ophthalmology, and there are various challenges remained in this essential task. Early approaches indicate that it is often difficult to obtain desirable segmentation performance on thin vessels and boundary areas due to the imbalance of vessel pixels with different thickness levels. In this paper, we propose a novel two-stream Meticulous-Processing Network (MP-Net) for tackling this problem. To pay more attention to the thin vessels and boundary areas, we firstly propose an efficient hierarchical model automatically stratifies th…
Automatic segmentation of retina vessels plays a pivotal role in clinical diagnosis of prevalent eye diseases, such as, Diabetic Retinopathy or Age-related Macular Degeneration. Due to the complex construction of blood vessels, with drastically varying thicknesses, accurate vessel segmentation can be quite a challenging task. In this work we show that it is possible to achieve near state-of-the-art performance, by crafting a careful thought pre-processing pipeline, without having to resort to complex networks and/or training routines. We also show that our model is able to maintain the same hi…
Generation of Structurally Realistic Retinal Fundus Images with Diffusion Models
Seoul National University College of Medicine（首尔大学医学院）；Seoul National University Bundang Hospital（首尔大学盆唐医院）；VUNO, Inc.（VUNO公司）；Kookmin University（国民大学）
Shenzhen International Graduate School, Tsinghua University（清华大学深圳国际研究生院）；Shenzhen Eye Hospital affiliated to Jinan University（暨南大学附属深圳眼科医院）
Ophthalmologists have used fundus images to screen and diagnose eye diseases. However, different equipments and ophthalmologists pose large variations to the quality of fundus images. Low-quality (LQ) degraded fundus images easily lead to uncertainty in clinical screening and generally increase the risk of misdiagnosis. Thus, real fundus image restoration is worth studying. Unfortunately, real clinical benchmark has not been explored for this task so far. In this paper, we investigate the real clinical fundus image restoration problem. Firstly, We establish a clinical dataset, Real Fundus (RF)…
Bioinformatics Institute（生物信息学研究所）；Universitat Rovira i Virgili（罗维拉-威尔吉利大学）
In this paper, we propose an efficient blood vessel segmentation method for the eye fundus images using adversarial learning with multiscale features and kernel factorization. In the generator network of the adversarial framework, spatial pyramid pooling, kernel factorization and squeeze excitation block are employed to enhance the feature representation in spatial domain on different scales with reduced computational complexity. In turn, the discriminator network of the adversarial framework is formulated by combining convolutional layers with an additional squeeze excitation block to differe…
Pattern Recognition Lab, FAU Erlangen-Nürnberg（埃尔朗根-纽伦堡大学模式识别实验室）；Department of Ophthalmology, Universitätsklinikum Erlangen（埃尔朗根大学医院眼科）
Ophthalmological imaging utilizes different imaging systems, such as color fundus, infrared, fluorescein angiography, optical coherence tomography (OCT) or OCT angiography. Multiple images with different modalities or acquisition times are often analyzed for the diagnosis of retinal diseases. Automatically aligning the vessel structures in the images by means of multi-modal registration can support the ophthalmologists in their work. Our method uses a convolutional neural network to extract features of the vessel structure in multi-modal retinal images. We jointly train a keypoint detection an…
Fundus photography (FP) remains the primary imaging modality in screening various retinal diseases including age-related macular degeneration, diabetic retinopathy and glaucoma. FP allows the clinician to examine the ocular fundus structures such as the macula, the optic disc (OD) and retinal vessels, whose visibility and clarity in an FP image remain central to ensuring diagnostic accuracy, and hence determine the diagnostic quality (DQ). Images with low DQ, resulting from eye movement, improper illumination and other possible causes, should obviously be recaptured. However, the technician, o…
Deepwise AI Lab（深度智耀人工智能实验室）；Northwestern Polytechnical University（西北工业大学）；Peking University（北京大学）
Analyzing the morphological attributes of blood vessels plays a critical role in the computer-aided diagnosis of many cardiovascular and ophthalmologic diseases. Although being extensively studied, segmentation of blood vessels, particularly thin vessels and capillaries, remains challenging mainly due to the lack of an effective interaction between local and global features. In this paper, we propose a novel deep learning model called PC-Net to segment retinal vessels and major arteries in 2D fundus image and 3D computed tomography angiography (CTA) scans, respectively. In PC-Net, the pyramid …
Institute of Microelectronics of Chinese Academy of Sciences（中国科学院微电子研究所）；University of Chinese Academy of Sciences（中国科学院大学）
Retinal vessel segmentation based on deep learning requires a lot of manual labeled data. That is time-consuming, laborious and professional. What is worse, the acquisition of abundant fundus images is difficult. These problems are more serious due to the presence of abnormalities, varying size and shape of the vessels, non-uniform illumination and anatomical changes. In this paper, we propose a data-efficient semi-supervised learning framework, which effectively combines the existing deep learning network with GAN and self-training ideas. In view of the difficulty of tuning hyper-parameters o…
International Max Planck Research School for Physics of Light（国际马克斯·普朗克光物理研究学院）；Erlangen Graduate School in Advanced Optical Technologies（埃尔朗根高级光学技术研究生院）
Retinal vessel segmentation is an essential step for fundus image analysis. With the recent advances of deep learning technologies, many convolutional neural networks have been applied in this field, including the successful U-Net. In this work, we firstly modify the U-Net with functional blocks aiming to pursue higher performance. The absence of the expected performance boost then lead us to dig into the opposite direction of shrinking the U-Net and exploring the extreme conditions such that its segmentation performance is maintained. Experiment series to simplify the network structure, reduc…
Eötvös Loránd University（罗兰大学）；Budapest University of Technology and Economics（布达佩斯技术与经济大学）；Jiangxi Normal University（江西师范大学）；Chinese Academy of Science（中国科学院）；Qinghai University（青海大学）
Reliable segmentation of retinal vessels can be employed as a way of monitoring and diagnosing certain diseases, such as diabetes and hypertension, as they affect the retinal vascular structure. In this work, we propose the Residual Spatial Attention Network (RSAN) for retinal vessel segmentation. RSAN employs a modified residual block structure that integrates DropBlock, which can not only be utilized to construct deep networks to extract more complex vascular features, but can also effectively alleviate the overfitting. Moreover, in order to further improve the representation capability of t…
Peking University（北京大学）；Peking University First Hospital（北京大学第一医院）；MGH/BWH Center for Clinical Data Science（麻省总医院/布莱根妇女医院临床数据科学中心）
Segmenting coronary arteries is challenging, as classic unsupervised methods fail to produce satisfactory results and modern supervised learning (deep learning) requires manual annotation which is often time-consuming and can some time be infeasible. To solve this problem, we propose a knowledge transfer based shape-consistent generative adversarial network (SC-GAN), which is an annotation-free approach that uses the knowledge from publicly available annotated fundus dataset to segment coronary arteries. The proposed network is trained in an end-to-end fashion, generating and segmenting synthe…
Early detection of microaneurysms (MAs), the first sign of Diabetic Retinopathy (DR), is an essential first step in automated detection of DR to prevent vision loss and blindness. This study presents a novel and different algorithm for automatic detection of MAs in fluorescein angiography (FA) fundus images, based on Radon transform (RT) and multi-overlapping windows. This project addresses a novel method, in detection of retinal land marks and lesions to diagnose the DR. At the first step, optic nerve head (ONH) was detected and masked. In preprocessing stage, top-hat transformation and avera…
International Prevention Research Institute（国际预防研究所）；Swansea University（斯旺西大学）；Diabetic Eye Screening Wales（威尔士糖尿病眼病筛查中心）；University of Strathclyde Institute of Global Public Health（思克莱德大学全球公共卫生学院）
In order to estimate a registration model of eye fundus images made of an affinity and two radial distortions, we introduce an estimation criterion based on an error between the vessels. In [1], we estimated this model by minimising the error between characteristics points. In this paper, the detected vessels are selected using the circle and ellipse equations of the overlap area boundaries deduced from our model. Our method successfully registers 96 % of the 271 pairs in a Public Health dataset acquired mostly with different cameras. This is better than our previous method [1] and better than…
Benchmarking Retinal Blood Vessel Segmentation Models for Cross-Dataset and Cross-Disease Generalization
University of Ibadan（伊巴丹大学）；African Institute for Mathematical Sciences（非洲数学科学研究所）；Hertie Institute for AI in Brain Health（赫蒂脑健康人工智能研究所）；University of Tübingen（蒂宾根大学）；University of Bern（伯尔尼大学）；University College London（伦敦大学学院）；Tübingen AI Center（蒂宾根人工智能中心）
Recently, many methods based on hand-designed convolutional neural networks (CNNs) have achieved promising results in automatic retinal vessel segmentation. However, these CNNs remain constrained in capturing retinal vessels in complex fundus images. To improve their segmentation performance, these CNNs tend to have many parameters, which may lead to overfitting and high computational complexity. Moreover, the manual design of competitive CNNs is time-consuming and requires extensive empirical knowledge. Herein, a novel automated design method, called Genetic U-Net, is proposed to generate a U…
Budapest University of Technology and Economics（布达佩斯技术与经济大学）；Jiangxi Normal University（江西师范大学）；Eötvös Loránd University（厄特沃什·罗兰大学）；Shenyang Aerospace University（沈阳航空航天大学）
Retinal vessel segmentation plays an imaportant role in the field of retinal image analysis because changes in retinal vascular structure can aid in the diagnosis of diseases such as hypertension and diabetes. In recent research, numerous successful segmentation methods for fundus images have been proposed. But for other retinal imaging modalities, more research is needed to explore vascular extraction. In this work, we propose an efficient method to segment blood vessels in Scanning Laser Ophthalmoscopy (SLO) retinal images. Inspired by U-Net, "feature map reuse" and residual learning, we pro…
A General Bézier Tree Encoding Counterfactual Framework for Retinal-Vessel-Mediated Disease Analysis
Department of Electronic and Electrical Engineering（电子与电气工程系）；School of Data Science（数据科学学院）；Research Institute of Electrical Communication（电气通信研究所）；J. Crayton Pruitt Family Department of Biomedical Engineering（姜·克雷顿·普瑞特家庭生物医学工程系）
Imaging methods by using computer techniques provide doctors assistance at any time and relieve their workload, especially for iterative processes like identifying objects of interest such as lesions and anatomical structures from the image. Detection of microaneurysms (MAs) as one of the lesions in the retina is considered to be a crucial step in some retinal image analysis algorithms for the identification of diabetic retinopathy (DR) as the second-largest eye diseases in developed countries. The objective of this study is to compare the effect of two preprocessing methods, Illumination Equa…
A Deep Learning-Based Unified Framework for Red Lesions Detection on Retinal Fundus Images
Computer and Information Science College, King Saud University（沙特王后大学计算机与信息科学学院）；Department of Ophthalmology, College of Medicine, Princess Nourah bint Abdulrahman University（普里丝特努尔·阿卜杜勒拉赫曼大学医学院眼科系）
National Institute of Technology Karnataka（卡纳塔克邦国家技术研究所）
Diabetic retinopathy (DR) is a severe complication of diabetes that can cause permanent blindness. Timely diagnosis and treatment of DR are critical to avoid total loss of vision. Manual diagnosis is time consuming and error-prone. In this paper, we propose a novel deep learning based method for automatic screening of retinal fundus images to detect and classify DR based on the severity. The method uses a dual-path configuration of deep neural networks to achieve the objective. In the first step, a modified UNet++ based retinal vessel segmentation is used to create a fundus image that emphasis…
