There is a rising need for computational models that can complementarily leverage data of different modalities while investigating associations between subjects for population-based disease analysis. Despite the success of convolutional neural networks in representation learning for imaging data, it is still a very challenging task. In this paper, we propose a generalizable framework that can automatically integrate imaging data with non-imaging data in populations for uncertainty-aware disease prediction. At its core is a learnable adaptive population graph with variational edges, which we mathematically prove that it is optimizable in conjunction with graph convolutional neural networks. To estimate the predictive uncertainty related to the graph topology, we propose the novel concept of Monte-Carlo edge dropout. Experimental results on four databases show that our method can consistently and significantly improve the diagnostic accuracy for Autism spectrum disorder, Alzheimer's disease, and ocular diseases, indicating its generalizability in leveraging multimodal data for computer-aided diagnosis.
Agriculture is the mainstay of human society because it is an essential need for every organism. Paddy cultivation is very significant so far as humans are concerned, largely in the Asian continent, and it is one of the staple foods. However, plant diseases in agriculture lead to depletion in productivity. Plant diseases are generally caused by pests, insects, and pathogens that decrease productivity to a large scale if not controlled within a particular time. Eventually, one cannot see an increase in paddy yield. Accurate and timely identification of plant diseases can help farmers mitigate l…
Bangladesh University of Business and Technology（孟加拉国商业技术大学）
A disease that limits a plant from its maximal capacity is defined as plant disease. From the perspective of agriculture, diagnosing plant disease is crucial, as diseases often limit plants' production capacity. However, manual approaches to recognize plant diseases are often temporal, challenging, and time-consuming. Therefore, computerized recognition of plant diseases is highly desired in the field of agricultural automation. Due to the recent improvement of computer vision, identifying diseases using leaf images of a particular plant has already been introduced. Nevertheless, the most intr…
We develop three efficient approaches for generating visual explanations from 3D convolutional neural networks (3D-CNNs) for Alzheimer's disease classification. One approach conducts sensitivity analysis on hierarchical 3D image segmentation, and the other two visualize network activations on a spatial map. Visual checks and a quantitative localization benchmark indicate that all approaches identify important brain parts for Alzheimer's disease diagnosis. Comparative analysis show that the sensitivity analysis based approach has difficulty handling loosely distributed cerebral cortex, and appr…
Mongolian University of Science and Technology（蒙古科技大学）；Irkutsk National Research Technical University（伊尔库茨克国立研究技术大学）
In the field of health-care and bio-medical research, understanding the relationship between the symptoms of diseases is crucial for early diagnosis and determining hidden relationships between diseases. The study aimed to understand the extent of symptom types in disease prediction tasks. In this research, we analyze a pre-generated symptom-based human disease dataset and demonstrate the degree of predictability for each disease based on the Convolutional Neural Network and the Support Vector Machine. Ambiguity of disease is studied using the K-Means and the Principal Component Analysis. Our …
McMaster University（麦克马斯特大学）；Rotman Research Institute at Baycrest, University of Toronto（多伦多大学贝克莱斯特罗特曼研究所）；Ryerson University（瑞尔森大学）
Recently, machine learning techniques especially predictive modeling and pattern recognition in biomedical sciences from drug delivery system to medical imaging has become one of the important methods which are assisting researchers to have deeper understanding of entire issue and to solve complex medical problems. Deep learning is a powerful machine learning algorithm in classification while extracting low to high-level features. In this paper, we used convolutional neural network to classify Alzheimer's brain from normal healthy brain. The importance of classifying this kind of medical data …
Apple diseases, if not diagnosed early, can lead to massive resource loss and pose a serious threat to humans and animals who consume the infected apples. Hence, it is critical to diagnose these diseases early in order to manage plant health and minimize the risks associated with them. However, the conventional approach of monitoring plant diseases entails manual scouting and analyzing the features, texture, color, and shape of the plant leaves, resulting in delayed diagnosis and misjudgments. Our work proposes an ensembled system of Xception, InceptionResNet, and MobileNet architectures to de…
We propose a Healthcare Graph Convolutional Network (HealGCN) to offer disease self-diagnosis service for online users based on Electronic Healthcare Records (EHRs). Two main challenges are focused in this paper for online disease diagnosis: (1) serving cold-start users via graph convolutional networks and (2) handling scarce clinical description via a symptom retrieval system. To this end, we first organize the EHR data into a heterogeneous graph that is capable of modeling complex interactions among users, symptoms and diseases, and tailor the graph representation learning towards disease di…
Analysis of Convolutional Neural Network-based Image Classifications: A Multi-Featured Application for Rice Leaf Disease Prediction and Recommendations for Farmers
Nepal Engineering College（尼泊尔工程学院）；Pokhara University（博卡拉大学）；Tribhuvan University（特里布万大学）；Institute of Engineering（工程学院）
Improving Sickle Cell Disease Classification: A Fusion of Conventional Classifiers, Segmented Images, and Convolutional Neural Networks
Institute of Exacts and Technological Sciences -- Federal University of Viçosa (UFV)（维索萨联邦大学精确与技术科学学院）；School of Computer Science -- Federal University of Uberlândia (UFU)（乌贝兰迪亚联邦大学计算机科学学院）
GL-ICNN: An End-To-End Interpretable Convolutional Neural Network for the Diagnosis and Prediction of Alzheimer's Disease
Erasmus MC（伊拉斯姆斯医学中心）；University Medical Center Groningen（格罗宁根大学医学中心）；University Medical Center Utrecht（乌得勒支大学医学中心）；Radboud University Medical Center（拉德堡德大学医学中心）；Leiden University Medical Center（莱顿大学医学中心）；Amsterdam University Medical Center（阿姆斯特丹大学医学中心）；Maastricht University Medical Center（马斯特里赫特大学医学中心）
Lakehead University（湖首大学）；University of Calgary（卡尔加里大学）
Objective: This paper presents an Alzheimer's disease (AD) detection method based on learning structural similarity between Magnetic Resonance Images (MRIs) and representing this similarity as a graph. Methods: We construct the similarity graph using embedded features of the input image (i.e., Non-Demented (ND), Very Mild Demented (VMD), Mild Demented (MD), and Moderated Demented (MDTD)). We experiment and compare different dimension-reduction and clustering algorithms to construct the best similarity graph to capture the similarity between the same class images using the cosine distance as a …
AI Framework for Early Diagnosis of Coronary Artery Disease: An Integration of Borderline SMOTE, Autoencoders and Convolutional Neural Networks Approach
Virginia Tech（弗吉尼亚理工大学）；Islamic Azad University（伊斯兰阿扎德大学）；Deakin University（迪肯大学）
Variational inference provides approximations to the computationally intractable posterior distribution in Bayesian networks. A prominent medical application of noisy-or Bayesian network is to infer potential diseases given observed symptoms. Previous studies focus on approximating a handful of complicated pathological cases using variational transformation. Our goal is to use variational transformation as part of a novel hybridized inference for serving reliable and real time diagnosis at web scale. We propose a hybridized inference that allows variational parameters to be estimated without d…
University of Amsterdam（阿姆斯特丹大学）；Inception Institute of Artificial Intelligence（Inception人工智能研究院）
Disease classification relying solely on imaging data attracts great interest in medical image analysis. Current models could be further improved, however, by also employing Electronic Health Records (EHRs), which contain rich information on patients and findings from clinicians. It is challenging to incorporate this information into disease classification due to the high reliance on clinician input in EHRs, limiting the possibility for automated diagnosis. In this paper, we propose \textit{variational knowledge distillation} (VKD), which is a new probabilistic inference framework for disease …
Charité – Universitätsmedizin Berlin（柏林夏里特医学院）；Freie Universität Berlin（柏林自由大学）；Humboldt-Universität zu Berlin（柏林洪堡大学）；Berlin Institute of Health (BIH)（柏林健康研究所）
Attribution methods are an easy to use tool for investigating and validating machine learning models. Multiple methods have been suggested in the literature and it is not yet clear which method is most suitable for a given task. In this study, we tested the robustness of four attribution methods, namely gradient*input, guided backpropagation, layer-wise relevance propagation and occlusion, for the task of Alzheimer's disease classification. We have repeatedly trained a convolutional neural network (CNN) with identical training settings in order to separate structural MRI data of patients with …
Institute of Machine Learning in Biomedical Imaging, Helmholtz Munich（亥姆霍兹慕尼黑生物医学成像机器学习研究所）；Helmholtz AI, Helmholtz Munich（亥姆霍兹慕尼黑人工智能中心）；School of Computation, Information and Technology, Technical University of Munich（慕尼黑工业大学计算、信息与技术学院）；School of Biomedical Engineering and Imaging Sciences, King's College London（伦敦国王学院生物医学工程与影像科学学院）
Center for Cognitive Skill Enhancement（认知技能提升中心）；Independent University Bangladesh（孟加拉国独立大学）；University of Nevada, Reno（内华达大学雷诺分校）
Diagnosing different retinal diseases from Spectral Domain Optical Coherence Tomography (SD-OCT) images is a challenging task. Different automated approaches such as image processing, machine learning and deep learning algorithms have been used for early detection and diagnosis of retinal diseases. Unfortunately, these are prone to error and computational inefficiency, which requires further intervention from human experts. In this paper, we propose a novel convolution neural network architecture to successfully distinguish between different degeneration of retinal layers and their underlying …
Monash University（莫纳什大学）；Alfred Hospital（阿尔弗雷德医院）；West China Hospital of Sichuan University（四川大学华西医院）
Thyroid disease instances have been continuously increasing since the 1990s, and thyroid cancer has become the most rapidly rising disease among all the malignancies in recent years. Most existing studies focused on applying deep convolutional neural networks for detecting thyroid cancer. Despite their satisfactory performance on binary classification tasks, limited studies have explored multi-class classification of thyroid disease types; much less is known of the diagnosis of co-existence situation for different types of thyroid diseases. Therefore, this study proposed a novel multi-channel …
Deep Neural Networks - especially Convolutional Neural Network (ConvNet) has become the state-of-the-art for image classification, pattern recognition and various computer vision tasks. ConvNet has a huge potential in medical domain for analyzing medical data to diagnose diseases in an efficient way. Based on extracted features by ConvNet model from MRI data, early diagnosis is very crucial for preventing progress and treating the Alzheimer's disease. Despite having the ability to deliver great performance, absence of interpretability of the model's decision can lead to misdiagnosis which can …
Institute of Visual and Analytic Computing（视觉与分析计算研究所）
Convolutional neural networks (CNN) have become a powerful tool for detecting patterns in image data. Recent papers report promising results in the domain of disease detection using brain MRI data. Despite the high accuracy obtained from CNN models for MRI data so far, almost no papers provided information on the features or image regions driving this accuracy as adequate methods were missing or challenging to apply. Recently, the toolbox iNNvestigate has become available, implementing various state of the art methods for deep learning visualizations. Currently, there is a great demand for a c…
Alzheimer's disease is a progressive neurodegenerative disorder that gradually deprives the patient of cognitive function and can end in death. With the advancement of technology today, it is possible to detect Alzheimer's disease through Magnetic Resonance Imaging (MRI) scans. So that MRI is the technique most often used for the diagnosis and analysis of the progress of Alzheimer's disease. With this technology, image recognition in the early diagnosis of Alzheimer's disease can be achieved automatically using machine learning. Although machine learning has many advantages, currently the use …
Lehigh University（里海大学）；University of Pennsylvania（宾夕法尼亚大学）
Identification of brain regions related to the specific neurological disorders are of great importance for biomarker and diagnostic studies. In this paper, we propose an interpretable Graph Convolutional Network (GCN) framework for the identification and classification of Alzheimer's disease (AD) using multi-modality brain imaging data. Specifically, we extended the Gradient Class Activation Mapping (Grad-CAM) technique to quantify the most discriminative features identified by GCN from brain connectivity patterns. We then utilized them to find signature regions of interest (ROIs) by detecting…
There is a need for automatic diagnosis of certain diseases from medical images that could help medical practitioners for further assessment towards treating the illness. Alzheimers disease is a good example of a disease that is often misdiagnosed. Alzheimers disease (Hear after referred to as AD), is caused by atrophy of certain brain regions and by brain cell death and is the leading cause of dementia and memory loss [1]. MRI scans reveal this information but atrophied regions are different for different individuals which makes the diagnosis a bit more trickier and often gets misdiagnosed [1…
In recent days, Convolutional Neural Networks (CNN) have demonstrated impressive performance in medical image analysis. However, there is a lack of clear understanding of why and how the Convolutional Neural Network performs so well for image analysis task. How CNN analyzes an image and discriminates among samples of different classes are usually considered as non-transparent. As a result, it becomes difficult to apply CNN based approaches in clinical procedures and automated disease diagnosis systems. In this paper, we consider this issue and work on visualizing and understanding the decision…
University of Engineering and Technology Taxila（塔克西拉工程技术大学）；University of Central Florida（中佛罗里达大学）
Alzheimer's disease (AD) is a progressive and incurable neurodegenerative disease which destroys brain cells and causes loss to patient's memory. An early detection can prevent the patient from further damage of the brain cells and hence avoid permanent memory loss. In past few years, various automatic tools and techniques have been proposed for diagnosis of AD. Several methods focus on fast, accurate and early detection of the disease to minimize the loss to patients mental health. Although machine learning and deep learning techniques have significantly improved medical imaging systems for A…
2D and 3D Deep Learning Models for MRI-based Parkinson's Disease Classification: A Comparative Analysis of Convolutional Kolmogorov-Arnold Networks, Convolutional Neural Networks, and Graph Convolutional Networks
University of Oxford（牛津大学）；King’s College London（伦敦国王学院）；Guy’s and St Thomas’ NHS Foundation Trust（盖伊和圣托马斯国民保健服务基金会信托）
FaraAI Company（法拉人工智能公司）；University of Tehran（德黑兰大学）
Optical coherence tomography (OCT) imaging is a well-known technology for visualizing retinal layers and helps ophthalmologists to detect possible diseases. Accurate and early diagnosis of common retinal diseases can prevent the patients from suffering critical damages to their vision. Computer-aided diagnosis (CAD) systems can significantly assist ophthalmologists in improving their examinations. This paper presents a new enhanced deep ensemble convolutional neural network for detecting retinal diseases from OCT images. Our model generates rich and multi-resolution features by employing the l…
Dynamic Dual-Graph Fusion Convolutional Network For Alzheimer's Disease Diagnosis
Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences（中国科学院深圳先进技术研究院）；University of Chinese Academy of Sciences（中国科学院大学）；The Second People's Hospital of Shenzhen（深圳市第二人民医院）
Deep Convolutional Neural Networks (CNNs) have achieved remarkable results on Single Image Super-Resolution (SISR). Despite considering only a single degradation, recent studies also include multiple degrading effects to better reflect real-world cases. However, most of the works assume a fixed combination of degrading effects, or even train an individual network for different combinations. Instead, a more practical approach is to train a single network for wide-ranging and variational degradations. To fulfill this requirement, this paper proposes a unified network to accommodate the variation…
Zonguldak Bulent Ecevit University（宗古尔达布伦特·埃杰维特大学）
The 2019 novel coronavirus disease (COVID-19), with a starting point in China, has spread rapidly among people living in other countries, and is approaching approximately 34,986,502 cases worldwide according to the statistics of European Centre for Disease Prevention and Control. There are a limited number of COVID-19 test kits available in hospitals due to the increasing cases daily. Therefore, it is necessary to implement an automatic detection system as a quick alternative diagnosis option to prevent COVID-19 spreading among people. In this study, five pre-trained convolutional neural netwo…
New York University（纽约大学）；New York University Langone Medical Center（纽约大学朗格尼医学中心）
Early detection is a crucial goal in the study of Alzheimer's Disease (AD). In this work, we describe several techniques to boost the performance of 3D deep convolutional neural networks (CNNs) trained to detect AD using structural brain MRI scans. Specifically, we provide evidence that (1) instance normalization outperforms batch normalization, (2) early spatial downsampling negatively affects performance, (3) widening the model brings consistent gains while increasing the depth does not, and (4) incorporating age information yields moderate improvement. Together, these insights yield an incr…
Southeast University（东南大学）；The first affiliated hospital of Nanjing medical university（南京医科大学第一附属医院）；Centre de Recherche en Information Biomédicale Sino-Français (CRIBs)（中法生物医学信息研究中心（CRIBs））；University of Western Ontario（西安大略大学）
Reliable automatic classification of colonoscopy images is of great significance in assessing the stage of colonic lesions and formulating appropriate treatment plans. However, it is challenging due to uneven brightness, location variability, inter-class similarity, and intra-class dissimilarity, affecting the classification accuracy. To address the above issues, we propose a Fourier-based Frequency Complex Network (FFCNet) for colon disease classification in this study. Specifically, FFCNet is a novel complex network that enables the combination of complex convolutional networks with frequenc…
Helmholtz Zentrum München - German Research Center for Environmental Health（慕尼黑亥姆霍兹中心 - 德国环境健康研究中心）；Technical University of Munich（慕尼黑工业大学）；University of Zurich（苏黎世大学）；Johns Hopkins University（约翰斯·霍普金斯大学）
Sickle cell disease (SCD) is a severe genetic hemoglobin disorder that results in premature destruction of red blood cells. Assessment of the severity of the disease is a challenging task in clinical routine since the causes of broad variance in SCD manifestation despite the common genetic cause remain unclear. Identification of the biomarkers that would predict the severity grade is of importance for prognosis and assessment of responsiveness of patients to therapy. Detection of the changes in red blood cell (RBC) density through separation of Percoll density gradient could be such marker as …
Graduate School of Medicine, Osaka University（大阪大学医学院）
Computer-aided diagnosis system for diffuse lung diseases (DLDs) is necessary for the objective assessment of the lung diseases. In this paper, we develop semantic segmentation model for 5 kinds of DLDs. DLDs considered in this work are consolidation, ground glass opacity, honeycombing, emphysema, and normal. Convolutional neural network (CNN) is one of the most promising technique for semantic segmentation among machine learning algorithms. While creating annotated dataset for semantic segmentation is laborious and time consuming, creating partially annotated dataset, in which only one chosen…
Bangladesh University of Engineering and Technology（孟加拉国工程技术大学）；Georgia Institute of Technology（佐治亚理工学院）
Thoracic disease detection from chest radiographs using deep learning methods has been an active area of research in the last decade. Most previous methods attempt to focus on the diseased organs of the image by identifying spatial regions responsible for significant contributions to the model's prediction. In contrast, expert radiologists first locate the prominent anatomical structures before determining if those regions are anomalous. Therefore, integrating anatomical knowledge within deep learning models could bring substantial improvement in automatic disease classification. Motivated by …
Alzheimer's disease (AD) is one of the most common public health issues the world is facing today. This disease has a high prevalence primarily in the elderly accompanying memory loss and cognitive decline. AD detection is a challenging task which many authors have developed numerous computerized automatic diagnosis systems utilizing neuroimaging and other clinical data. MRI scans provide high-intensity visible features, making these scans the most widely used brain imaging technique. In recent years deep learning has achieved leading success in medical image analysis. But a relatively little …
Maulana Azad National Institute of Technology（毛拉纳·阿扎德国家理工学院）
Automatic and rapid screening of COVID-19 from the chest X-ray images has become an urgent need in this pandemic situation of SARS-CoV-2 worldwide in 2020. However, accurate and reliable screening of patients is a massive challenge due to the discrepancy between COVID-19 and other viral pneumonia in X-ray images. In this paper, we design a new stacked convolutional neural network model for the automatic diagnosis of COVID-19 disease from the chest X-ray images. We obtain different sub-models from the VGG19 and developed a 30-layered CNN model (named as CovNet30) during the training, and obtain…
