低成本、高性能、现场可编程的引脚受限数字微流控生物芯片
Low-Cost Performance-Efficient Field-Programmable Pin-Constrained Digital Microfluidic Biochip
摘要:
数字微流控生物芯片(DMFB)是面向诊断和护理点应用的革命性生物医学设备;芯片提供执行广泛的生物化学和实验室程序的能力,提供各种机会,其中包括生物测定的自动化,小型化和成本可承受性。已经存在各种数字微流体生物芯片架构;专用芯片主要适合于执行预定义的一组生物测定,而更灵活的通用芯片允许在相同架构上执行广泛的生物测定。尽管在执行各种生物测定方面更加灵活,但与特定应用的芯片相比,通用芯片需要更复杂的设计,需要更大、更昂贵的设计。本文试图提出一种通用的现场可编程管脚约束DMFB设计与改进的特性方面的面积消耗,制造成本和性能。
英文摘要:
Digital microfluidic biochips (DMFBs) are revolutionary biomedical devices towards diagnostics and point-of-care applications; the chips provide the capability of performing wide ranges of biochemistry and laboratory procedures, offering various opportunities among which to mention are automation, miniaturization and cost-affordability of bioassays. There have been various digital microfluidic biochips architectures; the application-specific chips are mainly suited towards executing a predefined set of bioassays whereas the more flexible general-purpose chips allow executing wide ranges of bioassays on the same architecture. Though more flexible in terms of performing various bioassays the general-purpose chips require more complicated designs compared with application-specific counterparts necessitating larger and more costly designs. This paper attempts to propose a general-purpose field-programmable pin-constrained DMFB design with improved characteristics in terms area-consumption, manufacturing cost and performance.
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