面向3D打印微流控生物芯片的打印感知合成与物理设计方法
Print-Aware Synthesis and Physical Design Methodologies for 3D-Printed Microfluidic Biochips
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中文总结 AI 辅助
针对3D打印微流控生物芯片面临的设计流程复杂、材料刚性、制造误差等挑战，本文提出集成设计自动化框架，结合多种技术提升其设计与制造的可行性。
中文摘要 AI 辅助
微流控器件广泛应用于诊断、化学合成与生物分析，但其开发常依赖复杂的制造与设计流程。基于树脂的三维（3D）打印已成为传统微加工的有前景替代方案，因其可实现复杂多层结构的低成本快速原型制作。然而，3D打印微流控生物芯片的实际应用仍面临挑战，包括人工且依赖专业技能的设计工作流、常用打印材料的刚性特性，以及过固化等制造误差——这类误差会扭曲内部特征，可能阻塞狭窄通道。本文提出一种针对3D打印微流控的集成设计自动化框架，从器件设计与制造两方面应对上述挑战；该框架结合了交互式设计工具、功能型3D微流控器件的自动化合成方法、低成本3D打印混合器的开发技术，以及用于提升低成本树脂打印机打印保真度的可制造性设计策略。
英文摘要
Microfluidic devices are widely used in diagnostics, chemical synthesis, and biological analysis, but their development often depends on complex fabrication and design processes. Resin-based three-dimensional (3D) printing has emerged as a promising alternative to conventional microfabrication because it enables low-cost, rapid prototyping of complex multi-layer structures. However, the practical realization of 3D-printed microfluidic biochips remains challenging due to manual and expertise-intensive design workflows, the rigid nature of commonly used printing materials, and fabrication inaccuracies such as over-curing that distort internal features and may block narrow channels. In this paper, we present a cohesive design automation framework for 3D-printed microfluidics that addresses these challenges across both device design and fabrication. The framework combines interactive design tools, automated synthesis methods for functional 3D microfluidic devices, techniques for developing low-cost 3D-printed mixers, and design-for-manufacturing strategies to improve print fidelity on low-cost resin printers.
