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arXiv 2008.12173physics.optics
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基于纤维的高精细度微腔的三维布朗运动跟踪和单个纳米颗粒的表征

Tracking Brownian motion in three dimensions and characterization of individual nanoparticles using a fiber-based high-finesse microcavity

Larissa Kohler, Matthias Mader, Christian Kern, Martin Wegener, David Hunger

摘要:

纳米系统在溶液中的动力学包含了丰富的信息,这些信息与从材料科学到生物学和生物医学应用的各个领域有关。当纳米系统用荧光团或强散射体标记时,可以跟踪它们的位置并以高空间和时间分辨率揭示内部运动。然而,标记物可能是有毒的,昂贵的,或改变对象的内在属性。在这里,我们同时测量的三个横向模式的高精细度微腔的色散频移,以获得未标记的二氧化硅$_2$纳米球的三维路径与$300$ $\mathrmμ$的时间和下至$8$ nm的空间分辨率。这使我们能够定量地确定性质,如极化率,流体动力学半径,和有效折射率。基于光纤的腔体集成在直接激光写入的微流体设备中,该设备能够以超小的样品体积精确控制流体。我们的方法能够在高带宽下定量表征纳米材料和分析生物分子运动。

英文摘要:

The dynamics of nanosystems in solution contain a wealth of information with relevance for diverse fields ranging from materials science to biology and biomedical applications. When nanosystems are marked with fluorophores or strong scatterers, it is possible to track their position and reveal internal motion with high spatial and temporal resolution. However, markers can be toxic, expensive, or change the object's intrinsic properties. Here, we simultaneously measure dispersive frequency shifts of three transverse modes of a high-finesse microcavity to obtain the three-dimensional path of unlabeled SiO$_2$ nanospheres with $300$$\mathrmμ$s temporal and down to $8$nm spatial resolution. This allows us to quantitatively determine properties such as the polarizability, hydrodynamic radius, and effective refractive index. The fiber-based cavity is integrated in a direct-laser-written microfluidic device that enables the precise control of the fluid with ultra-small sample volumes. Our approach enables quantitative nanomaterial characterization and the analysis of biomolecular motion at high bandwidth.

机构、总结、中文摘要均由AI分析而来,可能存在错误,请以论文正文为准。

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