Madita Goeb, Tom Pfeiffer, Robert Huber
We demonstrate a preliminary setup of a combined MHz-OCT and RGB narrowband reflection microscope and investigate the performance of the new RGB branch and different display modes of colored OCT data sets.
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The EndoTOFPET-US project aims to jointly exploit Time-Of-Flight Positron Emission Tomography (TOFPET) and ultrasound endoscopy with a multi-modal instrument for the development of new biomarkers for pancreas and prostate oncology. The paper outlines the functionality of the proposed instrument and the challenges for its realization. The high level of miniaturization and integration poses strong demands to the fields of scintillating crystallography, ultra-fast photon detection, highly integrated electronics and system integration. Solutions are presented to obtain a coincidence time resolutio…
Shot-noise limited, 10 MHz swept-source optical coherence tomography for retinal imaging
本文提出一种基于全正常色散超连续谱和长啁啾光纤布拉格光栅的10 MHz低噪声扫频源，在1050 nm附近实现90 nm调谐，视网膜成像灵敏度达84 dB并接近散粒噪声极限。
There has been a longstanding expectation that the optical resolution embodiment of photoacoustic tomography could have a substantial impact on gastrointestinal endoscopy by enabling microscopic visualization of the vasculature based on the endogenous contrast mechanism. Although multiple studies have demonstrated the in vivo imaging capability of a developed imaging device over the last decade, the implementation of such an endoscopic system that can be applied immediately when necessary via the instrument channel of a video endoscope has been a challenge. In this study, we developed a 3.38 m…
Detection of Barrett's esophagus (BE) at points of care outside the endoscopy suite may improve screening access and reduce esophageal adenocarcinoma mortality. Tethered capsule optical coherence tomography (OCT) can volumetrically image esophageal mucosa and detect BE in unsedated patients. We investigated ultrahigh-speed tethered capsule, swept-source OCT (SS-OCT) in unsedated patients, improved device design, developed procedural techniques, measured how capsule contact and longitudinal pullback non-uniformity affect coverage, and assessed patient toleration. OCT was performed in 16 patient…
Optical coherence tomography (OCT) has proven to be a powerful technique for studying tissue morphology in ophthalmology, cardiology, and endomicroscopy. Its performance is limited by the fundamental trade-off between the imaging sensitivity and acquisition speed -- a predicament common in virtually all imaging systems. In this paper, we circumvent this limit by using distributed Raman post-amplification of the reflection from the sample. We combine the amplification with simultaneously performed dispersive Fourier transformation, a process that maps the optical spectrum into an easily measure…
Optical coherence tomography (OCT) applications like ultra-widefield and full eye-length imaging are of high interest for various diagnostic purposes. In swept-source OCT these techniques require a swept light source, which is coherent over the whole imaging depth. We present a zero roll-off 1060 nm Fourier Domain Mode Locked-Laser (FDML-Laser) for retinal OCT imaging at 1.7 MHz A-scan rate and first long-range imaging results with it. Several steps such as improved dispersion compensation and frequency regulation were performed and will be discussed. Besides virtually no loss in OCT signal ov…
3D-printed axicon enables extended depth-of-focus intravascular optical coherence tomography
本研究提出利用双光子直接激光写入（微型3D打印）制造自由曲面光束整形内窥镜探头，实现约8微米分辨率、>0.8 mm景深的血管内OCT成像，并在活体猪和离体人体动脉中验证，为衍射极限大景深探头奠定基础。
Clinical tracking systems are popular but typically require specific tracking markers. During the last years, scanning speed of optical coherence tomography (OCT) has increased to A-scan rates above 1 MHz allowing to acquire volume scans of moving objects. Thorefore, we propose a markerless tracking system based on OCT to obtain small volumetric images including information of sub-surface structures at high spatio-temporal resolution. In contrast to conventional vision based approaches, this allows identifying natural landmarks even for smooth and homogeneous surfaces. We describe the optomech…
Single-shot 3D photoacoustic computed tomography with a densely packed array for transcranial functional imaging
研究开发了一种配备3072通道密集半球形超声换能器阵列的PACT系统，实现20 Hz单次三维成像，成功克服颅骨声衰减与光穿透限制，在组织体模和人类受试者中验证了实时活体经颅功能成像的潜力。
Non-invasive Deep-Brain Imaging with 3D Integrated Photoacoustic Tomography and Ultrasound Localization Microscopy (3D-PAULM)
本研究提出3D-PAULM系统，将光声计算机断层扫描与超声定位显微镜集成，实现无创小鼠全脑血流动力学成像，成功量化缺血性中风导致的脑缺血、缺氧及血流减少。
An Ingestible Light Source for Deep Photoacoustic Imaging
本研究提出一种可吞食的声能驱动光源，实现深层组织光电声成像，突破传统光学限制，用于胃肠道等深层区域的成像。
Precise quantitative delineation of tumor hypoxia is essential in radiation therapy treatment planning to improve the treatment efficacy by targeting hypoxic sub-volumes. We developed a combined imaging system of positron emission tomography (PET) and electron para-magnetic resonance imaging (EPRI) of molecular oxygen to investigate the accuracy of PET imaging in assessing tumor hypoxia. The PET/EPRI combined imaging system aims to use EPRI to precisely measure the oxygen partial pressure in tissues. This will evaluate the validity of PET hypoxic tumor imaging by (near) simultaneously acquired…
Imaging of ultrasound specularity at cortical bone interfaces to detect unbalanced remodeling: A preliminary study
研究旨在通过分析皮质骨界面超声反射，结合信号处理与波束形成技术重建镜面反射图，检测不平衡重塑。发现镜面反射与骨微观结构相关，孔隙体积分数和孔径都与镜面反射密切相关，有望成为识别皮质骨退化的敏感标志物。
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