2019冠状病毒病视角下呼吸道飞沫干燥和沉淀动力学的见解
Insights on drying and precipitation dynamics of respiratory droplets in the perspective of Covid-19
摘要：
我们分离出一种替代性粘液唾液的纳米胶体液滴，以获得对2019冠状病毒病大流行期间空气传播核的传染性的基本见解。蒸发实验进行与盐-水溶液接种了病毒载量的非活性纳米粒子在声悬浮器。我们试图模仿这种空气传播的粘液唾液滴的干燥，流动和沉淀动力学。通过使用来自健康受试者的实际样品进行的类似实验来验证使用替代流体的观察结果。关于最终微晶尺寸出现了一个独特的特征;对于不同的尺寸和环境条件，它总是初始液滴直径的20-30%。从悬浮液滴中保存的沉淀物表明，总病毒粒子群体的15%仍然分散在空气干燥的空气传播的核的外表面上。如果呼吸液滴（较大的初始尺寸）沉降在表面上，然后以固着模式蒸发，则该分数增加至约90%。
英文摘要：
We isolate a nano-colloidal droplet of surrogate mucosalivary fluid to gain fundamental insights into the infectivity of air borne nuclei during the Covid-19 pandemic. Evaporation experiments are performed with salt-water solutions seeded with a viral load of inactive nanoparticles in an acoustic levitator. We seek to emulate the drying, flow and precipitation dynamics of such air borne mucosalivary droplets. Observations with the surrogate fluid are validated by similar experiments with actual samples from a healthy subject. A unique feature emerges with regards to the final crystallite dimension; it is always 20-30% of the initial droplet diameter for different sizes and ambient conditions. The preserved precipitates from levitated droplets show that 15% of the total virion population remain dispersed on the outer surface of air-desiccated air borne nuclei. This fraction increases to ~90% if the respiratory droplets (of larger initial size) settle on a surface and then evaporate in the sessile mode.
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