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arXiv 2007.07953stat.MEstat.CO
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高维多变量分类反应回归的似然方法

A likelihood-based approach for multivariate categorical response regression in high dimensions

Aaron J. Molstad, Adam J. Rothman

摘要:

本文提出了一种惩罚似然方法来拟合二元分类反应回归模型。我们的方法允许从业者估计哪些预测因子是不相关的,哪些预测因子只影响双变量响应的边缘分布,哪些预测因子影响边缘分布和对数优势比。为了计算我们的估计量,我们提出了一个有效的一阶算法,我们将其扩展到一些受试者只有一个响应变量测量的设置,即,半监督设置。我们推导出一个渐近误差界,说明了我们的估计在高维设置的性能。推广到多元分类响应回归模型的建议。最后,模拟研究和泛癌症风险预测中的应用表明,我们的方法在可解释性和预测精度方面的有用性。实现所提出的方法的R包可在github.com/ajmolstad/BvCategorical下载。

英文摘要:

We propose a penalized likelihood method to fit the bivariate categorical response regression model. Our method allows practitioners to estimate which predictors are irrelevant, which predictors only affect the marginal distributions of the bivariate response, and which predictors affect both the marginal distributions and log odds ratios. To compute our estimator, we propose an efficient first order algorithm which we extend to settings where some subjects have only one response variable measured, i.e., the semi-supervised setting. We derive an asymptotic error bound which illustrates the performance of our estimator in high-dimensional settings. Generalizations to the multivariate categorical response regression model are proposed. Finally, simulation studies and an application in pan-cancer risk prediction demonstrate the usefulness of our method in terms of interpretability and prediction accuracy. An R package implementing the proposed method is available for download at github.com/ajmolstad/BvCategorical.

机构、总结、中文摘要均由AI分析而来,可能存在错误,请以论文正文为准。

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