arXivDaily arXiv每日学术速递 周一至周五更新
arXiv 2007.04370q-bio.NCcond-mat.dis-nn
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猝灭无序下兴奋和抑制动力学的重建方案:应用于斑马鱼成像

Reconstruction scheme for excitatory and inhibitory dynamics with quenched disorder: application to zebrafish imaging

Lorenzo Chicchi, Gloria Cecchini, Ihusan Adam, Giuseppe de Vito, Roberto Livi, Francesco Saverio Pavone, Ludovico Silvestri, Lapo Turrini, Francesco Vanzi, Duccio Fanelli

摘要:

一个逆过程的开发和测试,以恢复功能和结构信息的大脑活动的全球信号。该方法假设一个泄漏集成和消防模型与兴奋性和抑制性神经元,通过有向网络耦合。神经元被赋予了一个异质的电流值,它设置了它们相关的动力学机制。通过利用一个异质的平均场近似,该方法试图重建从全球活动模式的传入程度的分布,兴奋性和抑制性神经元,以及分配的电流的分布。所提出的逆计划首先验证对合成数据。然后,用双光子光片显微镜记录的斑马鱼幼虫的延时采集被用作重建算法的输入。我们发现兴奋性神经元的连通性呈幂律分布,并通过对标注图谱中的子区域进行分割来计算局部度分布。

英文摘要:

An inverse procedure is developed and tested to recover functional and structural information from global signals of brains activity. The method assumes a leaky-integrate and fire model with excitatory and inhibitory neurons, coupled via a directed network. Neurons are endowed with a heterogenous current value, which sets their associated dynamical regime. By making use of a heterogenous mean-field approximation, the method seeks to reconstructing from global activity patterns the distribution of in-coming degrees, for both excitatory and inhibitory neurons, as well as the distribution of the assigned currents. The proposed inverse scheme is first validated against synthetic data. Then, time-lapse acquisitions of a zebrafish larva recorded with a two-photon light sheet microscope are used as an input to the reconstruction algorithm. A power law distribution of the in-coming connectivity of the excitatory neurons is found. Local degree distributions are also computed by segmenting the whole brain in sub-regions traced from annotated atlas.

机构、总结、中文摘要均由AI分析而来,可能存在错误,请以论文正文为准。

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