利用高强度γ射线源光激发制备医学上感兴趣的异构体
Photo-excitation production of medically interesting isomers using high-intensity γ-ray source
摘要：
光子诱导的核激发（即光激发）可以用来产生核同分异构体，这些同分异构体在天体物理、能量储存、医学诊断和治疗等方面具有潜在的应用。本文研究了利用激光-电子康普顿散射（LCS）产生高强度γ射线源制备四种核同分异构体（{99 m}^Tc，{103 m}^Rh和{113 m，115 m}^In）的可行性。综述了这些核异构体的衰变性质及其在医学上的应用。计算了各光激发过程的截面曲线、模拟产率和产物活度。通过调节电子能量来优化LCS γ射线束的截止能量，以使光激发产物的产率和活性最大化。结果表明，在10^{13} γ/s量级的辐照强度下，对靶照射6小时，上述异构体的活性可超过10 mCi。这种放射性强度满足医学诊断的剂量要求。我们的模拟结果表明，使用最先进的LCS γ射线束装置，利用光激发产生医学上感兴趣的异构体的前景。
英文摘要：
Photon-induced nuclear excitation (i.e. photo-excitation) can be used for production of nuclear isomers, which have potential applications in astrophysics, energy storing, and medical diagnosis and treatment. This paper presents a feasibility study on production of four nuclear isomers ({99m}^Tc, {103m}^Rh and {113m, 115m}^In) using high-intensity γ-ray source based on laser-electron Compton scattering (LCS), for use in the medical diagnosis and treatment. The decay properties and the medical applications of these nuclear isomers were reviewed. The cross-section curves, simulated yields and activity of product of each photo-excitation process were calculated. The cutoff energy of LCS γ-ray beam is optimized by adjusting the electron energy in order to maximize the yields as well as the activities of photo-excitation products. It is found that the achievable activity of above-mentioned isomers can exceed 10 mCi for 6-hour target irradiation at an intensity of the order of 10^{13} γ/s. Such magnitude of activity satisfies the dose requirement of medical diagnosis. Our simulation results suggest the prospect of producing medically interesting isomers with photo-excitation using the state-of-art LCS γ-ray beam facility.
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