We consider so-called univariate unlinked (sometimes ``decoupled,'' or ``shuffled'') regression when the unknown regression curve is monotone. In standard monotone regression, one observes a pair $(X,Y)$ where a response $Y$ is linked to a covariate $X$ through the model $Y= m_0(X) + ε$, with $m_0$ the (unknown) monotone regression function and $ε$ the unobserved error (assumed to be independent of $X$). In the unlinked regression setting one gets only to observe a vector of realizations from both the response $Y$ and from the covariate $X$ where now $Y \stackrel{d}{=} m_0(X) + ε$. There is no (observed) pairing of $X$ and $Y$. Despite this, it is actually still possible to derive a consistent non-parametric estimator of $m_0$ under the assumption of monotonicity of $m_0$ and knowledge of the distribution of the noise $ε$. In this paper, we establish an upper bound on the rate of convergence of such an estimator under minimal assumption on the distribution of the covariate $X$. We discuss extensions to the case in which the distribution of the noise is unknown. We develop a second order algorithm for its computation, and we demonstrate its use on synthetic data. Finally, we apply our method (in a fully data driven way, without knowledge of the error distribution) on longitudinal data from the US Consumer Expenditure Survey.
In many problems, a sensible estimator of a possibly multivariate monotone function may itself fail to be monotone. We study the correction of such an estimator obtained via projection onto the space of functions monotone over a finite grid in the domain. We demonstrate that this corrected estimator has no worse supremal estimation error than the initial estimator, and that analogously corrected confidence bands contain the true function whenever the initial bands do, at no loss to average or maximal band width. Additionally, we demonstrate that the corrected estimator is uniformly asymptotica…
This paper studies the problem of testing whether a function is monotone from a nonparametric Bayesian perspective. Two new families of tests are constructed. The first uses constrained smoothing splines, together with a hierarchical stochastic-process prior that explicitly controls the prior probability of monotonicity. The second uses regression splines, together with two proposals for the prior over the regression coefficients. The finite-sample performance of the tests is shown via simulation to improve upon existing frequentist and Bayesian methods. The asymptotic properties of the Bayes …
We consider the problem of constructing pointwise confidence intervals in the multiple isotonic regression model. Recently, [HZ19] obtained a pointwise limit distribution theory for the so-called block max-min and min-max estimators [FLN17] in this model, but inference remains a difficult problem due to the nuisance parameter in the limit distribution that involves multiple unknown partial derivatives of the true regression function. In this paper, we show that this difficult nuisance parameter can be effectively eliminated by taking advantage of information beyond point estimates in the block…
Most common parametric families of copulas are totally ordered, and in many cases they are also positively or negatively regression dependent and therefore they lead to monotone regression functions, which makes them not suitable for dependence relationships that imply or suggest a non-monotone regression function. A gluing copula approach is proposed to decompose the underlying copula into totally ordered copulas that combined may lead to a non-monotone regression function.
Shape constrained regression analysis has applications in dose-response modeling, environmental risk assessment, disease screening and many other areas. Incorporating the shape constraints can improve estimation efficiency and avoid implausible results. We propose two novel methods focusing on Bayesian monotone curve and surface estimation using Gaussian process projections. The first projects samples from an unconstrained prior, while the second projects samples from the Gaussian process posterior. Theory is developed on continuity of the projection, posterior consistency and rates of contrac…
In many applications there is interest in estimating the relation between a predictor and an outcome when the relation is known to be monotone or otherwise constrained due to the physical processes involved. We consider one such application--inferring time-resolved aerosol concentration from a low-cost differential pressure sensor. The objective is to estimate a monotone function and make inference on the scaled first derivative of the function. We proposed Bayesian nonparametric monotone regression which uses a Bernstein polynomial basis to construct the regression function and puts a Dirichl…
We consider a high-dimensional monotone single index model (hdSIM), which is a semiparametric extension of a high-dimensional generalize linear model (hdGLM), where the link function is unknown, but constrained with monotone and non-decreasing shape. We develop a scalable projection-based iterative approach, the "Sparse Orthogonal Descent Single-Index Model" (SOD-SIM), which alternates between sparse-thresholded orthogonalized "gradient-like" steps and isotonic regression steps to recover the coefficient vector. Our main contribution is that we provide finite sample estimation bounds for both …
Shape-constrained inference has wide applicability in bioassay, medicine, economics, risk assessment, and many other fields. Although there has been a large amount of work on monotone-constrained univariate curve estimation, multivariate shape-constrained problems are much more challenging, and fewer advances have been made in this direction. With a focus on monotone regression with multiple predictors, this current work proposes a projection approach to estimate a multiple monotone regression function. An initial unconstrained estimator -- such as a local polynomial estimator or spline estima…
We develop an adaptive monotone shrinkage estimator for regression models with the following characteristics: i) dense coefficients with small but important effects; ii) a priori ordering that indicates the probable predictive importance of the features. We capture both properties with an empirical Bayes estimator that shrinks coefficients monotonically with respect to their anticipated importance. This estimator can be rapidly computed using a version of Pool-Adjacent-Violators algorithm. We show that the proposed monotone shrinkage approach is competitive with the class of all Bayesian estim…
We consider a general monotone regression estimation where we allow for independent and dependent regressors. We propose a modification of the classical isotonic least squares estimator and establish its rate of convergence for the integrated $L_1$-loss function. The methodology captures the shape of the data without assuming additivity or a parametric form for the regression function. Furthermore, the degree of smoothing is chosen automatically and no auxiliary tuning is required for the theoretical analysis. Some simulations and two real data illustrations complement the study of the propose…
We consider bivariate observations $(X_1,Y_1), \ldots, (X_n,Y_n)$ such that, conditional on the $X_i$, the $Y_i$ are independent random variables with distribution functions $F_{X_i}$, where $(F_x)_x$ is an unknown family of distribution functions. Under the sole assumption that $x \mapsto F_x$ is isotonic with respect to stochastic order, one can estimate $(F_x)_x$ in two ways: (i) For any fixed $y$ one estimates the antitonic function $x \mapsto F_x(y)$ via nonparametric monotone least squares, replacing the responses $Y_i$ with the indicators $1_{[Y_i \le y]}$. (ii) For any fixed $β\in (0,1…
In observational studies, potential confounders may distort the causal relationship between an exposure and an outcome. However, under some conditions, a causal dose-response curve can be recovered using the G-computation formula. Most classical methods for estimating such curves when the exposure is continuous rely on restrictive parametric assumptions, which carry significant risk of model misspecification. Nonparametric estimation in this context is challenging because in a nonparametric model these curves cannot be estimated at regular rates. Many available nonparametric estimators are sen…
An efficient monotone data augmentation (MDA) algorithm is proposed for missing data imputation for incomplete multivariate nonnormal data that may contain variables of different types, and are modeled by a sequence of regression models including the linear, binary logistic, multinomial logistic, proportional odds, Poisson, negative binomial, skew-normal, skew-t regressions or a mixture of these models. The MDA algorithm is applied to the sensitivity analyses of longitudinal trials with nonignorable dropout using the controlled pattern imputations that assume the treatment effect reduces or di…
We consider survival data in the presence of a cure fraction, meaning that some subjects will never experience the event of interest. We assume a mixture cure model consisting of two sub-models: one for the probability of being uncured (incidence) and one for the survival of the uncured subjects (latency). Various approaches, ranging from parametric to nonparametric, have been used to model the effect of covariates on the incidence, with the logistic model being the most common one. We propose a monotone single-index model for the incidence and introduce a new estimation method that is based o…
We consider a Bayesian method for simultaneous quantile regression on a real variable. By monotone transformation, we can make both the response variable and the predictor variable take values in the unit interval. A representation of quantile function is given by a convex combination of two monotone increasing functions $ξ_1$ and $ξ_2$ not depending on the prediction variables. In a Bayesian approach, a prior is put on quantile functions by putting prior distributions on $ξ_1$ and $ξ_2$. The monotonicity constraint on the curves $ξ_1$ and $ξ_2$ are obtained through a spline basis expansion wi…
In this paper we consider a heteroscedastic transformation model, where the transformation belongs to a parametric family of monotone transformations, the regression and variance function are modelled nonparametrically and the error is independent of the multidimensional covariates. In this model, we first consider the estimation of the unknown components of the model, namely the transformation parameter, regression and variance function and the distribution of the error. We show the asymptotic normality of the proposed estimators. Second, we propose tests for the validity of the model, and es…
We consider the problem of nonparametric quantile regression for twice censored data. Two new estimates are presented, which are constructed by applying concepts of monotone rearrangements to estimates of the conditional distribution function. The proposed methods avoid the problem of crossing quantile curves. Weak uniform consistency and weak convergence is established for both estimates and their finite sample properties are investigated by means of a simulation study. As a by-product, we obtain a new result regarding the weak convergence of the Beran estimator for right censored data on the…
We consider efficient estimation of flexible transformation models with interval-censored data. To reduce the dimension of semi-parametric models, the unknown monotone transformation function is approximated via monotone splines. A penalization technique is used to provide more computationally efficient estimation of all parameters. To accomplish model fitting, a computationally efficient nested iterative expectation-maximization (EM) based algorithm is developed for estimation, and an easily implemented variance-covariance approach is proposed for inference on regression parameters. Theoretic…
Longitudinal data are characterized by the dependence between observations coming from the same individual. In a regression perspective, such a dependence can be usefully ascribed to unobserved features (covariates) specific to each individual. On these grounds, random parameter models with time-constant or time-varying structure are well established in the generalized linear model context. In the quantile regression framework, specifications based on random parameters have only recently known a flowering interest. We start from the recent proposal by Farcomeni (2012) on longitudinal quantile …
A nonparanormal graphical model is a semiparametric generalization of a Gaussian graphical model for continuous variables in which it is assumed that the variables follow a Gaussian graphical model only after some unknown smooth monotone transformations. We consider a Bayesian approach to inference in a nonparanormal graphical model in which we put priors on the unknown transformations through a random series based on B-splines. We use a regression formulation to construct the likelihood through the Cholesky decomposition on the underlying precision matrix of the transformed variables and put …
