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arXiv 2006.08229physics.med-pheess.IV
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基于MRI的壁面剪应力定量的参数序贯方法

Parametric Sequential Method for MRI-based Wall Shear Stress Quantification

Nina Shokina, Gabriel Teschner, Andreas Bauer, Cameron Tropea, Herbert Egger, Jürgen Hennig, Axel J. Krafft

摘要:

壁面切应力(WSS)已被认为是各种心血管疾病的潜在生物标志物,并且可以通过相位对比磁共振成像(PC-MRI)速度测量来估计。我们提出了一种新的基于MRI的WSS量化的参数顺序方法,包括几何形状识别和随后的速度场近似。新方法进行了验证良好的控制,高分辨率在体外测量的湍流静止流和生理脉动流的幻影。使用三名志愿者的升主动脉的2D PC-MRI数据证明了体内的基本适用性。

英文摘要:

Wall shear stress (WSS) has been suggested as a potential biomarker in various cardiovascular diseases and it can be estimated from phase-contrast Magnetic Resonance Imaging (PC-MRI) velocity measurements. We present a new parametric sequential method for MRI-based WSS quantification consisting of a geometry identification and a subsequent approximation of the velocity field. The new method was validated on well controlled, high resolution in vitro measurements of turbulent stationary flows and physiological pulsatile flows in phantoms. Basic applicability to in vivo was demonstrated using 2D PC-MRI data of the ascending aorta of three volunteers.

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