II和III近红外窗口中用于高效热疗的双曲超材料纳米颗粒
Hyperbolic Metamaterial Nanoparticles for Efficient Hyperthermia in the II and III Near-Infrared Windows
摘要：
由于金纳米颗粒在临床治疗应用中的潜在影响，在近红外（NIR）光谱区域中用于热疗治疗已经催化了大量的研究工作。然而，与纳米颗粒体积的平方成比例的光散射效应导致低吸收效率，这阻碍了金纳米颗粒在1000 nm以上的NIR II区域中的效用。在这里，我们通过引入由多层金/介电纳米盘制成的双曲超材料纳米颗粒来克服这一限制，并且在NIR II和III区域中表现出> 70%的吸收效率。它们的高光-热转换通过比具有相同量的金的金纳米盘大得多的温度增加来证明。有效的活细胞体外热疗与可忽略不计的细胞毒性显示了我们的方法为下一代生物医学应用的潜力。
英文摘要：
The use of gold nanoparticles for hyperthermia therapy in near infrared (NIR) spectral regions has catalysed substantial research efforts due to the potential impact in clinical therapy applications. However, the photoscattering effect scaling with the square of the nanoparticle volume leads to a low absorption efficiency, which has hindered the utility of gold nanoparticles in NIR II regions above 1000 nm. Here, we conquer this limit by introducing hyperbolic metamaterial nanoparticles that are made of multi-layered gold/dielectric nanodisks and exhibit >70% absorption efficiency in the NIR II and III regions. Their high light-to-heat conversion is demonstrated by a much larger temperature increase than that of gold nanodisks with the same amount of gold. Efficient in vitro hyperthermia of living cells with negligible cytotoxicity shows the potential of our approach for next-generation bio-medical applications.
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