arXivDaily arXiv每日学术速递 周一至周五更新
arXiv 2005.12838eess.IVcs.LGphysics.med-ph
收藏

Neuro4Neuro:一种基于大规模人群扩散成像的神经束分割神经网络方法

Neuro4Neuro: A neural network approach for neural tract segmentation using large-scale population-based diffusion imaging

Northeastern University(东北大学);Erasmus MC(伊拉斯姆斯医学中心);University of Edinburgh(爱丁堡大学)

Bo Li, Marius de Groot, Rebecca M. E. Steketee, Rozanna Meijboom, Marion Smits, Meike W. Vernooij, M. Arfan Ikram, Jiren Liu, Wiro J. Niessen, Esther E. Bron

摘要:

白质(WM)微结构的细微变化与正常衰老和神经退行性变有关。为了更详细地研究这些关联,非常重要的是,WM束可以准确地和可重复地从脑扩散MRI表征。此外,为了能够在大型数据集和临床实践中分析WM束,必须具有快速且易于应用的方法。因此,这项工作提出了一种新的方法WM束分割:Neuro 4 Neuro,这是能够直接提取WM束从扩散张量图像使用卷积神经网络(CNN)。这种3D端到端方法经过训练,可以从一项大型人群研究(N=9752,1.5T MRI)中分割25个老年人WM束。该方法具有良好的分割性能和高重复性,即,高空间一致性(Cohen’s kappa,k = 0.72 ~ 0.83)和在特定道扩散测量中的低扫描再扫描误差(例如,分数各向异性:误差= 1% ~ 5%)。所提出的方法的可重复性高于基于纤维束成像的分割算法,同时快了几个数量级(0.5s分割一个道)。此外,我们表明,该方法成功地推广到扩散扫描从外部痴呆数据集(N=58,3 T MRI)。在两个原理验证实验中,我们将使用所提出的方法获得的WM微观结构与正常老年人群的年龄以及痴呆队列中的疾病亚型相关联。与文献一致,结果表明,随着年龄的增长,痴呆亚型之间的微结构组织和大量的组间微结构差异普遍减少。总之,我们提出了一个高度可重复性和快速的方法WM束分割,有可能被用于大规模的研究和临床实践。

英文摘要:

Subtle changes in white matter (WM) microstructure have been associated with normal aging and neurodegeneration. To study these associations in more detail, it is highly important that the WM tracts can be accurately and reproducibly characterized from brain diffusion MRI. In addition, to enable analysis of WM tracts in large datasets and in clinical practice it is essential to have methodology that is fast and easy to apply. This work therefore presents a new approach for WM tract segmentation: Neuro4Neuro, that is capable of direct extraction of WM tracts from diffusion tensor images using convolutional neural network (CNN). This 3D end-to-end method is trained to segment 25 WM tracts in aging individuals from a large population-based study (N=9752, 1.5T MRI). The proposed method showed good segmentation performance and high reproducibility, i.e., a high spatial agreement (Cohen's kappa, k = 0.72 ~ 0.83) and a low scan-rescan error in tract-specific diffusion measures (e.g., fractional anisotropy: error = 1% ~ 5%). The reproducibility of the proposed method was higher than that of a tractography-based segmentation algorithm, while being orders of magnitude faster (0.5s to segment one tract). In addition, we showed that the method successfully generalizes to diffusion scans from an external dementia dataset (N=58, 3T MRI). In two proof-of-principle experiments, we associated WM microstructure obtained using the proposed method with age in a normal elderly population, and with disease subtypes in a dementia cohort. In concordance with the literature, results showed a widespread reduction of microstructural organization with aging and substantial group-wise microstructure differences between dementia subtypes. In conclusion, we presented a highly reproducible and fast method for WM tract segmentation that has the potential of being used in large-scale studies and clinical practice.

机构、总结、中文摘要均由AI分析而来,可能存在错误,请以论文正文为准。

↑