骨骼肌功回路的流变学基础
Rheological basis of skeletal muscle work loops
摘要：
骨骼肌在体内同时受到时变神经刺激和长度变化。功回路是这些体内条件的实验表示，并且表现出使用软物质流变学或肌肉的经典等长和等张表征无法解释的力与长度响应。我们理解上的这些差距常常促使我们寻找新的肌肉现象。然而，我们目前缺乏一个框架来解释工作回路的机械起源，该工作回路整合了当前对肌肉的理解的多个方面，作为流变材料，也是刺激响应致动器。在这里，我们提出了一个新的假设，工作循环出现拼接在一起的力与长度循环对应于不同的恒定刺激。使用已发表的肌肉数据集和详细的肌节模型，我们发现该假设准确地预测了工作循环，并有助于理解它们在固定刺激下测量的流变学行为。重要的是，这个框架确定的条件下，肌肉的流变学的理解无法解释紧急工作循环，新的肌肉现象可能是必要的，以解释其在体内的功能。
英文摘要：
Skeletal muscle is subjected to simultaneous time-varying neural stimuli and length changes in vivo. Work loops are experimental representations of these in vivo conditions and exhibit force versus length responses that are not explainable using either soft matter rheology or the classical isometric and isotonic characterizations of muscle. These gaps in our understanding have often prompted the search for new muscle phenomena. However, we presently lack a framework to explain the mechanical origins of work loops that integrates multiple facets of current understanding of muscle, as a rheological material and also a stimulus-responsive actuator. Here we present a new hypothesis that work loops emerge by splicing together force versus length loops corresponding to different constant stimuli. Using published muscle datasets and a detailed sarcomere model, we find that the hypothesis accurately predicts work loops and helps understand them in terms of rheological behaviors measured at fixed-stimuli. Importantly, this framework identifies conditions under which a rheological understanding of muscle fails to explain the emergent work loops, and new muscle phenomena may be necessary to explain its in vivo function.
机构、总结、中文摘要均由AI分析而来，可能存在错误，请以论文正文为准。
