In cluster-specific studies, ordinary logistic regression and conditional logistic regression for binary outcomes provide maximum likelihood estimator (MLE) and conditional maximum likelihood estimator (CMLE), respectively. In this paper, we show that CMLE is approaching to MLE asymptotically when each individual data point is replicated infinitely many times. Our theoretical derivation is based on the observation that a term appearing in the conditional average log-likelihood function is the coefficient of a polynomial, and hence can be transformed to a complex integral by Cauchy's differentiation formula. The asymptotic analysis of the complex integral can then be performed using the classical method of steepest descent. Our result implies that CMLE can be biased if individual weights are multiplied with a constant, and that we should be cautious when assigning weights to cluster-specific studies.
It is known that when the multicollinearity exists in the logistic regression model, variance of maximum likelihood estimator is unstable. As a remedy, in the context of biased shrinkage ridge estimation, Chang (2015) introduced an almost unbiased Liu estimator in the logistic regression model. Making use of his approach, when some prior knowledge in the form of linear restrictions are also available, we introduce a restricted almost unbiased Liu estimator in the logistic regression model. Statistical properties of this newly defined estimator are derived and some comparison result are also pr…
The behavior of the conditional logistic estimator is analyzed under a causal model for two-arm experimental studies with possible non-compliance in which the effect of the treatment is measured by a binary response variable. We show that, when non-compliance may only be observed in the treatment arm, the effect (measured on the logit scale) of the treatment on compliers and that of the control on non-compliers can be identified and consistently estimated under mild conditions. The same does not happen for the effect of the control on compliers. A simple correction of the conditional logistic …
In this paper a robust version of the classical Wald test statistics for linear hypothesis in the logistic regression model is introduced and its properties are explored. We study the problem under the assumption of random covariates although some ideas with non random covariates are also considered. The family of tests considered is based on the minimum density power divergence estimator instead of the maximum likelihood estimator and it is referred to as the Wald-type test statistic in the paper. We obtain the asymptotic distribution and also study the robustness properties of the Wald type …
We propose an estimator of the kernel-based conditional mean dependence measure obtained from an appropriate modification of a naive estimator based on usual empirical estimators. We then get asymptotic normality of this estimator both under conditional mean independence hypothesis and under the alternative hypothesis. A new test for conditional mean independence of random variables valued into Hilbert spaces is then introduced.
Computerized adaptive testing is becoming increasingly popular due to advancement of modern computer technology. It differs from the conventional standardized testing in that the selection of test items is tailored to individual examinee's ability level. Arising from this selection strategy is a nonlinear sequential design problem. We study, in this paper, the sequential design problem in the context of the logistic item response theory models. We show that the adaptive design obtained by maximizing the item information leads to a consistent and asymptotically normal ability estimator in the c…
This short note is to point the reader to notice that the proof of high dimensional asymptotic normality of MLE estimator for logistic regression under the regime $p_n=o(n)$ given in paper: "Maximum likelihood estimation in logistic regression models with a diverging number of covariates. Electronic Journal of Statistics, 6, 1838-1846." is wrong.
We address the estimation of "extreme" conditional quantiles i.e. when their order converges to one as the sample size increases. Conditions on the rate of convergence of their order to one are provided to obtain asymptotically Gaussian distributed kernel estimators. A Weissman-type estimator and kernel estimators of the conditional tail-index are derived, permitting to estimate extreme conditional quantiles of arbitrary order.
Finite-sample performance of the maximum likelihood estimator in logistic regression
Department of Statistics, University of California, Berkeley, USA（加州大学伯克利分校统计学系）；Department of Statistics, CREST/ENSAE Paris, Palaiseau, France（巴黎中央银行与应用经济学院统计学系）
Analyzing polytomous response from a complex survey scheme, like stratified or cluster sampling is very crucial in several socio-economics applications. We present a class of minimum quasi weighted density power divergence estimators for the polytomous logistic regression model with such a complex survey. This family of semiparametric estimators is a robust generalization of the maximum quasi weighted likelihood estimator exploiting the advantages of the popular density power divergence measure. Accordingly robust estimators for the design effects are also derived. Robust testing of general li…
We address the estimation of conditional quantiles when the covariate is functional and when the order of the quantiles converges to one as the sample size increases. In a first time, we investigate to what extent these large conditional quantiles can still be estimated through a functional kernel estimator of the conditional survival function. Sufficient conditions on the rate of convergence of their order to one are provided to obtain asymptotically Gaussian distributed estimators. In a second time, basing on these result, a functional Weissman estimator is derived, permitting to estimate la…
In this paper, we investigate the extreme-value methodology, to propose an improved estimator of the conditional tail expectation ($CTE$) for a loss distribution with a finite mean but infinite variance. The present work introduces a new estimator of the $CTE$ based on the bias-reduced estimators of high quantile for heavy-tailed distributions. The asymptotic normality of the proposed estimator is established and checked, in a simulation study. Moreover, we compare, in terms of bias and mean squared error, our estimator with the known old estimator.
In order to overcome multicollinearity, we propose a stochastic restricted Liu-type max- imum likelihood estimator by incorporating Liu-type maximum likelihood estimator (Inan and Erdo- gan, 2013) to the logistic regression model when the linear restrictions are stochastic. We also discuss the properties of the new estimator. Moreover, we give a method to choose the biasing parameter in the new estimator. Finally, a simulation study is given to show the performance of the new estimator.
Since its early use in least squares regression problems, the l1-penalization framework for variable selection has been employed in conjunction with a wide range of loss functions encompassing regression, classification and survival analysis. While a well developed theory exists for the l1-penalized least squares estimates, few results concern the behavior of l1-penalized estimates for general loss functions. In this paper, we derive two results concerning penalized estimates for a wide array of penalty and loss functions. Our first result characterizes the asymptotic distribution of penalized…
Inference based on the penalized density ratio model is proposed and studied. The model under consideration is specified by assuming that the log--likelihood function of two unknown densities is of some parametric form. The model has been extended to cover multiple samples problems while its theoretical properties have been investigated using large sample theory. A main application of the density ratio model is testing whether two, or more, distributions are equal. We extend these results by arguing that the penalized maximum empirical likelihood estimator has less mean square error than that …
Compared to the conditional mean as a simple point estimator, the conditional density function is more informative to describe the distributions with multi-modality, asymmetry or heteroskedasticity. In this paper, we propose a novel parametric conditional density estimation method by showing the connection between the general density and the likelihood function of inhomogeneous Poisson process models. The maximum likelihood estimates can be obtained via weighted logistic regressions, and the computation can be significantly relaxed by combining a block-wise alternating maximization scheme and …
In this paper, we study the local constant and the local linear estimators of the conditional density function with right-censored data which exhibit some type of dependence. It is assumed that the observations form a stationary $α-$mixing sequence. The asymptotic normality of the two estimators is established, which combined with the condition that $\lim\limits_{n\rightarrow\infty}nh_nb_n=\infty$ implies the consistency of the two estimators and can be employed to construct confidence intervals for the conditional density function. The result on the local linear estimator of the conditional d…
We find that, in a linear model, the James-Stein estimator, which dominates the maximum-likelihood estimator in terms of its in-sample prediction error, can perform poorly compared to the maximum-likelihood estimator in out-of-sample prediction. We give a detailed analysis of this phenomenon and discuss its implications. When evaluating the predictive performance of estimators, we treat the regressor matrix in the training data as fixed, i.e., we condition on the design variables. Our findings contrast those obtained by Baranchik (1973, Ann. Stat. 1:312-321) and, more recently, by Dicker (2012…
CREST, ENSAE, Institut Polytechnique de Paris（巴黎综合理工学院国立统计与经济行政学院 CREST）；CMAP, École polytechnique（巴黎综合理工学院应用数学中心）；LPSM, UMR 8001, Université de Paris（巴黎大学概率与统计实验室）；DMA, UMR 8553, Ecole normale supérieure（巴黎高等师范学院数学系）
We introduce a procedure for conditional density estimation under logarithmic loss, which we call SMP (Sample Minmax Predictor). This estimator minimizes a new general excess risk bound for statistical learning. On standard examples, this bound scales as $d/n$ with $d$ the model dimension and $n$ the sample size, and critically remains valid under model misspecification. Being an improper (out-of-model) procedure, SMP improves over within-model estimators such as the maximum likelihood estimator, whose excess risk degrades under misspecification. Compared to approaches reducing to the sequenti…
Logistic regression with unknown sizes has many important applications in biological and medical sciences. All models about this problem in the literature are parametric ones. A semiparametric regression model is proposed. This model incorporates overdispersion due to the variation of sizes, and allows general dose-response relations. An Expectation Conditional Maximization algorithm is provided to maximize the log likelihood. The bootstrap method can be used to construct confidence intervals for regression coefficients. Simulation is performed to study the behavior of the proposed model. Two …
Let $(X,Y)$ be a bivariate random vector. The estimation of a probability of the form $P(Y\leq y \mid X >t) $ is challenging when $t$ is large, and a fruitful approach consists in studying, if it exists, the limiting conditional distribution of the random vector $(X,Y)$, suitably normalized, given that $X$ is large. There already exists a wide literature on bivariate models for which this limiting distribution exists. In this paper, a statistical analysis of this problem is done. Estimators of the limiting distribution (which is assumed to exist) and the normalizing functions are provided, as …
In this paper, we study the asymptotic normality of the conditional maximum likelihood (ML) estimators for the truncated regression model and the Tobit model. We show that under the general setting assumed in his book, the conjectures made by Hayashi (2000) \footnote{see page 516, and page 520 of Hayashi (2000).} about the asymptotic normality of the conditional ML estimators for both models are true, namely, a sufficient condition is the nonsingularity of $\mathbf{x_tx'_t}$.
This paper studies the problem of statistical inference for genetic relatedness between binary traits based on individual-level genome-wide association data. Specifically, under the high-dimensional logistic regression models, we define parameters characterizing the cross-trait genetic correlation, the genetic covariance and the trait-specific genetic variance. A novel weighted debiasing method is developed for the logistic Lasso estimator and computationally efficient debiased estimators are proposed. The rates of convergence for these estimators are studied and their asymptotic normality is …
We study the weak convergence of conditional empirical copula processes, when the conditioning event has a nonzero probability. The validity of several bootstrap schemes is stated, including the exchangeable bootstrap. We define general - possibly conditional - multivariate dependence measures and their estimators. By applying our theoretical results, we prove the asymptotic normality of some estimators of such dependence measures.
This paper derives a new family of estimators, namely the minimum density power divergence estimators, as a robust generalization of the maximum likelihood estimator for the polytomous logistic regression model. Based on these estimators, a family of Wald-type test statistics for linear hypotheses is introduced. Robustness properties of both the proposed estimators and the test statistics are theoretically studied through the classical influence function analysis. Appropriate real life examples are presented to justify the requirement of suitable robust statistical procedures in place of the l…
The paper considers probability distribution, density, conditional distribution and density and conditional moments as well as their kernel estimators in spaces of generalized functions. This approach does not require restrictions on classes of distributions common in nonparametric estimation. Density in usual function spaces is not well-posed; this paper establishes existence and well-posedness of the generalized density function. It also demonstrates root-n convergence of the kernel density estimator in the space of generalized functions. It is shown that the usual kernel estimator of the co…
Labeling patients in electronic health records with respect to their statuses of having a disease or condition, i.e. case or control statuses, has increasingly relied on prediction models using high-dimensional variables derived from structured and unstructured electronic health record data. A major hurdle currently is a lack of valid statistical inference methods for the case probability. In this paper, considering high-dimensional sparse logistic regression models for prediction, we propose a novel bias-corrected estimator for the case probability through the development of linearization and…
The parameters of the log-logistic distribution are generally estimated based on classical methods such as maximum likelihood estimation, whereas these methods usually result in severe biased estimates when the data contain outliers. In this paper, we consider several alternative estimators, which not only have closed-form expressions, but also are quite robust to a certain level of data contamination. We investigate the robustness property of each estimator in terms of the breakdown point. The finite sample performance and effectiveness of these estimators are evaluated through Monte Carlo si…
In this paper, we propose improved estimation method for logistic regression based on subsamples taken according the optimal subsampling probabilities developed in Wang et al. 2018 Both asymptotic results and numerical results show that the new estimator has a higher estimation efficiency. We also develop a new algorithm based on Poisson subsampling, which does not require to approximate the optimal subsampling probabilities all at once. This is computationally advantageous when available random-access memory is not enough to hold the full data. Interestingly, asymptotic distributions also sho…
We consider the problem of estimating the conditional distribution of a post-model-selection estimator where the conditioning is on the selected model. The notion of a post-model-selection estimator here refers to the combined procedure resulting from first selecting a model (e.g., by a model selection criterion such as AIC or by a hypothesis testing procedure) and then estimating the parameters in the selected model (e.g., by least-squares or maximum likelihood), all based on the same data set. We show that it is impossible to estimate this distribution with reasonable accuracy even asymptoti…
We consider the problem of link prediction, based on partial observation of a large network, and on side information associated to its vertices. The generative model is formulated as a matrix logistic regression. The performance of the model is analysed in a high-dimensional regime under a structural assumption. The minimax rate for the Frobenius-norm risk is established and a combinatorial estimator based on the penalised maximum likelihood approach is shown to achieve it. Furthermore, it is shown that this rate cannot be attained by any (randomised) algorithm computable in polynomial time un…
The logistic regression analysis proposed by Schouten et al. (Stat Med. 1993;12:1733-1745) has been a standard method in current statistical analysis of case-cohort studies, and it enables effective estimation of risk ratio from selected subsamples. Schouten et al. (1993) also proposed the standard error estimate of the risk ratio estimator can be calculated by the robust variance estimator. In this article, however, we show that the robust variance estimator does not account for the duplications of case and subcohort samples and generally has certain bias, i.e., inaccurate confidence interval…
We present new stochastic geometry theorems that give bounds on the probability that $m$ random data classes all contain a point in common in their convex hulls. We apply these stochastic separation theorems to obtain bounds on the probability of existence of maximum likelihood estimators in multinomial logistic regression. We also discuss connections to condition numbers for analysis of steepest descent algorithms in logistic regression and to the computation of centerpoints of data clouds.
In this paper, we consider estimation of the conditional mode of an outcome variable given regressors. To this end, we propose and analyze a computationally scalable estimator derived from a linear quantile regression model and develop asymptotic distributional theory for the estimator. Specifically, we find that the pointwise limiting distribution is a scale transformation of Chernoff's distribution despite the presence of regressors. In addition, we consider analytical and subsampling-based confidence intervals for the proposed estimator. We also conduct Monte Carlo simulations to assess the…
Logistic regression remains one of the most widely used tools in applied statistics, machine learning and data science. However, in moderately high-dimensional problems, where the number of features $d$ is a non-negligible fraction of the sample size $n$, the logistic regression maximum likelihood estimator (MLE), and statistical procedures based the large-sample approximation of its distribution, behave poorly. Recently, Sur and Candès (2019) showed that these issues can be corrected by applying a new approximation of the MLE's sampling distribution in this high-dimensional regime. Unfortunat…
This paper studies binary logistic regression for rare events data, or imbalanced data, where the number of events (observations in one class, often called cases) is significantly smaller than the number of nonevents (observations in the other class, often called controls). We first derive the asymptotic distribution of the maximum likelihood estimator (MLE) of the unknown parameter, which shows that the asymptotic variance convergences to zero in a rate of the inverse of the number of the events instead of the inverse of the full data sample size. This indicates that the available information…
To address the problem of multicollinearity in the logistic regression model, in this paper we propose a new estimator called Stochastic restricted almost unbiased logistic Liu-estimator (SRAULLE) when the prior information is available in the form of stochastic linear restrictions. A Monte Carlo simulation study was carried out to compare the performance of the proposed estimator with some existing estimators in the scalar mean squared error (SMSE) sense. Finally, a real data example was given to appraise the performance of the estimators.
For massive data, the family of subsampling algorithms is popular to downsize the data volume and reduce computational burden. Existing studies focus on approximating the ordinary least squares estimate in linear regression, where statistical leverage scores are often used to define subsampling probabilities. In this paper, we propose fast subsampling algorithms to efficiently approximate the maximum likelihood estimate in logistic regression. We first establish consistency and asymptotic normality of the estimator from a general subsampling algorithm, and then derive optimal subsampling proba…
Matching, the stratification of observations, is of primary importance for the analysis of observational studies. We show that the score test of conditional logistic regression and the paired Student/Hotelling test, two tests for paired data, are asymptotically equivalent.
