arXivDaily arXiv每日学术速递 周一至周五更新
arXiv 2005.05502cs.LGcs.CYstat.ML
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基于深度序列学习的主动脉压预测

Aortic Pressure Forecasting with Deep Sequence Learning

Northeastern University(东北大学);Abiomed(艾比奥医疗公司);UC San Diego(加利福尼亚大学圣迭戈分校)

Eliza Huang, Rui Wang, Uma Chandrasekaran, Rose Yu

摘要:

平均主动脉压(MAP)是所有器官系统灌注的主要决定因素。预测MAP的能力将增强医生估计患者预后的能力,并有助于早期检测血流动力学不稳定性。然而,预测MAP是具有挑战性的,因为血压(BP)时间序列是有噪声的并且可以是高度非平稳的。本研究的目的是预测平均主动脉压提前五分钟,使用25 Hz的时间序列数据的前五分钟作为输入。我们为BP预测提供了不同深度学习模型的基准研究。我们研究了一种左心室驻留跨瓣微轴装置,Impella,在接受高风险经皮介入治疗的患者。Impella提供血流动力学支持,从而帮助自体心脏功能恢复。它还配备了压力传感器,以在原点而不是外围捕获高频MAP测量值。我们的数据集和临床应用在BP预测领域是新颖的。我们对具有增加、减少和平稳趋势的时间序列进行了全面的研究。实验结果表明,与勒让德记忆单元的递归神经网络达到最佳性能的整体预测误差为1.8 mmHg。

英文摘要:

Mean aortic pressure (MAP) is a major determinant of perfusion in all organs systems. The ability to forecast MAP would enhance the ability of physicians to estimate prognosis of the patient and assist in early detection of hemodynamic instability. However, forecasting MAP is challenging because the blood pressure (BP) time series is noisy and can be highly non-stationary. The aim of this study was to forecast the mean aortic pressure five minutes in advance, using the 25 Hz time series data of previous five minutes as input. We provide a benchmark study of different deep learning models for BP forecasting. We investigate a left ventricular dwelling transvalvular micro-axial device, the Impella, in patients undergoing high-risk percutaneous intervention. The Impella provides hemodynamic support, thus aiding in native heart function recovery. It is also equipped with pressure sensors to capture high frequency MAP measurements at origin, instead of peripherally. Our dataset and the clinical application is novel in the BP forecasting field. We performed a comprehensive study on time series with increasing, decreasing, and stationary trends. The experiments show that recurrent neural networks with Legendre Memory Unit achieve the best performance with an overall forecasting error of 1.8 mmHg.

机构、总结、中文摘要均由AI分析而来,可能存在错误,请以论文正文为准。

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