自然种群中的基因驱动动力学：密度依赖、空间和性别的重要性
Gene drive dynamics in natural populations: The importance of density-dependence, space and sex
摘要：
合成基因驱动器的传播通常在通过基因流连接的泛混居群体的背景下讨论，并用简单的确定性模型描述。在这样的假设下，通过释放一个携带入侵基因驱动（如标准归巢驱动）的个体，整个物种都可以改变。虽然这仍然是一种理论上的可能性，但基因驱动在自然种群中的传播更为复杂，值得进行更现实的评估。在种群中释放的任何基因驱动器的命运都与种群的生态环境密不可分。鉴于自然种群生态评估中经常涉及的不确定性，了解基因驱动传播对重要生态因子〈动〉的敏感性至关重要。在这里，我们回顾了不同形式的密度依赖性、空间异质性和交配行为如何影响自我维持基因驱动的传播。我们强调基因驱动动力学的具体方面和需要进一步研究的目标人群。
英文摘要：
The spread of synthetic gene drives is often discussed in the context of panmictic populations connected by gene flow and described with simple deterministic models. Under such assumptions, an entire species could be altered by releasing a single individual carrying an invasive gene drive, such as a standard homing drive. While this remains a theoretical possibility, gene drive spread in natural populations is more complex and merits a more realistic assessment. The fate of any gene drive released in a population would be inextricably linked to the ecology of the population. Given the uncertainty often involved in ecological assessment of natural populations, understanding the sensitivity of gene drive spread to important ecological factors is critical. Here we review how different forms of density-dependence, spatial heterogeneity and mating behaviors can impact the spread of self-sustaining gene drives. We highlight specific aspects of gene drive dynamics and the target populations that need further research.
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