Motivation: Disease diagnosis oriented dialogue system models the interactive consultation procedure as Markov Decision Process and reinforcement learning algorithms are used to solve the problem. Existing approaches usually employ a flat policy structure that treat all symptoms and diseases equally for action making. This strategy works well in the simple scenario when the action space is small, however, its efficiency will be challenged in the real environment. Inspired by the offline consultation process, we propose to integrate a hierarchical policy structure of two levels into the dialogue systemfor policy learning. The high-level policy consists of amastermodel that is responsible for triggering a low-levelmodel, the lowlevel policy consists of several symptom checkers and a disease classifier. The proposed policy structure is capable to deal with diagnosis problem including large number of diseases and symptoms.
Results: Experimental results on three real-world datasets and a synthetic dataset demonstrate that our hierarchical framework achieves higher accuracy and symptom recall in disease diagnosis compared with existing systems. We construct a benchmark including datasets and implementation of existing algorithms to encourage follow-up researches.
Availability: The code and data is available from https://github.com/FudanDISC/DISCOpen-MedBox-DialoDiagnosis
Contact: 21210980124@m.fudan.edu.cn
Supplementary information: Supplementary data are available at Bioinformatics online.
Spoken dialog systems have seen applications in many domains, including medical for automatic conversational diagnosis. State-of-the-art dialog managers are usually driven by deep reinforcement learning models, such as deep Q networks (DQNs), which learn by interacting with a simulator to explore the entire action space since real conversations are limited. However, the DQN-based automatic diagnosis models do not achieve satisfying performances when adapted to new, unseen diseases with only a few training samples. In this work, we propose the Prototypical Q Networks (ProtoQN) as the dialog man…
The purpose of write-missing diagnosis detection is to find diseases that have been clearly diagnosed from medical records but are missed in the discharge diagnosis. Unlike the definition of missed diagnosis, the write-missing diagnosis is clearly manifested in the medical record without further reasoning. The write-missing diagnosis is a common problem, often caused by physician negligence. The write-missing diagnosis will result in an incomplete diagnosis of medical records. While under DRG grouping, the write-missing diagnoses will miss important additional diagnoses (CC, MCC), thus affecti…
Current deep learning based disease diagnosis systems usually fall short in catastrophic forgetting, i.e., directly fine-tuning the disease diagnosis model on new tasks usually leads to abrupt decay of performance on previous tasks. What is worse, the trained diagnosis system would be fixed once deployed but collecting training data that covers enough diseases is infeasible, which inspires us to develop a lifelong learning diagnosis system. In this work, we propose to adopt attention to combine medical entities and context, embedding episodic memory and consolidation to retain knowledge, such …
A Multi-granularity Concept Sparse Activation and Hierarchical Knowledge Graph Fusion Framework for Rare Disease Diagnosis
School of Software, Yunnan University（云南大学软件学院）；Yunnan Key Laboratory of Software Engineering（云南软件工程重点实验室）；Yunnan Provincial Hospital of Traditional Chinese Medicine（云南中医药省人民医院）
Background and purpose: Heart disease has been one of the most important causes of death in the last 10 years, so the use of classification methods to diagnose and predict heart disease is very important. If this disease is predicted before menstruation, it is possible to prevent high mortality of the disease and provide more accurate and efficient treatment methods. Materials and Methods: Due to the selection of input features, the use of basic algorithms can be very time-consuming. Reducing dimensions or choosing a good subset of features, without risking accuracy, has great importance for b…
National Research University Higher School of Economics（国立研究型高等经济大学）
This article represents one of the contemporary trends in the application of the latest methods of information and communication technology for medicine through an expert system helps the doctor to diagnose some chest diseases which is important because of the frequent spread of chest diseases nowadays in addition to the overlap symptoms of these diseases, which is difficult to right diagnose by doctors with several algorithms: Forward Chaining, Backward Chaining, Neural Network(Back Propagation). However, this system cannot replace the doctor function, but it can help the doctor to avoid wron…
Human disease diagnosis is a complicated process and requires high level of expertise. Any attempt of developing a web-based expert system dealing with human disease diagnosis has to overcome various difficulties. This paper describes a project work aiming to develop a web-based fuzzy expert system for diagnosing human diseases. Now a days fuzzy systems are being used successfully in an increasing number of application areas; they use linguistic rules to describe systems. This research project focuses on the research and development of a web-based clinical tool designed to improve the quality …
Zhejiang University School of Medicine（浙江大学医学院）；National Clinical Research Center for Child Health（国家儿童健康与疾病临床医学研究中心）；Deepwise AI Lab（深睿医疗人工智能实验室）；Peking University（北京大学）；The University of Hong Kong（香港大学）
Respiratory diseases, including asthma, bronchitis, pneumonia, and upper respiratory tract infection (RTI), are among the most common diseases in clinics. The similarities among the symptoms of these diseases precludes prompt diagnosis upon the patients' arrival. In pediatrics, the patients' limited ability in expressing their situation makes precise diagnosis even harder. This becomes worse in primary hospitals, where the lack of medical imaging devices and the doctors' limited experience further increase the difficulty of distinguishing among similar diseases. In this paper, a pediatric fine…
We propose a Healthcare Graph Convolutional Network (HealGCN) to offer disease self-diagnosis service for online users based on Electronic Healthcare Records (EHRs). Two main challenges are focused in this paper for online disease diagnosis: (1) serving cold-start users via graph convolutional networks and (2) handling scarce clinical description via a symptom retrieval system. To this end, we first organize the EHR data into a heterogeneous graph that is capable of modeling complex interactions among users, symptoms and diseases, and tailor the graph representation learning towards disease di…
University of California Los Angeles（加利福尼亚大学洛杉矶分校）
With the recent availability of Electronic Health Records (EHR) and great opportunities they offer for advancing medical informatics, there has been growing interest in mining EHR for improving quality of care. Disease diagnosis due to its sensitive nature, huge costs of error, and complexity has become an increasingly important focus of research in past years. Existing studies model EHR by capturing co-occurrence of clinical events to learn their latent embeddings. However, relations among clinical events carry various semantics and contribute differently to disease diagnosis which gives prec…
Indian Institute of Information Technology Allahabad（阿拉哈巴德印度信息技术学院）
Vector-borne diseases (VBDs) are a kind of infection caused through the transmission of vectors generated by the bites of infected parasites, bacteria, and viruses, such as ticks, mosquitoes, triatomine bugs, blackflies, and sandflies. If these diseases are not properly treated within a reasonable time frame, the mortality rate may rise. In this work, we propose a set of ontologies that will help in the diagnosis and treatment of vector-borne diseases. For developing VBD's ontology, electronic health records taken from the Indian Health Records website, text data generated from Indian governme…
Dibrugarh University Institute of Engineering and Technology（迪布鲁加尔大学工程技术学院）；Tata Institute of Fundamental Research（塔塔基础研究所）
In this paper, we discuss the implementation of a rule based expert system for diagnosing neuromuscular diseases. The proposed system is implemented as a rule based expert system in JESS for the diagnosis of Cerebral Palsy, Multiple Sclerosis, Muscular Dystrophy and Parkinson's disease. In the system, the user is presented with a list of questionnaires about the symptoms of the patients based on which the disease of the patient is diagnosed and possible treatment is suggested. The system can aid and support the patients suffering from neuromuscular diseases to get an idea of their disease and …
learning algorithms. In this paper, we review the classification algorithms used in the health care system (chronic diseases) and present the neural network-based Ensemble learning method. We briefly describe the commonly used algorithms and describe their critical properties. Materials and Methods: In this study, modern classification algorithms used in healthcare, examine the principles of these methods and guidelines, and to accurately diagnose and predict chronic diseases, superior machine learning algorithms with the neural network-based ensemble learning Is used. To do this, we use exper…
Universiti Teknologi PETRONAS（马来西亚石油科技大学）；University California Irvine (UCI)（加州大学欧文分校）；Ipoh Specialist Hospital（怡保专科医院）
This research is about the development a fuzzy decision support system for the diagnosis of coronary artery disease based on evidence. The coronary artery disease data sets taken from University California Irvine (UCI) are used. The knowledge base of fuzzy decision support system is taken by using rules extraction method based on Rough Set Theory. The rules then are selected and fuzzified based on information from discretization of numerical attributes. Fuzzy rules weight is proposed using the information from support of extracted rules. UCI heart disease data sets collected from U.S., Switzer…
Cardiovascular Diseases (CVD) and strokes produce immense health and economic burdens globally. Coronary Artery Disease (CAD) is the most common type of cardiovascular disease. Coronary Angiography, which is an invasive treatment, is also the standard procedure for diagnosing CAD. In this work, we illustrate a Medical Decision Support System for the prediction of Coronary Artery Disease (CAD) utilizing Fuzzy Cognitive Maps (FCMs). FCMs are a promising modeling methodology, based on human knowledge, capable of dealing with ambiguity and uncertainty, and learning how to adapt to the unknown or c…
School of Life Science, Beijing Institute of Technology（北京理工大学生命学院）
As the second most common neurodegenerative disease, Parkinson's disease has caused serious problems worldwide. However, the cause and mechanism of PD are not clear, and no systematic early diagnosis and treatment of PD have been established. Many patients with PD have not been diagnosed or misdiagnosed. In this paper, we proposed an EEG-based approach to diagnosing Parkinson's disease. It mapped the frequency band energy of electroencephalogram(EEG) signals to 2-dimensional images using the interpolation method and identified classification using capsule network(CapsNet) and achieved 89.34% c…
Bangladesh University of Business and Technology（孟加拉国商业技术大学）
A disease that limits a plant from its maximal capacity is defined as plant disease. From the perspective of agriculture, diagnosing plant disease is crucial, as diseases often limit plants' production capacity. However, manual approaches to recognize plant diseases are often temporal, challenging, and time-consuming. Therefore, computerized recognition of plant diseases is highly desired in the field of agricultural automation. Due to the recent improvement of computer vision, identifying diseases using leaf images of a particular plant has already been introduced. Nevertheless, the most intr…
A Novel Multi-Task Model Imitating Dermatologists for Accurate Differential Diagnosis of Skin Diseases in Clinical Images
DAMO Academy, Alibaba Group（阿里巴巴集团达摩院）；Hupan Lab（湖畔实验室）；Beijing Normal University（北京师范大学）；Sir Run Run Shaw Hospital（邵逸夫医院）；The Second Affiliated Hospital Zhejiang University School of Medicine（浙江大学医学院附属第二医院）；Xiangya Hospital Central South University（中南大学湘雅医院）
We propose a Bayesian approach for both medical inquiry and disease inference, the two major phases in differential diagnosis. Unlike previous work that simulates data from given probabilities and uses ML algorithms on them, we directly use the Quick Medical Reference (QMR) belief network, and apply Bayesian inference in the inference phase and Bayesian experimental design in the inquiry phase. Moreover, we improve the inquiry phase by extending the Bayesian experimental design framework from one-step search to multi-step search. Our approach has some practical advantages as it is interpretabl…
medicalvalues GmbH（medicalvalues有限公司）；University of Mannheim（曼海姆大学）；Philipps-Universität Marburg（马尔堡菲利普斯大学）
Medical diagnosis is the process of making a prediction of the disease a patient is likely to have, given a set of symptoms and observations. This requires extensive expert knowledge, in particular when covering a large variety of diseases. Such knowledge can be coded in a knowledge graph -- encompassing diseases, symptoms, and diagnosis paths. Since both the knowledge itself and its encoding can be incomplete, refining the knowledge graph with additional information helps physicians making better predictions. At the same time, for deployment in a hospital, the diagnosis must be explainable an…
Texas Tech Neuroimaging Institute, Texas Tech University（德克萨斯理工大学神经影像研究所，德克萨斯理工大学）
Accurate diagnosis of Alzheimer's disease (AD) is both challenging and time consuming. With a systematic approach for early detection and diagnosis of AD, steps can be taken towards the treatment and prevention of the disease. This study explores the practical application of deep learning models for diagnosis of AD. Due to computational complexity, large training times and limited availability of labelled dataset, a 3D full brain CNN (convolutional neural network) is not commonly used, and researchers often prefer 2D CNN variants. In this study, full brain 3D version of well-known 2D CNNs were…
In Zambia, there is a serious shortage of medical staff where each practitioner attends to about 17000 patients in a given district while still, other patients travel over 10 km to access the basic medical services. In this research, we implement a deep learning model that can perform the clinical diagnosis process. The study will prove whether image analysis is capable of performing clinical diagnosis. It will also enable us to understand if we can use image analysis to lessen the workload on medical practitioners by delegating some tasks to an AI. The success of this study has the potential …
Highly Accurate Disease Diagnosis and Highly Reproducible Biomarker Identification with PathFormer
Washington University in St. Louis（圣路易斯华盛顿大学）；The Hong Kong Polytechnic University（香港理工大学）；Institute for Informatics (I2)（信息学研究所（I2））；Peking University（北京大学）；Washington University School of Medicine（华盛顿大学医学院）
Isik University（伊希克大学）；Istanbul Technical University（伊斯坦布尔技术大学）
Retinal optical coherence tomography (OCT) and optical coherence tomography angiography (OCTA) are promising tools for the (early) diagnosis of Alzheimer's disease (AD). These non-invasive imaging techniques are cost-effective and more accessible than alternative neuroimaging tools. However, interpreting and classifying multi-slice scans produced by OCT devices is time-consuming and challenging even for trained practitioners. There are surveys on machine learning and deep learning approaches concerning the automated analysis of OCT scans for various diseases such as glaucoma. However, the curr…
Dynamic Dual-Graph Fusion Convolutional Network For Alzheimer's Disease Diagnosis
Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences（中国科学院深圳先进技术研究院）；University of Chinese Academy of Sciences（中国科学院大学）；The Second People's Hospital of Shenzhen（深圳市第二人民医院）
University of Jammu（查谟大学）；Government Medical College（政府医学院）
Areas where Artificial Intelligence (AI) & related fields are finding their applications are increasing day by day, moving from core areas of computer science they are finding their applications in various other domains.In recent times Machine Learning i.e. a sub-domain of AI has been widely used in order to assist medical experts and doctors in the prediction, diagnosis and prognosis of various diseases and other medical disorders. In this manuscript the authors applied various machine learning algorithms to a problem in the domain of medical diagnosis and analyzed their efficiency in predict…
OpenAPMax: Abnormal Patterns-based Model for Real-World Alzheimer's Disease Diagnosis
Guangxi Normal University（广西师范大学）；Institute of Computing Technology, Chinese Academy of Sciences（中国科学院计算技术研究所）；Capital Medical University（首都医科大学）；Guilin Medical University（桂林医学院）
We consider the problem of image classification for the purpose of aiding doctors in dermatological diagnosis. Dermatological diagnosis poses two major challenges for standard off-the-shelf techniques: First, the data distribution is typically extremely long tailed. Second, intra-class variability is often large. To address the first issue, we formulate the problem as low-shot learning, where once deployed, a base classifier must rapidly generalize to diagnose novel conditions given very few labeled examples. To model diverse classes effectively, we propose Prototypical Clustering Networks (PC…
ConvNeXtv2 Fusion with Mask R-CNN for Automatic Region Based Coronary Artery Stenosis Detection for Disease Diagnosis
Nepal Applied Mathematics and Informatics Institute for research（尼泊尔应用数学与信息学研究所）；Fogsphere(Redev AI Ltd.)（Fogsphere（Redev AI有限公司））；University of Lausanne（洛桑大学）；University of Aberdeen（阿伯丁大学）
Collaborative Attention and Consistent-Guided Fusion of MRI and PET for Alzheimer's Disease Diagnosis
School of Software Yunnan University（软件学院 云南大学）；Department of Computer Science The University of Sheffield（计算机科学系 剑桥大学）；Department of Computing Xian JiaoTong-Liverpool University（计算系 西交利物浦大学）
HPOQuest: A Rare-Disease Diagnostic Agent Using Active Phenotype Acquisition
Technical University of Munich（慕尼黑工业大学）；Helmholtz Center Munich（亥姆霍兹慕尼黑中心）；Munich Center for Machine Learning (MCML)（慕尼黑机器学习中心）；Munich Data Science Institute (MDSI)（慕尼黑数据科学研究所）；Aalto University（阿尔托大学）
Adaptive Federated Few-Shot Rare-Disease Diagnosis with Energy-Aware Secure Aggregation
School of Information, Computer, and Communication Technology（信息、计算机与通信技术学院）；Sirindhorn International Institute of Technology, Thammasat University（泰国朱拉隆功大学国际技术学院）
Arison School of Business, Interdisciplinary Center（阿里森商学院，跨学科中心）
A key step in medical diagnosis is giving the patient a universally recognized label (e.g. Appendicitis) which essentially assigns the patient to a class(es) of patients with similar body failures. However, two patients having the same disease label(s) with high probability may still have differences in their feature manifestation patterns implying differences in the required treatments. Additionally, in many cases, the labels of the primary diagnoses leave some findings unexplained. Medical diagnosis is only partially about probability calculations for label X or Y. Diagnosis is not complete …
ImputeINR: Time Series Imputation via Implicit Neural Representations for Disease Diagnosis with Missing Data
Zhejiang Key Laboratory of Accessible Perception and Intelligent Systems, College of Computer Science, Zhejiang University（浙江可感知与智能系统重点实验室，计算机科学学院，浙江大学）；The Zhejiang University-University of Illinois Urbana-Champaign Institute（浙江大学-伊利诺伊大学厄巴纳-香槟分校联合研究所）
Carnegie Mellon University（卡内基梅隆大学）；Allegheny Health Network（阿勒格尼健康网络）；University of Colorado（科罗拉多大学）
In this paper, we focus on a new method of data augmentation to solve the data imbalance problem within imbalanced ECG datasets to improve the robustness and accuracy of heart disease detection. By using Optimal Transport, we augment the ECG disease data from normal ECG beats to balance the data among different categories. We build a Multi-Feature Transformer (MF-Transformer) as our classification model, where different features are extracted from both time and frequency domains to diagnose various heart conditions. Learning from 12-lead ECG signals, our model is able to distinguish five categ…
University of Pittsburgh（匹兹堡大学）；University of Notre Dame（圣母大学）；George Mason University（乔治梅森大学）；University of New Mexico（新墨西哥大学）；University of Pittsburgh Medical Center（匹兹堡大学医学中心）
Deep learning models have been deployed in an increasing number of edge and mobile devices to provide healthcare. These models rely on training with a tremendous amount of labeled data to achieve high accuracy. However, for medical applications such as dermatological disease diagnosis, the private data collected by mobile dermatology assistants exist on distributed mobile devices of patients, and each device only has a limited amount of data. Directly learning from limited data greatly deteriorates the performance of learned models. Federated learning (FL) can train models by using data distri…
