Cost-effectiveness Analysis of Antiepidemic Policies and Global Situation Assessment of COVID-19
Liyan Xu, Hongmou Zhang, Yuqiao Deng, Keli Wang, Fu Li, Qing Lu, Jie Yin, Qian Di, Tao Liu, Hang Yin, Zijiao Zhang, Qingyang Du, Hongbin Yu, Aihan Liu, Hezhishi… 展开作者
Liyan Xu, Hongmou Zhang, Yuqiao Deng, Keli Wang, Fu Li, Qing Lu, Jie Yin, Qian Di, Tao Liu, Hang Yin, Zijiao Zhang, Qingyang Du, Hongbin Yu, Aihan Liu, Hezhishi Jiang, Jing Guo, Xiumei Yuan, Yun Zhang, Liu Liu, Yu Liu
With a two-layer contact-dispersion model and data in China, we analyze the cost-effectiveness of three types of antiepidemic measures for COVID-19: regular epidemiological control, local social interaction control, and inter-city travel restriction. We find that: 1) intercity travel restriction has minimal or even negative effect compared to the other two at the national level; 2) the time of reaching turning point is independent of the current number of cases, and only related to the enforcement stringency of epidemiological control and social interaction control measures; 3) strong enforcement at the early stage is the only opportunity to maximize both antiepidemic effectiveness and cost-effectiveness; 4) mediocre stringency of social interaction measures is the worst choice. Subsequently, we cluster countries/regions into four groups based on their control measures and provide situation assessment and policy suggestions for each group.
The COVID-19 pandemic poses challenges for continuing economic activity while reducing health risks. While these challenges can be mitigated through testing, testing budget is often limited. Here we study how institutions, such as nursing homes, should utilize a fixed test budget for early detection of an outbreak. Using an extended network-SEIR model, we show that given a certain budget of tests, it is generally better to test smaller subgroups of the population frequently than to test larger groups but less frequently. The numerical results are consistent with an analytical expression we der…
Several European countries have suspended the inoculation of the AstraZeneca vaccine out of suspicion of causing deep vein thrombosis. In this letter we report some Fermi estimates performed using a stochastic model aimed at making a risk-benefit analysis of the interruption of the delivery of the AstraZeneca vaccine in France and Italy. Our results clearly show that excess deaths due to the interruption of the vaccination campaign injections largely overrun those due to thrombosis even in worst case scenarios of frequency and gravity of the vaccine side effects.
Within the context that Greece promises a success story in the fight against the disease, this paper proposes a novel method to study the evolution of the Greek COVID-19 infection-curve in relation to the anti-COVID-19 policies applied to control the pandemic. Based on the ongoing spreading of COVID-19 and the insufficient data for applying classic time-series approaches, the analysis builds on the visibility graph algorithm to study the Greek COVID-19 infection-curve as a complex network. By using the modularity optimization algorithm, the generated visibility graph is divided into communitie…
To reduce the impact of COVID-19 pandemic most countries have implemented several counter-measures to control the virus spread including school and border closing, shutting down public transport and workplace and restrictions on gathering. In this research work, we propose a deep-learning prediction model for evaluating and predicting the impact of various lockdown policies on daily COVID-19 cases. This is achieved by first clustering countries having similar lockdown policies, then training a prediction model based on the daily cases of the countries in each cluster along with the data descri…
By the end of May 2020, all states in the US have eased their COVID-19 mitigation measures. Different states adopted markedly different policies and timing for reopening. An important question remains in how the relaxation of mitigation measures is related to the number of casualties. To address this question, we compare the actual data to a hypothetical case in which the mitigation measures are left intact using a projection of the data from before mitigation measures were eased. We find that different states have shown significant differences in the number of deaths, possibly due to their di…
In response to the COVID-19 pandemic, governments have implemented policies to curb the spread of the novel virus. Little is known about how these policies impact various groups in society. This paper explores the relationship between social distancing policies, traffic volumes and air quality and how they impact various socioeconomic groups. This study aims to understand how disparate communities respond to Stay-at-Home Orders and other social distancing policies to understand how human behavior in response to policy may play a part in the prevalence of COVID-19 positive cases. We collected d…
A pandemic, the worldwide spread of a disease, can threaten human beings from the social as well as biological perspectives and paralyze existing living habits. To stave off the more devastating disaster and return to a normal life, people make tremendous efforts at multiscale levels from individual to worldwide: paying attention to hand hygiene, developing social policies such as wearing masks, social distancing, quarantine, and inventing vaccines and remedy. Regarding the current severe pandemic, namely the coronavirus disease 2019, we explore the spreading-suppression effect when adopting t…
To slow down the spread of Covid-19, administrative regions within Pakistan imposed complete and partial lockdown restrictions on socio-economic activities, religious congregations, and human movement. Here we examine the impact of regional lockdown strategies on Covid-19 outcomes. After conducting econometric analyses (Regression Discontinuity and Negative Binomial Regressions) on official data from the National Institute of Health (NIH) Pakistan, we find that the strategies did not lead to a similar level of Covid-19 caseload (positive cases and deaths) in all regions. In terms of reduction …
The implementation of social distancing policies is key to reducing the impact of the current COVID-19 pandemic. However, their effectiveness ultimately depends on human behavior. In the United States, compliance with social distancing policies has widely varied thus far during the pandemic. But what drives such variability? Through six open datasets, including actual human mobility, we estimated the association between mobility and the growth rate of COVID-19 cases across 3,107 U.S. counties, generalizing previous reports. In addition, data from the 2016 U.S. presidential election was used to…
The diffusion of COVID19 is calling governments and public health authorities to interventions that limit new infections and contain the expected number of critical cases and deaths. Most of these measures rely on the compliance of people, who are asked to reduce their social contacts to a minimum. In this note we argue that individuals' adherence to prescriptions and reduction of social activity may not be efficacious if not implemented robustly on all social groups, especially on those characterized by intense mixing patterns. Actually, it is possible that, if those who have many contacts re…
University of Louisiana at Lafayette（路易斯安那大学拉斐特分校）；Stanford University（斯坦福大学）
In this study, we propose a clustering-based approach on time-series data to capture COVID-19 spread patterns in the early period of the pandemic. We analyze the spread dynamics based on the early and post stages of COVID-19 for different countries based on different geographical locations. Furthermore, we investigate the confinement policies and the effect they made on the spread. We found that implementations of the same confinement policies exhibit different results in different countries. Specifically, lockdowns become less effective in densely populated regions, because of the reluctance …
Recent re-opening policies in the US, following a period of social distancing measures, introduced a significant increase in daily COVID-19 infections, calling for a roll-back or substantial revisiting of these policies in many states. The situation is suggestive of difficulties modeling the impact of partial distancing/re-opening policies on future epidemic spread for purposes of choosing safe alternatives. More specifically, one needs to understand the impact of manipulating the availability of social interaction venues (e.g., schools, workplaces, and retail establishments) on virus spread. …
We study how available data on COVID-19 cases and deaths in different countries are reliable. Our analysis is based on a modification of the law of anomalous numbers, the Newcomb-Benford law, applied to the daily number of deaths and new cases in each country. We first revisit the Newcomb-Benford law and show how to avoid false negative compliance of the data. We then compared deviation from this law, to a number of social and economic indices for each country by computing the Spearman rank order correlation between each index and the \c{hi}2 deviation of COVID- 19 data to the modified NB law.…
In this paper, I study epidemic diffusion in a generalized spatial SEIRD model, where individuals are initially connected in a social or geographical network. As the virus spreads in the network, the structure of interactions between people may endogenously change over time, due to quarantining measures and/or spatial-distancing policies. I explore via simulations the dynamic properties of the co-evolutionary process dynamically linking disease diffusion and network properties. Results suggest that, in order to predict how epidemic phenomena evolve in networked populations, it is not enough to…
We assess the epidemic situation caused by SARS-CoV-2 using Tsallis' proposal for determining the occurrence of the peak, and also the Susceptible-Infected-Recovered-Asymptomatic-Symptomatic and Dead (\textbf{SIRASD}) compartmental model. Using these two models, we determine a range of probable peak dates and study several social distancing scenarios during the epidemic. Due to the socioeconomic situation and the conflictive political climate, we take for our study the case of Bolivia, where a national election was originally scheduled to occur on September 6th and recently rescheduled on Octo…
While several non-pharmacological measures have been implemented for a few months in an effort to slow the coronavirus disease (COVID-19) pandemic in the United States, the disease remains a danger in a number of counties as restrictions are lifted to revive the economy. Making a trade-off between economic recovery and infection control is a major challenge confronting many hard-hit counties. Understanding the transmission process and quantifying the costs of local policies are essential to the task of tackling this challenge. Here, we investigate the dynamic contact patterns of the population…
We propose a multi-layer network model for the spread of COVID-19 that accounts for interactions within the family, between schoolmates, and casual contacts in the population. We utilize the proposed model-calibrated on epidemiological and demographic data-to investigate current questions concerning the implementation of non-pharmaceutical interventions (NPIs) during the vaccination campaign. Specifically, we consider scenarios in which the most fragile population has already received the vaccine, and we focus our analysis on the role of schools as drivers of the contagions and on the implemen…
In order to investigate the effectiveness of lockdown and social distancing restrictions, which have been widely carried out as policy choice to curb the ongoing COVID-19 pandemic around the world, we formulate and discuss a staged and weighed networked system based on a classical SEAIR epidemiological model. Five stages have been taken into consideration according to four-tier response to Public Health Crisis, which comes from the National Contingency Plan in China. Staggered basic reproduction number has been derived and we evaluate the effectiveness of lockdown and social distancing policie…
To date, the only effective means to respond to the spreading of COVID-19 pandemic are non-pharmaceutical interventions (NPIs), which entail policies to reduce social activity and mobility restrictions. Quantifying their effect is difficult, but it is key to reduce their social and economical consequences. Here, we introduce a meta-population model based on temporal networks, calibrated on the COVID-19 outbreak data in Italy and apt to evaluate the outcomes of these two types of NPIs. Our approach combines the advantages of granular spatial modelling of meta-population models with the ability …
Public transport is one of the most disrupted sectors of the COVID-19 pandemic with reported ridership drops up to 90% in majorly affected countries. As many government authorities strive to partially resume activities, public transport operators are in an urgent need for models that can evaluate the impact of different social distancing policies on operational and passenger-related costs. In this study, we introduce a mixed-integer quadratic programming model for the redesign of public transport services considering the operational, passenger, and revenue loss-related costs by evaluating the …
Frankfurt Institute for Advanced Studies（法兰克福高等研究院）；Beihang University（北京航空航天大学）；Black Hole KG；Goethe University Frankfurt（法兰克福歌德大学）
As the COVID-19 pandemic continues to ravage the world, it is of critical significance to provide a timely risk prediction of the COVID-19 in multi-level. To implement it and evaluate the public health policies, we develop a framework with machine learning assisted to extract epidemic dynamics from the infection data, in which contains a county-level spatiotemporal epidemiological model that combines a spatial Cellular Automaton (CA) with a temporal Susceptible-Undiagnosed-Infected-Removed (SUIR) model. Compared with the existing time risk prediction models, the proposed CA-SUIR model shows th…
As of December 2020, the COVID-19 pandemic has infected over 75 million people, making it the deadliest pandemic in modern history. This study develops a novel compartmental epidemiological model specific to the SARS-CoV-2 virus and analyzes the effect of common preventative measures such as testing, quarantine, social distancing, and vaccination. By accounting for the most prevalent interventions that have been enacted to minimize the spread of the virus, the model establishes a paramount foundation for future mathematical modeling of COVID-19 and other modern pandemics. Specifically, the mod…
The COVID-19 pandemic has posed a policy making crisis where efforts to slow down or end the pandemic conflict with economic priorities. This paper provides mathematical analysis of optimal disease control policies with idealized compartmental models for disease propagation and simplistic models of social and economic costs. Two locally optimal control strategies are found and categorized as `suppression' and `mitigation' strategies. We analyze how these strategies change when we incorporate vaccination into the model and find a new optimal `delay-mitigation' strategy.
Estimating the Impact of Social Distance Policy in Mitigating COVID-19 Spread with Factor-Based Imputation Approach
University of Hong Kong（香港大学）；Toulouse School of Management（图卢兹管理学院）；University of International Business and Economics（对外经济贸易大学）；Beijing University of Chemical Technology（北京化工大学）
We have developed a globally applicable diagnostic Covid-19 model by augmenting the classical SIR epidemiological model with a neural network module. Our model does not rely upon previous epidemics like SARS/MERS and all parameters are optimized via machine learning algorithms employed on publicly available Covid-19 data. The model decomposes the contributions to the infection timeseries to analyze and compare the role of quarantine control policies employed in highly affected regions of Europe, North America, South America and Asia in controlling the spread of the virus. For all continents co…
Countries and cities around the world have resorted to unprecedented mobility restrictions to combat Covid-19 transmission. Here we exploit a natural experiment whereby Colombian cities implemented varied lockdown policies based on ID number and gender to analyse the impact of these policies on urban mobility. Using mobile phone data, we find that the restrictiveness of cities' mobility quotas (the share of residents allowed out daily according to policy advice) does not correlate with mobility reduction Instead, we find that larger, wealthier cities with more formalized and complex industrial…
Since the outbreak of COVID-19 in early March 2020, UK supermarkets have implemented different policies to reduce the virus transmission in stores to protect both customers and staff, such as restricting the maximum number of customers in a store, changes to the store layout, or enforcing a mandatory face covering policy. To quantitatively assess these mitigation methods, we formulate an agent-based model of customer movement in a supermarket (which we represent by a network) with a simple virus transmission model based on the amount of time a customer spends in close proximity to infectious c…
The coronavirus disease 2019 (COVID-19) global pandemic has led many countries to impose unprecedented lockdown measures in order to slow down the outbreak. Questions on whether governments have acted promptly enough, and whether lockdown measures can be lifted soon have since been central in public discourse. Data-driven models that predict COVID-19 fatalities under different lockdown policy scenarios are essential for addressing these questions and informing governments on future policy directions. To this end, this paper develops a Bayesian model for predicting the effects of COVID-19 lockd…
We adapt a SEIRD differential model with asymptomatic population and Covid deaths, which we call SEAIRD, to simulate the evolution of COVID-19, and add a control function affecting both the diffusion of the virus and GDP, featuring all direct and indirect containment policies; to model feasibility, the control is assumed to be a piece-wise linear function satisfying additional constraints. We describe the joint dynamics of infection and the economy and discuss the trade-off between production and fatalities. In particular, we carefully study the conditions for the existence of the optimal poli…
We discuss the impact of a Covid-19--like shock on a simple model economy, described by the previously developed Mark-0 Agent-Based Model. We consider a mixed supply and demand shock, and show that depending on the shock parameters (amplitude and duration), our model economy can display V-shaped, U-shaped or W-shaped recoveries, and even an L-shaped output curve with permanent output loss. This is due to the economy getting trapped in a self-sustained "bad" state. We then discuss two policies that attempt to moderate the impact of the shock: giving easy credit to firms, and the so-called helic…
The COVID-19 pandemic has forced public health experts to develop contingent policies to stem the spread of infection, including measures such as partial/complete lockdowns. The effectiveness of these policies has varied with geography, population distribution, and effectiveness in implementation. Consequently, some nations (e.g., Taiwan, Haiti) have been more successful than others (e.g., United States) in curbing the outbreak. A data-driven investigation into effective public health policies of a country would allow public health experts in other nations to decide future courses of action to…
I develop a novel macroeconomic epidemiological agent-based model to study the impact of the COVID-19 pandemic under varying policy scenarios. Agents differ with regard to their profession, family status and age and interact with other agents at home, work or during leisure activities. The model allows to implement and test actually used or counterfactual policies such as closing schools or the leisure industry explicitly in the model in order to explore their impact on the spread of the virus, and their economic consequences. The model is calibrated with German statistical data on time use, d…
Dear Editor-in-Chief: We have given two articles published recently in Science of the Total Environment by Mandal and Pal (2020) and Zambrano-Monserrate et al. (2020) a thorough reading. Both articles present a significant association between the novel Coronavirus (COVID-19) social distancing policies and improvement in environmental quality such as air pollution, land surface temperature, and noise. Both articles present good research, complemented by detailed explanations and displays, yet we have a few concerns that affect the interpretation and meaning of the results.
We investigate adaptive strategies to robustly and optimally control the COVID-19 pandemic via social distancing measures based on the example of Germany. Our goal is to minimize the number of fatalities over the course of two years without inducing excessive social costs. We consider a tailored model of the German COVID-19 outbreak with different parameter sets to design and validate our approach. Our analysis reveals that an open-loop optimal control policy can significantly decrease the number of fatalities when compared to simpler policies under the assumption of exact model knowledge. In …
The COVID-19 pandemic has affected travel behaviors and transportation system operations, and cities are grappling with what policies can be effective for a phased reopening shaped by social distancing. This edition of the white paper updates travel trends and highlights an agent-based simulation model's results to predict the impact of proposed phased reopening strategies. It also introduces a real-time video processing method to measure social distancing through cameras on city streets.
The COVID-19 pandemic constitutes one of the largest threats in recent decades to the health and economic welfare of populations globally. In this paper, we analyze different types of policy measures designed to fight the spread of the virus and minimize economic losses. Our analysis builds on a multi-group SEIR model, which extends the multi-group SIR model introduced by Acemoglu et al.~(2020). We adjust the underlying social interaction patterns and consider an extended set of policy measures. The model is calibrated for Germany. Despite the trade-off between COVID-19 prevention and economic…
