This paper presents and explores a robust deep learning framework for auscultation analysis. This aims to classify anomalies in respiratory cycles and detect disease, from respiratory sound recordings. The framework begins with front-end feature extraction that transforms input sound into a spectrogram representation. Then, a back-end deep learning network is used to classify the spectrogram features into categories of respiratory anomaly cycles or diseases. Experiments, conducted over the ICBHI benchmark dataset of respiratory sounds, confirm three main contributions towards respiratory-sound analysis. Firstly, we carry out an extensive exploration of the effect of spectrogram type, spectral-time resolution, overlapped/non-overlapped windows, and data augmentation on final prediction accuracy. This leads us to propose a novel deep learning system, built on the proposed framework, which outperforms current state-of-the-art methods. Finally, we apply a Teacher-Student scheme to achieve a trade-off between model performance and model complexity which additionally helps to increase the potential of the proposed framework for building real-time applications.
Austria Institute of Technology（奥地利技术研究所）；Queen Mary University of London（伦敦玛丽女王大学）；University of Lübeck（吕贝克大学）；Singapore Institute of Technology（新加坡理工学院）
This paper presents an inception-based deep neural network for detecting lung diseases using respiratory sound input. Recordings of respiratory sound collected from patients are firstly transformed into spectrograms where both spectral and temporal information are well presented, referred to as front-end feature extraction. These spectrograms are then fed into the proposed network, referred to as back-end classification, for detecting whether patients suffer from lung-relevant diseases. Our experiments, conducted over the ICBHI benchmark meta-dataset of respiratory sound, achieve competitive I…
Recognizing patterns in lung sounds is crucial to detecting and monitoring respiratory diseases. Current techniques for analyzing respiratory sounds demand domain experts and are subject to interpretation. Hence an accurate and automatic respiratory sound classification system is desired. In this work, we took a data-driven approach to classify abnormal lung sounds. We compared the performance using three different feature extraction techniques, which are short-time Fourier transformation (STFT), Mel spectrograms, and Wav2vec, as well as three different classifiers, including pre-trained ResNe…
Improving Deep Learning-based Respiratory Sound Analysis with Frequency Selection and Attention Mechanism
TICLab, International University of Rabat（国际拉巴特大学TIC实验室）；College of Computing, Mohammed VI Polytechnic University（摩洛哥穆莱·伊斯梅尔polytechnic大学计算机学院）；Faculty of Engineering, University of Leeds（利兹大学工程学院）
Large annotated lung sound databases are publicly available and might be used to train algorithms for diagnosis systems. However, it might be a challenge to develop a well-performing algorithm for small non-public data, which have only a few subjects and show differences in recording devices and setup. In this paper, we use transfer learning to tackle the mismatch of the recording setup. This allows us to transfer knowledge from one dataset to another dataset for crackle detection in lung sounds. In particular, a single input convolutional neural network (CNN) model is pre-trained on a source …
In this paper, we use pre-trained ResNet models as backbone architectures for classification of adventitious lung sounds and respiratory diseases. The knowledge of the pre-trained model is transferred by using vanilla fine-tuning, co-tuning, stochastic normalization and the combination of the co-tuning and stochastic normalization techniques. Furthermore, data augmentation in both time domain and time-frequency domain is used to account for the class imbalance of the ICBHI and our multi-channel lung sound dataset. Additionally, we apply spectrum correction to consider the variations of the rec…
Donghua University（东华大学）；University of Catania（卡塔尼亚大学）；PIEAS（巴基斯坦工程与应用科学学院）；Islamia University of Bahawalpur（巴哈瓦尔布尔伊斯兰大学）
With the development of computer -systems that can collect and analyze enormous volumes of data, the medical profession is establishing several non-invasive tools. This work attempts to develop a non-invasive technique for identifying respiratory sounds acquired by a stethoscope and voice recording software via machine learning techniques. This study suggests a trained and proven CNN-based approach for categorizing respiratory sounds. A visual representation of each audio sample is constructed, allowing resource identification for classification using methods like those used to effectively des…
Auscultation of respiratory sounds is the primary tool for screening and diagnosing lung diseases. Automated analysis, coupled with digital stethoscopes, can play a crucial role in enabling tele-screening of fatal lung diseases. Deep neural networks (DNNs) have shown a lot of promise for such problems, and are an obvious choice. However, DNNs are extremely data hungry, and the largest respiratory dataset ICBHI has only 6898 breathing cycles, which is still small for training a satisfactory DNN model. In this work, RespireNet, we propose a simple CNN-based model, along with a suite of novel tec…
National Taiwan University（台湾大学）；Far Eastern Memorial Hospital（远东纪念医院）；Heroic Faith Medical Science Co. Ltd.（浩信医疗科技股份有限公司）；Avalanche Computing Inc.（雪崩计算公司）；Academia Sinica（中央研究院）；HCC Healthcare Group（HCC医疗集团）
A reliable, remote, and continuous real-time respiratory sound monitor with automated respiratory sound analysis ability is urgently required in many clinical scenarios-such as in monitoring disease progression of coronavirus disease 2019-to replace conventional auscultation with a handheld stethoscope. However, a robust computerized respiratory sound analysis algorithm has not yet been validated in practical applications. In this study, we developed a lung sound database (HF_Lung_V1) comprising 9,765 audio files of lung sounds (duration of 15 s each), 34,095 inhalation labels, 18,349 exhalati…
Patch-Mix Contrastive Learning with Audio Spectrogram Transformer on Respiratory Sound Classification
KAIST AI（韩国科学技术院人工智能学院）；Department of AI, Kyungpook National University（庆北国立大学人工智能系）；SmartSound（SmartSound公司）；Dongguk University（东国大学）；MODULABS（MODULABS机构）
Monash University（莫纳什大学）；Monash Children’s Hospital（莫纳什儿童医院）；BC Children’s Hospital Research Institute（不列颠哥伦比亚省儿童医院研究所）
Neonatal respiratory distress is a common condition that if left untreated, can lead to short- and long-term complications. This paper investigates the usage of digital stethoscope recorded chest sounds taken within 1min post-delivery, to enable early detection and prediction of neonatal respiratory distress. Fifty-one term newborns were included in this study, 9 of whom developed respiratory distress. For each newborn, 1min anterior and posterior recordings were taken. These recordings were pre-processed to remove noisy segments and obtain high-quality heart and lung sounds. The random unders…
Lung auscultation is the most effective and indispensable method for diagnosing various respiratory disorders by using the sounds from the airways during inspirium and exhalation using a stethoscope. In this study, the statistical features are calculated from intrinsic mode functions that are extracted by applying the HilbertHuang Transform to the lung sounds from 12 different auscultation regions on the chest and back. The classification of the lung sounds from asthma and healthy subjects is performed using Deep Belief Networks (DBN). The DBN classifier model with two hidden layers has been t…
A Dual-Purpose Deep Learning Model for Auscultated Lung and Tracheal Sound Analysis Based on Mixed Set Training
National Taiwan University（台湾大学）；Far Eastern Memorial Hospital（远东纪念医院）；Heroic Faith Medical Science Co., Ltd.（鸿信医学科技股份有限公司）；En Chu Kong Hospital（恩主公医院）；Oriental Institute of Technology（东方科技大学）；Avalanche Computing Inc.（雪崩计算公司）；Academia Sinica（中央研究院）；National Taiwan University Hospital（台湾大学医院）
Graduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University（国立台湾大学生物医学电子与生物信息学研究所）；Heroic Faith Medical Science Corporation Limited（恒信医学科技股份有限公司）；National Taiwan University-Stanford Joint Program Office of AI in Biotechnology, Ministry of Science and Technology Joint Research Center for Artificial Intelligence Technology and All Vista Healthcare（国立台湾大学-斯坦福大学生物技术人工智能联合项目办公室 科技部人工智能技术联合研究中心）；Department of Life Science, College of Life Science, National Taiwan University（国立台湾大学生命科学学院生命科学系）；Institute of Biomedical Sciences, Academia Sinica（中央研究院生物医学科学研究所）；Department of Critical Care, Far Eastern Memorial Hospital（远东纪念医院重症监护部）
Respiratory auscultation can help healthcare professionals detect abnormal respiratory conditions if adventitious lung sounds are heard. The state-of-the-art artificial intelligence technologies based on deep learning show great potential in the development of automated respiratory sound analysis. To train a deep learning-based model, a huge number of accurate labels of normal breath sounds and adventitious sounds are needed. In this paper, we demonstrate the work of developing a respiratory sound labeling software to help annotators identify and label the inhalation, exhalation, and adventiti…
Seoul National University of Science and Technology（首尔科学技术大学）
Lung sound classification is vital for early diagnosis of respiratory diseases. However, biomedical signals often exhibit inter-patient variability even among patients with the same symptoms, requiring a learning approach that considers individual differences. We propose a Patient-Aware Feature Alignment (PAFA) framework with two novel losses, Patient Cohesion-Separation Loss (PCSL) and Global Patient Alignment Loss (GPAL). PCSL clusters features of the same patient while separating those from other patients to capture patient variability, whereas GPAL draws each patient's centroid toward a gl…
StethoMe（StethoMe公司）；Poznań University of Technology（波兹南理工大学）；University of Medical Sciences（医科大学）；Adam Mickiewicz University（亚当·密茨凯维奇大学）
To perform a precise auscultation for the purposes of examination of respiratory system normally requires the presence of an experienced doctor. With most recent advances in machine learning and artificial intelligence, automatic detection of pathological breath phenomena in sounds recorded with stethoscope becomes a reality. But to perform a full auscultation in home environment by layman is another matter, especially if the patient is a child. In this paper we propose a unique application of Reinforcement Learning for training an agent that interactively guides the end user throughout the au…
SINTEF Digital（SINTEF数字研究院）；dedeX（dedeX公司）；Oklahoma State University（俄克拉荷马州立大学）
Lung sounds refer to the sound generated by air moving through the respiratory system. These sounds, as most biomedical signals, are non-linear and non-stationary. A vital part of using the lung sound for disease detection is discrimination between normal lung sound and abnormal lung sound. In this paper, several approaches for classifying between no-crackle and crackle lung sounds are explored. Decomposition methods such as Empirical Mode Decomposition, Ensemble Empirical Mode Decomposition, and Discrete Wavelet Transform are used along with several feature extraction techniques like Principa…
Obtaining high-quality heart and lung sounds enables clinicians to accurately assess a newborn's cardio-respiratory health and provide timely care. However, noisy chest sound recordings are common, hindering timely and accurate assessment. A new Non-negative Matrix Co-Factorisation-based approach is proposed to separate noisy chest sound recordings into heart, lung, and noise components to address this problem. This method is achieved through training with 20 high-quality heart and lung sounds, in parallel with separating the sounds of the noisy recording. The method was tested on 68 10-second…
Queensland University of Technology（昆士兰科技大学）；M3DICINE Pty Ltd（M3DICINE私人有限公司）
This paper proposes a novel framework for lung sound event detection, segmenting continuous lung sound recordings into discrete events and performing recognition on each event. Exploiting the lightweight nature of Temporal Convolution Networks (TCNs) and their superior results compared to their recurrent counterparts, we propose a lightweight, yet robust, and completely interpretable framework for lung sound event detection. We propose the use of a multi-branch TCN architecture and exploit a novel fusion strategy to combine the resultant features from these branches. This not only allows the n…
Queen Mary University of London（伦敦玛丽女王大学）；University of Luebeck（吕贝克大学）
This thesis focuses on dealing with the task of acoustic scene classification (ASC), and then applied the techniques developed for ASC to a real-life application of detecting respiratory disease. To deal with ASC challenges, this thesis addresses three main factors that directly affect the performance of an ASC system. Firstly, this thesis explores input features by making use of multiple spectrograms (log-mel, Gamma, and CQT) for low-level feature extraction to tackle the issue of insufficiently discriminative or descriptive input features. Next, a novel Encoder network architecture is introd…
Monash University（莫纳什大学）；Shiraz University（设拉子大学）；Emory University（埃默里大学）；Monash Children’s Hospital（莫纳什儿童医院）；University British Columbia（不列颠哥伦比亚大学）；BC Children’s Hospital Research Institute（不列颠哥伦比亚儿童医院研究所）
Stethoscope-recorded chest sounds provide the opportunity for remote cardio-respiratory health monitoring of neonates. However, reliable monitoring requires high-quality heart and lung sounds. This paper presents novel Non-negative Matrix Factorisation (NMF) and Non-negative Matrix Co-Factorisation (NMCF) methods for neonatal chest sound separation. To assess these methods and compare with existing single-source separation methods, an artificial mixture dataset was generated comprising of heart, lung and noise sounds. Signal-to-noise ratios were then calculated for these artificial mixtures. T…
Auscultation is the most efficient way to diagnose cardiovascular and respiratory diseases. To reach accurate diagnoses, a device must be able to recognize heart and lung sounds from various clinical situations. However, the recorded chest sounds are mixed by heart and lung sounds. Thus, effectively separating these two sounds is critical in the pre-processing stage. Recent advances in machine learning have progressed on monaural source separations, but most of the well-known techniques require paired mixed sounds and individual pure sounds for model training. As the preparation of pure heart …
Monash University（莫纳什大学）；Emory University（埃默里大学）；University of British Columbia（不列颠哥伦比亚大学）
Digital stethoscopes in combination with telehealth allow chest sounds to be easily collected and transmitted for remote monitoring and diagnosis. Chest sounds contain important information about a newborn's cardio-respiratory health. However, low-quality recordings complicate the remote monitoring and diagnosis. In this study, a new method is proposed to objectively and automatically assess heart and lung signal quality on a 5-level scale in real-time and to assess the effect of signal quality on vital sign estimation. For the evaluation, a total of 207 10s long chest sounds were taken from 1…
University of Augsburg（奥格斯堡大学）；Imperial College（帝国理工学院）；University Hospital Augsburg（奥格斯堡大学医院）；Ludwig-Maximilians-University Munich（慕尼黑路德维希-马克西米利安大学）
Chronic obstructive pulmonary disease (COPD) causes lung inflammation and airflow blockage leading to a variety of respiratory symptoms; it is also a leading cause of death and affects millions of individuals around the world. Patients often require treatment and hospitalisation, while no cure is currently available. As COPD predominantly affects the respiratory system, speech and non-linguistic vocalisations present a major avenue for measuring the effect of treatment. In this work, we present results on a new COPD dataset of 20 patients, showing that, by employing personalisation through spe…
