In this study, the problem of automatically classifying pulmonary diseases, including the recently emerged COVID-19, from X-Ray images, is considered. While the spread of COVID-19 is increased, new, automatic, and reliable methods for accurate detection are essential to reduce the exposure of the medical experts to the outbreak. X-ray imaging, although limited to specific visualizations, may be helpful for the diagnosis. Deep Learning has proven to be a remarkable method to extract massive high-dimensional features from medical images. Specifically, in this paper, the state-of-the-art Convolutional Neural Network called Mobile Net is employed and trained from scratch to investigate the importance of the extracted features for the classification task. A large-scale dataset of 3905 X-Ray images, corresponding to 6 diseases is utilized for training MobileNet v2, which has been proven to achieve remarkable results in related tasks. The results suggest that training CNNs from scratch may reveal vital biomarkers related but not limited to the COVID-19 disease, while an overall classification accuracy of the seven classes reaches 87.66%. Besides, this method achieves 99.18% accuracy, 97.36% Sensitivity, and 99.42% Specificity in the detection of COVID-19.
Athena-Research and Innovation Center in Information, Communication and Knowledge Technologies（雅典娜信息、通信与知识技术研究与创新中心）；Hellenic Open University（希腊开放大学）；Sismanogleio General Hospital（西斯马诺格利奥综合医院）
The main objective of this work is to utilize state-of-the-art deep learning approaches for the identification of pulmonary embolism in CTPA-Scans for COVID-19 patients, provide an initial assessment of their performance and, ultimately, provide a fast-track prototype solution (system). We adopted and assessed some of the most popular convolutional neural network architectures through transfer learning approaches, to strive to combine good model accuracy with fast training. Additionally, we exploited one of the most popular one-stage object detection models for the localization (through object…
Pulmonary lobe segmentation in computed tomography scans is essential for regional assessment of pulmonary diseases. Recent works based on convolution neural networks have achieved good performance for this task. However, they are still limited in capturing structured relationships due to the nature of convolution. The shape of the pulmonary lobes affect each other and their borders relate to the appearance of other structures, such as vessels, airways, and the pleural wall. We argue that such structural relationships play a critical role in the accurate delineation of pulmonary lobes when the…
Charité Universitätsmedizin Berlin（柏林夏里特医学院）；Technische Universität München（慕尼黑工业大学）
Segmentation of pulmonary infiltrates can help assess severity of COVID-19, but manual segmentation is labor and time-intensive. Using neural networks to segment pulmonary infiltrates would enable automation of this task. However, training a 3D U-Net from computed tomography (CT) data is time- and resource-intensive. In this work, we therefore developed and tested a solution on how transfer learning can be used to train state-of-the-art segmentation models on limited hardware and in shorter time. We use the recently published RSNA International COVID-19 Open Radiology Database (RICORD) to trai…
The University of British Columbia（不列颠哥伦比亚大学）；Xtract AI；Element AI；SapienML；AWS, Worldwide Public Sector（亚马逊云科技全球公共部门）
The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has rapidly spread into a global pandemic. A form of pneumonia, presenting as opacities with in a patient's lungs, is the most common presentation associated with this virus, and great attention has gone into how these changes relate to patient morbidity and mortality. In this work we provide open source models for the segmentation of patterns of pulmonary opacification on chest Computed Tomography (CT) scans which have been correlated with various stages and severities of infection. We have collected 663 chest CT scans of COVID-…
Scuola Normale Superiore（比萨高等师范学校）；National Institute of Nuclear Physics (INFN)（国家核物理研究所）；University of Pavia（帕维亚大学）；University of Pisa（比萨大学）；University of Sassari（萨萨里大学）；University of Florence（佛罗伦萨大学）
The automatic assignment of a severity score to the CT scans of patients affected by COVID-19 pneumonia could reduce the workload in radiology departments. This study aims at exploiting Artificial intelligence (AI) for the identification, segmentation and quantification of COVID-19 pulmonary lesions. We investigated the effects of using multiple datasets, heterogeneously populated and annotated according to different criteria. We developed an automated analysis pipeline, the LungQuant system, based on a cascade of two U-nets. The first one (U-net_1) is devoted to the identification of the lung…
Hunting imaging biomarkers in pulmonary fibrosis: Benchmarks of the AIIB23 challenge
Imperial College London（帝国理工学院）；Royal Brompton Hospital（皇家布朗普顿医院）；University of Parma（帕尔马大学）；Shanghai MicroPort MedBot (Group) Co., Ltd.（上海微创医疗机器人（集团）股份有限公司）；Shanghai United Imaging Intelligence Co., Ltd.（上海联影智能医疗科技有限公司）；Shanghai Jiao Tong University（上海交通大学）；Fudan University（复旦大学）；Cambridge International Exam Centre in Shanghai Experimental School（上海实验学校剑桥国际考试中心）；InferVision Medical Technology Co., Ltd.（推想医疗科技股份有限公司）；Shanghai MediWorks Precision Instruments Co., Ltd（上海美沃克斯精密仪器有限公司）；Sanmed Biotech Ltd.（三曼生物科技有限公司）；University of Cambridge（剑桥大学）；University of Palermo（巴勒莫大学）；IRCCS Istituto delle Scienze Neurologiche di Bologna（IRCCS博洛尼亚神经科学研究所）；Istituto Italiano di Tecnologia（意大利技术研究院）；University of Oxford（牛津大学）；Hong Kong University of Science and Technology (Guangzhou)（香港科技大学（广州））；INSA Rouen Normandie（鲁昂国立应用科学学院）；Univ Rouen Normandie（鲁昂诺曼底大学）；Université Le Havre Normandie（勒阿弗尔诺曼底大学）；Henri Becquerel Cancer Center（亨利·贝克勒尔癌症中心）；Wake Forest University School of Medicine（维克森林大学医学院）；University College London（伦敦大学学院）；King's College London（伦敦国王学院）
In recent years, the prevalence of several pulmonary diseases, especially the coronavirus disease 2019 (COVID-19) pandemic, has attracted worldwide attention. These diseases can be effectively diagnosed and treated with the help of lung imaging. With the development of deep learning technology and the emergence of many public medical image datasets, the diagnosis of lung diseases via medical imaging has been further improved. This article reviews pulmonary CT and X-ray image detection and classification in the last decade. It also provides an overview of the detection of lung nodules, pneumoni…
Idiopathic Pulmonary Fibrosis (IPF) is an inexorably progressive fibrotic lung disease with a variable and unpredictable rate of progression. CT scans of the lungs inform clinical assessment of IPF patients and contain pertinent information related to disease progression. In this work, we propose a multi-modal method that uses neural networks and memory banks to predict the survival of IPF patients using clinical and imaging data. The majority of clinical IPF patient records have missing data (e.g. missing lung function tests). To this end, we propose a probabilistic model that captures the de…
Tsinghua University（清华大学）；Capital Medical University（首都医科大学）；Beijing Ditan Hospital（北京地坛医院）
This paper proposes a semi-automatic system based on quantitative characterization of the specific image patterns in lung ultrasound (LUS) images, in order to assess the lung conditions of patients with COVID-19 pneumonia, as well as to differentiate between the severe / and no-severe cases. Specifically, four parameters are extracted from each LUS image, namely the thickness (TPL) and roughness (RPL) of the pleural line, and the accumulated with (AWBL) and acoustic coefficient (ACBL) of B lines. 27 patients are enrolled in this study, which are grouped into 13 moderate patients, 7 severe pati…
Seoul National University Hospital（首尔大学医院）；Massachusetts General Hospital（麻省总医院）；Kyungpook National University（庆北国立大学）；Yeungnam University College of Medicine（岭南大学医学院）；Catholic University of Daegu School of Medicine（大邱加图立大学医学院）；Keimyung University School of Medicine（启明大学医学院）
Purpose. Imaging plays an important role in assessing severity of COVID 19 pneumonia. However, semantic interpretation of chest radiography (CXR) findings does not include quantitative description of radiographic opacities. Most current AI assisted CXR image analysis framework do not quantify for regional variations of disease. To address these, we proposed a four region lung segmentation method to assist accurate quantification of COVID 19 pneumonia. Methods. A segmentation model to separate left and right lung is firstly applied, and then a carina and left hilum detection network is used, wh…
Imperial College London（伦敦帝国理工学院）；Imperial College NHS Trust（帝国理工学院国民医疗服务信托）
Automated lobar segmentation allows regional evaluation of lung disease and is important for diagnosis and therapy planning. Advanced statistical workflows permitting such evaluation is a needed area within respiratory medicine; their adoption remains slow, with poor workflow accuracy. Diseased lung regions often produce high-density zones on CT images, limiting an algorithm's execution to specify damaged lobes due to oblique or lacking fissures. This impact motivated developing an improved machine learning method to segment lung lobes that utilises tracheobronchial tree information to enhance…
COVID-19 is a new pulmonary disease which is driving stress to the hospitals due to the large number of cases worldwide. Imaging of lungs can play a key role in monitoring of the healthy status. Non-contrast chest computed tomography (CT) has been used for this purpose, mainly in China, with a significant success. However, this approach cannot be used massively mainly for both high risk and cost and in some countries also because this tool is not extensively available. Alternatively, chest X-ray, although less sensitive than CT-scan, can provide important information about the evolution of pul…
4D VQ-GAN: Synthesising Medical Scans at Any Time Point for Personalised Disease Progression Modelling of Idiopathic Pulmonary Fibrosis
Hawkes Institute, University College London（伦敦大学学院霍克斯研究所）；Department of Computer Science, University College London（伦敦大学学院计算机科学系）；Department of Med. Physics & Biomedical Engineering, University College London（伦敦大学学院医学物理与生物医学工程系）；Department of Respiratory Medicine, University Hospitals Leuven（鲁汶大学医院呼吸医学科）；NIHR Southampton Biomedical Research Centre and Clinical and Experimental Sciences, University of Southampton（南安普顿大学NIHR南安普顿生物医学研究中心与临床与实验科学系）；UCL Respiratory, University College London（伦敦大学学院呼吸科）
Lung X-ray images, if processed using statistical and computational methods, can distinguish pneumonia from COVID-19. The present work shows that it is possible to extract lung X-ray characteristics to improve the methods of examining and diagnosing patients with suspected COVID-19, distinguishing them from malaria, dengue, H1N1, tuberculosis, and Streptococcus pneumonia. More precisely, an intelligent computational model was developed to process lung X-ray images and classify whether the image is of a patient with COVID-19. The images were processed and extracted their characteristics. These …
Stony Brook University（石溪大学）；Stony Brook University Hospital（石溪大学医院）
Significant work has been done towards deep learning (DL) models for automatic lung and lesion segmentation and classification of COVID-19 on chest CT data. However, comprehensive visualization systems focused on supporting the dual visual+DL diagnosis of COVID-19 are non-existent. We present COVID-view, a visualization application specially tailored for radiologists to diagnose COVID-19 from chest CT data. The system incorporates a complete pipeline of automatic lungs segmentation, localization/ isolation of lung abnormalities, followed by visualization, visual and DL analysis, and measuremen…
In the research, we developed a computer vision solution to support diagnostic radiology in differentiating between COVID-19 pneumonia, influenza virus pneumonia, and normal biomarkers. The chest radiograph appearance of COVID-19 pneumonia is thought to be nonspecific, having presented a challenge to identify an optimal architecture of a convolutional neural network (CNN) that would classify with a high sensitivity among the pulmonary inflammation features of COVID-19 and non-COVID-19 types of pneumonia. Rahman (2021) states that COVID-19 radiography images observe unavailability and quality i…
In this paper, a 3D-RegNet-based neural network is proposed for diagnosing the physical condition of patients with coronavirus (Covid-19) infection. In the application of clinical medicine, lung CT images are utilized by practitioners to determine whether a patient is infected with coronavirus. However, there are some laybacks can be considered regarding to this diagnostic method, such as time consuming and low accuracy. As a relatively large organ of human body, important spatial features would be lost if the lungs were diagnosed utilizing two dimensional slice image. Therefore, in this paper…
Zhejiang University（浙江大学）；the First Affiliated Hospital, Zhejiang University（浙江大学附属第一医院）；Wenzhou central Hospital（温州中心医院）；First People's Hospital of Wenling（温岭市第一人民医院）；Hangzhou AiSmart-Image-Cloud-Analysis Co., Ltd.（杭州智影云分析科技有限公司）；College of Medicine, Zhejiang University（浙江大学医学院）
We found that the real time reverse transcription-polymerase chain reaction (RT-PCR) detection of viral RNA from sputum or nasopharyngeal swab has a relatively low positive rate in the early stage to determine COVID-19 (named by the World Health Organization). The manifestations of computed tomography (CT) imaging of COVID-19 had their own characteristics, which are different from other types of viral pneumonia, such as Influenza-A viral pneumonia. Therefore, clinical doctors call for another early diagnostic criteria for this new type of pneumonia as soon as possible.This study aimed to estab…
Multi-site, Multi-domain Airway Tree Modeling (ATM'22): A Public Benchmark for Pulmonary Airway Segmentation
Shanghai Jiao Tong University（上海交通大学）；InferVision Medical Technology Co., Ltd.（推想医疗科技股份有限公司）；University of California, Los Angeles（加州大学洛杉矶分校）；Imperial College London（帝国理工学院）
University of Saskatchewan（萨斯喀彻温大学）；University of Stanford（斯坦福大学）
The newly identified Coronavirus pneumonia, subsequently termed COVID-19, is highly transmittable and pathogenic with no clinically approved antiviral drug or vaccine available for treatment. The most common symptoms of COVID-19 are dry cough, sore throat, and fever. Symptoms can progress to a severe form of pneumonia with critical complications, including septic shock, pulmonary edema, acute respiratory distress syndrome and multi-organ failure. While medical imaging is not currently recommended in Canada for primary diagnosis of COVID-19, computer-aided diagnosis systems could assist in the …
Korea University（高丽大学）；George Washington University（乔治华盛顿大学）
Coronavirus disease 2019 (COVID-19) is an ongoing global pandemic that has spread rapidly since December 2019. Real-time reverse transcription polymerase chain reaction (rRT-PCR) and chest computed tomography (CT) imaging both play an important role in COVID-19 diagnosis. Chest CT imaging offers the benefits of quick reporting, a low cost, and high sensitivity for the detection of pulmonary infection. Recently, deep-learning-based computer vision methods have demonstrated great promise for use in medical imaging applications, including X-rays, magnetic resonance imaging, and CT imaging. Howeve…
Chest computed tomography (CT) is widely used for the management of Coronavirus disease 2019 (COVID-19) pneumonia because of its availability and rapidity. The standard of reference for confirming COVID-19 relies on microbiological tests but these tests might not be available in an emergency setting and their results are not immediately available, contrary to CT. In addition to its role for early diagnosis, CT has a prognostic role by allowing visually evaluating the extent of COVID-19 lung abnormalities. The objective of this study is to address prediction of short-term outcomes, especially n…
Korea Advanced Institute of Science and Technology (KAIST)（韩国科学技术院）
Under the global pandemic of COVID-19, the use of artificial intelligence to analyze chest X-ray (CXR) image for COVID-19 diagnosis and patient triage is becoming important. Unfortunately, due to the emergent nature of the COVID-19 pandemic, a systematic collection of the CXR data set for deep neural network training is difficult. To address this problem, here we propose a patch-based convolutional neural network approach with a relatively small number of trainable parameters for COVID-19 diagnosis. The proposed method is inspired by our statistical analysis of the potential imaging biomarkers…
The novel coronavirus 2019 (COVID-19) is a respiratory syndrome that resembles pneumonia. The current diagnostic procedure of COVID-19 follows reverse-transcriptase polymerase chain reaction (RT-PCR) based approach which however is less sensitive to identify the virus at the initial stage. Hence, a more robust and alternate diagnosis technique is desirable. Recently, with the release of publicly available datasets of corona positive patients comprising of computed tomography (CT) and chest X-ray (CXR) imaging; scientists, researchers and healthcare experts are contributing for faster and autom…
VinUniversity（文大大学）；Vinmec International Hospital（Vinmec国际医院）
The COVID-19 pandemic has exposed the vulnerability of healthcare services worldwide, raising the need to develop novel tools to provide rapid and cost-effective screening and diagnosis. Clinical reports indicated that COVID-19 infection may cause cardiac injury, and electrocardiograms (ECG) may serve as a diagnostic biomarker for COVID-19. This study aims to utilize ECG signals to detect COVID-19 automatically. We propose a novel method to extract ECG signals from ECG paper records, which are then fed into a one-dimensional convolution neural network (1D-CNN) to learn and diagnose the disease…
University of Cambridge（剑桥大学）；Indian Institute of Technology Madras（马德拉斯印度理工学院）；Indian Institute of Technology Patna（巴特那印度理工学院）；Kalinga Institute of Industrial Technology Bhubaneswar（布巴内斯瓦尔卡林加工业技术学院）
This paper introduces a paradigm of smartphone application based disease diagnostics that may completely revolutionise the way healthcare services are being provided. Although primarily aimed to assist the problems in rendering the healthcare services during the coronavirus pandemic, the model can also be extended to identify the exact disease that the patient is caught with from a broad spectrum of pulmonary diseases. The app inputs Chest X-Ray images captured from the mobile camera which is then relayed to the AI architecture in a cloud platform, and diagnoses the disease with state of the a…
Qatar University（卡塔尔大学）；Bangladesh University of Engineering and Technology（孟加拉国工程技术大学）；Reem Medical Center（Reem医疗中心）；Hamad General Hospital（哈马德综合医院）；Weill Cornell Medicine - Qatar（威尔康奈尔医学院卡塔尔分校）
Coronavirus disease 2019 (COVID-19) has been the main agenda of the whole world, since it came into sight in December 2019 as it has significantly affected the world economy and healthcare system. Given the effects of COVID-19 on pulmonary tissues, chest radiographic imaging has become a necessity for screening and monitoring the disease. Numerous studies have proposed Deep Learning approaches for the automatic diagnosis of COVID-19. Although these methods achieved astonishing performance in detection, they have used limited chest X-ray (CXR) repositories for evaluation, usually with a few hun…
Multimodal Deformable Image Registration for Long-COVID Analysis Based on Progressive Alignment and Multi-perspective Loss
University of Oxford（牛津大学）；Nuffield Department of Population Health, University of Oxford（牛津大学纳菲尔德人口健康系）；Big Data Institute, University of Oxford（牛津大学大数据研究所）；Oxford University Hospitals NHS Foundation Trust（牛津大学医院 NHS 基金会信托基金）；Oxford Radiology Research Unit（牛津放射学研究单元）
National Library of Medicine, National Institutes of Health（美国国立卫生研究院国家医学图书馆）
Chest X-ray (CXR) is a widely performed radiology examination that helps to detect abnormalities in the tissues and organs in the thoracic cavity. Detecting pulmonary abnormalities like COVID-19 may become difficult due to that they are obscured by the presence of bony structures like the ribs and the clavicles, thereby resulting in screening/diagnostic misinterpretations. Automated bone suppression methods would help suppress these bony structures and increase soft tissue visibility. In this study, we propose to build an ensemble of convolutional neural network models to suppress bones in fro…
The infection of respiratory coronavirus disease 2019 (COVID-19) starts with the upper respiratory tract and as the virus grows, the infection can progress to lungs and develop pneumonia. The conventional way of COVID-19 diagnosis is reverse transcription polymerase chain reaction (RT-PCR), which is less sensitive during early stages; especially if the patient is asymptomatic, which may further cause more severe pneumonia. In this context, several deep learning models have been proposed to identify pulmonary infections using publicly available chest X-ray (CXR) image datasets for early diagnos…
Université de Haute-Alsace（上阿尔萨斯大学）；Université de Strasbourg（斯特拉斯堡大学）；University of Lille（里尔大学）；YNCREA-ISEN Lille（里尔YNCREA-ISEN工程学院）；University of the Basque Country（巴斯克大学）；IKERBASQUE, Basque Foundation for Science（伊克尔巴斯克巴斯克科学基金会）；The University of Tokyo（东京大学）；CNRS（法国国家科学研究中心）；Inserm（法国国家健康与医学研究院）；CHU Lille（里尔大学医院）
Coronavirus disease 2019 (COVID-19) is an infectious disease with first symptoms similar to the flu. COVID-19 appeared first in China and very quickly spreads to the rest of the world, causing then the 2019-20 coronavirus pandemic. In many cases, this disease causes pneumonia. Since pulmonary infections can be observed through radiography images, this paper investigates deep learning methods for automatically analyzing query chest X-ray images with the hope to bring precision tools to health professionals towards screening the COVID-19 and diagnosing confirmed patients. In this context, traini…
School of Data Science, Fudan University（复旦大学数据科学学院）；School of Computer Science, Fudan University（复旦大学计算机科学学院）；Shanghai Public Health Clinical Center, Fudan University（复旦大学附属公共卫生临床中心）；AIMOMICS (BVI) Holdings Limited（AIMOMICS（BVI）控股有限公司）
The Coronavirus disease 2019 (COVID-19) has affected several million people. With the outbreak of the epidemic, many researchers are devoting themselves to the COVID-19 screening system. The standard practices for rapid risk screening of COVID-19 are the CT imaging or RT-PCR (real-time polymerase chain reaction). However, these methods demand professional efforts of the acquisition of CT images and saliva samples, a certain amount of waiting time, and most importantly prohibitive examination fee in some countries. Recently, some literatures have shown that the COVID-19 patients usually accompa…
University of Waterloo（滑铁卢大学）；National Research Council Canada（加拿大国家研究委员会）；Oakville Trafalgar Memorial Hospital（奥克维尔特拉法加纪念医院）；McMaster University（麦克马斯特大学）；Waterloo Artificial Intelligence Institute（滑铁卢人工智能研究所）
The Coronavirus Disease 2019 (COVID-19) pandemic has impacted many aspects of life globally, and a critical factor in mitigating its effects is screening individuals for infections, thereby allowing for both proper treatment for those individuals as well as action to be taken to prevent further spread of the virus. Point-of-care ultrasound (POCUS) imaging has been proposed as a screening tool as it is a much cheaper and easier to apply imaging modality than others that are traditionally used for pulmonary examinations, namely chest x-ray and computed tomography. Given the scarcity of expert ra…
The Coronavirus Disease (COVID-19) has affected 1.8 million people and resulted in more than 110,000 deaths as of April 12, 2020. Several studies have shown that tomographic patterns seen on chest Computed Tomography (CT), such as ground-glass opacities, consolidations, and crazy paving pattern, are correlated with the disease severity and progression. CT imaging can thus emerge as an important modality for the management of COVID-19 patients. AI-based solutions can be used to support CT based quantitative reporting and make reading efficient and reproducible if quantitative biomarkers, such a…
One of the main challenges in times of sanitary emergency is to quickly develop computer aided diagnosis systems with a limited number of available samples due to the novelty, complexity of the case and the urgency of its implementation. This is the case during the current pandemic of COVID-19. This pathogen primarily infects the respiratory system of the afflicted, resulting in pneumonia and in a severe case of acute respiratory distress syndrome. This results in the formation of different pathological structures in the lungs that can be detected by the use of chest X-rays. Due to the overloa…
University of Maryland, Baltimore County（马里兰大学巴尔的摩县分校）；University of Miami（迈阿密大学）；National Institutes of Health Clinical Center（美国国立卫生研究院临床中心）；Networking Health（网络健康）
We present a novel algorithm that is able to classify COVID-19 pneumonia from CT Scan slices using a very small sample of training images exhibiting COVID-19 pneumonia in tandem with a larger number of normal images. This algorithm is able to achieve high classification accuracy using as few as 10 positive training slices (from 10 positive cases), which to the best of our knowledge is one order of magnitude fewer than the next closest published work at the time of writing. Deep learning with extremely small positive training volumes is a very difficult problem and has been an important topic d…
Lister Hill National Center for Biomedical Communications, National Library of Medicine（美国国家医学图书馆利斯特·希尔国家生物医学通信中心）；Takeda Pharmaceuticals（武田制药）；Saint Louis University（圣路易斯大学）；National Institutes of Health（美国国立卫生研究院）；Walt Whitman High School（沃尔特·惠特曼高中）
We demonstrate use of iteratively pruned deep learning model ensembles for detecting pulmonary manifestation of COVID-19 with chest X-rays. This disease is caused by the novel Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) virus, also known as the novel Coronavirus (2019-nCoV). A custom convolutional neural network and a selection of ImageNet pretrained models are trained and evaluated at patient-level on publicly available CXR collections to learn modality-specific feature representations. The learned knowledge is transferred and fine-tuned to improve performance and generalizat…
The Coronavirus (COVID-19), which is an infectious pulmonary disorder, has affected millions of people and has been declared as a global pandemic by the WHO. Due to highly contagious nature of COVID-19 and its high possibility of causing severe conditions in the patients, the development of rapid and accurate diagnostic tools have gained importance. The real-time reverse transcription-polymerize chain reaction (RT-PCR) is used to detect the presence of Coronavirus RNA by using the mucus and saliva mixture samples. But, RT-PCR suffers from having low-sensitivity especially in the early stage. T…
Rensselaer Polytechnic Institute（伦斯勒理工学院）；Massachusetts General Hospital（麻省总医院）；Harvard Medical School（哈佛医学院）；Firoozgar Hospital（菲鲁兹加尔医院）；Iran University of Medical Sciences（伊朗医科大学）；Azienda Ospedaliero-universitaria di Cagliari（卡利亚里大学医院）
While image analysis of chest computed tomography (CT) for COVID-19 diagnosis has been intensively studied, little work has been performed for image-based patient outcome prediction. Management of high-risk patients with early intervention is a key to lower the fatality rate of COVID-19 pneumonia, as a majority of patients recover naturally. Therefore, an accurate prediction of disease progression with baseline imaging at the time of the initial presentation can help in patient management. In lieu of only size and volume information of pulmonary abnormalities and features through deep learning…
ETH Zurich（苏黎世联邦理工学院）；Medizinische Hochschule Brandenburg Theodor Fontane（勃兰登堡特奥多尔·冯塔纳医学院）
Controlling the COVID-19 pandemic largely hinges upon the existence of fast, safe, and highly-available diagnostic tools. Ultrasound, in contrast to CT or X-Ray, has many practical advantages and can serve as a globally-applicable first-line examination technique. We provide the largest publicly available lung ultrasound (US) dataset for COVID-19 consisting of 106 videos from three classes (COVID-19, bacterial pneumonia, and healthy controls); curated and approved by medical experts. On this dataset, we perform an in-depth study of the value of deep learning methods for differential diagnosis …
National Research Council Canada（加拿大国家研究委员会）；University of Waterloo（滑铁卢大学）；Ford Motor Company（福特汽车公司）
Chest radiography is an effective screening tool for diagnosing pulmonary diseases. In computer-aided diagnosis, extracting the relevant region of interest, i.e., isolating the lung region of each radiography image, can be an essential step towards improved performance in diagnosing pulmonary disorders. Methods: In this work, we propose a deep learning approach to enhance abnormal chest x-ray (CXR) identification performance through segmentations. Our approach is designed in a cascaded manner and incorporates two modules: a deep neural network with criss-cross attention modules (XLSor) for loc…
An Empirical Analysis for Zero-Shot Multi-Label Classification on COVID-19 CT Scans and Uncurated Reports
ARTORG Center for Biomedical Engineering Research（ARTORG生物医学工程研究中心）；University of Bern（伯尔尼大学）；Bern University Hospital（伯尔尼大学医院）；Lindenhofspital（林登霍夫医院）；Campus Stiftung Lindenhof Bern（伯尔尼林登霍夫基金会校区）
Predicting Lethal Outcome (Cause) And Understanding Key Biomarkers Linked With Acute Myocardial Infarction Using Deep Artificial Neural Network And Ensemble Of Machine Learning Methodologies
Nanjing University（南京大学）；National Institute of Healthcare Data Science at Nanjing University（南京大学医疗健康数据科学国家研究院）；Central South University（中南大学）；Second Xiangya Hospital, Central South University（中南大学湘雅二医院）；University of North Carolina（北卡罗来纳大学）
Understanding chest CT imaging of the coronavirus disease 2019 (COVID-19) will help detect infections early and assess the disease progression. Especially, automated severity assessment of COVID-19 in CT images plays an essential role in identifying cases that are in great need of intensive clinical care. However, it is often challenging to accurately assess the severity of this disease in CT images, due to variable infection regions in the lungs, similar imaging biomarkers, and large inter-case variations. To this end, we propose a synergistic learning framework for automated severity assessm…
University of Copenhagen（哥本哈根大学）；Cerebriu AS（Cerebriu公司）；Technical University of Denmark（丹麦技术大学）
Pulmonary opacification is the inflammation in the lungs caused by many respiratory ailments, including the novel corona virus disease 2019 (COVID-19). Chest X-rays (CXRs) with such opacifications render regions of lungs imperceptible, making it difficult to perform automated image analysis on them. In this work, we focus on segmenting lungs from such abnormal CXRs as part of a pipeline aimed at automated risk scoring of COVID-19 from CXRs. We treat the high opacity regions as missing data and present a modified CNN-based image segmentation network that utilizes a deep generative model for dat…
Qatar University（卡塔尔大学）；North South University（北南大学）；University of South Carolina（南卡罗来纳大学）；Hamad General Hospital（哈马德综合医院）；AFG College with the University of Aberdeen（阿伯丁大学AFG学院）
Fast and accurate detection of the disease can significantly help in reducing the strain on the healthcare facility of any country to reduce the mortality during any pandemic. The goal of this work is to create a multimodal system using a novel machine learning framework that uses both Chest X-ray (CXR) images and clinical data to predict severity in COVID-19 patients. In addition, the study presents a nomogram-based scoring technique for predicting the likelihood of death in high-risk patients. This study uses 25 biomarkers and CXR images in predicting the risk in 930 COVID-19 patients admitt…
One of the symptoms of Parkinson's disease (PD) is hypomimia or reduced facial expressions. In this paper, we present a digital biomarker for PD that utilizes the study of micro-expressions. We analyzed the facial action units (AU) from 1812 videos of 604 individuals (61 with PD and 543 without PD, mean age 63.9 yo, sd 7.8 ) collected online using a web-based tool (www.parktest.net). In these videos, participants were asked to make three facial expressions (a smiling, disgusted, and surprised face) followed by a neutral face. Using techniques from computer vision and machine learning, we objec…
Comparative Analysis of Deep Learning Architectures for Multi-Disease Classification of Single-Label Chest X-rays
Department of Computer Science, College of Science, Charmo University（查莫大学计算机科学系，科学学院）；Department of Software Engineering, University of Raparin（拉帕林大学软件工程系）
Mannheim University of Applied Science（曼海姆应用科技大学）；UT Southwestern Medical Center（德克萨斯大学西南医学中心）；DZHK (German Centre for Cardiovascular Research)（德国心血管研究中心）；German Heart Centre Munich（慕尼黑德国心脏中心）；Hannover Medical School（汉诺威医学院）；Heidelberg University Hospital（海德堡大学医院）
Planning the optimal time of intervention for pulmonary valve replacement surgery in patients with the congenital heart disease Tetralogy of Fallot (TOF) is mainly based on ventricular volume and function according to current guidelines. Both of these two biomarkers are most reliably assessed by segmentation of 3D cardiac magnetic resonance (CMR) images. In several grand challenges in the last years, U-Net architectures have shown impressive results on the provided data. However, in clinical practice, data sets are more diverse considering individual pathologies and image properties derived fr…
