Coronary Artery Segmentation from Intravascular Optical Coherence Tomography Using Deep Capsules
Harry Perkins Institute of Medical Research（哈里·珀金斯医学研究所）；The University of Western Australia（西澳大利亚大学）；Royal Perth Hospital（皇家珀斯医院）；University of Ottawa Heart Institute（渥太华大学心脏研究所）；The University of Edinburgh（爱丁堡大学）
Arjun Balaji, Lachlan Kelsey, Kamran Majeed, Carl Schultz, Barry Doyle
备注：
This version has been accepted in Artificial Intelligence in Medicine. Main paper: 28 pages, 9 figures, 4 tables. Supplementary Material: 3 pages, 3 figures
The segmentation and analysis of coronary arteries from intravascular optical coherence tomography (IVOCT) is an important aspect of diagnosing and managing coronary artery disease. Current image processing methods are hindered by the time needed to generate expert-labelled datasets and the potential for bias during the analysis. Therefore, automated, robust, unbiased and timely geometry extraction from IVOCT, using image processing, would be beneficial to clinicians. With clinical application in mind, we aim to develop a model with a small memory footprint that is fast at inference time without sacrificing segmentation quality. Using a large IVOCT dataset of 12,011 expert-labelled images from 22 patients, we construct a new deep learning method based on capsules which automatically produces lumen segmentations. Our dataset contains images with both blood and light artefacts (22.8%), as well as metallic (23.1%) and bioresorbable stents (2.5%). We split the dataset into a training (70%), validation (20%) and test (10%) set and rigorously investigate design variations with respect to upsampling regimes and input selection. We show that our developments lead to a model, DeepCap, that is on par with state-of-the-art machine learning methods in terms of segmentation quality and robustness, while using as little as 12% of the parameters. This enables DeepCap to have per image inference times up to 70% faster on GPU and up to 95% faster on CPU compared to other state-of-the-art models. DeepCap is a robust automated segmentation tool that can aid clinicians to extract unbiased geometrical data from IVOCT.
The Ohio State University College of Medicine（俄亥俄州立大学医学院）
We propose a fully automated algorithm based on a deep learning framework enabling screening of a coronary computed tomography angiography (CCTA) examination for confident detection of the presence or absence of coronary artery atherosclerosis. The system starts with extracting the coronary arteries and their branches from CCTA datasets and representing them with multi-planar reformatted volumes; pre-processing and augmentation techniques are then applied to increase the robustness and generalization ability of the system. A 3-dimensional convolutional neural network (3D-CNN) is utilized to mo…
Friedrich-Alexander-University Erlangen-Nuremberg（埃尔朗根-纽伦堡弗里德里希-亚历山大大学）；Siemens Healthineers（西门子医疗）；University Clinic Frankfurt（法兰克福大学诊所）；Cardioangiological Centrum Bethanien（贝塔宁心血管中心）
Analysing coronary artery plaque segments with respect to their functional significance and therefore their influence to patient management in a non-invasive setup is an important subject of current research. In this work we compare and improve three deep learning algorithms for this task: A 3D recurrent convolutional neural network (RCNN), a 2D multi-view ensemble approach based on texture analysis, and a newly proposed 2.5D approach. Current state of the art methods utilising fluid dynamics based fractional flow reserve (FFR) simulation reach an AUC of up to 0.93 for the task of predicting a…
Case Western Reserve University（凯斯西储大学）；The Hashemite University（哈希姆大学）；University Hospitals Cleveland Medical Center（克利夫兰大学医院医学中心）；Florida Institute of Technology（佛罗里达理工学院）；University of South Florida（南佛罗里达大学）
BACKGROUND Careful evaluation of the risk of stent under-expansions before the intervention will aid treatment planning, including the application of a pre-stent plaque modification strategy. OBJECTIVES It remains challenging to achieve a proper stent expansion in the presence of severely calcified coronary lesions. Building on our work in deep learning segmentation, we created an automated machine learning approach that uses lesion attributes to predict stent under-expansion from pre-stent images, suggesting the need for plaque modification. METHODS Pre- and post-stent intravascular optical c…
ImageCAS: A Large-Scale Dataset and Benchmark for Coronary Artery Segmentation based on Computed Tomography Angiography Images
Guangdong University of Technology（广东工业大学）；Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences)（广东省人民医院（广东省医学科学院））；Southern Medical University（南方医科大学）；Missouri University of Science and Technology（密苏里科技大学）
Utilizing AI Language Models to Identify Prognostic Factors for Coronary Artery Disease: A Study in Mashhad Residents
University of Turin（都灵大学）；Golestan University of Medical Sciences（戈勒斯坦医科大学）；Macquarie University（麦考瑞大学）；Mashhad University of Medical Sciences（马什哈德医科大学）
Metabolomic data can potentially enable accurate, non-invasive and low-cost prediction of coronary artery disease. Regression-based analytical approaches however might fail to fully account for interactions between metabolites, rely on a priori selected input features and thus might suffer from poorer accuracy. Supervised machine learning methods can potentially be used in order to fully exploit the dimensionality and richness of the data. In this paper, we systematically implement and evaluate a set of supervised learning methods (L1 regression, random forest classifier) and compare them to t…
INESC-ID（里斯本系统与计算机工程研究所）；Instituto Superior Técnico, University of Lisbon（里斯本大学高等技术学院）；Lisbon School of Medicine, University of Lisbon（里斯本大学里斯本医学院）
Coronary X-ray angiography is a crucial clinical procedure for the diagnosis and treatment of coronary artery disease, which accounts for roughly 16% of global deaths every year. However, the images acquired in these procedures have low resolution and poor contrast, making lesion detection and assessment challenging. Accurate coronary artery segmentation not only helps mitigate these problems, but also allows the extraction of relevant anatomical features for further analysis by quantitative methods. Although automated segmentation of coronary arteries has been proposed before, previous approa…
Instituto Superior Técnico（高等技术学院）；University of Lisbon（里斯本大学）；CCUL（里斯本大学中心学院）；Lisbon School of Medicine（里斯本医学院）
Coronary artery disease leading up to stenosis, the partial or total blocking of coronary arteries, is a severe condition that affects millions of patients each year. Automated identification and classification of stenosis severity from minimally invasive procedures would be of great clinical value, but existing methods do not match the accuracy of experienced cardiologists, due to the complexity of the task. Although a number of computational approaches for quantitative assessment of stenosis have been proposed to date, the performance of these methods is still far from the required levels fo…
Friedrich-Alexander-Universität Erlangen-Nürnberg（埃尔朗根-纽伦堡弗里德里希-亚历山大大学）；Siemens Healthcare GmbH（西门子医疗有限公司）；University Clinic Frankfurt（法兰克福大学诊所）；Cardioangiological Centrum Bethanien（贝塔尼恩心血管中心）
Assessing coronary artery plaque segments in coronary CT angiography scans is an important task to improve patient management and clinical outcomes, as it can help to decide whether invasive investigation and treatment are necessary. In this work, we present three machine learning approaches capable of performing this task. The first approach is based on radiomics, where a plaque segmentation is used to calculate various shape-, intensity- and texture-based features under different image transformations. A second approach is based on deep learning and relies on centerline extraction as sole pr…
Applied Science Private University（应用科学私立大学）；University of Sharjah（沙迦大学）
Coronary Artery Disease (CAD) is one of the leading causes of death worldwide, and so it is very important to correctly diagnose patients with the disease. For medical diagnosis, machine learning is a useful tool, however features and algorithms must be carefully selected to get accurate classification. To this effect, three feature selection methods have been used on 13 input features from the Cleveland dataset with 297 entries, and 7 were selected. The selected features were used to train three different classifiers, which are SVM, Naïve Bayes and KNN using 10-fold cross-validation. The resu…
Case Western Reserve University（凯斯西储大学）；University Hospitals Cleveland Medical Center（克利夫兰大学医院医疗中心）；The Hashemite University（哈希姆大学）；University of South Florida（南佛罗里达大学）
Thin-cap fibroatheroma (TCFA) and plaque rupture have been recognized as the most frequent risk factor for thrombosis and acute coronary syndrome. Intravascular optical coherence tomography (IVOCT) can identify TCFA and assess cap thickness, which provides an opportunity to assess plaque vulnerability. We developed an automated method that can detect lipidous plaque and assess fibrous cap thickness in IVOCT images. This study analyzed a total of 4,360 IVOCT image frames of 77 lesions among 41 patients. To improve segmentation performance, preprocessing included lumen segmentation, pixel-shifti…
Learning Hemodynamic Scalar Fields on Coronary Artery Meshes: A Benchmark of Geometric Deep Learning Models
Politecnico di Milano（米兰理工大学）；University of Twente（特文特大学）；Centro Cardiologico Monzino IRCCS（蒙齐诺心脏中心IRCCS）；University of Milan（米兰大学）；Amsterdam UMC（阿姆斯特丹大学医学中心）；University of Amsterdam（阿姆斯特丹大学）
From a fresh data science perspective, this thesis discusses the prediction of coronary artery disease based on genetic variations at the DNA base pair level, called Single-Nucleotide Polymorphisms (SNPs), collected from the Ontario Heart Genomics Study (OHGS). First, the thesis explains two commonly used supervised learning algorithms, the k-Nearest Neighbour (k-NN) and Random Forest classifiers, and includes a complete proof that the k-NN classifier is universally consistent in any finite dimensional normed vector space. Second, the thesis introduces two dimensionality reduction steps, Rando…
University of Birjand（比尔詹德大学）；Maragheh Faculty of Medical Sciences（马拉盖医科大学）；Queensland University of Technology（昆士兰科技大学）；Bauhaus Universität-Weimar（魏玛包豪斯大学）；Obuda University（奥布达大学）；Duy Tan University（越南大智大学）；Ton Duc Thang University（东德大学）
Heart disease is one of the most common diseases in middle-aged citizens. Among the vast number of heart diseases, the coronary artery disease (CAD) is considered as a common cardiovascular disease with a high death rate. The most popular tool for diagnosing CAD is the use of medical imaging, e.g., angiography. However, angiography is known for being costly and also associated with a number of side effects. Hence, the purpose of this study is to increase the accuracy of coronary heart disease diagnosis through selecting significant predictive features in order of their ranking. In this study, …
A Deep Learning Model for Coronary Artery Segmentation and Quantitative Stenosis Detection in Angiographic Images
School of Mathematical Sciences, Ocean University of China（中国海洋大学数学科学学院）；School of Haide, Ocean University of China（中国海洋大学海德学院）；School of Ocean and Atmosphere, Ocean University of China（中国海洋大学海洋与大气学院）；Qilu Hospital (Qingdao), Cheeloo College of Medicine, Shandong University（山东大学齐鲁医院（青岛））
Cross-Task Data Augmentation by Pseudo-label Generation for Region Based Coronary Artery Instance Segmentation
Nepal Applied Mathematics and Informatics Institute for research(NAAMII)（尼泊尔应用数学与信息学研究所）；Fogsphere(Redev AI Ltd.)（Fogsphere（Redev AI有限公司））；University of Lausanne（洛桑大学）；School of Natural and Computing Sciences, University of Aberdeen（阿伯丁大学自然与计算科学学院）
Coronary heart disease (CHD) is the leading cause of adult death in the United States and worldwide, and for which the coronary angiography procedure is the primary gateway for diagnosis and clinical management decisions. The standard-of-care for interpretation of coronary angiograms depends upon ad-hoc visual assessment by the physician operator. However, ad-hoc visual interpretation of angiograms is poorly reproducible, highly variable and bias prone. Here we show for the first time that fully-automated angiogram interpretation to estimate coronary artery stenosis is possible using a sequenc…
Machine learning prediction of obstructive coronary artery disease using opportunistic coronary calcium and epicardial fat assessments from CT calcium scoring scans
Department of Biomedical Engineering, Virginia Commonwealth University（弗吉尼亚联邦大学生物医学工程系）；Department of Biomedical Engineering, Case Western Reserve University（凯斯西储大学生物医学工程系）；Harrington Heart and Vascular Institute, University Hospitals Cleveland Medical Center（克利夫兰医学中心哈灵顿心脏和血管研究所）；BHF Centre for Cardiovascular Science, University of Edinburgh（爱丁堡大学BHF心血管科学中心）；Department of Radiology, Case Western Reserve University（凯斯西储大学放射学系）
In this paper, a novel method for lumen boundary identification is proposed using Neutrosophic c_means. This method clusters pixels of the intravascular optical coherence tomography image into several clusters using indeterminacy and Neutrosophic theory, which aims to detect the boundaries. Intravascular optical coherence tomography images are cross-sectional and high-resolution images which are taken from the coronary arterial wall. Coronary Artery Disease cause a lot of death each year. The first step for diagnosing this kind of diseases is to detect lumen boundary. Employing this approach, …
Massachusetts Institute of Technology（麻省理工学院）；Massachusetts General Hospital（麻省总医院）
Current clinical practice guidelines for managing Coronary Artery Disease (CAD) account for general cardiovascular risk factors. However, they do not present a framework that considers personalized patient-specific characteristics. Using the electronic health records of 21,460 patients, we created data-driven models for personalized CAD management that significantly improve health outcomes relative to the standard of care. We develop binary classifiers to detect whether a patient will experience an adverse event due to CAD within a 10-year time frame. Combining the patients' medical history an…
Georgia State University（佐治亚州立大学）；Emory University（埃默里大学）；University of North Georgia（北佐治亚大学）
Hospital Readmissions within 30 days after discharge following Coronary Artery Bypass Graft (CABG) Surgery are substantial contributors to healthcare costs. Many predictive models were developed to identify risk factors for readmissions. However, majority of the existing models use statistical analysis techniques with data available at discharge. We propose an ensembled model to predict CABG readmissions using pre-discharge perioperative data and machine learning survival analysis techniques. Firstly, we applied fifty one potential readmission risk variables to Cox Proportional Hazard (CPH) su…
Feature Selection (FS) has become the focus of much research on decision support systems areas for which data sets with tremendous number of variables are analyzed. In this paper we present a new method for the diagnosis of Coronary Artery Diseases (CAD) founded on Genetic Algorithm (GA) wrapped Bayes Naive (BN) based FS. Basically, CAD dataset contains two classes defined with 13 features. In GA BN algorithm, GA generates in each iteration a subset of attributes that will be evaluated using the BN in the second step of the selection procedure. The final set of attribute contains the most rele…
Recent years have seen growing interest in the diagnosis of Coronary Artery Disease (CAD) with machine learning methods to reduce the cost and health implications of conventional diagnosis. This paper introduces a CAD diagnosis method with a novel feature extraction technique called the Profile-Based Binary Feature Extraction (PBBFE). In this method, after partitioning numerical features, frequent itemsets are extracted by the Apriori algorithm and then used as features to increase the CAD diagnosis accuracy. The proposed method consists of two main phases. In the first phase, each patient is …
Physics-informed self-supervised learning for predictive modeling of coronary artery digital twins
Chair of Mathematical Data Science, EPFL, Lausanne, Switzerland（数学数据科学教授职位，苏黎世联邦理工学院，拉沃斯，瑞士）；LTS4 laboratory, EPFL, Lausanne, Switzerland（LTS4实验室，苏黎世联邦理工学院，拉沃斯，瑞士）；School of AI and Advanced Computing, Xi’an Jiaotong-Liverpool University, China（人工智能与高级计算学院，西安交通大学利物浦大学，中国）；Cardiology Department, Lausanne University Center Hospital, Lausanne, Switzerland（心血管科，拉沃斯大学中心医院，拉沃斯，瑞士）；OLV Hospital, Aalst, Belgium（OLV医院，阿尔斯特，比利时）；AI Center, EPFL, Lausanne, Switzerland（人工智能中心，苏黎世联邦理工学院，拉沃斯，瑞士）
A machine learning approach for Premature Coronary Artery Disease Diagnosis according to Different Ethnicities in Iran
Fasa University（法萨大学）；Deakin University（迪肯大学）；Queensland University of Technology（昆士兰科技大学）；Isfahan University of Medical Sciences（伊斯法罕医科大学）；University of Tabriz（大不里士大学）；Iran University of Medical Sciences（伊朗医科大学）；University of British Columbia（不列颠哥伦比亚大学）
LASTIMI, High School of Technology Mohammed V University in Rabat Sale, Morocco；LASTIMI, Mohammedia School of Engineers Mohammed V University in Rabat Rabat, Morocco；CISIEV. Faculty of Science；Technology in Marrakech Cadi Ayyad University Marrakech, Morocco
Coronary artery disease (CAD) is one of the most common cardiac diseases worldwide and causes disability and economic burden. It is the world's leading and most serious cause of mortality, with approximately 80% of deaths reported in low- and middle-income countries. The preferred and most precise diagnostic tool for CAD is angiography, but it is invasive, expensive, and technically demanding. However, the research community is increasingly interested in the computer-aided diagnosis of CAD via the utilization of machine learning (ML) methods. The purpose of this work is to present an e-diagnos…
University of Birjand（比尔詹德大学）；Deakin University（迪肯大学）；Iran University of Medical Sciences（伊朗医科大学）；Omid hospital（奥米德医院）；Maragheh Faculty of Medical Sciences（马拉盖医学院）；Universiti Kebangsaan Malaysia（马来西亚国民大学）
Cardiovascular disease is one of the most challenging diseases in middle-aged and older people, which causes high mortality. Coronary artery disease (CAD) is known as a common cardiovascular disease. A standard clinical tool for diagnosing CAD is angiography. The main challenges are dangerous side effects and high angiography costs. Today, the development of artificial intelligence-based methods is a valuable achievement for diagnosing disease. Hence, in this paper, artificial intelligence methods such as neural network (NN), deep neural network (DNN), and Fuzzy C-Means clustering combined wit…
Hankuk University of Foreign Studies（韩国外国语大学）；Seoul National University Bundang Hospital（首尔大学盆唐医院）
The Coronary Artery Occlusion (CAO) acutely comes to human, and it highly threats the human's life. When CAO detected, Percutaneous Coronary Intervention (PCI) should be conducted timely. Before PCI, localizing the CAO is needed firstly, because the heart is covered with various arteries. We handle the three kinds of CAO in this paper and our purpose is not only localization of CAO but also improving the localizing performance via preprocessing method. We improve localization performance from a minimum of 0.150 to a maximum of 0.372 via our noise reduction and pulse extraction based method.
Machine Learning-Based Model for Postoperative Stroke Prediction in Coronary Artery Disease
University of Southern California（南加州大学）；Iran University of Medical Sciences（伊朗医科大学）；California State University, Long Beach (CSULB)（加州州立大学长滩分校）；California State Polytechnic University, Pomona（加州州立理工大学波莫纳分校）
GReAT: leveraging geometric artery data to improve wall shear stress assessment
Technical University of Munich（慕尼黑技术大学）；Munich Center for Machine Learning（慕尼黑机器学习中心）；Erasmus Medical Center（埃因霍温医学中心）；University of Twente（埃因霍温大学）；Imperial College London（伦敦帝国理工学院）
