In universal environment, a patient-friendly inexpensive method is needed to realize the early diagnosis of depression, which is believed to be an effective way to reduce the mortality of depression. The purpose of this study is only to collect EEG signal from three electrodes Fp1, Fpz and Fp2, then the linear and nonlinear features of EEG used to classify depression patients and healthy controls. The EEG recordings were carried out on a group of 18 medication-free depressive patients and 25 gender and age matched controls. In this paper, the selected features include three linear (maximum, mean and center values of the power) and three nonlinear features (correlation dimension, Renyi entropy and C0 complexity). The accuracy and effectiveness of classification model between depressive and control subjects were calculated using leave-one-out cross-validation. The experimental results indicate that selected three channel EEG and features can distinguish the subjects between depression and normal beings, the classification accuracy is 72.25%. It is hoped that the performed results can provide more choices for the early diagnosis of depression in a universal environment.
This study explores the responses to ketamine in patients with treatment-resistant depression (TRD) using a wearable forehead electroencephalography (EEG) device. We recruited fifty-five outpatients with TRD who were randomised into three approximately equal-sized groups (A: 0.5 mg/kg ketamine; B: 0.2 mg/kg ketamine; and C: normal saline) under double-blind conditions. The ketamine responses were measured by EEG signals and Hamilton Depression Rating Scale (HDRS) scores. At baseline, responders showed a significantly weaker EEG theta power than did non- responders (p < 0.05). Responders exhibi…
Effective analysis of EEG signals for potential clinical applications remains a challenging task. So far, the analysis and conditioning of EEG have largely remained sex-neutral. This paper employs a machine learning approach to explore the evidence of sex effects on EEG signals, and confirms the generality of these effects by achieving successful sex prediction of resting-state EEG signals. We have found that the brain connectivity represented by the coherence between certain sensor channels are good predictors of sex.
University of Belgrade（贝尔格莱德大学）；Amsterdam Health and Technology Institute（阿姆斯特丹健康与技术研究所）；HealthInc；Universidad Complutense（康普顿斯大学）
In this paper, we aimed at reviewing present literature on employing nonlinear analysis in combination with machine learning methods, in depression detection or prediction task. We are focusing on an affordable data-driven approach, applicable for everyday clinical practice, and in particular, those based on electroencephalographic (EEG) recordings. Among those studies utilizing EEG, we are discussing a group of applications used for detecting the depression based on the resting state EEG (detection studies) and interventional studies (using stimulus in their protocols or aiming to predict the…
Background: Depression has become a major health burden worldwide, and effective detection depression is a great public-health challenge. This Electroencephalography (EEG)-based research is to explore the effective biomarkers for depression recognition. Methods: Resting state EEG data was collected from 24 major depressive patients (MDD) and 29 normal controls using 128 channel HydroCel Geodesic Sensor Net (HCGSN). To better identify depression, we extracted different types of EEG features including linear features, nonlinear features and functional connectivity features phase lagging index (P…
iCV Lab, University of Tartu（塔尔图大学 iCV 实验室）；Biosignal Processing Laboratory, Tallinn University of Technology（塔林理工大学生物信号处理实验室）；Yildiz Technical University（耶尔德兹技术大学）
Depression is a public health issue which severely affects one's well being and cause negative social and economic effect for society. To rise awareness of these problems, this publication aims to determine if long lasting effects of depression can be determined from electoencephalographic (EEG) signals. The article contains accuracy comparison for SVM, LDA, NB, kNN and D3 binary classifiers which were trained using linear (relative band powers, APV, SASI) and non-linear (HFD, LZC, DFA) EEG features. The age and gender matched dataset consisted of 10 healthy subjects and 10 subjects with depre…
Resting state electroencephalogram (EEG) abnormalities in clinically high-risk individuals (CHR), clinically stable first-episode patients with schizophrenia (FES), healthy controls (HC) suggest alterations in neural oscillatory activity. However, few studies directly compare these anomalies among each types. Therefore, this study investigated whether these electrophysiological characteristics differentiate clinical populations from one another, and from non-psychiatric controls. To address this question, resting EEG power and coherence were assessed in 40 clinically high-risk individuals (CHR…
University of Rajshahi（拉杰沙希大学）；Hajee Mohammad Danesh Science and Technology University（哈吉·穆罕默德·达内什科技大学）；Deakin University（迪肯大学）；Charles Sturt University（查尔斯·斯特特大学）；COMSATS University Islamabad（伊斯兰堡COMSATS大学）
Historically, the analysis of stimulus-dependent time-frequency patterns has been the cornerstone of most electroencephalography (EEG) studies. The abnormal oscillations in high-frequency waves associated with psychotic disorders during sensory and cognitive tasks have been studied many times. However, any significant dissimilarity in the resting-state low-frequency bands is yet to be established. Spectral analysis of the alpha and delta band waves shows the effectiveness of stimulus-independent EEG in identifying the abnormal activity patterns of pathological brains. A generalized model incor…
Event-related potential (ERP) speller can be utilized in device control and communication for locked-in or severely injured patients. However, problems such as inter-subject performance instability and ERP-illiteracy are still unresolved. Therefore, it is necessary to predict classification performance before performing an ERP speller in order to use it efficiently. In this study, we investigated the correlations with ERP speller performance using a resting-state before an ERP speller. In specific, we used spectral power and functional connectivity according to four brain regions and five freq…
University of Stavanger（斯塔万格大学）；Stavanger University Hospital（斯塔万格大学医院）；Universidad de Antioquia（安蒂奥基亚大学）
Resting-state EEG (rs-EEG) has been demonstrated to aid in Parkinson's disease (PD) diagnosis. In particular, the power spectral density (PSD) of low-frequency bands (δ and θ) and high-frequency bands (α and \b{eta}) has been shown to be significantly different in patients with PD as compared to subjects without PD (non-PD). However, rs-EEG feature extraction and the interpretation thereof can be time-intensive and prone to examiner variability. Machine learning (ML) has the potential to automatize the analysis of rs-EEG recordings and provides a supportive tool for clinicians to ease their wo…
A Hybrid Deep Spatio-Temporal Attention-Based Model for Parkinson's Disease Diagnosis Using Resting State EEG Signals
École de technologie supérieure (ÉTS), Université du Québec（魁北克大学高等技术学院）；Dibrugarh University（Dibrugarh大学）；Vytautas Magnus University（维陶塔斯马格努斯大学）；University of Southern Queensland（南昆士兰大学）
Sabanci University（萨班哲大学）；Hacettepe University（哈塞特佩大学）；University of Rochester（罗切斯特大学）
Resting-state brain networks represent the intrinsic state of the brain during the majority of cognitive and sensorimotor tasks. However, no study has yet presented concise predictors of task-induced vigilance variability from spectrospatial features of the pre-task, resting-state electroencephalograms (EEG). We asked ten healthy volunteers (6 females, 4 males) to participate in 105-minute fixed-sequence-varying-duration sessions of sustained attention to response task (SART). A novel and adaptive vigilance scoring scheme was designed based on the performance and response time in consecutive t…
Baylor College of Medicine（贝勒医学院）；Michael E. DeBakey VA Medical Center（迈克尔·E·德贝基退伍军人事务医疗中心）
The Early diagnosis and treatment of depression is essential for effective treatment. Depression, while being one of the most common mental illnesses, is still poorly understood in both research and clinical practice. Among different treatments, drug prescription is widely used, however the drug treatment is not effective for many patients. In this work, we propose a method for major depressive disorder (MDD) diagnosis as well as a method for predicting the drug response in patient with MDD using EEG signals. Method: We employ transformers, which are modified recursive neural networks with nov…
Subject-independent Classification of Meditative State from the Resting State using EEG
Dept. of Elect. and Comm. Engg. College of Engineering Trivandrum（电子与通信工程系 工程学院特里凡布尔姆）；Centre for Brain Research Indian Institute of Science, Bangalore（脑研究中心印度科学研究院，班加罗尔）；Language Technologies Institute Carnegie Mellon University（语言技术研究所卡内基梅隆大学）；School of Psychology and Education Rishihood University, Sonipat（心理学与教育学院里希大学，索尼帕特）；Dept. of Heritage Science and Technology Indian Institute of Technology, Hyderabad（遗产科学与技术系印度理工学院，海得拉巴）
Integration of Simultaneous Resting-State Electroencephalography, Functional Magnetic Resonance Imaging, and Eye-Tracker Methods to Determine and Verify Electroencephalography Vigilance Measure
EEG is a non-invasive technique for recording brain bioelectric activity, which has potential applications in various fields such as human-computer interaction and neuroscience. However, there are many difficulties in analyzing EEG data, including its complex composition, low amplitude as well as low signal-to-noise ratio. Some of the existing methods of analysis are based on feature extraction and machine learning to differentiate the phase of schizophrenia that samples belong to. However, medical research requires the use of machine learning not only to give more accurate classification resu…
Prior studies have proposed methods to recover multi-channel electroencephalography (EEG) signal ensembles from their partially sampled entries. These methods depend on spatial scenarios, yet few approaches aiming to a temporal reconstruction with lower loss. The goal of this study is to retrieve the temporal EEG signals independently which was overlooked in data pre-processing. We considered EEG signals are impinging on tensor-based approach, named nonlinear Canonical Polyadic Decomposition (CPD). In this study, we collected EEG signals during a resting-state task. Then, we defined that the s…
X, the Moonshot Factory（X，登月工厂）；DeepMind（深度心智）；Florida State University（佛罗里达州立大学）
Despite extensive standardization, diagnostic interviews for mental health disorders encompass substantial subjective judgment. Previous studies have demonstrated that EEG-based neural measures can function as reliable objective correlates of depression, or even predictors of depression and its course. However, their clinical utility has not been fully realized because of 1) the lack of automated ways to deal with the inherent noise associated with EEG data at scale, and 2) the lack of knowledge of which aspects of the EEG signal may be markers of a clinical disorder. Here we adapt an unsuperv…
Time-Resolved EEG Decoding of Semantic Processing Reveals Altered Neural Dynamics in Depression and Suicidality
Alfred E. Mann Department of Biomedical Engineering, University of Southern California（阿尔弗雷德·E·曼生物医学工程系，南加州大学）；Ming Hsieh Department of Electrical and Computer Engineering, University of Southern California（明世系电气与计算机工程系，南加州大学）；Thomas Lord Department of Computer Science, University of Southern California（托马斯·洛德计算机科学系，南加州大学）；Brain and Creativity Institute, University of Southern California（创造力与大脑研究所，南加州大学）；Department of Psychology, University of Southern California（心理学系，南加州大学）；Information Science Institute, University of Southern California（信息科学研究所，南加州大学）；Department of Psychiatry and Behavioral Sciences, University of Southern California（精神病学与行为科学系，南加州大学）；Department of Psychology, University of California, Los Angeles（心理学系，加州大学洛杉矶分校）；Department of Linguistics, University of Southern California（语言学系，南加州大学）
Northeastern University（东北大学）；Graz University of Technology（格拉茨工业大学）
Recent promises of generative deep learning lately brought interest to its potential uses in neural engineering. In this paper we firstly review recently emerging studies on generating artificial electroencephalography (EEG) signals with deep neural networks. Subsequently, we present our feasibility experiments on generating condition-specific multichannel EEG signals using conditional variational autoencoders. By manipulating real resting-state EEG epochs, we present an approach to synthetically generate time-series multichannel signals that show spectro-temporal EEG patterns which are expect…
COMSATS University Islamabad（伊斯兰堡COMSATS大学）；University of Okara（奥卡拉大学）；Ca’ Foscari University of Venice（威尼斯大学）；Ege University（埃格大学）；Université Paris-Est Créteil (UPEC)（巴黎东克雷泰伊大学（UPEC））
Mental disorders represent critical public health challenges as they are leading contributors to the global burden of disease and intensely influence social and financial welfare of individuals. The present comprehensive review concentrate on the two mental disorders: Major depressive Disorder (MDD) and Bipolar Disorder (BD) with noteworthy publications during the last ten years. There is a big need nowadays for phenotypic characterization of psychiatric disorders with biomarkers. Electroencephalography (EEG) signals could offer a rich signature for MDD and BD and then they could improve under…
Depression is a common psychiatric disorder, which causes significant patient distress. Bipolar disorder is characterized by mood fluctuations between depression and mania. Unipolar and bipolar depression can be easily confused because of similar symptom profiles, but their adequate treatment plans are different. Therefore, a precise data-driven diagnosis is essential for successful treatment. In order to aid diagnosis, research applied machine learning to brain imaging data, in particular to electroencephalography (EEG), with accuracies reaching 99.5% (unipolar vs. healthy) or 85% (bipolar vs…
Mild Traumatic Brain Injury (mTBI) is a common brain injury and affects a diverse group of people: soldiers, constructors, athletes, drivers, children, elders, and nearly everyone. Thus, having a well-established, fast, cheap, and accurate classification method is crucial for the well-being of people around the globe. Luckily, using Machine Learning (ML) on electroencephalography (EEG) data shows promising results. This survey analyzed the most cutting-edge articles from 2017 to the present. The articles were searched from the Google Scholar database and went through an elimination process bas…
Indian Institute of Technology, Madras（印度理工学院马德拉斯分校）
Speech cognition bears potential application as a brain computer interface that can improve the quality of life for the otherwise communication impaired people. While speech and resting state EEG are popularly studied, here we attempt to explore a "non-speech"(NS) state of brain activity corresponding to the silence regions of speech audio. Firstly, speech perception is studied to inspect the existence of such a state, followed by its identification in speech imagination. Analogous to how voice activity detection is employed to enhance the performance of speech recognition, the EEG state activ…
University of Stavanger（斯塔万格大学）；Stavanger University Hospital（斯塔万格大学医院）；Universidad de Antioquia（安蒂奥基亚大学）
As the number of automatic tools based on machine learning (ML) and resting-state electroencephalography (rs-EEG) for Parkinson's disease (PD) detection keeps growing, the assessment of possible exacerbation of health disparities by means of fairness and bias analysis becomes more relevant. Protected attributes, such as gender, play an important role in PD diagnosis development. However, analysis of sub-group populations stemming from different genders is seldom taken into consideration in ML models' development or the performance assessment for PD detection. In this work, we perform a systema…
University of Canberra（堪培拉大学）；Kuwait College of Science and Technology（科威特科技学院）
While Parkinson's disease (PD) is typically characterized by motor disorder, there is evidence of diminished emotion perception in PD patients. This study examines the utility of affective Electroencephalography (EEG) signals to understand emotional differences between PD vs Healthy Controls (HC), and for automated PD detection. Employing traditional machine learning and deep learning methods, we explore (a) dimensional and categorical emotion recognition, and (b) PD vs HC classification from emotional EEG signals. Our results reveal that PD patients comprehend arousal better than valence, and…
This paper deals with the detection of mu-suppression from electroencephalographic (EEG) signals in brain-computer interface (BCI). For this purpose, an efficient algorithm is proposed based on a statistical model and a linear classifier. Precisely, the generalized extreme value distribution (GEV) is proposed to represent the power spectrum density of the EEG signal in the central motor cortex. The associated three parameters are estimated using the maximum likelihood method. Based on these parameters, a simple and efficient linear classifier was designed to classify three types of events: ima…
Objective. Consistently changing physiological properties in developing children's brains challenges new data heavy technologies, like brain-computer interfaces (BCI). Advancing signal processing methods in such technologies to be more sensitive to developmental changes could help improve their function and usability in paediatric populations. Taking advantage of the multi-dimensional structure of EEG data through tensor analysis offers a framework to extract relevant developmental features present in paediatric resting-state EEG datasets. Methods. Three paediatric datasets from varying develo…
EEG Right & Left Voluntary Hand Movement-based Virtual Brain-Computer Interfacing Keyboard Using Hybrid Deep Learning Approach
Nepal Engineering College（尼泊尔工程学院）；Pokhara University（博卡拉大学）；University of Delaware（特拉华大学）；Institute of Engineering Pulchowk Campus（工程学院普尔乔克校区）；Tribhuvan University（特里布文大学）；Nepal Research and Collaboration Center（尼泊尔研究与合作中心）
