来自选择性隔离的简单翻译后生物钟模型
Simple post-translational circadian clock models from selective sequestration
摘要：
在不同生物体的许多细胞类型中，可能存在翻译后昼夜节律振荡器，它们在没有负反馈转录抑制的情况下继续发挥作用。除了来自蓝藻的KaiABC系统之外，在不同细胞类型中产生体外（“试管”）昼夜节律振荡所需的分子组分和相互作用目前尚不清楚。受KaiABC系统的启发，我提供了“原理证明”数学模型，即具有2个（或更多个）修饰位点的蛋白质选择性地螯合效应子/辅因子分子可以起到昼夜节律计时器的作用。两个网站的机制可以实现使用两个相对简单的耦合非线性常微分方程的网站占用方面，该模型不需要过于特殊的微调参数产生稳定的极限环振荡。
英文摘要：
It is possible that there are post-translational circadian oscillators that continue functioning in the absence of negative feedback transcriptional repression in many cell types from diverse organisms. Apart from the KaiABC system from cyanobacteria, the molecular components and interactions required to create in-vitro ("test-tube") circadian oscillations in different cell types are currently unknown. Inspired by the KaiABC system, I provide "proof-of-principle" mathematical models that a protein with 2 (or more) modification sites which selectively sequesters an effector/cofactor molecule can function as a circadian time-keeper. The 2-site mechanism can be implemented using two relatively simple coupled non-linear ODEs in terms of site occupancy; the models do not require overly special fine-tuning of parameters for generating stable limit cycle oscillations.
机构、总结、中文摘要均由AI分析而来，可能存在错误，请以论文正文为准。
