Ostreococcus tauri生物钟对不同光周期光/暗周期的鲁棒和灵活响应
Robust and flexible response of Ostreococcus tauri circadian clock to light/dark cycles of varying photoperiod
摘要：
绿色显微镜下的金牛星链球菌（Ostreococcus tauri）最近成为一种很有前途的模型，可以用来了解生物钟如何在天气和季节变化的情况下与昼夜周期同步，生物钟驱动着许多生物体的日常生物节律。在这里，我们分析了翻译报告时间序列数据的中心时钟基因CCA 1和TOC 1为广泛的日光持续时间（光周期）。时间剖面随白天持续时间的变化是复杂的，两个演员跟踪一天中的不同时刻。然而，所有的配置文件准确地再现了一个简单的两个基因的转录环模型，其参数受光的影响，只有通过光周期值。我们表明，这种非直观的行为允许生物钟结合灵活性和鲁棒性日光波动。
英文摘要：
The green microscopic alga Ostreococcus tauri has recently emerged as a promising model for understanding how circadian clocks, which drive the daily biological rythms of many organisms, synchronize to the day/night cycle in changing weather and seasons. Here, we analyze translational reporter time series data of its central clock genes CCA1 and TOC1 for a wide range of daylight durations (photoperiods). The variation of temporal profiles with day duration is complex, with the two actors tracking different moments of the day. Nevertheless, all profiles are accurately reproduced by a simple two-gene transcriptional loop model whose parameters are affected by light only through the photoperiod value. We show that this non-intuitive behavior allows the circadian clock to combine flexibility and robustness to daylight fluctuations.
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