一个稳定的双基因振荡子在Ostreococcus tauri生物钟的核心
A robust two-gene oscillator at the core of Ostreococcus tauri circadian clock
摘要：
显微镜下可见的绿色微藻--特别地，Corellou等人[Plant Cell，21，3436（2009）]和Corellou等人[PLoS Comput. Biol.6，e1000990（2010）]强烈地表明其昼夜节律钟是拟南芥时钟的简化版本，并且其被构造为对自然日光波动具有鲁棒性。在这项工作中，我们分析了时间序列数据从发光报告的两个中心时钟基因TOC 1和CCA 1，并将它们与微阵列数据先前分析。我们的数学分析强烈支持存在一个简单的两个基因振荡器的核心Ostreococcus tauri时钟和事实，即其动态不受光在正常夹带条件下，其鲁棒性的签名。
英文摘要：
The microscopic green alga Ostreococcus tauri is rapidly emerging as a promising model organism in the green lineage. In particular, recent results by Corellou et al. [Plant Cell, 21, 3436 (2009)] and Thommen et al. [PLoS Comput. Biol. 6, e1000990 (2010)] strongly suggest that its circadian clock is a simplified version of Arabidopsis thaliana clock, and that it is architectured so as to be robust to natural daylight fluctuations. In this work, we analyze time series data from luminescent reporters for the two central clock genes TOC1 and CCA1 and correlate them with microarray data previously analyzed. Our mathematical analysis strongly supports both the existence of a simple two-gene oscillator at the core of Ostreococcus tauri clock and the fact that its dynamics is not affected by light in normal entrainment conditions, a signature of its robustness.
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