Meta Segmentation Network for Ultra-Resolution Medical Images
Fujian Key Laboratory of Sensing and Computing for Smart City, School of Informatics（智慧城市感知与计算福建省重点实验室、信息学院）；School of Computer Science and Technology, East China Normal University（华东师范大学计算机科学与技术学院）
Despite recent progress on semantic segmentation, there still exist huge challenges in medical ultra-resolution image segmentation. The methods based on multi-branch structure can make a good balance between computational burdens and segmentation accuracy. However, the fusion structure in these methods require to be designed elaborately to achieve desirable result, which leads to model redundancy. In this paper, we propose Meta Segmentation Network (MSN) to solve this challenging problem. With the help of meta-learning, the fusion module of MSN is quite simple but effective. MSN can fast generate the weights of fusion layers through a simple meta-learner, requiring only a few training samples and epochs to converge. In addition, to avoid learning all branches from scratch, we further introduce a particular weight sharing mechanism to realize a fast knowledge adaptation and share the weights among multiple branches, resulting in the performance improvement and significant parameters reduction. The experimental results on two challenging ultra-resolution medical datasets BACH and ISIC show that MSN achieves the best performance compared with the state-of-the-art methods.
Australian Institute for Machine Learning, The University of Adelaide（阿德莱德大学澳大利亚机器学习研究所）；Institute for Systems and Robotics, Instituto Superior Tecnico（高等技术学院系统与机器人研究所）
Meta-training has been empirically demonstrated to be the most effective pre-training method for few-shot learning of medical image classifiers (i.e., classifiers modeled with small training sets). However, the effectiveness of meta-training relies on the availability of a reasonable number of hand-designed classification tasks, which are costly to obtain, and consequently rarely available. In this paper, we propose a new method to unsupervisedly design a large number of classification tasks to meta-train medical image classifiers. We evaluate our method on a breast dynamically contrast enhanc…
IRIT UMR CNRS 5505（法国国家科学研究中心IRIT联合研究单元（UMR 5505））；University of Toulouse（图卢兹大学）
The interest of compressive sampling in ultrasound imaging has been recently extensively evaluated by several research teams. Following the different application setups, it has been shown that the RF data may be reconstructed from a small number of measurements and/or using a reduced number of ultrasound pulse emissions. Nevertheless, RF image spatial resolution, contrast and signal to noise ratio are affected by the limited bandwidth of the imaging transducer and the physical phenomenon related to US wave propagation. To overcome these limitations, several deconvolution-based image processing…
A Labeled Ophthalmic Ultrasound Dataset with Medical Report Generation Based on Cross-modal Deep Learning
School of Electrical and Control Engineering, North China University of Technology（北方工业大学电气与控制工程学院）；School of Automation and Electrical Engineering, Shenyang Ligong University（沈阳理工大学自动化与电气工程学院）；The Fourth Affiliated Hospital of China Medical University（中国医科大学附属第四医院）
Middle East Technical University（中东技术大学）；ASELSAN（阿瑟尔桑公司）；Selcuk University（塞尔丘克大学）
Computer vision systems recently made a big leap thanks to deep neural networks. However, these systems require correctly labeled large datasets in order to be trained properly, which is very difficult to obtain for medical applications. Two main reasons for label noise in medical applications are the high complexity of the data and conflicting opinions of experts. Moreover, medical imaging datasets are commonly tiny, which makes each data very important in learning. As a result, if not handled properly, label noise significantly degrades the performance. Therefore, a label-noise-robust learni…
Pre-training a recognition model with contrastive learning on a large dataset of unlabeled data has shown great potential to boost the performance of a downstream task, e.g., image classification. However, in domains such as medical imaging, collecting unlabeled data can be challenging and expensive. In this work, we propose to adapt contrastive learning to work with meta-label annotations, for improving the model's performance in medical image segmentation even when no additional unlabeled data is available. Meta-labels such as the location of a 2D slice in a 3D MRI scan or the type of device…
We propose a three-dimensional (3D) multimodal medical imaging system that combines freehand ultrasound and structured light 3D reconstruction in a single coordinate system without requiring registration. To the best of our knowledge, these techniques have not been combined before as a multimodal imaging technique. The system complements the internal 3D information acquired with ultrasound, with the external surface measured with the structure light technique. Moreover, the ultrasound probe's optical tracking for pose estimation was implemented based on a convolutional neural network. Experime…
Beamforming in ultrasound imaging has significant impact on the quality of the final image, controlling its resolution and contrast. Despite its low spatial resolution and contrast, delay-and-sum is still extensively used nowadays in clinical applications, due to its real-time capabilities. The most common alternatives are minimum variance method and its variants, which overcome the drawbacks of delay-and-sum, at the cost of higher computational complexity that limits its utilization in real-time applications. In this paper, we propose to perform beamforming in ultrasound imaging through a reg…
DGIST（大邱庆北科学技术院）；Yeungnam University College of Medicine（岭南大学医学院）；Yeungnam University Hospital（岭南大学医院）
Non-rigid registration is a necessary but challenging task in medical imaging studies. Recently, unsupervised registration models have shown good performance, but they often require a large-scale training dataset and long training times. Therefore, in real world application where only dozens to hundreds of image pairs are available, existing models cannot be practically used. To address these limitations, we propose a novel unsupervised registration model which is integrated with a gradient-based meta learning framework. In particular, we train a meta learner which finds an initialization poin…
Fudan University（复旦大学）；Shanghai Center for Brain Science and Brain-inspired Technology（上海脑科学与类脑研究中心）
The performance of medical image classification has been enhanced by deep convolutional neural networks (CNNs), which are typically trained with cross-entropy (CE) loss. However, when the label presents an intrinsic ordinal property in nature, e.g., the development from benign to malignant tumor, CE loss cannot take into account such ordinal information to allow for better generalization. To improve model generalization with ordinal information, we propose a novel meta ordinal regression forest (MORF) method for medical image classification with ordinal labels, which learns the ordinal relatio…
This study focuses on automatic skin cancer detection using a Meta-learning approach for dermoscopic images. The aim of this study is to explore the benefits of the generalization of the knowledge extracted from non-medical data in the classification performance of medical data and the impact of the distribution shift problem within limited data by using a simple class and distribution balancer algorithm. In this study, a small sample of a combined dataset from 3 different sources was used to fine-tune a ResNet model pre-trained on non-medical data. The results show an increase in performance …
Eindhoven University of Technology（埃因霍温理工大学）；Erasmus Medical Center（伊拉斯谟医学中心）；University Medical Center Utrecht（乌得勒支大学医学中心）
Supervised learning is ubiquitous in medical image analysis. In this paper we consider the problem of meta-learning -- predicting which methods will perform well in an unseen classification problem, given previous experience with other classification problems. We investigate the first step of such an approach: how to quantify the similarity of different classification problems. We characterize datasets sampled from six classification problems by performance ranks of simple classifiers, and define the similarity by the inverse of Euclidean distance in this meta-feature space. We visualize the s…
Few-shot medical image classification with simple shape and texture text descriptors using vision-language models
RIKEN Center for Brain Science（理化学研究所脑科学中心）；Institute of Fundamental Technological Research, Polish Academy of Sciences（波兰科学院基础技术研究所）；Faculty of Computer Science, Universitas Indonesia（印度尼西亚大学计算机学院）
MetaLR: Meta-tuning of Learning Rates for Transfer Learning in Medical Imaging
The Chinese University of Hong Kong (Shenzhen)（香港中文大学（深圳））；Shenzhen Research Institute of Big Data（深圳大数据研究院）；The Hong Kong University of Science and Technology (Guangzhou)（香港科技大学（广州））；Fudan University（复旦大学）；Johns Hopkins University（约翰斯·霍普金斯大学）
Video is an essential imaging modality for diagnostics, e.g. in ultrasound imaging, for endoscopy, or movement assessment. However, video hasn't received a lot of attention in the medical image analysis community. In the clinical practice, it is challenging to utilise raw diagnostic video data efficiently as video data takes a long time to process, annotate or audit. In this paper we introduce a novel, fully automatic video summarization method that is tailored to the needs of medical video data. Our approach is framed as reinforcement learning problem and produces agents focusing on the prese…
Deep learning models with large learning capacities often overfit to medical imaging datasets. This is because training sets are often relatively small due to the significant time and financial costs incurred in medical data acquisition and labelling. Data augmentation is therefore often used to expand the availability of training data and to increase generalization. However, augmentation strategies are often chosen on an ad-hoc basis without justification. In this paper, we present an augmentation policy search method with the goal of improving model classification performance. We include in …
This paper addresses the problem of high-resolution Doppler blood flow estimation from an ultrafast sequence of ultrasound images. Formulating the separation of clutter and blood components as an inverse problem has been shown in the literature to be a good alternative to spatio-temporal singular value decomposition (SVD)-based clutter filtering. In particular, a deconvolution step has recently been embedded in such a problem to mitigate the influence of the experimentally measured point spread function (PSF) of the imaging system. Deconvolution was shown in this context to improve the accurac…
Current medical image synthetic augmentation techniques rely on intensive use of generative adversarial networks (GANs). However, the nature of GAN architecture leads to heavy computational resources to produce synthetic images and the augmentation process requires multiple stages to complete. To address these challenges, we introduce a novel generative meta curriculum learning method that trains the task-specific model (student) end-to-end with only one additional teacher model. The teacher learns to generate curriculum to feed into the student model for data augmentation and guides the stude…
Tsinghua University（清华大学）；University of South Carolina（南卡罗来纳大学）；Shenzhen Hospital of Peking University（北京大学深圳医院）
Objective: Breast cancer screening is of great significance in contemporary women's health prevention. The existing machines embedded in the AI system do not reach the accuracy that clinicians hope. How to make intelligent systems more reliable is a common problem. Methods: 1) Ultrasound image super-resolution: the SRGAN super-resolution network reduces the unclearness of ultrasound images caused by the device itself and improves the accuracy and generalization of the detection model. 2) In response to the needs of medical images, we have improved the YOLOv4 and the CenterNet models. 3) Multi-…
Stanford University（斯坦福大学）；Harvard T.H. Chan School of Public Health（哈佛陈曾熙公共卫生学院）
We propose a selective learning method using meta-learning and deep reinforcement learning for medical image interpretation in the setting of limited labeling resources. Our method, MedSelect, consists of a trainable deep learning selector that uses image embeddings obtained from contrastive pretraining for determining which images to label, and a non-parametric selector that uses cosine similarity to classify unseen images. We demonstrate that MedSelect learns an effective selection strategy outperforming baseline selection strategies across seen and unseen medical conditions for chest X-ray …
The Efficacy of Semantics-Preserving Transformations in Self-Supervised Learning for Medical Ultrasound
Cheriton School of Computer Science, University of Waterloo（滑铁卢大学计算机科学学院）；Department of Systems Design Engineering, University of Waterloo（滑铁卢大学系统设计工程系）；Schulich School of Medicine and Dentistry, Western University（西部大学施乐希医学与牙科学校）
The Chinese University of Hong Kong (Shenzhen)（香港中文大学（深圳））；Institute of Information Engineering, Chinese Academy of Sciences（中国科学院信息工程研究所）；Shenzhen Research Institute of Big Data（深圳大数据研究院）
Well-annotated medical datasets enable deep neural networks (DNNs) to gain strong power in extracting lesion-related features. Building such large and well-designed medical datasets is costly due to the need for high-level expertise. Model pre-training based on ImageNet is a common practice to gain better generalization when the data amount is limited. However, it suffers from the domain gap between natural and medical images. In this work, we pre-train DNNs on ultrasound (US) domains instead of ImageNet to reduce the domain gap in medical US applications. To learn US image representations bas…
Vision Models for Medical Imaging: A Hybrid Approach for PCOS Detection from Ultrasound Scans
Department of CSE, CCN University of Science & Technology（计算机科学与工程系，CCN科学与技术大学）；Department of EEE,International Islamic University Chittagong（电子工程系，国际伊斯兰大学恰tagong分校）；Faculty of Engineering, Multimedia University（工程学院，多媒体大学）；Department of CSE, Stamford University of Bangladesh（计算机科学与工程系，斯塔福德大学孟加拉国分校）；Department of Biology, Lucknow University（生物学系，拉胡尔大学）；Department of CSE, Bangladesh Army International University of Science & Technology（计算机科学与工程系，孟加拉国军队国际科学与技术大学）
Boosting Few-Shot Learning with Disentangled Self-Supervised Learning and Meta-Learning for Medical Image Classification
Institute of Information Science and Technologies, National Research Council（国家研究委员会信息科学与技术研究所）；Department of Information Engineering, University of Pisa（比萨大学信息工程系）；School of Engineering, University of Edinburgh（爱丁堡大学工程学院）
Optimization of Convolutional Neural Network Hyperparameter for Medical Image Diagnosis using Metaheuristic Algorithms: A short Recent Review (2019-2022)
Universiti Sains Malaysia（马来西亚理科大学）；King Fahd University of Petroleum and Minerals（法赫德国王石油与矿业大学）；University of Information Technology and Communications（信息技术与通信大学）
In this paper, we propose a novel approach for few-shot semantic segmentation with sparse labeled images. We investigate the effectiveness of our method, which is based on the Model-Agnostic Meta-Learning (MAML) algorithm, in the medical scenario, where the use of sparse labeling and few-shot can alleviate the cost of producing new annotated datasets. Our method uses sparse labels in the meta-training and dense labels in the meta-test, thus making the model learn to predict dense labels from sparse ones. We conducted experiments with four Chest X-Ray datasets to evaluate two types of annotatio…
A Systematic Review of Few-Shot Learning in Medical Imaging
Institute of Information Science and Technologies “Alessandro Faedo”, National Research Council of Italy (ISTI-CNR)（意大利国家研究委员会信息科学与技术研究所）；Department of Information Engineering, University of Pisa（比萨大学信息工程系）
University of Arkansas（阿肯色大学）；VNUHCM-University of Science（越南胡志明市国家大学科学大学）
Deep learning methods have been successful in solving tasks in machine learning and have made breakthroughs in many sectors owing to their ability to automatically extract features from unstructured data. However, their performance relies on manual trial-and-error processes for selecting an appropriate network architecture, hyperparameters for training, and pre-/post-procedures. Even though it has been shown that network architecture plays a critical role in learning feature representation feature from data and the final performance, searching for the best network architecture is computational…
Variable-frame CNNLSTM for Breast Nodule Classification using Ultrasound Videos
Beijing Normal University（北京师范大学）；Xi’an Jiaotong University（西安交通大学）；The First Affiliated Hospital of Xi’an Jiaotong University（西安交通大学第一附属医院）；Xiangya Hospital, Central South University（中南大学湘雅医院）；Frontline Intelligent Technology (Nanjing) Co., Ltd.（南京前沿智能科技有限公司）；The Second Hospital of Hebei Medical University（河北医科大学第二医院）
Recent advances in deep learning have achieved promising performance for medical image analysis, while in most cases ground-truth annotations from human experts are necessary to train the deep model. In practice, such annotations are expensive to collect and can be scarce for medical imaging applications. Therefore, there is significant interest in learning representations from unlabelled raw data. In this paper, we propose a self-supervised learning approach to learn meaningful and transferable representations from medical imaging video without any type of human annotation. We assume that in …
Comprehensive Review of Reinforcement Learning for Medical Ultrasound Imaging
Concordia University（康考迪亚大学）；Ecole de Technologie Superieure (ETS)（高等技术学院）；Laval University（拉瓦尔大学）；Khalifa University（哈利法大学）；Lebanese American University（黎巴嫩美国大学）
Deep learning models perform best when tested on target (test) data domains whose distribution is similar to the set of source (train) domains. However, model generalization can be hindered when there is significant difference in the underlying statistics between the target and source domains. In this work, we adapt a domain generalization method based on a model-agnostic meta-learning framework to biomedical imaging. The method learns a domain-agnostic feature representation to improve generalization of models to the unseen test distribution. The method can be used for any imaging task, as it…
CONNECT-AI Research Center, Yonsei University College of Medicine（延世大学医学院CONNECT-AI研究中心）；Gordon Center for Medical Imaging, Massachusetts General Hospital（麻省总医院戈登医学影像中心）；Harvard Medical School（哈佛医学院）
Medical imaging, including MRI, CT, and Ultrasound, plays a vital role in clinical decisions. Accurate segmentation is essential to measure the structure of interest from the image. However, manual segmentation is highly operator-dependent, which leads to high inter and intra-variability of quantitative measurements. In this paper, we explore the feasibility that Bayesian predictive distribution parameterized by deep neural networks can capture the clinicians' inter-intra variability. By exploring and analyzing recently emerged approximate inference schemes, we evaluate whether approximate Bay…
University of Oxford（牛津大学）；Tel-Aviv University（特拉维夫大学）
Self-supervised contrastive representation learning offers the advantage of learning meaningful visual representations from unlabeled medical datasets for transfer learning. However, applying current contrastive learning approaches to medical data without considering its domain-specific anatomical characteristics may lead to visual representations that are inconsistent in appearance and semantics. In this paper, we propose to improve visual representations of medical images via anatomy-aware contrastive learning (AWCL), which incorporates anatomy information to augment the positive/negative pa…
Xiamen University（厦门大学）；Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences（中国科学院深圳先进技术研究院）；Deepwise AI Laboratory（深睿医疗人工智能实验室）
Medical imaging datasets usually exhibit domain shift due to the variations of scanner vendors, imaging protocols, etc. This raises the concern about the generalization capacity of machine learning models. Domain generalization (DG), which aims to learn a model from multiple source domains such that it can be directly generalized to unseen test domains, seems particularly promising to medical imaging community. To address DG, recent model-agnostic meta-learning (MAML) has been introduced, which transfers the knowledge from previous training tasks to facilitate the learning of novel testing tas…
Massachusetts General Hospital（麻省总医院）；Massachusetts Institute of Technology（麻省理工学院）
Modern deep learning algorithms geared towards clinical adaption rely on a significant amount of high fidelity labeled data. Low-resource settings pose challenges like acquiring high fidelity data and becomes the bottleneck for developing artificial intelligence applications. Ultrasound images, stored in Digital Imaging and Communication in Medicine (DICOM) format, have additional metadata data corresponding to ultrasound image parameters and medical exams. In this work, we leverage DICOM metadata from ultrasound images to help learn representations of the ultrasound image. We demonstrate that…
University of California, San Diego（加利福尼亚大学圣地亚哥分校）；Institute of Fundamental Technological Research, Polish Academy of Sciences（波兰科学院基础技术研究所）；Polish-Japanese Academy of Information Technology（波兰-日本信息技术学院）；The Maria Skłodowska-Curie Memorial Cancer Centre and Institute of Oncology（玛丽·斯克洛多夫斯卡-居里纪念癌症中心和肿瘤研究所）
Deep learning algorithms, especially convolutional neural networks, have become a methodology of choice in medical image analysis. However, recent studies in computer vision show that even a small modification of input image intensities may cause a deep learning model to classify the image differently. In medical imaging, the distribution of image intensities is related to applied image reconstruction algorithm. In this paper we investigate the impact of ultrasound image reconstruction method on breast lesion classification with neural transfer learning. Due to high dynamic range raw ultrasoni…
Stanford University（斯坦福大学）；School of Medicine, Stanford University（斯坦福大学医学院）
Self-supervised contrastive learning between pairs of multiple views of the same image has been shown to successfully leverage unlabeled data to produce meaningful visual representations for both natural and medical images. However, there has been limited work on determining how to select pairs for medical images, where availability of patient metadata can be leveraged to improve representations. In this work, we develop a method to select positive pairs coming from views of possibly different images through the use of patient metadata. We compare strategies for selecting positive pairs for ch…
Medical Image Deidentification, Cleaning and Compression Using Pylogik
Northwestern University（西北大学）；Northwestern University Feinberg School of Medicine（西北大学范伯格医学院）；Northwestern Memorial Hospital（西北纪念医院）；The University of Queensland（昆士兰大学）
In this work we examine the performance enhancement in classification of medical imaging data when image features are combined with associated non-image data. We compare the performance of eight state-of-the-art deep neural networks in classification tasks when using only image features, compared to when these are combined with patient metadata. We utilise transfer learning with networks pretrained on ImageNet used directly as feature extractors and fine tuned on the target domain. Our experiments show that performance can be significantly enhanced with the inclusion of metadata and use interp…
Transfer learning is an important step to extract meaningful features and overcome the data limitation in the medical Visual Question Answering (VQA) task. However, most of the existing medical VQA methods rely on external data for transfer learning, while the meta-data within the dataset is not fully utilized. In this paper, we present a new multiple meta-model quantifying method that effectively learns meta-annotation and leverages meaningful features to the medical VQA task. Our proposed method is designed to increase meta-data by auto-annotation, deal with noisy labels, and output meta-mod…
