Continuous Glucose Monitoring (CGM) has enabled important opportunities for diabetes management. This study explores the use of CGM data as input for digital decision support tools. We investigate how Recurrent Neural Networks (RNNs) can be used for Short Term Blood Glucose (STBG) prediction and compare the RNNs to conventional time-series forecasting using Autoregressive Integrated Moving Average (ARIMA). A prediction horizon up to 90 min into the future is considered. In this context, we evaluate both population-based and patient-specific RNNs and contrast them to patient-specific ARIMA models and a simple baseline predicting future observations as the last observed. We find that the population-based RNN model is the best performing model across the considered prediction horizons without the need of patient-specific data. This demonstrates the potential of RNNs for STBG prediction in diabetes patients towards detecting/mitigating severe events in the STBG, in particular hypoglycemic events. However, further studies are needed in regards to the robustness and practical use of the investigated STBG prediction models.
In many forecasting applications, it is valuable to predict not only the value of a signal at a certain time point in the future, but also the values leading up to that point. This is especially true in clinical applications, where the future state of the patient can be less important than the patient's overall trajectory. This requires multi-step forecasting, a forecasting variant where one aims to predict multiple values in the future simultaneously. Standard methods to accomplish this can propagate error from prediction to prediction, reducing quality over the long term. In light of these c…
Institute for Basic Science (IBS)（基础科学研究院）；Seoul National University（首尔大学）；Pohang University of Science and Technology（浦项科技大学）
Machine learning shows remarkable success for recognizing patterns in data. Here we apply the machine learning (ML) for the diagnosis of early stage diabetes, which is known as a challenging task in medicine. Blood glucose levels are tightly regulated by two counter-regulatory hormones, insulin and glucagon, and the failure of the glucose homeostasis leads to the common metabolic disease, diabetes mellitus. It is a chronic disease that has a long latent period the complicates detection of the disease at an early stage. The vast majority of diabetics result from that diminished effectiveness of…
GlyRAG: Context-Aware Retrieval-Augmented Framework for Blood Glucose Forecasting
College of Health Solutions, Arizona State University（亚利桑那州立大学健康解决方案学院）；School of Computing and Augmented Intelligence, Arizona State University（亚利桑那州立大学计算与增强智能学院）
AI procedures joined with wearable gadgets can convey exact transient blood glucose level forecast models. Also, such models can learn customized glucose-insulin elements dependent on the sensor information gathered by observing a few parts of the physiological condition and every day movement of a person. Up to this point, the predominant methodology for creating information driven forecast models was to gather "however much information as could be expected" to help doctors and patients ideally change treatment. The goal of this work was to examine the base information assortment, volume, and…
Ohio University（俄亥俄大学）；University of North Carolina at Charlotte（北卡罗来纳大学夏洛特分校）
To avoid serious diabetic complications, people with type 1 diabetes must keep their blood glucose levels (BGLs) as close to normal as possible. Insulin dosages and carbohydrate consumption are important considerations in managing BGLs. Since the 1960s, models have been developed to forecast blood glucose levels based on the history of BGLs, insulin dosages, carbohydrate intake, and other physiological and lifestyle factors. Such predictions can be used to alert people of impending unsafe BGLs or to control insulin flow in an artificial pancreas. In past work, we have introduced an LSTM-based …
This work proposes a smartphone video-based approach for the estimation of blood glucose in a non-invasive way. Videos using smartphone camera are collected from the tip of the subjects finger and the frames are subsequently converted into Photoplethysmography (PPG) waveform. Gaussian filter along with Asymmetric Least Square methods have been applied on the PPG signals to remove the high-frequency noise, optical and motion interferences. Different signal features such as Systolic and Diastolic Peaks, the time difference between consecutive peaks (DelT), First Derivative peaks, and Second deri…
To best of the authors knowledge, this article presents the first-ever non-invasive glucometer that takes into account serum glucose for high accuracy. In case of blood glucose measurement, serum glucose value has always been considered precise blood glucose value during prandial modes. Serum glucose can be measured in laboratory and more stable glucose level compare to capillary glucose. However, this invasive approach is not convenient for frequent measurement. Sometimes, Conventional invasive blood glucose measurement may be responsible for cause of trauma and chance of blood related infect…
In the case of diabetes, fingertip pricking for a blood sample is inconvenient for glucose measurement. Invasive approaches like laboratory test and one-touch glucometer enhance the risk of blood-related infections. To mitigate this important issue, in the current paper, we propose a novel Internet-of-Medical-Things (IoMT) enabled edge-device for precise, non-invasive blood glucose measurement. In this work, a near-infrared (NIR) spectroscopic technique using two wavelengths (940 nm, 1300 nm) is taken to detect the glucose molecule from human blood. The novel device called iGLU is based on NIR…
There has been a recent tremendous interest in label-free detection of biomarkers which is a critical enabler of point-of-need diagnostics. A low-power, small form factor, multiplexed wearable system is proposed for continuous detection of glucose in passively expressed sweat using electrochemical impedance spectroscopy (EIS) measurement. The wearable EIS system consists of a sensing analog front end integrated with low-volume (1-5 $μ$L) ultra-sensitive flexible biosensors. A passive sweat sensor was designed to integrate a glucose oxidase electrochemical system on active semiconducting materi…
Microwave sensors are very promising for sensing the blood glucose levels non-invasively for their non-ionizing nature, miniaturized sizing, and low health risks for diabetics. All these features offer the possibility for realizing a portable non-invasive glucose sensor for monitoring glucose levels in real time. In this article, we propose a triple poles complementary split ring resonator (CSRR) produced on a FR4 substrate in microstrip technology in the cm-wave band (1-6 GHz). The proposed bio-sensor can detect the small variations in the dielectric properties (relative permittivity and diel…
In this work, we present the Senbiosys blood pressure monitoring algorithm (SB-BPM) that solely requires a photoplethysmography (PPG) signal. The technology is based on pulse wave analysis (PWA) of PPG signals retrieved from different body locations to continuously estimate the systolic blood pressure (SBP) and the diastolic blood pressure (DBP).
Institute for Maternal and Child Health – IRCCS, Burlo Garofolo（布罗·加罗福洛妇幼健康研究所（IRCCS））；Department of Engineering and Architecture at the University of Trieste（的里雅斯特大学工程与建筑系）；Department of Medicine, Surgery and Health Sciences at the University of Trieste（的里雅斯特大学医学、外科学与健康科学系）
The accurate measurement of blood pressure (BP) is an important prerequisite for the reliable diagnosis and efficient management of hypertension and other medical conditions. Office Blood Pressure Measurement (OBP) is a technique performed in-office with the sphygmomanometer, while Ambulatory Blood Pressure Monitoring (ABPM) is a technique that measures blood pressure during 24h. The BP fluctuations also depend on other factors such as physical activity, temperature, mood, age, sex, any pathologies, a hormonal activity that may intrinsically influence the differences between OBP and ABPM. The …
Imperial College London（伦敦帝国学院）；University College London（伦敦大学学院）
People with Type 1 diabetes (T1D) require regular exogenous infusion of insulin to maintain their blood glucose concentration in a therapeutically adequate target range. Although the artificial pancreas and continuous glucose monitoring have been proven to be effective in achieving closed-loop control, significant challenges still remain due to the high complexity of glucose dynamics and limitations in the technology. In this work, we propose a novel deep reinforcement learning model for single-hormone (insulin) and dual-hormone (insulin and glucagon) delivery. In particular, the delivery stra…
Photoplethysmogram (PPG) signal-based blood pressure (BP) estimation is a promising candidate for modern BP measurements, as PPG signals can be easily obtained from wearable devices in a non-invasive manner, allowing quick BP measurement. However, the performance of existing machine learning-based BP measuring methods still fall behind some BP measurement guidelines and most of them provide only point estimates of systolic blood pressure (SBP) and diastolic blood pressure (DBP). In this paper, we present a cutting-edge method which is capable of continuously monitoring BP from the PPG signal a…
